The Incubator

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14. Mai
Kindererziehung

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28. Mai
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3. Juni

vor 1 Tag

#450 - [Journal Club] - 🫀From The Heart - When Nitric Oxide Fails: Is the Left Ventricle the Culprit in Septic Preterm Infants?

In this retrospective single-center study from Toronto, Adrianne and Nim explore the echo findings of preterm infants with septic shock and hypoxemic respiratory failure. Contrary to the common assumption that elevated pulmonary vascular resistance drives hypoxemia in sepsis, the data points to left ventricular dysfunction as a key contributor. Babies with hypoxemic respiratory failure showed lower LV systolic and diastolic performance, while pulmonary pressures were similar between groups. Mortality was significantly higher in the hypoxemic group. This challenges the reflex to reach for nitric oxide first and asks clinicians to look at the whole heart. ---- Cardiopulmonary Physiology of Hypoxemic Respiratory Failure Among Preterm Infants with Septic Shock. Kharrat A, Nissimov S, Zhu F, Deshpande P, Jain A.J Pediatr. 2025 Mar;278:114384. doi: 10.1016/j.jpeds.2024.114384. Epub 2024 Nov 6.PMID: 39510164 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

vor 1 Tag

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22 Min.
20.06.2023 • Nur Abonnent:innen

#176 - Infectious Disease - CMV, toxoplasmosis

To learn more and have access to show notes and articles mentioned in this episode, go to www.the-incubator.org/review Please subscribe to the podcast for access to daily episodes. If you have any questions feel free to email the show at nicupodcast@gmail.com You can also contact Ben and Daphna directly via their twitter profiles: @drnicu and @doctordaphnamd.

20.06.2023

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29 Min.
9. Juni

#447 - [Journal Club] - 📌 Are we missing UTIs in neonates hospitalized for unexplained jaundice?

In this Journal Club episode, Daphna reviews a retrospective cohort study from Istanbul examining clinical, laboratory, and ultrasound factors associated with UTI in neonates hospitalized for unexplained hyperbilirubinemia. Among 96 term and near-term infants, 31% had culture-proven UTIs, a striking prevalence. Pathological renal ultrasound findings were independently associated with UTI, with affected neonates 4.6 times more likely to have a concurrent infection. Notably, standard laboratory markers including CRP and white blood cell count failed to distinguish UTI-positive from UTI-negative infants. The findings prompt a practical question: should urine culture be part of the routine workup for neonatal hyperbilirubinemia? ---- Renal ultrasonography findings are associated with urinary tract infection in neonates with asymptomatic hyperbilirubinemia. Sarı EE, Salihoğlu Ö.J Perinatol. 2026 Apr 13. doi: 10.1038/s41372-026-02686-x. Online ahead of print.PMID: 41975209 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

9. Juni

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15 Min.
25.03.2022 • Nur Abonnent:innen

#065 - Metabolic - pyruvate carboxylase def, lipidoses, mitochondrial disorders, and carbohydrate disorders.

In this episode we review questions 1, 4, 5, 18 and 19 from the Metabolic of Teaching section of the Neonatology Review Q&A book (3rd edition). Please subscribe to the podcast for access to daily episodes, and tips/strategies from Dr. Brodsky and Dr. Martin. If you have any questions feel free to email the show at nicupodcast@gmail.com You can also contact Ben and Daphna directly via their twitter profiles: @drnicu and @doctordaphnamd. You can purchase copies of Neonatology books by following this link: https://www.lulu.com/spotlight/neonatologyreview

25.03.2022

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34 Min.
16. Juni

#060 - Que deviennent nos grands prématurés à long terme ?

Dans cet épisode de L'Incubateur Néonat, Ben et Gabriel reçoivent la Dre Thuy Mai Luu, pédiatre et directrice médicale du programme de suivi néonatal au CHU Sainte-Justine, ainsi que directrice du Canadian Neonatal Follow-Up Network (CNFUN). La discussion explore le modèle de suivi neurodéveloppemental des grands prématurés au Canada, de la clinique spécialisée multidisciplinaire jusqu'à l'entrée à l'école, et les défis liés aux distances géographiques et aux ressources inégales. La Dre Luu aborde également les limites de l'évaluation à deux ans d'âge corrigé comme seul marqueur d'outcome, l'importance d'intégrer la perspective des parents et le fonctionnement quotidien de l'enfant dans nos mesures de recherche, et la nécessité de ne pas mettre dans le même panier des atteintes qui n'ont pas la même valeur clinique ni la même signification pour les familles. L'épisode se termine sur le programme HAPI (Health of Adults Born Preterm), qui documente l'impact de la prématurité sur la santé cardiovasculaire, rénale et métabolique des adultes nés prématurément, et ouvre une réflexion sur ce que la néonatologie peut faire dès aujourd'hui pour changer leur trajectoire de santé à long terme. Comme d'habitude, n'hésitez pas à nous envoyer vos questions, commentaires ou suggestions à notre courriel : nicupodcast@gmail.com. Vous pouvez également contacter l'émission via Instagram ou Twitter, @nicupodcast Ou contactez Ben et Gabriel directement via leurs profils Twitter : @drnicu et @CardioNeo. Les documents discutés dans l'épisode d'aujourd'hui sont listés et horodatés sur la page web liée ci-dessous. Bonne lecture ! _____________________________________________________________________________________ Les notes de l'émission, les articles et le formulaire de FMC sont disponibles sur notre site Web : www.lincubateur.org

16. Juni

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43 Min.
13. Apr.

#434 - [Journal Club] - 📌 AAP update on therapeutic hypothermia for neonates with HIE

In this Journal Club episode, Ben and Daphna dive into the American Academy of Pediatrics' February Clinical Report on Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy. Daphna, who presented this paper at the Florida Neonatal Neurologic Network, walks us through the key action statements — from the established 33.5°C target temperature to the more nuanced discussions around late cooling (6–24 hours), gestational age eligibility at 35 weeks, and the controversial question of cooling mild HIE. They also cover optimal MRI timing post-rewarming, continuous EEG monitoring, early enteral feeds during cooling, and the growing evidence supporting the "cool cuddle." A must-listen for anyone navigating the evolving landscape of HIE management! ---- Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: Clinical Report. Zanelli SA, Wusthoff CJ, Lucke AM, Kaufman DA; Committee on Fetus and Newborn; Section on Neurology.Pediatrics. 2026 Feb 1;157(2):e2025073627. doi: 10.1542/peds.2025-073627.PMID: 41581784 Review. Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

13. Apr.

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32 Min.
10. Juni

#447 - [Journal Club] - 📌 Does Extended CPAP Reduce Intermittent Hypoxemia in Stable Preterm Infants?

What happens to intermittent hypoxemia when you keep a stable preterm infant on CPAP for two extra weeks? In this Journal Club episode, Ben and Daphna review a secondary analysis from the Journal of Pediatrics by Mamidi and McEvoy. Among 95 infants randomized to either two additional weeks of bubble CPAP on room air or discontinued CPAP, those in the extended CPAP group experienced significantly fewer intermittent hypoxemia episodes (57.6 versus 151.7), higher baseline saturations, and greater functional residual capacity. The episode also touches on the practical implications for units navigating oral feeding protocols alongside extended CPAP. ---- Extended Continuous Positive Airway Pressure in Infants Born Preterm Decreases Intermittent Hypoxemia: A Secondary Analysis of a Randomized Controlled Trial. Mamidi RR, Go MDA, Harris J, Olson M, Milner K, Tepper RS, Morris C, Park B, Schelonka R, MacDonald KD, McEvoy CT.J Pediatr. 2026 May 25:115165. doi: 10.1016/j.jpeds.2026.115165. Online ahead of print.PMID: 42190903 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

10. Juni

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18 Min.
11. Juni

#447 - [Journal Club] - 📌 Is a Five-Day Antibiotic Course Enough to Treat UTIs in the NICU?

Is five days of antibiotics enough to treat a urinary tract infection in a NICU infant? In this Journal Club episode, Ben and Daphna review a single-center study from Nationwide Children's Hospital examining adherence and safety of a five-day antibiotic treatment guideline for culture and urinalysis-proven UTIs in the NICU. Among 77 infants with 93 bacterial UTIs, the five-day course was associated with a 1% failure rate, defined as reinitiation of antibiotics within seven days for the same organism. The episode also explores the potential role of enteral antibiotic therapy and what shorter treatment courses could mean for babies still weeks away from discharge. ---- Urinary tract infection in the neonatal intensive care unit. Magers J, Burton A, Prusakov P, White NO, Miller RR, Moraille R, Theile AR, Sánchez PJ; Nationwide Children’s Hospital Neonatal Antimicrobial Stewardship Program (NEO-ASP).J Perinatol. 2026 May;46(5):754-760. doi: 10.1038/s41372-026-02690-1. Epub 2026 Apr 29.PMID: 42056240 Free PMC article. Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

11. Juni

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22 Min.
29. Mai

#445 - [Journal Club] - 📌 Can symptom-based dosing cut hospitalization time for babies with neonatal opioid withdrawal syndrome?

One infant is diagnosed with neonatal opioid withdrawal syndrome every 27 minutes, and rates are rising. In this episode of Journal Club, Ben and Daphna review the Optimized NOW randomized clinical trial, a landmark multicenter study published in JAMA. The trial compared symptom-based dosing, a single opioid dose given when a withdrawal threshold is met against the traditional scheduled opioid taper in infants managed with Eat Sleep Console. The results are striking: symptom-based dosing reduced time to medical readiness for discharge by nearly two and a half days, and 65% of pharmacologically treated infants avoided scheduled opioid dosing entirely. Could this be the evidence-based approach that finally reshapes how we treat NOWS pharmacologically? ---- Symptom-Based Dosing for Neonatal Opioid Withdrawal: The OPTimize NOW Randomized Clinical Trial. Devlin LA et al HEAL Evaluation of Limited Pharmacotherapies for Neonatal Opioid Withdrawal Syndrome (HELP for NOWS) Consortium.JAMA. 2026 Apr 25:e265782. doi: 10.1001/jama.2026.5782. Online ahead of print. PMID: 42033722 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

29. Mai

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24 Min.
17. Juni

#028 - Can a Dual Career Couple Build One Lab and Two Careers?

What happens when a scientist and a clinician scientist build a lab together, and an entire career, around the same disease? On this episode of At the Bench, Misty Good and Ben Fensterheim sit down with Professors Claudia and Marcel Nold, a husband and wife team running their lab at Monash University and the Hudson Institute. They trace their path from Charles Dinarello's cytokine lab in Denver to Melbourne, where they built a research program on IL-1 biology in bronchopulmonary dysplasia and necrotizing enterocolitis. They discuss the long road from preclinical models to their first anakinra clinical trial, the realities of running a dual career lab, and what it takes to keep going when experiments do not go your way.

17. Juni

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54 Min.

Ben and Daphna go through daily neonatal board questions. If you are studying for the upcoming neonatal boards exam or just want to keep your neonatal knowledge sharp, this is the podcast for you. This show is done in collaboration with Neonatology Review (Dr. Dara Brodsky and Dr. Camilia Martin).

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The neonatology focused podcast hosted by Dr. Ben Courchia MD & Dr. Daphna Yasova Barbeau.

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