Amanda King ND is a nutritional therapist, naturopathic practitioner, and author of Metabolic Drugs for Cancer (co-written with Dr. Hari Kuhan). She also writes The Metabolic Nutritionist on Substack—followed by 30,000+ subscribers—where she breaks down off-label oncology drugs, supplements, and metabolic approaches to cancer care in clear, practical language. In this episode, Dr. King joins Dr. Michael Karlfeldt to explain why “cancer is a disease of metabolism” is more than a slogan—and how understanding metabolic weaknesses can empower smarter, more personalized integrative strategies. You’ll hear how repurposed medications can target cancer’s metabolic pathways (glucose, mitochondria, inflammatory signaling, and more), and why personalization matters more than internet protocols. Amanda and Dr. Karlfeldt discuss the Care Oncology “METRICS” drug set (including metformin, statins, doxycycline, and mebendazole), plus additional tools like ivermectin, fenbendazole, DCA, 2-DG, anti-inflammatories (aspirin/COX pathways), histamine blockers (cimetidine), and even PDE5 inhibitors like sildenafil/tadalafil—along with real cautions around dosing, contraindications, and interactions (including potential conflicts with immunotherapy). The conversation also ties metabolic therapy to the “press–pulse” concept and terrain-based care: ketogenic nutrition, inflammation reduction, oxygenation, and lifestyle foundations that strengthen the body while making cancer more vulnerable. Whether you’re a patient, caregiver, or practitioner, this episode offers a grounded roadmap for thinking about integrative oncology without guesswork—using a “test, assess, address” mindset to build a strategy that evolves with labs, symptoms, treatment phases, and the individual. Key Topics Covered Why cancer metabolism (not just genetics) is a key lever in integrative oncologyWhat repurposed/off-label drugs can target: glucose pathways, mitochondria, signaling pathways (e.g., EGFR/AKT/mTOR)Why one-size-fits-all protocols are risky—and how to personalize using “test, assess, address”The Care Oncology/METRICS drug set and when it may (or may not) fitSafety and dosing concerns with high-dose ivermectin/fenbendazole and DIY internet protocolsWhen metformin vs berberine may be appropriate—and why they can sometimes be combinedDoxycycline: potential synergy (e.g., with IV vitamin C) vs contraindications (including immunotherapy concerns)Anti-inflammatory strategy: COX pathways, aspirin vs selective COX-2 approaches, plus natural options“Press–pulse” metabolic strategy and why protocols should evolve over timeOther emerging tools discussed: DCA, 2-DG, cimetidine, itraconazole, PDE5 inhibitors (Viagra/Cialis) ----------------------------------------------- A Better Way to Treat Cancer: A Comprehensive Guide to Understanding, Preventing and Most Effectively Treating Our Biggest Health ThreatGrab my book here: https://www.amazon.com/dp/B0CM1KKD9X?ref_=pe_3052080_397514860 Unleashing 10X Power: A Revolutionary Approach to Conquering CancerGet it here: https://store.thekarlfeldtcenter.com/products/unleashing-10x-powerPrice: $24.99100% Off Discount Code: CANCERPODCAST1 Healing Within: Unraveling the Emotional Roots of CancerGet it here: https://store.thekarlfeldtcenter.com/products/healing-withinPrice: $24.99100% Off Discount Code: CANCERPODCAST2 ----------------------------------------------- Integrative Cancer Solutions was created to instill hope and empowerment. Other people have been where you are right now and have already done the research for you. Listen to their stories and journeys and apply what they learned to achieve similar outcomes as they have, cancer remission and an even more fullness of life than before the diagnosis. Guests will discuss what therapies, supplements, and practitioners they relied on to beat cancer. Once diagnosed, time is of the essence. This podcast will dramatically reduce your learning curve as you search for your own solution to cancer. To learn more about the cutting-edge integrative cancer therapies Dr. Karlfeldt offer at his center, please visit www.TheKarlfeldtCenter.com
