170 episodi

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

The Peter Attia Drive Peter Attia, MD

    • Medicina
    • 4.6 • 5 valutazioni

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

    James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise.

    James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise.

    James O’Keefe is a preventative cardiologist and bestselling author of The Forever Young Diet and Lifestyle. In this episode, James discusses cardiac physiology and what makes the human heart susceptible to disease. He provides evidence for what supports his approach to exercise--elucidating both positive and negative kinds of exercise for heart health. He also discusses the role of nutrition, specific nutrients, and pharmacological interventions to support heart and brain longevity.
     
    We discuss:
    James’ background and why he favors a preventative approach to cardiology [3:15]; Understanding atherosclerosis and the misconception that it’s a “plumbing problem” [10:15]; The danger in excessive exercise—a reverse J-shaped mortality curve [21:15]; The story of Micah True—A case study of excessive exercise [49:15]; The best kinds of exercise for longevity—The Copenhagen City Heart Study [53:00]; Being a more balanced athlete and finding the right exercise intensity [58:45]; Heart rate during exercise, resting heart rate, and other important metrics [1:04:00]; Nutrition for cardiovascular health [1:09:45]; Important nutrients: Magnesium, potassium, calcium, sodium, and collagen [1:19:30]; SGLT2 inhibition for diabetes, cardio-protection, and general longevity [1:24:15]; GLP-1 agonists for weight loss and reducing cardiovascular risk [1:34:15]; Statins—Mechanism of action, safety, and useful alternatives [1:37:25]; A 40-year view on cardiovascular risk, and the possibility of reversing arterial calcification [1:45:45]; Evidence for high dose EPA and DHA for the reduction of cardiovascular disease risk [1:53:30]; The impact of omega-3, curcumin, and other compounds on mental health and dementia [1:59:00]; James’ focus beyond cardiology [2:02:15]; and More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/JamesOKeefe 

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    • 2 ore 9 min
    Vinay Prasad, M.D., M.P.H: Hallmarks of successful cancer policy

    Vinay Prasad, M.D., M.P.H: Hallmarks of successful cancer policy

    Vinay Prasad is a practicing hematologist-oncologist who doubles as a “meta-researcher,” studying the quality of medical evidence, health policy, and clinical trials. In this episode, Vinay discusses the differences in clinical treatment from the existing medical evidence, often leading to useless, or even harmful, outcomes for patients. With a focus in oncology, he takes a deep dive into the field’s structural problems, which include the disconnect between progress and funding, drug costs, and financial conflicts of interest. He concludes with his “six hallmarks of successful cancer policy” as a potential roadmap to sustained progress against cancer and a way to avoid repeating the policy and practice mistakes of the past.

     

    We discuss:

    Vinay’s background and unique perspective [3:15]; Medical reversal—the disconnect between research findings and clinical applications in medicine [10:15]; The uniquely challenging field of oncology [22:45]; The importance of bedside manner with cancer patients [30:00]; Structural problems in oncology—Problem #1: Huge costs for small improvements [37:00]; Structural problems in oncology—Problem #2: Medical reversal—when medical practices are adopted based on low levels of evidence [40:15]; Structural problems in oncology—Problem #3: Slow progress in cancer research (despite all the hype and propaganda) [45:00]; Structural problems in oncology—Problem #4: The burden of payment is not matched with those making treatment decisions [54:45]; “No-brainer” moves in oncology [1:06:45]; “Fool’s gold” treatments in oncology [1:09:30]; The six hallmarks of successful cancer policy [1:16:00]; Cancer policy hallmark #1: Independence [1:18:00]; Cancer policy hallmark #2: Evidence [1:28:15]; Cancer policy hallmark #3: Relevance [1:31:30]; Cancer policy hallmark #4: Affordability [1:32:00]; Cancer policy hallmark #5: Possibility [1:47:00]; Cancer policy hallmark #6: Agenda [1:52:00]; Tumor genome sequencing and liquid biopsies [1:54:30]; Vinay’s clinical philosophy, being skeptical without being too contrarian, and practicing medicine without perfect information [2:03:30]; and More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/VinayPrasad 

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    • 2 ore 12 min
    AMA #16: Exploring hot and cold therapy

    AMA #16: Exploring hot and cold therapy

    In this “Ask Me Anything” (AMA) episode, Peter and Bob explore the quality of evidence for hot and cold therapy. In the discussion, they evaluate the safety, efficacy, and opportunity costs of various hot and cold therapy protocols, and Peter ultimately considers the addition of dry sauna to his longevity toolkit. Once again, Bob Kaplan, Peter’s head of research, will be asking the questions. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #16 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.
    We discuss:
    How stress can show up as physical pain, and tips for changing time zones [1:45]; Literature overview of heat and cold therapy [7:15]; Cold therapy for delayed onset muscle soreness (DOMS) [12:00]; Quality of evidence for cold therapy for depression or immune enhancement [19:30]; Cold therapy and brown adipose tissue (BAT) [21:15]; Weighing the safety, efficacy, and opportunity cost of cold therapy [28:45]; An overview of heat therapy benefits [40:00]; Longevity benefits of sauna—reviewing the studies [41:30]; Limitations in the sauna literature—Where might we be fooled? [54:30]; Possible mechanisms conferring the longevity benefits of sauna, and how it compares to exercise [1:02:15]; Parting thoughts on sauna, opportunity costs, and Bob’s personal regimen [1:06:30]; and More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/ama16/

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    • 19 min
    Beth Lewis: The Art of Stability: Learning about pain, mitigating injury, and moving better through life

    Beth Lewis: The Art of Stability: Learning about pain, mitigating injury, and moving better through life

    Beth Lewis is a former professional dancer and a self-described “educator of movement” who has an unmatched ability to assimilate information and customize training plans from multiple training systems. In this episode, Beth takes us through how she identifies problematic movement patterns and postures to help individuals relieve pain, avoid injury, and move better within all types of exercise. She explains how movement is in fact a trainable skill and provides suggestions for what people can add to their exercise routine to benefit their health and longevity.
    We discuss:
    Beth’s “way of no way” training philosophy [4:45] Beth’s background in dancing and how she ended up in New York City [7:30] Beth’s transition to fitness coaching and how her training philosophy has evolved [12:45]; Functional Range Conditioning and scapular mobility [21:50]; An overview of Postural Restoration Institute and Peter’s squat assessment [35:30]; The important connection between the ribs and breathing [39:45]; The role of sitting and external stress in chronic muscular tension [42:30]; The important role of your toes, minimalist footwear, and toe yoga [44:30]; Dynamic Neuromuscular Stabilization (DNS) [48:30]; A different view on knee valgus [52:45]; Is there such a thing as “bad posture”? [56:30]; How Beth identifies an issue, addresses it, and keeps clients motivated [58:45]; Lifting weights, the Centenarian Olympics, and dancing into old age [1:11:00]; The importance of the hamstrings versus abs [1:21:15]; Benefits of rowing, and why everyone should add it to their exercise regimen [1:27:15] Different roles of concentric versus eccentric strength [1:35:15]; Flexibility and high-intensity interval training (HIIT) [1:39:40]; Training versus playing sports, and the best type of activity for kids [1:43:00]; and More. Learn more: https://peterattiamd.com/
     
    Show notes page for this episode: https://peterattiamd.com/bethlewis 
     
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    • 1h 51 min
    Carol Tavris, Ph.D. & Elliot Aronson, Ph.D.: Recognizing and overcoming cognitive dissonance

    Carol Tavris, Ph.D. & Elliot Aronson, Ph.D.: Recognizing and overcoming cognitive dissonance

    Renowned social psychologists Carol Tavris and Elliot Aronson are the co-authors of Mistakes Were Made (But Not By Me), a book which explores the science of cognitive biases and discusses how the human brain is wired for self-justification. In this episode, Carol and Elliot discuss how our desire to reconcile mental conflicts adversely affects many aspects of society. The two give real-world examples to demonstrate the pitfalls in attempts to reduce mental conflict, or dissonance. The examples reveal that no one is immune to dissonance reduction behavior, how intellectual honesty can be trained and lastly, how to think critically in order to avoid engaging in harmful dissonant behaviors.
    We discuss:
    Carol and Elliot’s respective background, collaboration history, and their decision to write Mistakes Were Made (But Not By Me) [4:00]; The theory of cognitive dissonance, and real examples of dissonance reduction in action [11:15]; How Elliot advanced the theory of cognitive dissonance [23:00]; The evolutionary reason for dissonance reduction, and cultural differences in what causes cognitive dissonance [30:30]; The great danger of smart, powerful people engaging in dissonance reduction [35:15]; Two case studies of cognitive dissonance in criminal justice [39:30]; The McMartin preschool case study—The danger in making judgements before knowing all the information [43:30]; How ideology distorts science and public opinion [56:30]; How time distorts memories [58:30]; The downside of certainty [1:05:30]; Are we all doomed to cognitive dissonance?—How two people with similar beliefs can diverge [1:09:00]; Cognitive dissonance in the police force [1:21:00]; A toolkit for overcoming cognitive dissonance [1:27:30]; Importance of separating identity from beliefs, thinking critically, & and the difficulty posed by political polarity [1:30:30]; How to impart the lessons from their work into future generations [1:48:00]; and More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/caroltavris-elliotaronson/ 

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    • 1h 59 min
    Tom Dayspring, M.D.: The latest insights into cardiovascular disease and lipidology

    Tom Dayspring, M.D.: The latest insights into cardiovascular disease and lipidology

    World-renowned lipidologist Tom Dayspring returns to give an update on the current thinking in lipidology as a follow-up to his 2018 five-part podcast series. In this episode, Tom discusses the growing consensus that atherogenic lipoproteins are essential drivers of atherosclerotic vascular disease. Tom further emphasizes apolipoprotein B (apoB) and lipoprotein(a) (Lp(a)). He provides insights into risk assessment, including which lab metrics to use, how to interpret them, and the appropriate therapeutic targets. Additionally, Tom discusses the most recent developments in lipid-lowering drug therapies—from the continued evolution of PCSK9 inhibitors, to the latest understanding of EPA and DHA, and the most recent addition of bempedoic acid to the list of therapeutic agents.
    We discuss:
    The latest in the field of lipidology and cardiovascular disease [3:45]; Apolipoproteins—the key to understanding lipid biology [9:30]; ApoB as a preferred metric over LDL-P [16:30]; Therapeutic goals for apoB concentration [21:45]; Drivers of atherosclerosis [34:15]; Overview and current thinking on high density lipoproteins (HDLs)—Is it a useful metric? [37:00]; Lipoprotein(a)—the most dangerous particle you’ve never heard of [55:00]; Are low density lipoprotein triglycerides (LDL-TGs) a useful metric? [1:13:15]; Tom’s preferred lab measurements [1:17:45]; The latest in lipid-lowering therapies [1:21:30]; The different pathways among various lipid-lowering drugs [1:30:45]; The latest on EPA and DHA [1:38:15]; Fibrates—an underappreciated treatment for hypercholesterolemia [1:49:45] and; More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/tomdayspring6 

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    • 2 ore

Recensioni dei clienti

4.6 su 5
5 valutazioni

5 valutazioni

@K_Speckmann ,

Audio Library of mine for Medical Insight

Dr. Atria and guests are one of my sources of choice for how my body works and what medical research to trust.
Some of the probably deepest and most detailed conversations with experts I have found. Highly recommended to everyone interested in one's own health - albeit really deep and sometimes daunting. Certainly worth sharing with our own medical practitioner.
As podcast itself, I like a lot that chapters with headings are available to later jump back to. Excellent job, Dr. Attia and Team!

Bart485 ,

Deep but worth it

Sometimes a bit too deep for any lay person, but always interesting. Peter Attia rocks.

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