The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey

For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™. You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human. Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward. Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life. 

  1. Why Women’s Joints Are Failing 10x Faster

    9 HR AGO

    Why Women’s Joints Are Failing 10x Faster

    Modern joint pain isn’t just wear and tear—it’s a systemic, metabolic disease that starts years before symptoms show. In this episode, you’ll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Kiran Krishnan, a research microbiologist and Chief Scientific Officer at Calroy Health Sciences. He’s the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He’s a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results.   He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You’ll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration.  You’ll learn:  • How cartilage cells (chondrocytes) rely on mitochondria for tissue repair  • Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog  • How cartilage begins to break down in your teens—and what to do about it now  • The surprising clinical data on walking distance, inflammation markers, and recovery  • Why most supplements and NSAIDs fail—and what actually rebuilds joints  • How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal  • The mitochondrial link between joint pain, cardiovascular risk, and depression  • Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it  • How to track your biological joint age using imaging and systemic inflammation labs  This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you’re lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation  **Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave **  Thank you to our sponsors!  -BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.  -BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order.  -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.  -Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.  Resources:   • Danger Coffee: https://dangercoffee.com/discount/dave15  • Dave Asprey’s BEYOND Conference: https://beyondconference.com  • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Upgrade Collective: https://www.ourupgradecollective.com  • Upgrade Labs: https://upgradelabs.com  • 40 Years of Zen: https://40yearsofzen.com  Timestamps:  0:00 — Trailer  1:25 — Introduction  2:01 — Why Modern Medicine Fails at Joint Pain  3:07 — Painkillers That Accelerate Joint Damage  7:35 — Rheumatoid vs. Osteoarthritis Explained  8:54 — Cytokines That Destroy Cartilage  12:10 — Arthritis Begins in Your Teens  15:35 — 75% Pain Reduction in 7 Days  18:35 — The Science Behind Boswellia & Celery Seed  24:10 — Six-Minute Walk Test Results  25:45 — The $200/Month Painkiller Trap  28:53 — Proof Cartilage Can Regrow  31:01 — Mitochondria and Joint Repair  32:29 — Inflammation Links to Heart Disease  35:52 — Why Glucosamine Doesn’t Work  37:07 — Silent Arthritis in 90% of Adults  40:44 — Why Women Face Higher Joint Risk After 40  45:52 — Food as the #1 Inflammation Trigger  47:23 — Fasting & Cartogenics Stack for Repair  50:27 — Movement Snacks and Efficient Training  55:54 — Why Joints Heal Slower Than Muscles  57:48 — Dave’s Stack and Final Takeaways  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    57 min
  2. Why You Still Feel Tired And Foggy On A Perfect Diet

    2 DAYS AGO

    Why You Still Feel Tired And Foggy On A Perfect Diet

    Biohacking isn’t just food + exercise, it’s about fixing the invisible disruptors wrecking your biology. EMFs, mold, toxins, mitochondrial stress, these are the real reasons you still feel tired, foggy, or inflamed even on a perfect diet. I’ve been there. I lost 100 lbs, built Bulletproof Coffee, and discovered why food alone isn’t enough. In this video, I’ll show you what’s actually holding back your energy, focus, and longevity… and how to finally feel truly bulletproof. Chapters: 0:00 – Introduction 1:30 – The hidden disruptors wrecking your health 2:15 – EMFs: invisible energy thieves 3:00 – Mold exposure: the silent killer in your home 4:00 – How toxins block your nutrients 5:10 – Mitochondria: the real source of energy 6:20 – Detox hacks that actually work 7:30 – Binders: the secret to flushing toxins 8:30 – Rebuilding nutrients for lasting energy 9:20 – The missing biological switch: nervous system safety 10:30 – Resetting your circadian rhythm naturally 11:30 – Box breathing: a biohack for instant calm 12:20 – Gratitude, digestion & unlocking thrival mode Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Coffee: https://dangercoffee.com/DAVE15 Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Collective: https://www.ourupgradecollective.com Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    13 min
  3. 10 Minute Weekly Biohacking Update

    4 DAYS AGO

    10 Minute Weekly Biohacking Update

    Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. T This episode covers: • Longevity Scores Are Going Mainstream Elegant Hoopoe’s new clinics are using 56 biomarkers to track biological aging — and early users are reporting up to six years reversed in under two months. Could scoring systems replace reactive healthcare? Source: Morningstar via PR Newswire — https://www.morningstar.com/news/pr-newswire/20251014ln95054 • AI Heart Scans Spot Trouble Sooner Hospitals are using machine learning to analyze echocardiograms in real time — making heart diagnostics faster, cheaper, and more accurate, even without top specialists on site. Source: Crescendo.AI News — https://www.crescendo.ai/news/latest-ai-news-and-updates • Brain Training That Rebuilds Neurotransmitters McGill’s INHANCE trial shows that 10 weeks of digital training on BrainHQ doesn’t just improve memory — it chemically rejuvenates acetylcholine pathways. That’s measurable neuroplasticity. Source: Longevity.Technology — https://longevity.technology/news/brain-training-restores-youth-to-aging-minds/ • HLTH 2025 Unveils Digital Twins & Real-Time Immune Wearables This year’s HLTH conference put bio-individuality front and center: AI twins that simulate your biology, hormone-tracking wearables, and apps syncing with EMRs to turn raw data into real decisions. Source: HLTH Official — https://hlth.com/2025event • One Blood Test, Many Diagnoses New multi-panel tests rolling out in clinics screen for dozens of diseases from a single draw — boosting compliance, streamlining early detection, and making full-spectrum testing routine. Source: Instagram Science Updates — https://www.instagram.com/p/DP0oGGTiiT5/ This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: longevity score, elegant hoopoe, AI heart scans, brainHQ, acetylcholine, McGill INHANCE trial, HLTH 2025, digital twins, hormone wearables, immune tracking, biological age, multi-panel blood test, early detection, personalized medicine, Dave Asprey, Human Upgrade, biohacking news, health tech, performance medicine, smart diagnostics Thank you to our sponsors!   -SKILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. -EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. Resources:   • Danger Coffee: https://dangercoffee.com/discount/dave15  • Dave Asprey’s BEYOND Conference: https://beyondconference.com  • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Upgrade Collective: https://www.ourupgradecollective.com  • Upgrade Labs: https://upgradelabs.com  • 40 Years of Zen: https://40yearsofzen.com  Timestamps:  0:00 — Introduction 0:18 — Story 1: Elegant Hoopoe Longevity Score 1:26 — Story 2: AI-Assisted Echocardiograms 2:17 — Story 3: Brain HQ Cognitive Training Study 3:03 — Story 4: Digital Twins at HLTH Conference 4:13 — Story 5: Single Vial Blood Testing 5:04 — Five Day Experiment 5:46 — Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    6 min
  4. These Plants Turn On 1,100 Healing Genes In 24 Hours (Ancient Biohacks)

    5 DAYS AGO

    These Plants Turn On 1,100 Healing Genes In 24 Hours (Ancient Biohacks)

    Most people try to “heal” their brain with supplements, mindset, or meditation—but this episode reveals the deeper protocol to actually grow a new brain, reverse stress damage, activate 1,100 healing genes, and unlock higher human performance at any age. You’ll learn how neuroplasticity, mitochondria repair, plant-based NRF2 activators, and energetic practices work together to rebuild the brain and extend longevity.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Alberto Villoldo, Ph.D.—medical anthropologist, neuroscientist, energy medicine pioneer, and founder of The Four Winds Society, the gold-standard school for modern shamans. He has spent 25+ years studying Amazonian and Andean healing traditions, led the Biological Self-Regulation Lab at San Francisco State University to explore psychosomatic medicine, and authored more than 25 bestselling books on neuroscience, functional medicine, and energy healing. Few people on earth bridge ancient biohacking and modern brain science at this level.  He also reveals the forms of nicotine that are safest (spoiler: it’s not vapes or cigarettes), how nicotine works at the receptor level, and what the science says about long-term health effects. This episode blends functional medicine, brain optimization, and biohacking into one powerful, myth-busting breakdown.  You'll learn:  • How to grow a new brain every 22 days using neuroplasticity and mitochondria support  • Why plant medicines and NRF2 activators can turn on 1,100 healing genes in 24 hours  • The surprising link between nootropics, psychedelics, serotonin, and endogenous DMT  • How mindset, belief systems, and placebo/nocebo shape immune function and metabolism  • Why RFK’s chronic disease warning connects to viral evolution and immune collapse  • The real reason carnivore diets work—and when they fail without gut repair  • Peptides, GLP-1 agonists, and the future of functional medicine hacking  • Why most people sabotage themselves and how to stop fighting your own biology  This is essential listening for anyone serious about biohacking, human performance, and longevity, and for those who want to understand how functional biology and mitochondrial science are redefining recovery, energy, and aging.   Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.   Keywords: NRF2 activation, Neurogenesis and hippocampus repair, Plant-based epigenetic triggers, Psychosomatic health, Serotonin to DMT conversion, Pineal gland methylation, Parasites and brain inflammation, Viral-driven evolution, GLP-1 agonists and longevity, Psilocybin lifespan extension, Autophagy and brain cleanup, Energetic medicine training, Functional peptides, BPC-157, Breathwork and CO2 tolerance, mTOR cycling, Cold exposure and dopamine, Mindset-driven immune function  Thank you to our sponsors!  • EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.  • Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.  • Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  • fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.  Resources:   • Learn more from Alberto at: www.thefourwinds.com and www.albertovilloldo.net  • Buy the book ‘Grow A New Brain’: https://a.co/d/5lVhrVy  • Business of Biohacking | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/  • Danger Coffee: https://dangercoffee.com/discount/dave15  • Dave Asprey’s BEYOND Conference: https://beyondconference.com  • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Upgrade Collective: https://www.ourupgradecollective.com  • Upgrade Labs: https://upgradelabs.com  • 40 Years of Zen: https://40yearsofzen.com    Timestamps:  0:00 — Trailer  1:25 — Introduction & Ayahuasca Story  3:15 — Shamanism Beyond Plant Medicine  6:53 — Losing Your Mind to Evolve  10:45 — The 22-Day New Brain Cycle  12:53 — Plant Communication & Direct Knowing  15:35 — Parasites, Liver Failure & Brain Damage  20:25 — Remote Healing & CIA Research  22:40 — Tryptophan, Turkey Farmers & Brain Chemistry  25:19 — Viruses as Evolutionary Drivers  30:30 — Psilocybin & Life Extension  35:25 — Healing with Mindset + Biology  38:52 — Spirit, Purpose & Growing Gods  43:49 — Plants, Protein & mTOR  49:07 — Training the Four Brains  51:16 — Cold Exposure: Pain vs Suffering  54:40 — Who Am I? Living the Question  55:25 — Closing  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    57 min
  5. Solo Episode - Nicotine Masterclass (pt. 1)

    14 OCT

    Solo Episode - Nicotine Masterclass (pt. 1)

    Nicotine isn’t just addictive—it might be one of the most misunderstood nootropics in modern medicine. In this masterclass, you’ll learn how controlled, low-dose nicotine may enhance brain performance, boost neuroplasticity, improve mitochondrial function, and potentially extend lifespan. Host Dave Asprey breaks down the surprising science behind this controversial compound, separating fact from fear—and exposing the real risks that nobody talks about.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR  You’ll discover how nicotine affects neurotransmitters, why it may help with ADHD and focus, and how it compares to other cognitive enhancers like caffeine, nootropics, and even smart drugs. Dave explores how nicotine can be used to hack metabolism, enhance sleep optimization, and support fasting or ketosis protocols—if used properly.  He also reveals the forms of nicotine that are safest (spoiler: it’s not vapes or cigarettes), how nicotine works at the receptor level, and what the science says about long-term health effects. This episode blends functional medicine, brain optimization, and biohacking into one powerful, myth-busting breakdown.  You’ll Learn:  • How nicotine affects mitochondria, neurotransmitters, and dopamine signaling  • Why nicotine may boost neuroplasticity, memory, and attention span  • How low-dose nicotine compares to caffeine, modafinil, and other nootropics  • The safest delivery forms (and the ones to avoid)  • Whether nicotine supports or hinders longevity and cognitive resilience  • How it can be stacked with supplements, fasting, or ketosis  • What functional medicine says about chronic use, addiction, and withdrawal  This is essential listening for anyone serious about biohacking, human performance, and longevity, and for those who want to understand how functional biology and mitochondrial science are redefining recovery, energy, and aging.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Nicotine microdosing, Nicotinic acetylcholine receptors, Dopamine and motivation, Cognitive enhancement, Alzheimer’s prevention, Neuroinflammation, Mitochondrial function, TNF-alpha reduction, Vagus nerve activation, Longevity biohacking, Nicotine vs smoking, Nootropics, Attention and vigilance, Ketosis and metabolism, Functional medicine, Nicotine patches and gum, Addiction and tolerance, Receptor desensitization, Withdrawal protocols, Deep work performance   Thank you to our sponsors!  -TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off.  -HeartMath | Go to https://www.heartmath.com/dave to save 15% off.  -Leela Quantum Tech | Check out all HEAL360 products and research and get 10% off at https://leelaq.com/DAVE.  -Calroy | Head to https://calroy.com/dave for an exclusive discount.  Resources:   • Business of Biohacking | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/  • Danger Coffee: https://dangercoffee.com/discount/dave15  • Dave Asprey’s BEYOND Conference: https://beyondconference.com  • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Upgrade Collective: https://www.ourupgradecollective.com  • Upgrade Labs: https://upgradelabs.com  • 40 Years of Zen: https://40yearsofzen.com    Timestamps:  0:00 — Introduction  1:27 — History & Background of Nicotine  4:34 — How Nicotine Works  15:12 — Benefits & Research  16:43 — Risks & Who Should Avoid It  21:39 — Delivery Methods & Dosing  26:30 — Conclusion & Next Steps  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    27 min
  6. 7 Toxic Foods POISONING Your Family's Health (Avoid These!)

    13 OCT

    7 Toxic Foods POISONING Your Family's Health (Avoid These!)

    These "toxic foods" are one of the biggest hidden threats to your health and most people are eating them every single day without realizing it. These cheap industrial foods are marketed as “healthy,” but the truth is they damage your cells, drive inflammation, and speed up aging. In this video, I’m exposing the dark history behind how they ended up in our food system, why regulators don’t protect you, and the toxic process used to make them. I’ll also show you what to cook with instead so you can lower inflammation, protect your brain, and get back the vitality the food industry has been stealing from you. If you care about longevity, energy, and real health, not marketing lies, this is one video you don’t want to miss. Chapters: 0:00 – Introduction 0:50 – What They Don’t Tell You About This 2:40 – How Healthy Fats Become Toxic Poisons 3:40 – The Food Industry’s Biggest Switch 5:37 – #1: The Everyday Additive That Wrecks Your Brain 6:51 – #2: The Snack Food Staple That Fuels Inflammation 7:55 – #3: The “Healthy” Oil Used in Engines 8:57 – #4: The Candle Wax That Became Food 9:40 – #5: The Cooking Oil That Ages You Faster 10:23 – #6: The Gasoline Replacement You’re Eating 11:01 – #7: The Wine Waste Product in Your Pantry 12:19 – Bonus: The One Contaminated with Heavy Metals 13:59 – How To Protect Yourself & Choose Real Fats 15:36 – Final Warning: The Food System Is Rigged _______ Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Coffee: https://dangercoffee.com/DAVE15 Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Collective: https://www.ourupgradecollective.com Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    16 min
  7. The WATER Hack That Boosts Mitochondria by 11%!

    10 OCT

    The WATER Hack That Boosts Mitochondria by 11%!

    What if you could improve your mitochondria, oxygen efficiency, and recovery in just 20 minutes a day—by breathing energized water? This episode explores one of the most surprising breakthroughs in biohacking and how it can help you live longer, think clearer, and perform better.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey talks with Rowena Gates, co-founder of NanoVi, a therapeutic device backed by biophysics research that supports protein repair and mitochondrial communication. Her work reveals how structured water inside your cells drives neuroplasticity, cellular regeneration, and stress resilience—offering a new pathway to recovery, energy, and longevity.   You’ll learn how structured water affects mitochondrial efficiency, how it compares to recovery methods like cold therapy and fasting, and why improved VO₂ max may correlate with a longer lifespan. Dave and Rowena also explore how NanoVi stacks with supplements, nootropics, ketosis, and functional medicine to enhance brain optimization, metabolism, and human performance.   You’ll Learn:  • How structured water boosts mitochondrial function and VO₂ max  • The difference between hydration and energized cellular water  • What happens to your brain and heart rate variability in 20 minutes of NanoVi use  • The link between water structure, protein repair, and recovery  • How biohackers combine NanoVi with fasting, cold therapy, and sleep optimization for faster results  • Why stronger mitochondrial communication can extend lifespan and upgrade cognitive function  They explore how structured water, mitochondrial repair, and recovery science intersect to create a smarter approach to health and longevity. You’ll also learn how optimizing cellular communication, oxygen efficiency, and stress resilience can accelerate healing, improve focus, and extend lifespan.  This is essential listening for anyone serious about biohacking, human performance, and longevity, and for those who want to understand how functional biology and mitochondrial science are redefining recovery, energy, and aging.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.   Keywords: NanoVi, Structured water, Energized water, Biohacking, Dave Asprey, Mitochondrial repair, Mitochondrial communication, Human performance, Longevity, Recovery science, Oxidative stress, Protein repair, Redox signaling, Cellular hydration, Functional medicine, VO₂ max, Neuroplasticity, Brain optimization, Cellular energy, Stress resilience, Cold therapy, Fasting, Sleep optimization, Breathwork, Nootropics, Metabolism, Oxygen efficiency, ATP production, Cellular regeneration, Anti-aging, Smarter Not Harder  **To level up your mitochondria with a NanoVi: visit https://eng3corp.com/dave/ **  Resources:   • Business of Biohacking Summit | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/  • Danger Coffee: https://dangercoffee.com/discount/dave15  • Dave Asprey’s BEYOND Conference: https://beyondconference.com  • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Upgrade Collective: https://www.ourupgradecollective.com  • Upgrade Labs: https://upgradelabs.com  • 40 Years of Zen: https://40yearsofzen.com   Timestamps:  0:00 — Trailer  1:25 — Introduction to NanoVi  4:01 — How to Use NanoVi  6:23 — Understanding Ordered Water  9:16 — Scientific Evidence & Studies  13:02 — Pricing & Accessibility  15:02 — Mitochondrial Function & MiScreen Results  19:55 — Brain Function & Cognitive Benefits  23:47 — How Ordered Water Works  27:34 — Cellular Communication & Fascia  30:14 — Heart Rate Variability & Stress Reduction  34:54 — Athletic Performance & Recovery  38:52 — Mental Health & Sleep Benefits  42:00 — Supplement Stacking  45:50 — Deep Sleep & Parasympathetic State  48:48 — Chronic Conditions & Fatigue  51:54 — Meditation & Brain Training  55:42 — Brain Injury & Resilience  59:36 — Conclusion & Where to Get It  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    1 hr
  8. Digital Twins: The End of Human Drug Testing for Biohackers

    9 OCT

    Digital Twins: The End of Human Drug Testing for Biohackers

    AI is transforming medicine at a speed never seen before. In this episode, you’ll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtual cells and tissues, running clinical experiments in minutes instead of years to create truly individualized medicine.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR  Dr. Derya Unutmaz is a world-renowned immunologist, systems biologist, and professor at The Jackson Laboratory. With more than 150 scientific papers, he’s a leading expert in immune system research and one of the first scientists to pioneer the concept of digital twins for biology. His groundbreaking work uses AI to model how immunity, metabolism, and aging interact—creating new possibilities for personalized medicine, disease prevention, and lifespan extension.  Host Dave Asprey and Dr. Unutmaz reveal how AGI will soon outperform doctors, accelerate functional medicine, and optimize human biology far beyond today’s standards. You’ll learn how the immune system drives inflammation and aging, how to re-engineer it for resilience, and why compounds like GLP-1 and metformin may add years to your life.  You’ll Learn:  • How digital twins will end human drug testing  • Why AGI could replace doctors and computer jobs within five years  • How AI models immune function, metabolism, and aging  • The role of mitochondria and inflammation in longevity  • How GLP-1 drugs and metformin extend lifespan  • What continuous biological monitoring means for health tracking  • How AI is transforming functional medicine and personalized care  • Why NAD and energy metabolism are key to human performance  They explore how artificial intelligence, biohacking, and systems biology intersect to create a smarter approach to health and longevity. You’ll also learn how understanding immune balance, metabolism, and mitochondrial function helps build resilience and extend your lifespan.  This is essential listening for anyone serious about biohacking, hacking human performance, and extending longevity through personalized medicine, functional biology, and cutting-edge AI innovation.  This is essential listening for anyone serious about biohacking, hacking human performance, improving mobility, and extending longevity. You’ll also learn how neuroplasticity, metabolism, and brain optimization all connect to the way you move.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: AI medicine, Digital twins, Functional medicine, Biohacking, Longevity, Immune system, Inflammation, Personalized medicine, GLP-1 therapy, Metformin, NAD boosters, Mitochondrial function, Metabolism, AGI, Clinical trials, Human performance, Aging research, Systems biology, Immunology, Smarter Not Harder  Thank you to our sponsors!   BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.  ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order  Resources:   • Keep up with Derya’s work: https://x.com/derya_?lang=en  • Business of Biohacking Summit | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/  • Danger Coffee: https://dangercoffee.com/discount/dave15  • Dave Asprey’s BEYOND Conference: https://beyondconference.com  • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Upgrade Collective: https://www.ourupgradecollective.com  • Upgrade Labs: https://upgradelabs.com  • 40 Years of Zen: https://40yearsofzen.com    Timestamps:  00:00 — Trailer  01:25 — Intro  02:26 — AI’s Role in Extending Lifespan  02:56 — Regulatory Frameworks and Medical Adoption  05:19 — Problems with the Immune System  08:19 — Chronic Fatigue and Long COVID Research  10:32 — Modern Testing and Multi-Omic Analysis  14:07 — Personal Longevity Strategy and Supplements  15:17 — Understanding Exhausted Cells  23:43 — Personalization in Medicine and AI Analysis  31:35 — Longevity Escape Velocity  36:13 — AI Doctors and Prescriptions  39:55 — Data Quality Concerns in AI Training  43:19 — The Future of Wearable Technology  45:50 — Revolutionizing Education with AI  49:04 — The Future of Higher Education  52:03 — Future of Work and AI Agents  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™. You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human. Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward. Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life. 

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