The Incubator

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09/12/2025

#386 - 🟢 HOT TOPICS 2025 COVERAGE - Breaking the Innovation Plateau with Dr. Daniele De Luca and the Lancet Commission's Blueprint for Neonatology's Future

Send us a text In this episode of The Incubator Podcast, recorded live at Hot Topics in Neonatology in Washington, DC, we sit down with Dr. Daniele De Luca, Chief of Pediatric and Neonatal Critical Care at AP-HP Paris-Saclay University and leader of one of Europe's largest NICUs. Dr. De Luca discusses the groundbreaking Lancet Child & Adolescent Health Commission on the Future of Neonatology, a three-year initiative involving over 100 global key opinion leaders addressing the critical innovation gap in our specialty. He explores why neonatal medicine has experienced a slowdown in therapeutic advances since the 1990s, despite treating patients who will become citizens for decades ahead. The conversation covers the multifactorial barriers to innovation—from regulatory challenges to funding constraints—and the Commission's comprehensive recommendations for industry, regulators, academic centers, and patient representatives. Dr. De Luca emphasizes the urgent need to avoid treating babies in 20 years the same way we did 20 years ago, highlighting specific examples like the decades-long journey from drug development to registration and the paradox of FDA-approved equipment. He calls for a united approach to elevate neonatology's profile, establish formal specialty recognition, and accelerate the translation of research into bedside care. Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

09/12/2025

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16 min
09/12/2025

#386 - 🟢 HOT TOPICS 2025 COVERAGE - Discussing the results of the PDA trial with Dr. Matthew Laughon

Send us a text Dr. Matthew Laughon, Professor at University of North Carolina and NICHD Neonatal Research Network investigator, presents the landmark PDA Management Trial comparing expectant management versus active medical treatment (indomethacin, ibuprofen, or acetaminophen). The trial stopped early due to futility and safety concerns—mortality exceeded 10% in the treatment group versus 4% with expectant management, with more infection-related deaths among treated infants. Secondary outcomes (BPD, NEC, ROP) showed no differences. The study included infants with symptomatic PDAs but excluded those with severe cardiopulmonary compromise. Findings support expectant management for symptomatic PDAs through 21 days of life, aligning with recent guidelines recommending no routine treatment in the first two weeks. Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

09/12/2025

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21 min
19/01/2025

#273 - 📑 Journal Club - The Complete Episode from January 19th 2024

Send us a text In this week’s Journal Club, Ben and Daphna discuss six impactful studies shaping neonatal care. The conversation opens with a retrospective study exploring the timeline and factors influencing liberation from respiratory support in infants with severe bronchopulmonary dysplasia (BPD), offering valuable insights for parental counseling and care planning. A survey on enteral nutrition practices in U.S. NICUs highlights variability in feeding protocols and fortification strategies, with an encouraging trend toward donor milk use. The hosts then delve into a study on anti-seizure medication protocols, showing how structured pathways can significantly reduce the number of infants discharged on these medications. A European survey on anemia of prematurity reveals wide variations in iron supplementation and erythropoietin use, emphasizing the need for standardized practices. They also review a commentary on the evolving design of NICUs, which warns against sensory deprivation and advocates for balancing protective and nurturing environments. Finally, the discussion turns to a Spanish study on bemiparin, a low molecular weight heparin for neonatal thrombosis. While safe, the treatment faces challenges in achieving full thrombus resolution, highlighting the complexities of managing neonatal clotting disorders. Packed with insights and updates, this episode is a must-listen for neonatal professionals. Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

19/01/2025

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1h 18m
17/11/2025

#377 - 💡 Rethinking Phototherapy – Phototherapy as Pharmacotherapy with Dr. Daniel Rauch

Send us a text In the second installment of our Rethinking Phototherapy series, Ben and Daphna welcome Dr. Daniel Rauch, Professor of Pediatrics at the Hackensack Meridian School of Medicine and Division Chief of Pediatric Hospital Medicine and General Academic Pediatrics at Joseph Sanzari Children’s Hospital. Dr. Rauch co-authored the AAP technical report on phototherapy and brings a unique perspective on how light therapy should be understood and applied in clinical practice. This conversation reframes phototherapy as a true pharmacotherapy—an intervention that must be delivered in precise doses with attention to wavelength, irradiance, body surface exposure, and treatment duration. Dr. Rauch explains why more light is not always better, how technology has evolved from “easy-bake oven” style lamps to modern LED systems, and why maximizing body surface exposure often matters more than piling on extra light banks. The discussion also touches on cycling strategies, the value and limitations of transcutaneous monitoring, and the potential of home phototherapy to reduce unnecessary hospitalizations while supporting family bonding. Listeners will gain practical insights into the art and science of phototherapy: how to optimize treatment, minimize harm, and communicate clearly with families navigating jaundice management. Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

17/11/2025

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44 min
01/12/2024

#260 - 📑 Journal Club - The Complete Episode from December 1st 2024

Send us a text In this episode of Journal Club, Ben and Daphna review several recent studies that hold meaningful implications for neonatal care. They begin by discussing a comprehensive meta-analysis on postnatal corticosteroids, exploring their impact on bronchopulmonary dysplasia (BPD) and cerebral palsy outcomes. The conversation highlights the nuanced findings, including the benefits for high-risk infants and the risks for those at lower risk, and considers how these insights could guide clinical decisions. Next, they analyze a large observational study investigating thrombocytopenia and its relationship to major bleeds in preterm infants. The discussion focuses on whether low platelet counts directly contribute to bleeding or are merely a marker of other conditions, with potential implications for transfusion thresholds. The episode also features an EBNeo segment with guest experts, who provide an in-depth discussion of a pivotal trial comparing video and direct laryngoscopy for neonatal intubation. They evaluate the study’s design, its impact on procedural success, and its role in enhancing trainee education. This episode of Journal Club offers evidence-based insights and actionable takeaways for neonatal clinicians, with a focus on advancing care and improving outcomes for vulnerable newborns. Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

01/12/2024

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2h 4m
22/09/2025

#050 - 📑 Journal Club - Les derniers articles de recherche en néonatologie (22 septembre 2025)

Dans ce nouvel épisode de Journal Club, Ben et Gabriel discutent de plusieurs publications récentes qui pourraient influencer la pratique en néonatologie.La conversation débute avec une étude parue dans The Lancet Child & Adolescent Health sur l’utilisation du CPAP nasal dès la salle de naissance, comparé au masque facial classique. Les auteurs suggèrent que cette approche pourrait réduire la nécessité de ventilation à pression positive chez les prématurés de moins de 32 semaines.Ils abordent ensuite l’essai BORN, un essai multicentrique italien qui explore l’utilisation de globules rouges provenant de sang de cordon ombilical plutôt que de sang adulte pour les transfusions. Bien que les résultats primaires ne montrent pas de différence significative, des analyses secondaires suggèrent un effet potentiel sur la réduction de la rétinopathie sévère et de la dysplasie bronchopulmonaire.Enfin, Ben et Gabriel analysent des données internationales portant sur les enfants nés à 22–23 semaines de gestation. Les variations de survie et de morbidité entre réseaux soulèvent des questions éthiques et organisationnelles sur la prise en charge de ces nouveau-nés extrêmement prématurés. Liens vers les articles revus dans cet episode: Face mask versus nasal mask device use for initial resuscitation in extremely and very preterm infants (FONDUE): an open-label, single-centre, randomised, controlled trial. Blank DA, Zhou L, Malhotra A, Bhatia R, Badurdeen S, Davies-Tuck M, Duthie K, Tuttle Z, Gilby DM, Polglase GR, Hooper SB, Roberts CT.Lancet Child Adolesc Health. 2025 Oct;9(10):715-723. doi: 10.1016/S2352-4642(25)00193-2.PMID: 40908053 Clinical Trial. Cord red blood cell transfusions for severe retinopathy in preterm neonates in Italy: a multicenter randomized controlled trial. Teofili L, Papacci P, Pellegrino C, Dani C, Cresi F, Remaschi G, Ansaldi G, Giannantonio C, Campagnoli MF, Vania B, Fabbri M, de Vera d' Aragona RP, Molisso A, Beccastrini E, Dragonetti A, Pasciuto T, Gabbriellini S, Baroni S, Serrao F, Purcaro V, Raffaeli G, Villa S, Prati D, Mondello I, Falcone A, Patti ML, Boggini T, Bergamaschi P, Lepore D, Franco FGS, Orazi L, Mozzetta I, Baldascino A, Valentini CG, Locatelli E, Albiani R, Besso FG, Cantone GV, Coscia A, Trimarchi A, Cavallaro G, Ghirardello S, Vento G.EClinicalMedicine. 2025 Aug 13;87:103426. doi: 10.1016/j.eclinm.2025.103426. eCollection 2025 Sep.PMID: 40838199 Free Delayed cord clamping in preterm twin infants: a systematic review and meta-analysis.Chartrand L, Barrington KJ, Dodin P, Villeneuve A.Am J Obstet Gynecol. 2025 Mar;232(3):271-279.e1. doi: 10.1016/j.ajog.2024.10.024. Epub 2024 Oct 28.PMID: 39477050 Outcomes of Preterm Infants Born at 22 to 23 Weeks' Gestation in 11 International Neonatal Networks. Isayama T, Norman M, Kusuda S, Reichman B, Lehtonen L, Lui K, Adams M, Vento Torres M, Filippi L, Battin M, Guinsburg R, Modi N, Håkansson S, Klinger G, de Almei Comme d'habitude, n'hésitez pas à nous envoyer vos questions, commentaires ou suggestions à notre courriel : nicupodcast@gmail.com. Vous pouvez également contacter l'émission via Instagram ou Twitter, @nicupodcast Ou contactez Ben et Gabriel directement via leurs profils Twitter : @drnicu et @CardioNeo. Les documents discutés dans l'épisode d'aujourd'hui sont listés et horodatés sur la page web liée ci-dessous. Bonne lecture ! _____________________________________________________________________________________ Les notes de l'émission, les articles et le formulaire de FMC sont disponibles sur notre site Web : www.lincubateur.org

22/09/2025

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1 hr
28/09/2025

#362 - 50 Studies Every Neonatologist Should Know

Send us a text What if you could hold in your hands a roadmap to the most influential studies that have shaped modern neonatology? In this special episode of The Incubator Podcast, Ben and Daphna sit down with Dr. John Zupancic, Dr. Susanna Hay, and Dr. Roger Soll to discuss the release of their new book, 50 Studies Every Neonatologist Should Know. Together with their co-editors Dr. Barbara Schmidt and Dr. Haresh Kirpalani, the team has distilled decades of neonatal research into an accessible, thoughtfully structured volume designed to guide clinicians, trainees, and educators. The conversation explores the motivation behind the book, the editorial process of selecting just 50 landmark trials from thousands, and the importance of revisiting historical studies to understand how evidence has evolved over time. From the groundbreaking DART trial to the early work of pioneers like Bill Silverman, the authors emphasize not only the science but also the stories, challenges, and human insights that lie behind each study. Whether you are a seasoned neonatologist or just beginning your training, this episode provides a behind-the-scenes look at a project that brings clarity and context to evidence-based practice. 📖 Get your copy of the book here: https://amzn.to/4nVTqcq Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

28/09/2025

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52 min
7 JAN

#392 - [Journal Club] - 📌 Could Longer Caffeine Treatment Reduce Hypoxia and Speed Discharge?

Send us a text Ben and Daphna review the ICAF randomized clinical trial evaluating extended caffeine therapy in preterm infants and its impact on intermittent hypoxia through 41 weeks postmenstrual age. They discuss the study design, oximetry outcomes across multiple saturation thresholds, inflammatory biomarkers including TNF-α, and clinically relevant safety signals such as oxygen restart rates, length of stay, and weight gain. The conversation focuses on what intermittent hypoxia may mean for ongoing risk, and whether a targeted subgroup of infants might benefit from extending caffeine beyond traditional stopping points. ---- Intermittent hypoxia and caffeine in infants born preterm: the ICAF Randomized Clinical Trial. Eichenwald E, Corwin M, McEntire B, Knoblach S, Limperopoulos C, Kapse K, Kerr S, Heeren TC, Ikponmwonba C, Hunt CE; ICAF Study Group.Arch Dis Child Fetal Neonatal Ed. 2025 Nov 24:fetalneonatal-2025-329230. doi: 10.1136/archdischild-2025-329230. Online ahead of print.PMID: 41285561 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

7 Jan

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15 min
10/11/2024

#254 - 📑 Journal Club - The Complete Episode from November 9th 2024

Send us a text In this latest episode of The Incubator Podcast Journal Club, Ben and Daphna explore studies that may shift clinical practices in neonatal care. They begin with a study from India examining oral calcium phosphate as an adjunct to phototherapy in treating neonatal jaundice. This double-blind, randomized, placebo-controlled trial investigates how calcium phosphate may help reduce bilirubin levels by binding to unconjugated bilirubin in the gut, potentially minimizing the need for prolonged phototherapy. The findings suggest that calcium phosphate could lower phototherapy duration and decrease cases of rebound hyperbilirubinemia, offering a possible new approach for jaundiced newborns. The episode also covers an intriguing study on alternative treatments for persistent pulmonary hypertension of the newborn (PPHN). By comparing oral sildenafil to bosentan, this research sheds light on the potential of sildenafil to reduce PASP more efficiently, especially in resource-limited settings. The team discusses these insights and examines how they may influence care for PPHN cases worldwide. Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

10/11/2024

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1h 31m
18/11/2025

#378 - 💡 Rethinking Phototherapy – Considerations for Preterm Infants with Dr. Deepak Manhas

Send us a text What happens when we challenge our long-standing assumptions about phototherapy in the NICU? In this special installment of our Rethinking Phototherapy series, Ben and Daphna are joined by Dr. Deepak Manhas to examine one of the most complex questions: how should we manage hyperbilirubinemia in preterm infants? Unlike term babies, preemies face unique risks—shorter red blood cell lifespan, immature bilirubin conjugation, lower albumin binding, and increased blood-brain barrier permeability—all of which make them more vulnerable to bilirubin-induced neurologic dysfunction. This conversation explores why traditional guidelines cannot simply be applied to preterm infants and why clinicians often initiate phototherapy earlier. Dr. Manhas discusses the creation of gestation-specific treatment charts, the challenges and dangers of exchange transfusion in this fragile population, and the uncertain role of therapies such as IVIG, albumin, and phenobarbital. The team also unpacks practical issues: what “double phototherapy” should really mean, how to order irradiance and body surface area coverage with precision, and the role of bili blankets in promoting family bonding. By situating this discussion in the broader Rethinking Phototherapy series, the episode highlights both the progress and the unanswered questions in caring for preterm infants. 📖 Reference: Pathogenesis and Management of Indirect Hyperbilirubinemia in Preterm Neonates Less Than 35 Weeks: Moving Toward a Standardized Approach (NeoReviews) Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

18/11/2025

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43 min

Ben and Daphna go through daily neonatal board questions. If you are studying for the upcoming neonatal boards exam or just want to keep your neonatal knowledge sharp, this is the podcast for you. This show is done in collaboration with Neonatology Review (Dr. Dara Brodsky and Dr. Camilia Martin).

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The neonatology focused podcast hosted by Dr. Ben Courchia MD & Dr. Daphna Yasova Barbeau.

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