LessWrong (Curated & Popular)

LessWrong

Audio narrations of LessWrong posts. Includes all curated posts and all posts with 125+ karma.If you'd like more, subscribe to the “Lesswrong (30+ karma)” feed.

  1. 1 DAY AGO

    "Some things I noticed while LARPing as a grantmaker" by Zach Stein-Perlman

    Written to a new grantmaker. Most value comes from finding/creating projects many times your bar, rather than discriminating between opportunities around your bar. If you find/create a new opportunity to donate $1M at 10x your bar (and cause it to get $1M, which would otherwise be donated to a 1x thing), you generate $9M of value (at your bar).[1] If you cause a $1M at 1.5x opportunity to get funded or a $1M at 0.5x opportunity to not get funded, you generate $500K of value. The former is 18 times as good. You should probably be like I do research to figure out what projects should exist, then make them exist rather than I evaluate the applications that come to me. That said, most great ideas come from your network, not from your personal brainstorming. In some buckets, the low-hanging fruit will be plucked. In others, nobody's on the ball and amazing opportunities get dropped. If you're working in a high-value bucket where nobody's on the ball, tons of alpha is on the table. (Assuming enough donors or grantmakers will listen to you to fund your best stuff.) I talk about "10x opportunities" and "1x opportunities" for simplicity here. It [...] The original text contained 1 footnote which was omitted from this narration. --- First published: March 23rd, 2026 Source: https://www.lesswrong.com/posts/CzoiqGzpShprcv2Jd/some-things-i-noticed-while-larping-as-a-grantmaker --- Narrated by TYPE III AUDIO.

    12 min
  2. 6 DAYS AGO

    "The Case for Low-Competence ASI Failure Scenarios" by Ihor Kendiukhov

    I think the community underinvests in the exploration of extremely-low-competence AGI/ASI failure modes and explain why. Humanity's Response to the AGI Threat May Be Extremely Incompetent There is a sufficient level of civilizational insanity overall and a nice empirical track record in the field of AI itself which is eloquent about its safety culure. For example: At OpenAI, a refactoring bug flipped the sign of the reward signal in a model. Because labelers had been instructed to give very low ratings to sexually explicit text, the bug pushed the model into generating maximally explicit content across all prompts. The team noticed only after the training run had completed, because they were asleep. The director of alignment at Meta's Superintelligence Labs connected an OpenClaw agent to her real email, at which point it began deleting messages despite her attempts to stop it, and she ended up running to her computer to manually halt the process. An internal AI agent at Meta posted an answer publicly without approval; another employee acted on the inaccurate advice, triggering a severe security incident that temporarily allowed employees to access sensitive data they were not authorized to view. AWS acknowledged that [...] --- Outline: (00:19) Humanitys Response to the AGI Threat May Be Extremely Incompetent (02:26) Many Existing Scenarios and Case Studies Assume (Relatively) High Competence (04:31) Dumb Ways to Die (07:31) Undignified AGI Disaster Scenarios Deserve More Careful Treatment (10:43) Why This Might Be Useful --- First published: March 19th, 2026 Source: https://www.lesswrong.com/posts/t9LAhjoBnpQBa8Bbw/the-case-for-low-competence-asi-failure-scenarios --- Narrated by TYPE III AUDIO.

    12 min
  3. 24 MAR

    "Is fever a symptom of glycine deficiency?" by Benquo

    A 2022 LessWrong post on orexin and the quest for more waking hours argues that orexin agonists could safely reduce human sleep needs, pointing to short-sleeper gene mutations that increase orexin production and to cavefish that evolved heightened orexin sensitivity alongside an 80% reduction in sleep. Several commenters discussed clinical trials, embryo selection, and the evolutionary puzzle of why short-sleeper genes haven't spread. I thought the whole approach was backwards, and left a comment: Orexin is a signal about energy metabolism. Unless the signaling system itself is broken (e.g. narcolepsy type 1, caused by autoimmune destruction of orexin-producing neurons), it's better to fix the underlying reality the signals point to than to falsify the signals. My sleep got noticeably more efficient when I started supplementing glycine. Most people on modern diets don't get enough; we can make ~3g/day but can use 10g+, because in the ancestral environment we ate much more connective tissue or broth therefrom. Glycine is both important for repair processes and triggers NMDA receptors to drop core temperature, which smooths the path to sleep. While drafting that, I went back to Chris Masterjohn's page on glycine requirements. His estimate for total need [...] --- Outline: (01:49) Glycine helps us sleep by cooling the body (02:26) Glycine cleans our mitochondria as we sleep (04:12) Most people could use more glycine (05:28) Fever is plan B for fighting infection; glycine supports plan A (09:28) Glycines cooling effect via the SCN is unrelated to its immune benefits (10:35) Glycine turns out to be a legitimate antipyretic after all (11:51) Practical considerations --- First published: March 22nd, 2026 Source: https://www.lesswrong.com/posts/87XoatpFkdmCZpvQK/is-fever-a-symptom-of-glycine-deficiency --- Narrated by TYPE III AUDIO.

    14 min

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Audio narrations of LessWrong posts. Includes all curated posts and all posts with 125+ karma.If you'd like more, subscribe to the “Lesswrong (30+ karma)” feed.

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