Longevity Optimization with Kayla Barnes-Lentz

Kayla Barnes-Lentz

Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.

  1. 1 DAY AGO

    Cynthia Thurlow, NP: Perimenopause, Insulin Resistance and Midlife Metabolism

    Perimenopause is not just about hormones, it’s a metabolic transition that affects insulin sensitivity, gut health, stress tolerance, and long-term disease risk. In this episode, Cynthia Thurlow, board-certified nurse practitioner and functional medicine expert, explains how women’s metabolism changes in midlife and why insulin resistance, poor stress resilience, and gut dysfunction often appear years before menopause. She breaks down how perimenopause can begin earlier than most women expect, why symptoms vary so widely, and how lifestyle factors like fasting, exercise intensity, sleep, alcohol, and chronic stress interact with hormones during this transition. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-member This conversation explores: Why insulin resistance often emerges in perimenopause How stress and trauma shape metabolic and hormonal health The role of gut health in PMS, mood, and estrogen balance When fasting helps women and when it makes things worse Why “doing everything right” can still lead to symptoms How to individualize nutrition, training, and recovery in midlife Connect with Kayla: Instagram:https://www.instagram.com/kaylabarnes/ TikTok:https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ YouTube: www.youtube.com/@KaylaBarnesLentz Apple: https://podcasts.apple.com/us/podcast...Website:https://www.protocol.kaylabarnes.com Learn more about Cynthia Thurlow Instagram: https://www.instagram.com/cynthia_thurlow_/ YouTube: https://www.youtube.com/cynthiathurlow Website: https://www.cynthiathurlow.com/ Pre-order her upcoming book: The Menopause Gut (28th of April 2026):https://www.penguinrandomhouse.com/books/777129/the-menopause-gut-by-cynthia-thurlow-np/?mcp… ACE (Adverse Childhood Experiences) questionnaire:https://www.acesaware.org/wp-content/uploads/2022/07/ACE-Questionnaire-for-Adults-Identified-English-rev.7.26.22.pdf

    59 min

  2. 5 FEB

    Dr. Chris Masterjohn, PhD - Mitochondria, Micronutrients, and How Nutrition Actually Drives Longevity

    When cellular energy production is impaired, no diet, supplement, or health protocol can work as intended. In this episode, Dr. Chris Masterjohn, nutrition scientist and expert in micronutrients and metabolism, explains why mitochondrial function is the limiting factor behind stalled progress, persistent fatigue, and supplements that stop working over time. He breaks down why vitamin D supplementation often creates new problems when it is taken without proper nutrient balance, how high doses can disrupt other systems in the body, and why sunlight has biological effects that vitamin D pills alone cannot replicate. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-member This conversation explores: Why mitochondrial bottlenecks explain most energy and health plateaus How micronutrient deficiencies undermine supplements and biohacks When creatine supports cellular energy and why it works differently than most supplements Why vitamin D supplementation can backfire without context and balance Why sunlight affects biology in ways supplements cannot replace How diet, fasting, and exercise interact with mitochondrial capacity Why optimizing one system often breaks another without proper foundations Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify:https://open.spotify.com/show/4OLWWn22... Apple: https://podcasts.apple.com/us/podcast... Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr Chris Masterjohn’s work: Website: https://www.chrismasterjohn-phd.com/Instagram: https://www.instagram.com/chrismasterjohn/YouTube: https://www.youtube.com/@chrismasterjohn

    2h 40m

  3. 29 JAN

    Dr. Jessica Shepherd, MD – Menopause, Hormone Therapy and Bone Health

    In this episode, Dr. Jessica Shepard, board-certified OB/GYN and Chief Medical Officer of Hers, shares that the FDA just removed the black box warning on hormone replacement therapy after 23 years. We discuss what actually happened with the WHI study that created all the fear around estrogen and breast cancer, and why the research never actually supported that narrative.Dr. Shepard explains why you shouldn't wait until menopause to start the HRT conversation and how starting in your perimenopausal years can make all the difference for long-term health. Dr. Shepard shares the essential labs she runs on patients including ApoB, HbA1c, and thyroid optimization, plus the longevity metrics women should be tracking.We also get into supplement recommendations including why she recommends 10 grams of creatine daily, the role of inflammation in aging, and how estrogen is naturally anti-inflammatory which is why women see increased cardiovascular risk and metabolic dysfunction after menopause. Kayla's social + website: Instagram:  kaylabarnes TikTok:  femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com Spotify: https://open.spotify.com/show/4OLWWn2... Apple: https://podcasts.apple.com/us/podcast... Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Dr. Jessica Shepherd's social + website: Website: https://www.jessicashepherdmd.com/ Instagram: https://www.instagram.com/jessicashepherdmd/ Transform Your Health: https://eudemonia.net/?utm_source=podcast&utm_medium=kayla-podcast&utm_campaign=jessica-shepherd

    49 min

  4. 22 JAN

    Dr. Khanh Nguyen - The Blood Swap: Why Doctors Are Replacing Your Plasma With THIS

    What if your blood is what’s making you sick and the key to reversing it is removing it? In this episode, I sit down with Dr. Khanh Nguyen, a regenerative and anti-aging physician, to explore therapeutic plasma exchange and the rising use of young plasma. We talk detox, autoimmune disease, aging, peptides, and why your blood might be holding you back. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/... Kayla's social + website: Instagram:  kaylabarnes TikTok:  femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com Spotify: https://open.spotify.com/show/4OLWWn2... Apple: https://podcasts.apple.com/us/podcast... Follow Her Female Protocol: https://www.protocol.kaylabarnes.comDr. Khanh's social + website: Instagram: https://www.instagram.com/regenwithdrnguyen/ Website: Austin Regenerative Therapy

    1h 9m

  5. 15 JAN

    Dr. Ann Shippy, MD - The Fertility Alarm: Why 1 in 31 Kids Now Has Autism

    Is your environment silently sabotaging your fertility? Dr. Ann Shippy joins the show to reveal how hidden toxins, mold, and overlooked cellular damage may be accelerating ovarian aging and how to reclaim your fertility before it’s too late. From infertility misdiagnoses to rising autism rates, we dive deep into the tests most doctors never run, and the real impact your body’s toxic load has on future generations.  Kayla's social + website: Instagram:  kaylabarnes TikTok:  femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com Spotify: https://open.spotify.com/show/4OLWWn2... Apple: https://podcasts.apple.com/us/podcast... Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Dr. Ann Shippy social + website: Instagram: https://www.instagram.com/annshippymd/Website: https://annshippymd.com/

    1h 2m

  6. 8 JAN

    Ashley Koff, RD - Dietitian Reveals: The Hormone Problem That Makes You Eat Everything

    Ashley Koff is a registered dietitian and author who spent 20 years discovering that weight and health aren't separate issues, they're connected through "weight health hormones." After her own struggles with restrictive eating despite doing everything "right," a functional medicine doctor helped her understand what was actually broken, and that was, her body's natural hormone function. In this episode, Ashley explains why GLP-1 medications like Ozempic work, who actually needs them, and the critical foundational work required to avoid devastating rebounds. She reveals why current dietary guidelines fail women, shares her free weight health hormone assessment, cuts through the seed oil controversy, and offers practical strategies for eating healthy on any budget. If you're confused about nutrition, frustrated that eating healthy isn't working, or curious about GLP-1 medications, this conversation provides the clarity you've been missing. Guest’s socials + website: Instagram: @ashleykoffapproved Website: https://thebetternutritionprogram.com/  Kayla's social + website: Instagram:  https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol:  https://www.protocol.kaylabarnes.com Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

    1h 16m

  7. 1 JAN

    Dr. Will Bulsiewicz, MD - The #1 Nutrient for Longevity That Everybody Still Ignores

    In this video, Dr. Will Bulsiewicz shares his transformation from an overweight, depressed gastroenterologist to a gut health expert after meeting his now-wife changed his entire approach to food. He reveals why 95% of Americans are fiber deficient and how this single nutrient could be the key to longevity. Dr. B breaks down the science of the gut microbiome, explains why hyperpalatable foods force us to overeat 500 extra calories per day, and shares actionable strategies for rebuilding your gut health in as little as 3-5 days. Guest’s socials + website Instagram: @theguthealthmd  Website: https://theguthealthmd.com/  Kayla's social + website: Instagram:  https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

    1h 39m

  8. 1 JAN

    How to Make 2026 Your Healthiest Year Ever (Complete Guide)

    Women don’t fail January — January fails women. Nearly 80% of New Year health goals are abandoned within weeks, not because of discipline, but because most plans ignore female biology. That’s why I created the 30-Day Female Longevity Challenge — a physiology-first way to prepare calmly and build health that actually lasts. Save $50 with code 2026. https://kayla-barnes-lentz.circle.so/checkout/female-longevity-challenge-2026?coupon_code=2026When you join, you also get one full year access to my female membership for on-going accountability, my monthly AMAs, a female support community, access to my 20 other courses and more! Optimizing your home: https://www.youtube.com/watch?v=Ni5GFTRWjikHome inspection: https://www.youtube.com/watch?v=8si4I1Bt5nMAt home health tracking: https://www.youtube.com/watch?v=23RUCOpBCE8&t=235s Kayla's social + website: Instagram:  https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

    25 min
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Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.

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