Kevin J. Tracey, MD is president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of the recent book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes. This episode is brought to you by: Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (Use code TIM to get $350 off your very own Pod 5 Ultra.) AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.) Wealthfront high-yield cash account: https://Wealthfront.com/Tim New clients get 3.30% base APY from program banks + additional 0.75% boost for 3 months on your uninvested cash (max $150k balance). Terms and conditions apply. The Cash Account offered by Wealthfront Brokerage LLC (“WFB”) member FINRA/SIPC, not a bank. The base APY as of 1/30/26 is representative, can change, and requires no minimum. Tim Ferriss, a non-client, receives compensation from WFB for advertising and holds a non-controlling equity interest in the corporate parent of WFB, which creates a conflict of interest. Individual experiences and outcomes will differ. Instant withdrawals may be limited by your receiving firm and other factors. Investment advisory services provided by Wealthfront Advisers LLC, an SEC-registered investment adviser. Securities investments: not bank deposits, not bank-guaranteed or FDIC-insured, and may lose value. Timestamps: 00:00 Tim’s intro: why he dismissed vagus-nerve hype 06:34 What the vagus nerve actually is, plus common myths 11:31 Breaking news: FDA approval for SetPoint’s RA implant + Kelly Owens’s turnaround 21:11 Inflammation 101: when healing turns harmful 31:37 Bioelectronic medicine: from lab insight to real devices 55:26 TNF, IL-1, and IL-6: immune drivers and what VNS modulates 56:06 Exercise & recovery: vagal signals, IL-6, and adaptation 56:30 Cold exposure & breathwork: sympathetic spike, parasympathetic payoff 59:04 Chronic inflammation today: prevalence, diagnostics, and uncertainty 59:53 Autoimmunity: genes, environment, infections 01:01:08 Stress hormones, personality traits, and metabolic fallout 01:05:41 VNS tech landscape: implants, focused ultrasound, and what’s just TENS 01:11:14 Ear maps, revisited: the real science behind auricular stimulation 01:27:52 Ulf Andersson: auricular TENS, famotidine, and a depression turnaround 01:36:48 Depression & inflammation: where VNS helps (and where it doesn’t) 01:41:38 Body-brain loop: how inflammation signals ride the vagus nerve 01:42:56 Why VNS can lift mood: a working theory 01:43:22 Ulf’s setup: electrode placement and twice-daily routine 01:44:37 Acupuncture, fertility, and plausible vagal links 01:47:23 Chronic pain through an inflammation lens 01:48:34 Neural “engrams”: how the brain can store inflammatory memories 02:02:35 Cervical TENS vs. true VNS: mechanisms and open questions 02:12:15 On stage with the Dalai Lama: blue energy and two vagus nerves 02:16:55 Closing thoughts: self-care vs. medical devices, and what’s next * For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast. For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday. For transcripts of episodes, go to tim.blog/transcripts. Discover Tim’s books: tim.blog/books. Follow Tim: Twitter: twitter.com/tferriss Instagram: instagram.com/timferriss YouTube: youtube.com/timferriss Facebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferriss Past guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
