Stress, anxiety, trauma, poor sleep, burnout. These aren’t edge cases anymore. They’re the operating system most people are running on. In this episode, I sit down with Jim Poole, CEO of NuCalm, for one of the most illuminating conversations I’ve had about the brain, stress, and performance. Jim has spent the last 17 years pioneering a field most people have never heard of but desperately need to understand: applied neuropsychobiology, or how the brain actually regulates stress, fear, sleep, and focus. Jim shares his personal background, from growing up with two psychotherapist parents and moving 14 times before graduating high school, to working in private equity and mental health institutions, to ultimately finding his life’s work through NuCalm. He explains why stress is responsible for 95–99% of disease, why our nervous systems are stuck in survival mode, and why most people don’t fail because of mindset, but because of physiology. This conversation breaks down complex neuroscience in a way that finally makes sense. We talk about the amygdala, oxygen, brainwave frequency, sleep architecture, trauma, and why mindfulness works when it works—and why it often doesn’t. If you’ve ever felt like you’re doing “all the right things” but still living in stress, exhaustion, or fight-or-flight, this episode will change how you understand your brain and what’s actually within your control. What We Talked About: Bullets: Why chronic stress is at an all-time high and how the nervous system is wired for survival, not modern lifeThe role of the amygdala, oxygen-rich blood, and brainwave frequency in stress, anxiety, focus, and sleepWhy mindfulness works physiologically, not philosophically, and why most people struggle to practice itHow trauma and prolonged stress trap the brain in high-frequency survival statesThe science behind NuCalm and how it guides the brain into specific states like deep sleep, focus, creativity, and recoveryWhy sleep is non-negotiable for health, performance, and longevityHow entrepreneurs and high performers can self-regulate without burnout 3️⃣ ⏱ TimestampsThese come after the bullets. Timestamps: 00:00 Introduction to Jim Poole and NuCalm04:49 Jim Poole's Background and Early Influences08:14 The Journey to NuCalm and Its Impact11:38 Dr. Blake Holloway's Story and Motivation15:08 The Entrepreneurial Partnership Between Jim and Blake20:41 Understanding Stress, Trauma, and the Nervous System27:58 Understanding Our Shared Human Experience30:20 The Battle for Brain Resources32:11 The Importance of Mindfulness and Oxygenli...
