Longevity Optimization with Kayla Barnes-Lentz

Kayla Barnes-Lentz
  • 4.8 (119)
  • Health & Fitness
  • Updated Weekly

Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.

  1. Sep 24

    Carolina Reis Oliveira, PhD: Senescent Cells, Retinol Myths, and the Skin Barrier Body Connection

    Most skincare is designed to improve how aging looks. But can it change what is happening inside the skin itself? In this conversation, I sit down with Carolina Reis Oliveira, PhD, co-founder and CEO of OneSkin, to explore what actually drives skin aging at the cellular level. Carolina explains how senescent “zombie” cells, UV exposure, inflammation, hormonal changes and a weakened skin barrier affect how skin functions, not just how it looks. Get OneSkin's new Rich Cream and the rest of the OS-01 line at: oneskin.co/KAYLA with code KAYLA. We break down the benefits and limitations of retinol, why chronic redness and flaking are not signs that a product is working better, and whether popular ingredients such as NAD+ precursors, methylene blue and GHK-Cu can penetrate the skin and remain stable. We also discuss collagen supplementation, red light therapy, hyperbaric oxygen, sauna, exercise, sun exposure and the relationship between skin-barrier health and systemic inflammation. Carolina also shares the science behind OneSkin's OS-01 peptide and its new Face Rich Cream, including findings related to collagen, hyaluronic acid, elastin, filaggrin, hydration, firmness and fine lines. In this conversation: -Why many anti-aging products target visible symptoms rather than the biology of skin aging -How senescent “zombie” cells contribute to inflammation and tissue decline -How to use retinol without chronically damaging the skin barrier -Why ingredient penetration, stability and formulation matter -How skin-barrier dysfunction may affect inflammation throughout the body -What collagen, red light, hyperbaric oxygen, sauna and exercise can do for the ski - What OneSkin found when testing GHK-Cu copper peptides -Why moisturizer alone may not solve age-related dryness -How OS-01 is designed to target the underlying biology of skin aging Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/female-longevity-community Optimize your sleep with the Eight Sleep Pod.  Get up to $350 off at https://www.eightsleep.com/Kayla with code “KAYLA” Support lean muscle and recovery with PerfectAmino essential amino acids: https://bodyhealth.com/products/perfectamino“Kayla20” Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Connect with Carolina Reis Oliveira: Instagram: https://www.instagram.com/carolina.reis.phd/ LinkedIn: https://www.linkedin.com/in/carolina-reis-oliveira-a69b8a27/ X: https://x.com/Carol_roliveira Learn more about OneSkin: Shop OneSkin: https://oneskin.pxf.io/LKgxy0 Website: https://www.oneskin.co/ Instagram: https://www.instagram.com/oneskin.co/ LinkedIn: https://www.linkedin.com/company/oneskin/ Scientific publications: https://www.oneskin.co/pages/scientific-publications #SkinLongevity #SkinHealth #HealthyAging #OneSkin #Retinol #SenescentCells #FemaleLongevity #KaylaBarnes

  2. Sep 17

    Dr. Abud Bakri, MD: Thymus Health, Circadian Biology, and the Truth About Peptides

    Most longevity conversations focus on the brain, heart, muscle, and metabolism. Far less attention goes to the thymus, an immune organ that starts shrinking almost as soon as puberty ends, and new research suggests it may be quietly linked to fertility, hormones, and even how millions of women taking birth control are aging on the inside. I sit down with Dr. Abud Bakri, a board-certified internal medicine physician and hospitalist who founded Systems, a performance and longevity practice built around treating the body system by system rather than symptom by symptom. We start with the foundations that determine whether any advanced intervention can actually work: light exposure, circadian timing, mitochondrial health, metabolic function, and the parts of modern life working against all of it. Then we get into the thymus itself: why it shrinks after puberty, what that has to do with an unexpected finding in ovarian development, and a harder question Dr. Bakri raises about whether birth control may be accelerating that shrinkage in ways no one is currently studying. We close on peptides: why Dr. Bakri treats them like drugs rather than supplements, what separates receptor-based peptides from the ones we understand far less, what we actually know about BPC-157, thymosin alpha-1, SS-31, and GHK-Cu, and how a peptide protocol could eventually be timed to a woman's cycle instead of applied the same way to everyone. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/female-longevity-community Optimize your sleep with the Eight Sleep Pod.  Get up to $350 off at https://www.eightsleep.com/Kayla with code “KAYLA” Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Connect with Dr Abud: Instagram: https://www.instagram.com/abud_bakri/ Website: https://abudbakri.com/ X: https://x.com/AbudBakri

  3. Sep 10

    Dr. Will Cole: How to Heal Your Cells, Leaky Gut, Light Exposure, and Why Your Gut Sets the Pace To Aging

    We talk about aging like it happens to a whole person at once. It doesn't. It happens organ by organ, at different speeds, and most people never find out which part of them is running ahead until something breaks. Dr. Will Cole has spent sixteen years running one of the first functional medicine telehealth centers in the world, and he came to this conversation with a case that is both clinical and personal. In 2023 his father lost consciousness at the wheel and died in the crash. The autopsy pointed to cardiometabolic changes, and his heart cells had been aging faster than the rest of him. That same year, Stanford researchers found that one in five adults over fifty has at least one organ aging faster than the others, and that when it's the heart, the risk of a cardiac event more than triples. His new book with Dr. Josh Axe, Heal Your Cells, makes an argument that reframes most of what gets called normal aging. Exhaustion, brain fog, the weight that will not move, the hormone shifts nobody can explain. These are not the calendar. They are cells that have stopped reading their own instructions clearly, and that is a state you can change. We get into what actually makes a cell feel unsafe, why your gut lining is one cell thick and therefore the first thing to break, and the point almost nobody makes about elimination diets: the reintroduction matters as much as the elimination, and a protocol you never came off of is a cast you left on until the muscle atrophied. We also get into light. Not just morning sun, but the darkness half, which matters more for women than most people realize. Melatonin is not only a sleep hormone, it's one of the more important antioxidants for ovarian aging, and light levels most people would call almost nothing can cut its production substantially. Track your sleep, recovery, strain, and HRV with WHOOP.  Get one month free at https://join.whoop.com/kaylabarnes Optimize your sleep with the Eight Sleep Pod.  Get up to $350 off at https://www.eightsleep.com/Kayla with code “KAYLA” Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/female-longevity-community Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Connect with Dr. Will:Website: http://drwillcole.com/ Book: https://drwillcole.com/books-home-page/ Instagram: https://www.instagram.com/drwillcole LinkedIn: https://www.linkedin.com/in/drwillcole/ YouTube: https://www.youtube.com/user/DrWillCole #cellularhealth #longevity #femalelongevity #guthealth #healthspan #leakygut #womenshealth #functionalmedicine #circadianhealth #autophagy #mitochondria #healthoptimization

  4. Sep 3

    Dr. Tania Dempsey, MD: Mast Cell Activation Syndrome, PMOS, and the Hidden Cause of Women's Chronic Symptoms

    Most women who deal with unexplained allergies, stubborn inflammation, heavy periods or a PMOS (formerly PCOS) diagnosis are never told to look at the same underlying cause: an immune cell most doctors were never taught to test for. Dr. Tania Dempsey, MD, trained in internal medicine at Johns Hopkins before leaving conventional practice to focus on mast cell activation syndrome, a condition she believes explains far more chronic illness in women than most doctors realize. She's the founder of The AIM Center for Personalized Medicine and helped found the International Society for Mast Cell Activation Syndromes, where she now serves as treasurer. This isn't some rare, fringe diagnosis. Dr. Dempsey estimates it may affect as many as one in five people, and in women it hides behind a long list of other labels, PMOS, endometriosis, hypermobility, unexplained heavy periods, that rarely get connected back to the same root. Optimize your sleep with the Eight Sleep Pod. Get up to $350 off at https://www.eightsleep.com/Kayla with code “KAYLA”. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/female-longevity-community This conversation explores The overreaction inside your immune system that never fully resets Why PMOS and mast cell activation almost always show up together The natural blood thinner behind unusually heavy periods Where treatment actually starts, from vitamin D to advanced IV therapy Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Connect with Dr. Tania Dempsey: Instagram: https://www.instagram.com/drtaniadempseymd/ LinkedIn: https://www.linkedin.com/in/taniadempsey/ Website: https://drtaniadempsey.com/ YouTube: https://www.youtube.com/@DrTaniaDempsey #longevity #womenslongevity #mastcellactivationsyndrome #mcas #pmos #histamineintolerance #endometriosis #womenshealth #chronicillness #rootcausemedicine #hormonehealth #inflammation

  5. Aug 27

    Dr. Margie Davenport, PhD: Exercise in Pregnancy, the 140 BPM Myth, and Why Pregnancy Complications Predict Heart Disease

    Pregnancy has long been treated as a season to slow down and play it safe. The data tells a different story, and it starts with a number most women were taught to fear. Dr. Margie Davenport, PhD, is an exercise physiologist and professor at the University of Alberta who has spent over a decade studying how the body moves through pregnancy, postpartum, and the years before. What stayed with me most: a pregnancy complication isn't just a pregnancy problem. It's information about a woman's future heart health that most of us are never told to pay attention to. Track your hormones at home with Mira.  Get 25% off Mira kits at https://www.miracare.com/ with code “KAYLA” Support cellular health with Solaray Spermidine, featuring 3.3 mg of spermidine from rice germ extract: https://solaray.com/products/spermidine   Use the code “KAYLABARNES” at checkout for 30% off your order. This conversation explores Why the “stay under 140 beats per minute” rule taught to pregnant women for decades was already outdated before most of us ever heard it What Dr. Davenport's lab is learning by tracking a baby's heart rate and blood flow in real time during heavy lifting and high intensity training Why gestational diabetes, preeclampsia, and gestational hypertension are now considered a risk factor for future heart disease as strong as smoking Why the “high risk at 35” label given to so many pregnancies is based on outdated data rather than a woman's actual health Why almost no strength exercise, including deadlifts and heavy squats, has been shown to need to be avoided in a low risk pregnancy Why the standard advice to wait six weeks and then resume normal activity after birth has little evidence behind it How staying active after birth is tied to a real reduction in postpartum depression and noticeably better sleep quality, even when total sleep doesn't change Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/female-longevity-community Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr Margie: Instagram: https://www.instagram.com/drmargiedavenport/ LinkedIn: https://www.linkedin.com/in/margie-davenport-b3095825/  X: https://x.com/ExercisePreg  Website: https://www.ksr.ualberta.ca/exerciseandpregnancy/index.php #womenshealth #gestationaldiabetes #preeclampsia #pelvicfloor #diastasisrecti #fertility #cardiovascularhealth #strengthtraining #hiit#longevity #womenslongevity #pregnancyexercise #exerciseinpregnancy #postpartumrecovery #prenatalfitness

  6. Aug 20

    Dr. Gabrielle Lyon, DO: Muscle as the Organ of Longevity, Protein Mistakes, and the Truth About Menopause Muscle Loss

    Muscle is not just something you build in the gym. Dr. Gabrielle Lyon has spent her career arguing it's the organ that actually determines how well you age, and almost none of us have been taught to think about it that way. Dr. Gabrielle Lyon, DO, is the founder of Muscle-Centric Medicine and the New York Times bestselling author of Forever Strong. She's spent over two decades studying muscle as the most overlooked organ in medicine. The line that stuck with me most: she believes we're on track to trade an obesity epidemic for a sarcopenia epidemic, and most people won't see it coming until it's already happened. It's the kind of prediction I can't stop turning over, especially knowing how many women are on these medications right now without anyone telling them how to protect their muscles while they're on them.  Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/checkout/become-a-member This conversation explores: Why muscle, not weight, decides how you age Why most women are not eating enough protein The protein habit most people get backwards Why menopause doesn't have to mean muscle loss What GLP1 users need to know to protect muscle Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr. Gabrielle Lyon:YouTube: https://www.youtube.com/@DrGabrielleLyon Instagram: https://www.instagram.com/drgabriellelyon/ X: https://x.com/drgabriellelyon Website: https://drgabriellelyon.com/ #longevity #musclecentricmedicine #muscle #proteinintake #strengthtraining #womenslongevity #sarcopenia #menopause #perimenopause #womenshealth #hormonereplacement #longevityoptimization #biohacking #GLP1

  7. Aug 6

    Dr. Christin Glorioso, MD, PhD: The Alzheimer's Blood Test, How to Cut Your Dementia Risk by 30%, and Why Women Are at Higher Risk

    Brain aging does not start when memory loss shows up. It starts around age 25, decades before anyone notices anything is different. By the time a symptom appears, the window for the highest-leverage prevention has usually already closed. Today I'm talking with Dr. Christin Glorioso, an MD and PhD who has spent her career studying Alzheimer's, partly because of her own family history and partly because she carries the ApoE4 gene herself. She has since used her own brain scans, blood work, and lifestyle changes to lower her own brain age, and she's built a company around helping other people do the same. This conversation covers what actually causes Alzheimer's versus what we got wrong for decades, why the brain can grow back the same way muscle does, and why a ten minute daily habit has better evidence behind it than any drug currently on the market. We also get into hormone therapy, cholesterol, the ketogenic diet, and why women are so consistently underserved on all three. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/checkout/become-a-member Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr Christin Glorioso, MD, PhD LinkedIn: https://www.linkedin.com/in/christin-glorioso-md-phd-39627719/  Website: https://www.neuroagetx.com/ #BrainHealth #AlzheimersPrevention #DementiaPrevention #BrainAging #Neuroscience #CognitiveHealth #HRT #Perimenopause #Menopause #Cholesterol #Nootropics

  8. Jul 31

    Dr. Colleen Cutcliffe, PhD: Natural GLP-1 Production, Fiber Deficiency, Akkermansia and the Gut Microbiome Connection

    Most people think of the gut as a digestive organ. It is not. It is the upstream controller of your metabolism, immune function, brain health, skin, and hormones and almost everyone is running it on a depleted, misfed microbiome without knowing it. Dr. Colleen Cutcliffe, PhD is the co-founder and CEO of Pendulum Therapeutics, holds a PhD in biochemistry from Johns Hopkins, and spent over 15 years in pharma and biotech before pioneering next-generation probiotic science. Her team was the first in the world to manufacture Akkermansia, a strain found at high levels in virtually every centenarian population studied and depleted in almost every major chronic disease.  What makes this conversation different from most gut health discussions is the level of scientific rigor behind it. This is not wellness theory. This is published research, clinical data, and a decade of actually building the science from the ground up. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/checkout/become-a-member In this conversation we explore: How your gut produces its own GLP-1 naturally and why synthetic versions may blunt that system over time Why Akkermansia is elevated in centenarians and depleted across virtually every chronic disease The fiber gap: 95% of people are under-threshold and it is driving metabolic and colon health decline What early antibiotic use does to the microbiome and how to rebuild at any age Why soap may be fueling the allergy and asthma epidemic by stripping the skin's protective barrier How butyrate links gut health, colon cancer risk, and natural GLP-1 production Why most probiotics on Amazon do not contain what the label claims Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr Coleen Instagram: https://www.instagram.com/drcolleencutcliffe/ Pendulum Life Instagram: https://www.instagram.com/pendulumlifeco/ Website: https://pendulumlife.com/

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4.8
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Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.

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