Longevity.Technology UNLOCKED

Longevity.Technology

Longevity.Technology UNLOCKED brings together science, business, and human potential to explore the frontier of longer, healthier living. 🎙 Mondays: In-depth conversations with scientists, founders, investors, operators, and elite performers shaping the longevity ecosystem. 🧠 Fridays: A sharp weekly round-up of the biggest stories, trends, and insights from across the longevity space. If you’re curious about the future of health, performance, and lifespan, this is where it gets UNLOCKED.

  1. 4 days ago

    The Longevity Tests That Actually Matter

    Hosts: Phil Newman: ⁠qrco.de/bgXpNY⁠ Nina Patrick: ⁠⁠⁠qrco.de/bgXpKn⁠ ---------- Sponsor: YEARS YEARS is a physician-led longevity clinic in Berlin that takes a proactive approach to health. Combining advanced diagnostics, biomarkers, imaging, and longitudinal data, YEARS helps identify health risks earlier and build personalized strategies designed to support healthier, longer lives. Link: www.years.co/en ---------- Guests: Jürgen Mehrtens Co-Founder & CEO of YEARS LinkedIn: www.linkedin.com/in/j%C3%BCrgen-mehrtens-116303b1/ Website: www.years.co/en Alexandru Ardelean, MD Specialist in Internal Medicine of YEARS LinkedIn: www.linkedin.com/in/alexandru-c-ardelean-md-aba522109/ Website: www.years.co/en ---------- What if the future of preventive medicine is not simply better treatment, but knowing what is changing in the body years before disease appears? Phil Newman and Dr. Nina Patrick sit down with Dr. Alexandru Ardelean, internal medicine specialist at YEARS, and Jürgen Mehrtens, CEO of YEARS, to explore how predictive biomarkers and longitudinal health data could reshape the way we understand aging and prevention. Together they unpack the growing role of biomarkers such as GDF-15 and P-tau217. GDF-15 can reflect processes including mitochondrial dysfunction, hypoxia, oxidative stress, and chronic inflammation, while longitudinal measurements may reveal patterns that a single test cannot. They also discuss why these biomarkers are not yet used to prescribe specific treatments, but can help measure whether lifestyle interventions are working. The conversation also explores how YEARS is building a standardized longitudinal dataset by requiring clients to undergo the same diagnostic framework over time, creating data that could eventually help researchers and pharmaceutical companies better understand aging. They discuss biomarker variability, false negatives, patient adherence, community-based interventions, the role of partner gyms, YEARS' upcoming app, and the potential for private preventive medicine models to influence broader healthcare systems. In this episode, you’ll learn: Why GDF-15 is emerging as a marker of cellular stress and how it relates to mitochondrial dysfunction, oxidative stress, hypoxia, and chronic inflammation.Why P-tau217 and other predictive biomarkers still require careful interpretation, longitudinal measurement, and clinical context before they can guide primary prevention.How YEARS is building longitudinal datasets through standardized diagnostics repeated annually or every two years. Why lifestyle interventions remain the foundation of prevention, even as increasingly sophisticated biomarkers become available. How community events, partner gyms, and digital monitoring can help patients stay engaged between clinical visits. If you want to understand how predictive biomarkers could move healthcare from reacting to disease toward continuously measuring and managing risk, this episode connects emerging biomarker science with the practical realities of preventive medicine, patient behavior, and the future of longevity clinics. Subscribe for weekly episodes exploring longevity science, preventative medicine, and the systems shaping how we live longer and better.

  2. 5 days ago

    The Longevity Industry Is Building Its Own Rules | Longevity News Roundup - Week 33, 2026

    Sponsor: FlexBeam FlexBeam is a wearable red light therapy system that brings targeted support directly to where you need it most. Lightweight, portable, and easy to use, it fits naturally into your daily routine, making recovery and self-care more accessible whether you're at home, traveling, or between activities. Click the link below to learn more and use code LONGEVITY.TECHNOLOGY for 10% off. Link: rechargehealthas.sjv.io/jRQyQ5 ---------- In this week’s Longevity News Roundup, Phil Newman examines how longevity is developing the clinical standards, biological models and infrastructure needed to move from promising technology toward real-world medicine. Viome’s acquisition of Circulate Health brings therapeutic plasma exchange into a platform built around diagnostics, nutrition and coaching. Circulate’s network spans more than 200 partner clinics, creating a “measure, act, remeasure” model, while recent data on microplastics and biological age highlight the gap between measurable changes and proven healthspan outcomes.Longevity Clinics World and the Healthy Longevity Medicine Society have signed an MOU focused on evidence-based medicine, shared terminology, education, quality improvement and standardization. The collaboration also emphasizes that future accreditation must have separate governance and independent oversight.Kailera Therapeutics reported an active IND for ribupatide oral, with initiation of global Phase 3 obesity trials planned for the first half of 2027, and says its ribupatide injection Phase 2b high-dose obesity trial is fully enrolled with data anticipated in mid-2027; global Phase 3 KaiNETIC enrollment is on track for more than 4,700 participants with data expected in 2028.Immorta Bio proposes combining multi-omics, AI, digital twins and secure patient-owned data into a continuously learning precision-medicine system. Exploratory metabolomic data from more than 2,000 individuals identified nine metabolites associated with age.Insilico Medicine is developing its Virtual Aging Cell platform to model biological change across six interconnected scales, making biological age a core variable rather than simply an output. The key question is whether these simulations can generate predictions that survive experimental and clinical validation. ---------- News & References: Virtual cells learn to grow old → longevity.technology/news/virtual-cells-learn-to-grow-old/Immorta Bio maps out AI’s next move in longevity → longevity.technology/news/immorta-bio-maps-out-ais-next-move-in-longevity/Kailera Therapeutics reports Q2 2026 results, updates progress on obesity trials → longevity.technology/news/kailera-therapeutics-reports-q2-2026-results-updates-progress-on-obesity-trials/HLMS and Longevity Clinics World join forces on standards → longevity.technology/news/hlms-and-longevity-clinics-world-join-forces-on-standards/Is blood filtering the new wellness flex? → longevity.technology/news/is-blood-filtering-the-new-wellness-flex/ ---------- Hosts: Phil Newman: https://qrco.de/bgXpNY

  3. 10 Aug

    Are GLP-1 Drugs Costing You Muscle? The Truth About Protein & Weight Loss

    Hosts: Phil Newman: ⁠https://qrco.de/bgXpNY⁠ Nina Patrick: ⁠⁠⁠https://qrco.de/bgXpKn ⁠---------- Sponsor: YEARS YEARS is a physician-led longevity clinic in Berlin that takes a proactive approach to health. Combining advanced diagnostics, biomarkers, imaging, and longitudinal data, YEARS helps identify health risks earlier and build personalized strategies designed to support healthier, longer lives. Link: www.years.co/en ---------- Guest: Tom Rifai MD FACP DipABLM Founder and CEO at Reality Meets Science® LinkedIn: www.linkedin.com/in/flex5/ Website: realitymeetsscience.com/ Cristopher Gardner, PhD Professor of Medicine and Director at Stanford Nutrition Studies Research Group LinkedIn: www.linkedin.com/in/christopher-gardner-phd/ Website: med.stanford.edu/profiles/christopher-gardner Stuart Phillips, PhD Professor; Director, PACE and Professor, Kinesiology, Faculty of Science at McMaster University LinkedIn: www.linkedin.com/in/stuartmphillips/ Website: mira.mcmaster.ca/our-faculty/stuart-phillips/ ---------- What if the biggest advances in longevity have less to do with finding the perfect diet, and more to do with preserving muscle, improving movement, and building habits that last? Phil Newman and Dr. Nina Patrick sit down with Dr. Christopher Gardner, Professor of Medicine at Stanford University and one of the world's leading nutrition researchers, Dr. Stuart Phillips, internationally recognized expert in skeletal muscle, aging, exercise, and protein metabolism, and Dr. Tom Rifai, lifestyle medicine physician and nutrition specialist, to separate nutrition science from social media hype. Together they unpack why popular diet labels often distract from what truly matters, why muscle is emerging as one of the most important predictors of healthy aging, and how exercise, dietary quality, and sustainable behavior change consistently outperform quick fixes. From Mediterranean and vegan diets producing remarkably similar health outcomes when built around whole foods, to the growing challenges of preserving muscle during GLP-1 driven weight loss, the discussion highlights where the evidence is strongest and where public perception has drifted away from the science. The panel also explores whether most people really need more protein, why resistance training matters far more than simply increasing protein intake, how clinicians should approach muscle preservation in older adults, and why food policy, environment, and long-term coaching may ultimately have a greater impact on population health than the latest nutrition trend. In this episode, you’ll learn: Why the quality of your diet matters far more than choosing keto, vegan, carnivore, or MediterraneanHow skeletal muscle supports mobility, glucose regulation, metabolic health, and healthy aging What current evidence actually says about protein requirements for longevity and muscle maintenance Why GLP-1 medications should ideally be paired with resistance training, nutrition guidance, and lifestyle support How small, sustainable behavior changes consistently outperform restrictive diets and short-term fixes Why whole foods, vegetables, legumes, and minimally processed diets remain the strongest common ground across nutrition research Whether you're trying to make sense of conflicting nutrition advice, optimize healthy aging, or understand where longevity science is actually headed, this conversation brings together decades of clinical research, practical medicine, and real-world experience to reveal the bigger picture. Subscribe for weekly conversations exploring longevity science, preventative medicine, biotechnology, and the innovations shaping how we live longer, healthier lives.

  4. 7 Aug

    Why Women May Need a Completely Different Longevity Playbook | Longevity News Roundup—Week 32, 2026

    Sponsor: FlexBeam FlexBeam is a wearable red light therapy system that brings targeted support directly to where you need it most. Lightweight, portable, and easy to use, it fits naturally into your daily routine, making recovery and self-care more accessible whether you're at home, traveling, or between activities. Click the link below to learn more and use code LONGEVITY.TECHNOLOGY for 10% off. Link: rechargehealthas.sjv.io/jRQyQ5 ---------- In this week's Longevity News Roundup, Phil Newman explores whether aging research has overlooked half the population, why supplement quality is becoming a scientific issue, how NAD+ science is moving into pharmaceutical development, and what superagers reveal about the limits of genetic prediction. A new $7.5 million NIH-funded center at USC will investigate sex differences in aging after decades of male-biased research. The initiative could reshape biomarkers, clinical trials, and personalized longevity interventions.Swiss longevity company Timeline won a $5.3 million judgment against sellers falsely marketing products as containing urolithin A. The ruling reinforces that scientific evidence depends on products containing the same ingredient and dose used in clinical research.Niagen Bioscience has partnered with Evotec to advance NB4168, an oral NAD+ small molecule for a rare pediatric neurodegenerative disease. The collaboration highlights how longevity companies are increasingly translating supplement science into regulated drug development.Researchers found that superagers shared similar Alzheimer's genetic risk profiles with cognitively average older adults. Rather than supporting a DNA destiny narrative, the findings point toward resilience mechanisms that future studies will explore through biomarkers, immune profiling, brain imaging, and lifestyle. ---------- News & References: What if aging research has been studying the wrong sex? → https://longevity.technology/news/what-if-aging-research-has-been-studying-the-wrong-sex/Timeline wins $5.3m in fake urolithin A case → https://longevity.technology/news/timeline-wins-5-3m-in-fake-urolithin-a-case/Niagen Bioscience teams up with Evotec to prepare rare disease drug for human trials → https://longevity.technology/news/niagen-bioscience-teams-up-with-evotec-to-prepare-rare-disease-drug-for-human-trials/SuperAgers challenge the DNA destiny narrative → https://longevity.technology/news/superagers-challenge-the-dna-destiny-narrative/ ---------- Hosts: Phil Newman: ⁠https://qrco.de/bgXpNY⁠

  5. 3 Aug

    Why “Normal” Blood Results Could Be Misleading

    Hosts: Phil Newman: https://qrco.de/bgXpNY Nina Patrick: ⁠⁠https://qrco.de/bgXpKn ---------- Sponsor: Stride Stride helps people understand and improve their wellbeing and longevity through personalised DNA, microbiome, blood biomarker testing, expert guidance, tailored supplements, and actionable insights grounded in robust human science. Click the link below to learn more and use the code 'UNLOCKED' for your 10% discount. Link: www.getstride.com/unlocked/ ---------- Guest: Andrew Steele Co-Founder & CEO of Stride LinkedIn: www.linkedin.com/in/andrewsteeleathlete/ Website: www.getstride.com/eu/ ---------- What if the future of healthcare isn't about finding disease earlier, but preventing it from developing in the first place? Phil Newman and Dr. Nina Patrick sit down with Andrew Steele, founder and CEO of Stride and former Olympic sprinter, to explore how personalized health is evolving beyond wearables, blood tests, and genetic reports into a truly integrated model of prevention. Drawing on his experience as an elite athlete and entrepreneur, Andrew explains why collecting more health data isn't enough, and why the real challenge is helping people make better decisions that actually change long term behavior. The conversation explores how Stride combines genetics, microbiome testing, advanced blood biomarkers, wearable data, and practitioner coaching into a single preventive health platform designed to prioritize the actions that matter most. Rather than overwhelming people with hundreds of recommendations, Andrew argues that sustainable health improvement comes from identifying a few highly personalized interventions that create momentum for broader lifestyle change. They also discuss how longitudinal testing can reveal patterns that traditional healthcare often misses. Instead of relying on whether a biomarker sits inside or outside a population reference range, Andrew explains why understanding an individual's direction of travel over time may provide much earlier signals of future health risks. The discussion explores how integrating multiple biological data layers could eventually allow AI powered systems to identify preclinical risk years before disease develops. The episode also examines the growing role of consumer health technologies, the limitations of existing healthcare systems, and why prevention increasingly sits outside traditional medicine. Andrew shares why he believes younger generations are embracing longevity as part of their identity, how behavioral psychology influences successful health interventions, and why human coaching remains essential even in an AI driven future. In this episode, you’ll learn: Why personalized health requires more than DNA tests or wearable devicesHow combining genetics, microbiome data, blood biomarkers, and lifestyle creates a more complete picture of health Why focusing on three meaningful actions is more effective than dozens of recommendations How longitudinal biomarker tracking may detect risk before conventional clinical thresholds are reached Why AI works best when combined with experienced healthcare practitioners If you want to understand where personalized medicine is heading, how AI could transform prevention, and why the next generation of healthcare may be built around continuous, individualized guidance rather than reactive treatment, this episode offers an insightful look at the future of longevity. Subscribe for weekly conversations exploring longevity science, precision medicine, biotechnology, AI, and the innovations shaping healthier, longer lives.

  6. 31 Jul

    One-Shot Gene Therapies & Peptides | Longevity News Roundup—Week 31, 2026

    Hosts: Phil Newman: https://qrco.de/bgXpNY Nina Patrick: ⁠⁠https://qrco.de/bgXpKn ---------- Sponsor: FlexBeam FlexBeam is a wearable red light therapy system that brings targeted support directly to where you need it most. Lightweight, portable, and easy to use, it fits naturally into your daily routine, making recovery and self-care more accessible whether you're at home, traveling, or between activities. Click the link below to learn more and use code LONGEVITY.TECHNOLOGY for 10% off. Link: rechargehealthas.sjv.io/jRQyQ5 ---------- In this week's Longevity News Roundup, Phil Newman and Nina Patrick examine new Alzheimer's therapies, the growing debate around experimental peptides, expanding access to investigational treatments, rapid advances in metabolic disease and encouraging progress in longevity gene therapy. Voyager Therapeutics reported that its investigational gene therapy VY1706 reduced tau protein by up to 75% in non-human primates for six months after a single intravenous dose, using a novel blood-brain barrier delivery approach.An advisory panel to the US Food and Drug Administration recommended broader access to compounded wellness peptides despite concerns over limited human evidence, highlighting the growing tension between consumer demand, regulatory oversight and the need for robust clinical trials.Vandria announced that its oral mitochondrial therapy VNA-318  safely reached the brain in its first human study, supporting once-daily dosing ahead of planned Alzheimer's trials.Montana advanced Right to Try legislation that could expand patient access to investigational therapies beyond traditional approval pathways, raising new questions about evidence, transparency and responsible implementation.D&D Pharmatech reported that its once-weekly dual GLP-1/glucagon receptor agonist zabopegdutide rapidly reduced liver fat and stiffness, with benefits seen even among participants who experienced minimal weight loss.Genflow Biosciences reported positive early results from its SIRT6 gene therapy trial in aging dogs, supporting the growing use of companion animals as a bridge toward future human longevity therapies ---------- News & References: Voyager’s single-dose gene therapy cuts tau by 75% → https://longevity.technology/news/voyagers-single-dose-gene-therapy-cuts-tau-by-75/FDA panel backs peptides over its own scientists → https://longevity.technology/news/fda-panel-backs-peptides-over-its-own-scientists/Vandria’s experimental Alzheimer’s pill proves safe, reaches target in first human study → https://longevity.technology/news/vandrias-experimental-alzheimers-pill-proves-safe-reaches-target-in-first-human-study/Montana takes next step on experimental therapies → https://longevity.technology/news/montana-takes-next-step-on-experimental-therapies/Zabopegdutide shows rapid, weight-independent liver benefits in Phase 2 → https://longevity.technology/news/zabopegdutide-shows-rapid-weight-independent-liver-benefits-in-phase-2/Genflow reports positive early results in aging-dog gene therapy trial → https://longevity.technology/news/genflow-reports-positive-early-results-in-aging-dog-gene-therapy-trial/

  7. 27 Jul

    Can Longevity Become Public Policy?

    Hosts: Phil Newman: ⁠https://qrco.de/bgXpNY⁠ Nina Patrick: ⁠⁠⁠https://qrco.de/bgXpKn⁠ ---------- Sponsor: FlexBeam FlexBeam is a wearable red light therapy system that brings targeted support directly to where you need it most. Lightweight, portable, and easy to use, it fits naturally into your daily routine, making recovery and self-care more accessible whether you're at home, traveling, or between activities. Click the link below to learn more and use code LONGEVITY.TECHNOLOGY for 10% off. Link: ⁠rechargehealthas.sjv.io/jRQyQ5⁠ ---------- Guests: Dylan V. Livingston Founder and CEO of The Alliance for Longevity Initiatives (A4LI) LinkedIn: ⁠www.linkedin.com/in/dylan-v-livingston/⁠ Website: ⁠a4li.org/⁠ ---------- What if the biggest barrier to longer, healthier lives isn't scientific discovery, but public policy? In this episode, Phil Newman and Dr. Nina Patrick sit down with Dylan V. Livingston, founder and CEO of the Alliance for Longevity Initiatives (A4LI), to explore how Washington is becoming one of the most important frontiers in healthy aging. Based on his unusual journey from political campaigning to longevity advocacy, Dylan explains why extending healthy lifespan requires more than innovative biotechnology. It also requires regulatory reform, stronger public investment, and policymakers who understand the biology of aging. From his work advancing state-level Right to Try legislation to proposals for new FDA pathways that recognize therapies targeting multiple age-related diseases, he shares how policy could dramatically accelerate the translation of longevity science into clinical practice. The conversation explores the growing role of biomarkers, surrogate endpoints, and ARPA-H's PROSPR program in creating clearer regulatory pathways for aging interventions. Dylan also discusses proposals for expanding NIH support for aging biology research, why the current funding landscape remains misaligned with the burden of age-related disease, and how advocacy organizations can help bridge the gap between researchers, biotech companies, regulators, and elected officials. They also examine whether the United States can maintain its leadership in longevity innovation as countries around the world invest in their own longevity ecosystems, and why creating the right incentives today could determine who leads the next generation of medicine. In this episode, you’ll learn: Why public policy may become the biggest accelerator, or bottleneck, for longevity science.How a proposed multi-disease therapeutic designation could speed the development of aging interventions.- Why validated biomarkers and surrogate endpoints are essential for future FDA approval pathways.How Right to Try legislation could expand safe access to experimental longevity therapies while generating valuable clinical data.Why stronger NIH investment, regulatory reform, and grassroots advocacy are all needed to bring longevity medicine into mainstream healthcare. If you want to understand how longevity is evolving from a scientific discipline into a healthcare and public policy movement, this episode explores the people, institutions, and regulatory decisions that could shape the future of healthy aging for decades to come. Subscribe for weekly conversations exploring longevity science, biotechnology, preventative medicine, and the innovations transforming how we live longer and better.

  8. 24 Jul

    The First Real Longevity Drugs Are Getting Closer | Longevity News Roundup – Week 30, 2026

    Hosts: Phil Newman: https://qrco.de/bgXpNY Nina Patrick: ⁠⁠https://qrco.de/bgXpKn ---------- Sponsor: FlexBeam FlexBeam is a wearable red light therapy system that brings targeted support directly to where you need it most. Lightweight, portable, and easy to use, it fits naturally into your daily routine, making recovery and self-care more accessible whether you're at home, traveling, or between activities. Click the link below to learn more and use code LONGEVITY.TECHNOLOGY for 10% off. Link: https://rechargehealthas.sjv.io/jRQyQ5 ---------- In this week's Longevity News Roundup, Phil Newman and Nina Patrick examine major advances in Alzheimer's research, growing investment in national longevity infrastructure, the challenges facing longevity clinics, and why microbiome science is becoming increasingly important for brain and women's health. Biogen and Ionis reported encouraging Phase II results for a tau-targeting Alzheimer's therapy. While the trial missed its primary endpoint, the treatment reduced tau biomarkers and slowed clinical decline, supporting plans for a Phase III study.Lighthouse Pharmaceuticals presented new data showing its gingipain inhibitor reduced agitation, caregiver distress, and cognitive decline in Alzheimer's patients who tested positive for p. gingivalis. The discussion explores what these findings could mean for the growing evidence linking oral health and neurodegeneration.Nova Capital committed $100 million to build a UAE longevity platform integrating clinics, preventive healthcare, digital health, and wellness services. Phil also explores what this investment could signal for the future geography of the global longevity industry.Eternal announced the closure of its longevity clinics, prompting a discussion about why data, defensible technology, and scalable business models may become increasingly important as the sector matures.Juno Bio raised $3.8 million to launch a CLIA-certified sequencing laboratory and expand provider-led vaginal microbiome diagnostics, moving precision women's healthcare beyond traditional symptom-based testing. ---------- News & References: Biogen, Ionis therapy slows early Alzheimer’s progression in Phase 2 trial → https://longevity.technology/news/biogen-ionis-therapy-slows-early-alzheimers-progression-in-phase-2-trial/Lighthouse Pharma’s Alzheimer’s drug reduces agitation, caregiver distress in clinical trial → https://longevity.technology/news/lighthouse-pharmas-alzheimers-drug-reduces-agitation-caregiver-distress-in-clinical-trial/Nova Capital commits $100m to back UAE longevity platform → https://longevity.technology/news/nova-capital-commits-100m-to-back-uae-longevity-platform/Eternal calls time on its longevity clinics → https://longevity.technology/news/eternal-calls-time-on-its-longevity-clinics/Startup Juno Bio raises $3.8m for smarter women’s diagnostics → https://longevity.technology/news/startup-juno-bio-raises-3-8m-for-smarter-womens-diagnostics/

About

Longevity.Technology UNLOCKED brings together science, business, and human potential to explore the frontier of longer, healthier living. 🎙 Mondays: In-depth conversations with scientists, founders, investors, operators, and elite performers shaping the longevity ecosystem. 🧠 Fridays: A sharp weekly round-up of the biggest stories, trends, and insights from across the longevity space. If you’re curious about the future of health, performance, and lifespan, this is where it gets UNLOCKED.

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