Hart2Heart with Dr. Mike Hart

Dr. Mike Hart
  • 4.2 (5)
  • Medicine
  • Updated Biweekly

Hart2Heart is the show where Dr. Mike Hart breaks down evidence-based health, longevity, performance, and modern medicine without the fluff. Each episode explores practical, evidence-based strategies for improving your life, including hormone health, peptides, sleep optimization, nutrition, supplements, exercise, sunlight, psychedelics, and smarter medication use. The goal is simple: help you understand what actually works so you can make better decisions for your health. The show also looks at the bigger picture, including how public health policy and politics influence personal well-being, and what you can do to take back control. If you want clear, actionable, no-BS conversations about living healthier, performing better, and thinking for yourself, this podcast is for you.

  1. 1d ago

    #230 Progesterone for Sleep, GLP-1 Microdosing, and HRT/Peptide Insights with Dr. K

    Dr. Mike Hart welcomes Ksenia Petrushkina back for a wide-ranging conversation about using hormones, GLP-1 medications, and peptides more thoughtfully. They explore why lower, individualized doses of tirzepatide may improve tolerability, which blood markers should be monitored during treatment, and how progesterone may support sleep through its effects on GABA. They also discuss women's hormone replacement therapy, personalized testosterone dosing, TRT and fertility, thyroid treatment, low-dose naltrexone, and the difference between evidence-based peptide use and exaggerated online claims. Ksenia Petrushkina is a clinician whose work focuses on hormone optimization, peptide therapy, metabolic health, and highly individualized treatment. Through comprehensive blood testing, symptom assessment, careful dose adjustments, and ongoing patient monitoring, she helps men and women better understand how hormones, medications, and peptides may affect their energy, sleep, inflammation, fertility, body composition, and long-term health. Her approach challenges standardized protocols and social-media biohacking trends, emphasizing personalized medicine, responsible prescribing, and evaluating one intervention at a time.   Quick Coherence Technique — HeartMath https://help.heartmath.com/introduction/quick-coherence-technique/ The Levels of Ghrelin, Glucagon, Visfatin and GLP-1 Are Decreased in the Peritoneal Fluid of Women with Endometriosis — Aleksey M. Krasnyi et al. https://pubmed.ncbi.nlm.nih.gov/36142272/ Women's Health Initiative — National Heart, Lung, and Blood Institute, National Institutes of Health https://www.nhlbi.nih.gov/science/womens-health-initiative-whi Facial Beauty Age Support Serum for Estrogen Deficiency — Quicksilver Scientific https://www.quicksilverscientific.com/products/facial-beauty-serum Peptides: The Science, Uses & Safety — Dr. Andrew Huberman and Dr. Abud Bakri https://www.hubermanlab.com/episode/peptides-the-science-uses-and-safety-abud-bakri Vladimir Khavinson Publications — Professor Vladimir Khavinson https://khavinson.info/publications   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:57 GLP-1 Starting Doses 03:39 GLP-1 Anti Inflammation Aging 07:15 Motility Supplements Side Effects 09:02 Tirzepatide vs Semaglutide 11:46 Adrenal Fatigue Myth 13:23 Fatigue Bloodwork Checklist 16:16 TRT Hematocrit Sleep Apnea 19:01 Underrated Blood Tests 20:06 Womens HRT Basics 22:21 Testosterone for Women 25:19 Thyroid Treatment LDN NAD 29:31 Progesterone GABA Sleep 32:25 Progesterone for Men Debate 33:43 Testosterone Injection Frequency 36:05 TRT Dosing Frequency 36:45 Why TRT Stops Working 37:50 Creams vs Injections 39:08 Fertility and HCG 41:46 Peptides vs Pharma 44:17 HGH and Secretagogues 45:12 5-Amino-1-MQ Hype 48:15 Topical GHK-Cu Skincare 50:25 Injectable Copper Peptide Hair 52:26 BPC 157 and TB500 58:25 Thymosin Alpha 1 Immunity 01:01:13 Mitochondrial Peptides 01:03:20 Endo 205 and New Peptides 01:04:17 Kavinson and Epitalon 01:08:21 Wrap Up and Where to Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  2. Jul 16

    #229 Supplements, Methylation, and Genetics: Why "Healthy" Stacks Can Trigger Anxiety

    Dr. Tyler Panzner joins Dr. Mike Hart to explain how genetics, supplement combinations, and individual brain chemistry can influence anxiety, irritability, brain fog, and the persistent "monkey on your back" feeling. They examine why the MTHFR gene is scientifically valid but often overmarketed, and why methylated B vitamins, SAMe, creatine, phosphatidylcholine, and other methylation-related supplements may help some people while overstimulating others. The conversation also explores hidden "adrenaline trappers" such as quercetin, polyphenols, and greens powders; why NAC, glutathione, and high-dose antioxidants may cause unwanted effects; and how lithium orotate, melatonin, nicotine, methylene blue, omega-3s, collagen, mitochondrial enhancers, and DHT-lowering supplements can affect people differently. Dr. Panzner also discusses pharmacogenomics, SSRI response, supplement timing around exercise, the limitations of genetic testing, and the importance of combining DNA data with bloodwork, symptoms, medication history, and baseline nutrient status. Dr. Tyler Panzner is a pharmacology and genetics expert whose work focuses on personalized supplementation, genetic testing, neurotransmitter pathways, and understanding why the same health intervention can affect people very differently. Through DNA analysis, laboratory review, supplement audits, and individualized coaching, he helps clients identify which biological pathways may need support and which commonly recommended supplements may be working against them. His approach challenges one-size-fits-all biohacking and emphasizes using genetics, bloodwork, symptoms, and personal response patterns to make more informed decisions about mental health, performance, and long-term wellness.   Work with Dr. Tyler Panzner! Unlock Your Genetic Potential — Dr. Tyler Panzner https://drtylerpanzner.com/ Dr. Tyler Panzner on Instagram — Tyler Panzner https://www.instagram.com/drtylerpanzner/ Quieting an Overactive Mind Webinar — Tyler Panzner https://overstimulated.drtylerpanzner.com/webinar-registration-page   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:47 MTHFR Hype vs Reality 02:14 Methylated Bs and Anxiety 03:48 Creatine Choline and SAMe 07:43 Beyond One Gene Test 11:14 Lithium Orotate Basics 15:18 Supplements That Backfire 17:36 Antioxidant Overload Effects 21:01 Melatonin Dose Debate 23:56 Antioxidants Around Workouts 26:48 Collagen What Actually Works 30:07 SSRIs and Genetic Fit 34:23 Herbal SSRI Alternatives 37:18 DHT Lowering Side Effects 41:54 Biohacking Marketing Hype 43:25 Fish Oil Mood Ratios 46:16 Oral Nicotine Tradeoffs 52:03 Methylene Blue Risks 54:46 Mitochondria Boosters Anxiety 57:13 Greens Powders Overstimulation 01:01:04 Magnesium Forms For Sleep 01:04:51 DNA Testing And ChatGPT 01:12:23 Genetics For Caffeine Sensitivity 01:16:23 Psychedelics And DNA 01:18:50 Coaching Logistics Wrap Up   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  3. Jul 9

    #228 Minoxidil for Hair Loss: Topical vs Oral, Tretinoin, and Microneedling

    The episode explains how to use minoxidil for hair loss, emphasizing that it supports follicles and prolongs the anagen phase but does not block DHT (with topical dutasteride mentioned as a scalp-focused DHT option). It reviews evidence that 5% topical minoxidil is optimal (better than 2% and superior to 10%), works best on the crown/vertex, and should be applied to the scalp—not the hair—with expectations set for gradual results and possible early shedding. Twice-daily topical use is recommended unless combined with 0.01% tretinoin, which can make once-daily use similarly effective, though irritation can occur. Microneedling combined with minoxidil is strongly recommended based on a 2013 RCT, with guidance on depth (0.5–1.0 mm), frequency, and waiting 12–24 hours (or longer with tretinoin) before applying minoxidil. The episode also compares oral minoxidil dosing, notes a 2024 RCT showing similar outcomes to topical at 5 mg, and details systemic side effects, monitoring, and cautions including pet toxicity with topical use.   Full Hair Loss Podcast — Wnt vs DHT https://www.youtube.com/watch?v=bswq-Qhfebs   Minoxidil + Microneedling — 2013 Study https://pmc.ncbi.nlm.nih.gov/articles/PMC3746236/   5% vs 2% Topical Minoxidil https://pubmed.ncbi.nlm.nih.gov/12196747/   5% vs 10% Topical Minoxidil https://pubmed.ncbi.nlm.nih.gov/31403367/   Minoxidil + 0.01% Tretinoin Study https://pubmed.ncbi.nlm.nih.gov/17902730/   Oral vs Topical Minoxidil — 2024 Study https://pmc.ncbi.nlm.nih.gov/articles/PMC11007651/   Topical Dutasteride Study https://pmc.ncbi.nlm.nih.gov/articles/PMC12405733/   Topical Minoxidil Drug Information https://medlineplus.gov/druginfo/meds/a689003.html   Oral Minoxidil Drug Information https://medlineplus.gov/druginfo/meds/a682608.html   Tretinoin Drug Information https://medlineplus.gov/druginfo/meds/a682437.html   Dutasteride Drug Information https://medlineplus.gov/druginfo/meds/a603001.html   Minoxidil Toxicity in Dogs and Cats https://pubmed.ncbi.nlm.nih.gov/34370845/   Sildenafil / Viagra Drug Information https://medlineplus.gov/druginfo/meds/a699015.html   Tadalafil / Cialis Drug Information https://medlineplus.gov/druginfo/meds/a604008.html   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:45 Minoxidil Basics 01:43 DHT And What It Misses 03:07 How Minoxidil Works 03:55 Best Areas To Treat 04:30 Choosing The Right Strength 05:55 Once Or Twice Daily 08:28 Applying It Correctly 10:10 Microneedling Protocol 15:17 Formulations And Routine 18:14 Topical Side Effects 19:34 Shedding And Pet Safety 20:44 Oral Minoxidil Overview 22:53 Dosing And Risks 27:39 Combining Oral And Topical 28:36 Final Takeaways The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  4. Jul 2

    #227 Diet Update: High-Protein, High-Fiber Meal Plan Built for Training and Consistency

    The speaker shares a structured, consistent diet designed to support hard training (three strength sessions, Norwegian 4x4, Zone 2 cardio, and one MMA session weekly), reduce "food noise," and stay full with high protein and fiber. He explains cooling/freezing rice to increase resistant starch and lower glycemic impact, then details his daily routine: a morning shake with creatine, collagen peptides, greens/red powder, and beta-alanine; four eggs mid-morning; high-protein Greek yogurt mixed with psyllium husk and acacia fiber; a pre-workout oats-and-whey bowl; a post-workout shake with whey, berries, vegetables, and sauerkraut; and a batch-prepped dinner of extra-lean ground beef, basmati rice, avocado, and sauce, plus a small yogurt-and-berries snack. Daily totals are about 2600 calories with ~260g protein, ~262g carbs, ~62–80g fat, and ~42g fiber, with weekend flexibility including two gin martinis and restaurant meals like steak or occasional pasta.   Norwegian 4x4 Protocol https://www.ntnu.edu/cerg/advice   VO2 Max / Zone 2 Cardio https://health.clevelandclinic.org/zone-2-cardio   Creatine / Athletic Performance https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-Consumer/   Creatine / Sleep Deprivation Study https://pmc.ncbi.nlm.nih.gov/articles/PMC10902318/   Multi Collagen Peptides https://pmc.ncbi.nlm.nih.gov/articles/PMC8521576/   Collagen Before Exercise Study https://pmc.ncbi.nlm.nih.gov/articles/PMC5183725/   ATP Labs Greens & Reds https://atplab.com/products/green-red-whole-foods-100-organic   Beta-Alanine https://pmc.ncbi.nlm.nih.gov/articles/PMC4501114/   Coenzyme Q10 https://www.nccih.nih.gov/health/coenzyme-q10   Fish Oil / Omega-3 https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/   Oikos High Protein Greek Yogurt https://www.oikos.ca/en/oikos-high-protein   Psyllium Husk / LDL Cholesterol https://www.canada.ca/en/health-canada/services/food-nutrition/food-labelling/health-claims/assessments/psyllium-products-blood-cholesterol-lowering-nutrition-health-claims-food-labelling.html   Acacia Fiber / Gut Microbiome https://pmc.ncbi.nlm.nih.gov/articles/PMC8296006/   Short-Chain Fatty Acids / Butyrate https://pmc.ncbi.nlm.nih.gov/articles/PMC8153313/   Grass-Fed Whey Protein https://atplab.com/products/grass-fed-whey   Fermented Foods / Sauerkraut https://pmc.ncbi.nlm.nih.gov/articles/PMC9020749/   Resistant Starch / Cooled Rice Study https://pmc.ncbi.nlm.nih.gov/articles/PMC9013350/   Quest Protein Bars https://www.questnutrition.com/collections/protein-bars   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:45 Diet Goals and Structure 01:58 Training Schedule and Carbs 03:42 Morning Supplements Stack 07:19 First Meal Eggs and Fats 09:00 Greek Yogurt Fiber Snack 11:26 Pre Workout Oats and Whey 13:22 Post Workout Shake and Gut Health 15:19 Dinner Meal Prep Beef Rice Avocado 18:40 Evening Snack and Sleep Timing 19:58 Daily Macros and Protein Targets 20:58 Weekend Flex Meals and Alcohol 24:30 Extra Foods and Final Takeaways 28:23 Wrap Up and Thanks   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  5. Jun 25

    #226 Viewpoint Diversity, Physician-Assisted Suicide, AI, and Human Dignity in Medicine

    Dr. Kristin Collier joins Dr. Mike Hart to discuss the ethical, cultural, and technological forces reshaping modern medicine. Reflecting on the 2022 white coat speech walkout, she explores viewpoint diversity, self-censorship, moral courage, and the importance of cultivating wisdom alongside technical skill in medical education. The conversation also examines physician-assisted suicide, its relationship to suicide prevention, mental illness, disability, chronic disease, palliative care, healthcare funding, and the protection of vulnerable patients. They also discuss the promise and risks of artificial intelligence in medicine, including concerns about weakened clinical reasoning and the loss of person-to-person care, as well as spirituality, meaning, reproductive ethics, IVF, abortion, and human dignity. Dr. Kristin Collier is a physician, medical educator, and bioethics scholar whose work focuses on medical education, spirituality in healthcare, human dignity, and the moral responsibilities of physicians. Drawing from her experience teaching future doctors and caring for patients, she examines how wisdom, compassion, intellectual freedom, and ethical reflection can help medicine remain both scientifically rigorous and deeply human. Truth Matters — Robert P. George and Cornel West https://www.simonandschuster.com/books/Truth-Matters/Robert-P-George/9798888451700 The Age of Feelings: Recovering the Truth https://robertpgeorge.com/articles/the-age-of-feelings-recovering-the-truth/ Meditations — Marcus Aurelius https://www.gutenberg.org/ebooks/2680 Medical Wisdom with Kristin Collier https://community.hippsoc.org/podcasts/the-hippocratic-society-podcast/episodes/2149039113 Moral Diversity for Medical Trainees https://pubmed.ncbi.nlm.nih.gov/39247933/ Moral Diversity for Medical Trainees — DOI https://doi.org/10.1353/pbm.2024.a936219 Professionalism in Modern Medicine: Does the Emperor Have Any Clothes? https://pubmed.ncbi.nlm.nih.gov/17198290/ The Patient as a Person — Abraham Joshua Heschel https://pubmed.ncbi.nlm.nih.gov/30411181/ Physician-Assisted Suicide Isn't Healthcare https://www.wsj.com/opinion/free-expression/physician-assisted-suicide-isnt-healthcare-0a9141c6 AMA Code of Medical Ethics — Physician-Assisted Suicide https://code-medical-ethics.ama-assn.org/ethics-opinions/physician-assisted-suicide AMA Report on Assisted-Suicide Terminology https://councilreports.ama-assn.org/councilreports/downloadreport?uri=%2Fcouncilreports%2FA_25_ceja_report_3.pdf AMA Physician-Assisted Suicide Report https://www.ama-assn.org/system/files/2019-05/a19-ceja2.pdf Stephanie Packer's Story https://patientsrightsaction.org/stephanie-packer/ Oregon Death With Dignity Act Reports https://www.oregon.gov/oha/ph/providerpartnerresources/evaluationresearch/deathwithdignityact/pages/ar-index.aspx Oregon Death With Dignity Act 2025 Report https://www.oregon.gov/oha/PH/PROVIDERPARTNERRESOURCES/EVALUATIONRESEARCH/DEATHWITHDIGNITYACT/Documents/year28.pdf The Death Treatment — Rachel Aviv https://www.newyorker.com/magazine/2015/06/22/the-death-treatment Canadian MAID Public-Opinion Survey https://researchco.ca/2023/05/05/maid-canada-2023/ Health Canada Annual MAID Report https://www.canada.ca/en/health-canada/services/publications/health-system-services/annual-report-medical-assistance-dying-2024.html Physician-Assisted Suicide and MAID Debate https://www.youtube.com/watch?v=fhT2eLrTq_Y In Vitro Fertilization: A Good End by Bad Means https://pubmed.ncbi.nlm.nih.gov/41909105/ In Vitro Fertilization Article — DOI https://doi.org/10.1177/00243639261421221 Roe v. Wade https://www.oyez.org/cases/1971/70-18 Kristin Collier — University of Michigan https://medschool.umich.edu/profile/4378/kristin-m-collier Kristin Collier X / Twitter https://x.com/HSRDirector Kristin Collier — PubMed Publications https://pubmed.ncbi.nlm.nih.gov/?term=Kristin+M+Collier%5BAuthor%5D Kristin Collier — Google Scholar https://scholar.google.com/scholar?q=%22Kristin+M.+Collier%22 Kristin Collier — Apple Podcasts https://podcasts.apple.com/us/search?term=Kristin%20Collier   Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:44 Patients React to Intolerance 04:14 Cancel Culture in Medicine 08:05 Private Support and Fear 09:22 Moral Courage in Academia 11:17 Courage Versus Conformity 13:30 Why Medicine Needs Wisdom 16:45 Viewpoint Diversity in Training 22:29 Stoicism and Detached Concern 25:36 Physician Assisted Suicide Debate 29:51 Is It Ever Compassionate 31:49 Hard Cases and Suffering Care 32:20 Compassion Beyond Killing 33:09 Why People Request MAID 33:56 Suicide Prevention Paradox 37:00 Mental Illness and Euthanasia 40:02 Psychedelics Versus MAID 42:12 Euthanasia as a Hammer 46:23 AI Threats to Medicine 51:40 AI in Training Today 52:45 Spirituality and Meaning 56:11 Pro Life Pro Woman 58:33 Human Dignity Closing The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  6. Jun 18

    #225 GLP-1 Masterclass: Dosing, Optimal Use, Lifestyle Changes, and Benefits Beyond Weight Loss

    This episode explores how to use GLP-1 medications like semaglutide/Ozempic and tirzepatide/Mounjaro safely and effectively. Dr. Mike Hart and Dr. Christle Guevarra Do discuss once-weekly dosing, individualized titration, optimal dose selection, food noise, appetite suppression, and the risks of dosing mistakes with vials or gray-market peptides. They also cover why resistance training, protein, fiber, and realistic nutrition habits are essential for preserving muscle and maintaining results. The conversation expands into GLP-1 benefits beyond weight loss, including cardiovascular protection, inflammation, autoimmune flares, addiction-related behaviors, alcohol cravings, libido, menstrual cycles, PCOS, sleep apnea, and what to expect when stopping the medication. Dr. Christle Guevarra Do is a physician focused on obesity medicine, GLP-1 education, weight management, and sustainable lifestyle change. Drawing from both her clinical experience and her own long-term use of GLP-1 medication, she helps patients understand how these medications fit into the bigger picture of long-term health. Her approach emphasizes individualized care, strength training, nutrition, behavior change, and realistic maintenance strategies rather than quick fixes. In this episode, she shares practical guidance for using GLP-1s responsibly while protecting muscle, managing hunger, and building habits that support lasting results. Dr. Christle Guevarra Website https://www.drchristle.com/ Dr. Christle's Free GLP-1 Guide https://www.drchristle.com/glp1-guide Dr. Christle Instagram https://www.instagram.com/dr.christle/ Ozempic — semaglutide https://www.ozempic.com/ Wegovy — semaglutide for weight management https://www.wegovy.com/ Mounjaro — tirzepatide https://mounjaro.lilly.com/ Zepbound — tirzepatide for weight management / sleep apnea https://zepbound.lilly.com/ FDA: Concerns With Unapproved GLP-1 Drugs https://www.fda.gov/drugs/drug-alerts-and-statements/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss Retatrutide Clinical Trial Info https://clinicaltrials.gov/study/NCT05882045 Vyvanse — lisdexamfetamine https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=704e4378-ca83-445c-8b45-3cfa51c1ecad Creatine — NIH Supplement Info https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/ Psyllium Husk / Fiber — MedlinePlus https://medlineplus.gov/druginfo/meds/a601104.html Berberine — NCCIH https://www.nccih.nih.gov/health/berberine-and-weight-loss-what-you-need-to-know Tesamorelin — MedlinePlus https://medlineplus.gov/druginfo/meds/a611035.html CJC-1295 — PubMed Research https://pubmed.ncbi.nlm.nih.gov/16352683/ Ipamorelin — PubMed Research https://pubmed.ncbi.nlm.nih.gov/9849822/ FDA: Peptides / Compounding Safety Concerns https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks Oura Ring https://ouraring.com/ White Claw https://www.whiteclaw.com/   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:45 Weekly Dosing Debate 03:41 Starting Dose Basics 06:28 Pens vs Vials Safety 08:37 Finding Your Sweet Spot 11:01 Nighttime Binge Window 13:32 Lifestyle Work Still Matters 14:30 Benefits Beyond Weight 17:27 Libido and Low Calories 22:26 Alcohol Hits Different 24:59 Cancer Claims Reality Check 26:59 Strength Training Priority 29:06 Supplements and Creatine 29:38 Creatine Protein Fiber Basics 31:50 Berberine Pros and Cons 32:37 Peptides Sleep and Muscle 35:28 Too Lean for GLP-1 38:52 Cycles PCOS and Fertility 40:45 Food Noise vs Appetite 44:42 Staying On or Stopping 49:19 Heart Rate and HRV Concerns 51:38 Ozempic vs Mounjaro Choices 54:45 Sleep Apnea and Wrap Up The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  7. Jun 11

    #224 Dr. Alex Tatum on Peptides, FDA Crackdowns, TRT Nuance, and Safe Penis Enhancement

    Dr. Mike Hart interviews board-certified urologist Dr. Alex Tatum about peptide access, compounding, and men's health. Tatum argues many peptides are naturally occurring and lacked FDA commercialization incentives, says the FDA's 2023 move banning 19 compounds from Category 1 was contested due to no produced adverse-safety evidence, and describes the patient impact and advocacy around a July PCAC meeting. He explains most peptide APIs and many compounded GLP-1 ingredients come from China, while pharma-grade GLP-1s have more U.S. production. The discussion covers retatrutide's potential biologic classification (40–amino acid rule) and pricing implications, MOTS-c as an adjunct for low energy on GLP-1s, skepticism about cardarine, growth hormone secretagogues and cancer fears, TRT dosing frequency, sleep apnea screening, HCG's roles, and penis enhancement via traction for length and hyaluronic acid filler for girth, emphasizing expectations and mental health. Dr. Alex Tatem is a board-certified urologist focused on men's health, hormone optimization, male fertility, and sexual wellness. In this episode, he joins Dr. Mike Hart to discuss the changing landscape of peptide therapy, including FDA restrictions, compounding pharmacies, drug supply chains, and the growing debate around access to treatments such as BPC-157, MOTS-c, and retatrutide. He also breaks down practical considerations for men using testosterone replacement therapy, including HCG, fertility preservation, dosing frequency, estrogen-related side effects, and sleep apnea risk. Drawing from his experience treating a wide range of patients, he shares a harm-reduction approach to performance medicine and explains what men should understand before considering growth hormone peptides, GLP-1 medications, or penile enhancement procedures. Dr. Alex Tatem Website https://dralextatem.com/ Dr. Alex Tatem Instagram https://www.instagram.com/dralextatem/ Huberman Lab — Peptides: The Science, Uses & Safety | Dr. Abud Bakri https://www.hubermanlab.com/episode/peptides-the-science-uses-and-safety-abud-bakri FDA Pharmacy Compounding Advisory Committee Meeting — July 23–24, 2026 https://www.fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026 FDA Bulk Drug Substances Under Section 503A https://www.fda.gov/drugs/human-drug-compounding/bulk-drug-substances-used-compounding-under-section-503a-fdc-act FDA Compounding Safety Risks https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks Semaglutide / Ozempic https://medlineplus.gov/druginfo/meds/a618008.html Tirzepatide / Mounjaro https://medlineplus.gov/druginfo/meds/a622044.html Retatrutide Clinical Trial https://clinicaltrials.gov/study/NCT05929066 Testosterone Cypionate https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=testosterone%20cypionate Human Chorionic Gonadotropin / HCG https://pubmed.ncbi.nlm.nih.gov/?term=human+chorionic+gonadotropin BPC-157 https://pubmed.ncbi.nlm.nih.gov/?term=BPC-157 KPV Peptide https://pubmed.ncbi.nlm.nih.gov/?term=KPV+peptide TB-500 / Thymosin Beta-4 https://pubmed.ncbi.nlm.nih.gov/?term=thymosin+beta-4 MOTS-c https://pubmed.ncbi.nlm.nih.gov/?term=MOTS-c CJC-1295 https://pubmed.ncbi.nlm.nih.gov/?term=CJC-1295 Ibutamoren / MK-677 https://pubmed.ncbi.nlm.nih.gov/?term=ibutamoren+MK-677 Cardarine / GW501516 https://pubmed.ncbi.nlm.nih.gov/?term=GW501516+cardarine PhalloFILL at Urology of Indiana https://menshealthin.com/services/phallofill/ Hyaluronic Acid Penile Girth Enhancement Overview https://auanews.net/issues/articles/2024/august-extra-2024/office-and-surgical-technologies-the-evolving-landscape-of-penile-girth-enhancement   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:33 Are Peptides Threatening Pharma 01:17 Patent Law and FDA Categories 02:19 The 2023 Peptide Ban Fallout 03:59 Safety or Money Debate 06:09 China Supply Chain Exposed 11:33 RFK Jr Peptide Messaging 16:01 Retatrutide Biologic Fight 20:51 What Biologic Status Costs 25:27 MOTS-c as GLP-1 Booster 28:43 Growth Hormone Cancer Myth 32:18 Sleep Effects and Bryan Johnson 35:04 Microplastics and Saunas 36:48 Cardarine Cancer Risk 40:07 TRT and HCG Basics 45:08 HCG Dosing Nuance 49:06 Daily TRT Microdosing 52:03 Sleep Apnea on TRT 56:34 Penis Enhancement Options 01:02:54 Realistic Expectations 01:04:46 Wrap Up and Where to Follow   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  8. May 28

    #223 How I Increased My VO2 Max at 41 With the Norwegian 4x4 Protocol

    The host explains how he raised his estimated VO2 max in 2026 in his 40s, emphasizing that the biggest driver was structured hard training with progressive overload, not "hacks" like peptides, supplements, sauna, red light, or ketones. After years of mostly zone 2 cardio (under ~124 bpm) plus weekly MMA, he shifted to one zone 2 session, one Norwegian 4x4 VO2 max workout, and one MMA session weekly. He defines VO2 max and details the 4x4 protocol (4 minutes hard/3 minutes easy for 4 rounds plus brief warmup/cooldown), using a COROS heart rate monitor to track significant zone 5 time. Starting at 8.0 mph, he increased treadmill speed by 0.1 mph weekly to 9.3 mph, discussing deload weeks, fatigue limits, body weight changes, footwear, sauna frequency, and mixed views on supplements like beta-alanine, beetroot, and ketones.   Norwegian 4x4 Protocol https://www.myworkout.com/en/4x4-intervals VO2 Max / Zone 2 Cardio https://health.clevelandclinic.org/zone-2-cardio Stats Canada VO2 Max Percentile Table https://www150.statcan.gc.ca/n1/pub/82-003-x/2019010/article/00002/tbl/tbl02-eng.htm Oura Ring https://ouraring.com/ COROS Heart Rate Monitor https://coros.com/heart-rate-monitor Freak Athlete Nordic Hyper / Hyper Pro https://freakathlete.co/products/hyper-pro HOKA Clifton 10 https://www.hoka.com/en/ph/clifton-10-run-smooth/ Nike Zoom Fly https://www.nike.com/ph/w/nike-zoom-fly-running-shoes-37v7jz7oc5azy7ok Post-Exercise Sauna Bathing Study https://pubmed.ncbi.nlm.nih.gov/16877041/ Urolithin A https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244 Beetroot / Dietary Nitrate https://www.ausport.gov.au/ais/nutrition/supplements/group_a/performance-supplements2/beetroot-juicenitrate Ketone-IQ https://ketone.com/ Beta-Hydroxybutyrate / BHB Ketones https://www.ncbi.nlm.nih.gov/books/NBK493179/ L-Citrulline https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/ Creatine https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/ Beta-Alanine https://examine.com/supplements/beta-alanine/ MOTS-c https://pmc.ncbi.nlm.nih.gov/articles/PMC9905433/ Cardarine / GW501516 https://www.wada-ama.org/en/news/wada-issues-alert-gw501516 Brady Holmer https://www.bradyholmer.com/ Hart2Heart Episode with Brady Holmer https://open.spotify.com/episode/0DxQVb0Mkah57ZgHbWmWUy   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:33 VO2 Max Story Setup 01:27 Baseline Training Split 02:58 What VO2 Max Means 05:10 Why Add Structure 06:01 Norwegian 4x4 Explained 06:49 Starting Speeds Recovery 08:07 Zone 5 Targets 10:55 Tracking Heart Rate 12:23 Estimating VO2 Max 14:37 Zone 2 And MMA Role 17:20 Bodyweight And Running 19:46 Shoes Sauna Supplements 24:44 Progressive Overload Plan 29:34 Deloads Plateaus Mindset 31:29 Final Takeaways Encouragement   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

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About

Hart2Heart is the show where Dr. Mike Hart breaks down evidence-based health, longevity, performance, and modern medicine without the fluff. Each episode explores practical, evidence-based strategies for improving your life, including hormone health, peptides, sleep optimization, nutrition, supplements, exercise, sunlight, psychedelics, and smarter medication use. The goal is simple: help you understand what actually works so you can make better decisions for your health. The show also looks at the bigger picture, including how public health policy and politics influence personal well-being, and what you can do to take back control. If you want clear, actionable, no-BS conversations about living healthier, performing better, and thinking for yourself, this podcast is for you.

Information

  • Creator
    Dr. Mike Hart
  • Years Active
    2020 - 2026
  • Episodes
    226
  • Rating
    Explicit
  • Copyright
    © Copyright 2023 | Upfire Digital LLC
  • Show Website
    Hart2Heart with Dr. Mike Hart

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