9 episodes

Lifespan with Dr. David Sinclair is a new podcast from world renowned aging research doctor, David Sinclair, Ph.D. Dr. Sinclair is a professor of genetics and co-director of Harvard Medical School's Center for Biology of Aging Research. Topics discussed include the science behind why we age and interventions for slowing and even reversing aging.

This podcast is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice.

Lifespan with Dr. David Sinclair Scicomm Media

    • Health & Fitness
    • 4.9 • 53 Ratings

Lifespan with Dr. David Sinclair is a new podcast from world renowned aging research doctor, David Sinclair, Ph.D. Dr. Sinclair is a professor of genetics and co-director of Harvard Medical School's Center for Biology of Aging Research. Topics discussed include the science behind why we age and interventions for slowing and even reversing aging.

This podcast is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice.

    Biotracking, Age Reversal & Other Advanced Health Technologies | Episode 8

    Biotracking, Age Reversal & Other Advanced Health Technologies | Episode 8

    In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered.

    Thank you to our sponsors:


    Levels - https://levels.link/sinclair
    Athletic Greens - https://athleticgreens.com/sinclair
    InsideTracker - https://insidetracker.com/sinclair

    Our Patreon page: https://www.patreon.com/davidsinclair 

    Lifespan book: https://amzn.to/3sUqurT

    Dr. David Sinclair Social:


    Instagram
    Twitter
    Facebook

    Matthew LaPlante's Social:


    Twitter

    To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

    Timestamps:

    (00:00:00) Introducing Episode Eight: The Future of Anti-aging Medicine

    (00:03:49) Thanking the Sponsors

    (00:06:48) Modern Healthcare, Disease Detection, and Circulating DNA

    (00:11:30) Wearable Monitors: A Dashboard for your Body

    (00:20:31) Types of Health Sensors

    (00:24:20) Big Data, Privacy, and Criminal Investigation

    (00:30:16) Cutting-edge Testing and Biological Age

    (00:36:40) Using Personalized Data to Inform your Diet

    (00:41:48) Optimizing Exercise and Activity-mimetics

    (00:45:02) Resetting the Aging Clock

    (00:53:45) Repeatable Age Reversal and Safety

    (00:56:11) Longer Life, Population Size, and Economics

    (01:00:18) Skillbatical

    (01:03:06) Putting in the Work for Longevity

    (01:04:56) Thanking the Podcast Team and Wrapping Up Season One

    (01:08:27) Options for Subscription and Support

    For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

    Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac

    Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

    • 1 hr 9 min
    The Science of Keeping the Brain Healthy | Episode 7

    The Science of Keeping the Brain Healthy | Episode 7

    In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep.

    Thank you to our sponsors:


    Athletic Greens - https://athleticgreens.com/sinclair
    Levels - https://levels.link/sinclair
    InsideTracker - https://insidetracker.com/sinclair

    Our Patreon page: https://www.patreon.com/davidsinclair 

    Lifespan book: https://amzn.to/3sUqurT

    Dr. David Sinclair Social:


    Instagram
    Twitter
    Facebook

    Matthew LaPlante's Social:


    Twitter

    To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

    Timestamps:

    (00:00:00) Introducing Episode Seven: Aging of the Brain

    (00:04:39) Thanking the Sponsors

    (00:07:38) Ex-differentiation as a Driver of Aging

    (00:09:22) The Brain Ages Slowly

    (00:14:17) Cognitive Function and Plasticity

    (00:17:44) Three Longevity Pathways: mTOR, AMPK, and Sirtuins

    (00:23:26) Plant-based Diets and B-vitamins

    (00:28:32) Homocysteine, Plaque, and Vasculature

    (00:32:35) Fatty Acids

    (00:35:48) Physical Activity

    (00:39:14) Metformin

    (00:46:02) NAD Boosters

    (00:50:33) Increasing Blood Flor

    (00:53:20) Sleep

    (00:58:02) Overall Message: Keep your Brain Healthy

    (00:58:50) Next Week’s Episode and the Future of Medicine

    (01:01:21) Options for Subscription for Support

    For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

    Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac

    Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

    • 1 hr 2 min
    The Science of Looking Younger, Longer | Episode 6

    The Science of Looking Younger, Longer | Episode 6

    In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections.

    Thank you to our sponsors:


    Athletic Greens - https://athleticgreens.com/sinclair
    Levels - https://levels.link/sinclair
    InsideTracker - https://insidetracker.com/sinclair

    Our Patreon page: https://www.patreon.com/davidsinclair 

    Lifespan book: https://amzn.to/3sUqurT

    Dr. David Sinclair Social:


    Instagram
    Twitter
    Facebook

    Matthew LaPlante's Social:


    Twitter

    To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

    Timestamps:

    (00:00:00) Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair

    (00:02:54) Estrogen, Progesterone, and Menopause

    (00:09:51) Thanking the Sponsors

    (00:12:57) The Pinch Test, Epidermal Thinning, and Foot Ulcers

    (00:18:29) Skin and Biological Aging

    (00:23:19) Cellular Senescence, Ultraviolet Light, and Skin Aging

    (00:28:15) Collagen, Keratin, and Skin Health

    (00:33:38) A Quick Aside about Nails

    (00:34:45) Autophagy and Retinoids

    (00:36:57) Resveratrol, NAD Boosters, and Hyaluronic Acid

    (00:41:44) Botox, Skin Peels, and Microneedling

    (00:43:28) No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food

    (00:45:42) Hair Loss and Hair Graying

    (00:49:45) Topical Treatments, Pills, and Dihydrotestosterone

    (00:55:19) Frickin Laser Beams: Low-level Laser Therapy

    (00:57:59) Platelet-rich Plasma (PRP) Injections

    (01:00:11) Hair Aging, Stress, and Gray Hair Reversal

    (01:06:11) Targeting Aging Upstream

    (01:07:37) Today’s Takeaways

    (01:09:25) Subscription and Support Options

    For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

    Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac

    Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

    • 1 hr 10 min
    Medical Interventions (TRT, HGH, Stem Cells, Peptides, etc.) For Longevity | Episode 5

    Medical Interventions (TRT, HGH, Stem Cells, Peptides, etc.) For Longevity | Episode 5

    In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed.

    Thank you to our sponsors:


    Athletic Greens - https://athleticgreens.com/sinclair
    InsideTracker - https://insidetracker.com/sinclair
    Levels - https://levels.link/sinclair

    Our Patreon page: https://www.patreon.com/davidsinclair 

    Lifespan book: https://amzn.to/3sUqurT

    Dr. David Sinclair Social:


    Instagram
    Twitter
    Facebook

    To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

    Matthew LaPlante's Social:


    Twitter

    Timestamps:

    (00:00:00) Kicking Off Episode Five: Interventions on the Cutting Edge

    (00:02:39) Expressing Gratitude to the Sponsors

    (00:05:28) Testosterone Replacement Therapy

    (00:10:09) Human Growth Hormone

    (00:13:56) Peptide Supplementation and Regenerative Signaling

    (00:18:11) MOTS-c, Humanin, and Other Peptides

    (00:25:05) Exosome Therapy

    (00:31:56) A Primer on Stem Cells and Yamanaka Factors

    (00:37:59) Stem Cell Aging and Cord Blood Banking

    (00:41:42) The Therapeutic Potential of Stem Cells

    (00:43:37) Cellular Reprogramming

    (00:51:35) Resetting the Aging Clock

    (00:56:50) The Future Looks Bright

    (00:58:15) Next Week’s Episode: External Aging

    (00:58:36) Subscription and Support Options

    For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

    Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac

    Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

    • 59 min
    NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4

    NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4

    In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted.

    Correction and clarification: At time point 1:07:37, Dr. Sinclair says he takes 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. We apologize for the confusion.

    Thank you to our sponsors:


    Athletic Greens - https://athleticgreens.com/sinclair
    InsideTracker - https://insidetracker.com/sinclair
    Levels - https://levels.link/sinclair

    Our Patreon page: https://www.patreon.com/davidsinclair 

    Lifespan book: https://amzn.to/3sUqurT

    Dr. David Sinclair Social:


    Instagram
    Twitter
    Facebook

    To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

    Matthew LaPlante's Social:


    Twitter

    Timestamps:

    (00:00:00) Kicking Off Episode Four: Longevity Molecules

    (00:02:15) Thanks the Sponsors

    (00:04:46) An An Additional Boost Beyond Adversity Mimetics

    (00:05:52) Drugs vs. Supplements and Highlight Points

    (00:09:54) Longevity Molecules Target the Survival Circuit

    (00:11:33) NAD Boosters

    (00:13:32) Nicotinamide Riboside

    (00:21:26) Nicotinamide Mononucleotide

    (00:29:22) NAD Intravenous Drips

    (00:32:45) Bioavailability of NAD Boosters

    (00:33:40) NAD and Cancer

    (00:35:33) Resveratrol

    (00:42:26) Red Wine and the French Paradox

    (0043:08) Fisetin and Quercetin

    (00:47:09) Rapamycin and Rapalogs

    (00:49:10) Spermidine

    (00:51:27) Metformin

    (01:00:27) Berberine

    (01:02:43) Dr. Sinclair’s Protocol for Longevity Molecules

    (01:08:51) Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge

    (01:09:52) Options for Subscription and Support

    For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

    Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac 

    Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

    • 1 hr 10 min
    Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3

    Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3

    In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity. David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels.

    Thank you to our sponsors:


    Athletic Greens - https://athleticgreens.com/sinclair 
    Levels - https://levels.link/sinclair 
    InsideTracker - https://insidetracker.com/sinclair 

    Our Patreon page: 


    https://www.patreon.com/davidsinclair

    Timestamps:

    (00:00:00) Introducing Episode 3: Exercise Hot Cold

    (00:01:01) A Pernicisous Element Called Iron

    (00:02:46) A Quick Primer on Free Radicals

    (00:05:42) Review of Dietary Takeaways

    (00:07:01) Sponsors

    (00:09:32 Biological Adversity & the Survival Circuit

    (00:13:24) Survival Sensors (i.e., mTOR, AMPK, and Sirtuins) & Communicators (e.g., Insulin)

    (00:17:25) Get Off Your Butt

    (00:19:40) Exercise Protects against Disease & Mortality

    (00:21:17) Daily Step Count and Walking After Eating

    (00:22:33) Exercise Activates AMPK and Creates More Mitochondria

    (00:24:03) Vigorous Exercise, Hypoxia, the Electron Transport Chain

    (00:28:19) Exercise Increases Glucose Sensitivity and Stimulates Blood Vessel Formation

    (00:32:13) The Epigenome and Biological Age are Impacted by Exercise

    (00:36:43) How to Measure your Biological Age

    (00:37:31) Exercise Recommendations

    (00:39:28) Wearables and Individualized Health Tracking

    (00:43:14) The Importance of Weight Training

    (00:46:08) Physical Activity & Senescent Cells

    (00:48:01) Wrap-up & Takeaways

    (00:49:47) Hyperbaric Oxygen Therapy

    (00:57:24) Cold Therapy

    (01:03:50) Applying Heat

    (01:07:04) Adversity Mimetics Produce Endorphins

    (01:08:07) A Basic Protocol for Mimicking Adversity

    (01:10:04) Next Week: Molecules & Supplements

    (01:10:45) Subscription & Support

    For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

    Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Title Card Photo Credit: Mike Blabac

    Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

    • 1 hr 11 min

Customer Reviews

4.9 out of 5
53 Ratings

53 Ratings

pihagirl ,

Should be mandatory listening

This podcast is simply inspirational. My husband and I have been thrilled to have the science digested for us and intend to follow almost all of David‘s recommendations. As carers of an elderly parent we wholeheartedly agree that everyone has the obligation to live as well as they can until they die and certainly hope to do so.

fragmented5 ,

Simply Brilliant

David Sinclair’s work and research is just amazing. Put in terms thawed can all understand this podcast is life changing.

Sukigeri ,

Do another series!!!

I have loved the first series and think you should do another. As a woman, I would appreciate one on female ageing especially around hormone levels as we age and what we can safely do about it.

Thanks

Susan

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