Clearly Hormonal

Komal Patil-Sisodia, MD

Have you ever wondered why your body feels like it's falling apart just as you're hitting your stride in other areas of your life? Join Dr. Komal Patil-Sisodia as she explores women’s metabolic health changes that start in perimenopause. The episodes center around educating and empowering women to have open dialogue with their doctors so that they can achieve their best metabolic health. Dr. Patil-Sisodia is board certified in Endocrinology,  Obesity Medicine and Internal Medicine. She is also a Menopause Society Certified Practitioner. Any medical discussion on this podcast is purely for educational purposes and is not individualized medical advice. Please consult with your doctor to discuss any health concerns you may have.

  1. 3d ago

    Menopause Society Conference Recap: Why Midlife Care Must Be Individualized

    📱 Send Us a Text Message! We’d love to hear from you! Please include your name and email address so we can reply. Don’t worry — this won’t sign you up for our email list. We’ll only use your info to respond to your question. I just got back from the Menopause Society annual meeting in San Diego, and in this episode I share what I am bringing back to my clinic and my patients. Women's health is having a moment, and with that attention has come a lot of polarization. My take as an endocrinologist is simple: there is no one-size-fits-all menopause, and good care combines the data we have with clinical nuance, your symptoms, and your goals. We walk through the biggest themes from the meeting: how body composition and bone change during the transition, where exercise and hormone therapy fit, what the FDA label changes do and do not mean, nonhormonal options for hot flashes, sleep and mood, heart health screening, sexual health, hair loss, supplements, and why bleeding after menopause always needs evaluation. You will leave with clear questions to bring to your next visit. TIMESTAMPS 00:00 | Podcast welcome 01:03 | Conference context 01:56 | Nuance over hype 03:42 | Key themes recap 05:35 | Body changes explained 07:17 | Bone loss window 08:18 | Exercise practicalities 09:14 | Hormones' role 10:09 | Hormone therapy labels 12:56 | Sleep and insomnia 14:15 | Mood and brain fog 15:09 | Heart health screening 16:33 | Sex, hair, and skin 18:19 | Supplements and safety 18:48 | Postmenopausal bleeding 19:18 | Care that fits your life 20:26 | Wrap up and takeaways Thanks for listening. Find more info about Clearly Hormonal on the website or Instagram.

  2. Oct 14

    Why Your Body Composition Changes in Midlife (Even If the Scale Doesn't)

    📱 Send Us a Text Message! We’d love to hear from you! Please include your name and email address so we can reply. Don’t worry — this won’t sign you up for our email list. We’ll only use your info to respond to your question. Your weight has not changed, but your body has. In this episode, Dr. Komal Patil-Sisodia explains why body composition shifts during the menopause transition, why the scale cannot tell the whole story, and what you can do about it. She shares her own experience after a hysterectomy, breaks down the difference between subcutaneous and visceral fat, explains insulin resistance with a classic TV analogy, and walks through a realistic foundation of strength, nutrition, sleep, and sustainable planning. She also covers where menopause hormone therapy and obesity medications fit, and why higher body fat after menopause is linked to breast cancer risk without placing blame on anyone. Clearly Hormonal is for education and is not personalized medical advice. Take what resonates and discuss it with your own healthcare team. IN THIS EPISODE Why you can gain fat and lose lean tissue without a big change on the scaleWhat body composition is, and why lean tissue is more than muscleWhat the SWAN study found about fat and lean mass during the menopause transitionWhy abdominal fat storage can shift before your periods stopOther contributors beyond hormones: aging, activity, sleep, stress, medications, and conditions like hypothyroidism, prediabetes, and insulin resistanceSubcutaneous versus visceral fat, and what a changing waist measurement may signalInsulin resistance explained, and why less muscle means less sugar used upStrength training at least twice a week, plus building toward 150 to 300 minutes of moderate activityProtein and fiber at meals, personalized protein needs, and why restriction is not the goalSleep, night sweats, sleep apnea, and when to ask about a sleep studyMenopause hormone therapy and body composition: what the evidence does and does not sayWhen obesity medications may be appropriateThe breast health connection, discussed without blameTIMESTAMPS 00:00 | Welcome to Clearly Hormonal 01:03 | PMOS Course Announcement 01:41 | Midlife Body Changes 03:41 | What Is Body Composition 05:03 | Hormones and Other Factors 06:59 | Visceral Fat and Waist 07:58 | Insulin Resistance Explained 10:59 | What Helps Most 11:06 | Strength and Movement 12:36 | Nutrition Basics 13:58 | Sleep and Barriers 15:25 | Hormone Therapy and Meds 18:11 | Breast Health Connection 19:01 | Key Takeaways and Next Week Course announcement The PMOS Conversation You Deserve is Dr. Komal’s patient course on understanding PMOS and advocating for yourself in the doctor’s office. It includes three months of access plus a monthly live Q&A webinar with Dr. Komal. Introductory pricing runs through October 13, with regular pricing beginning October 20. Monthly webinar calls begin October 21, 2026.  Details and enrollment: The Perimenopause Conversation You Deserve Connect Instagram and TikTok: @drpatilsisodiaWebsite: eastsidemm.comQuestions about the course: send a message through the website or DM on socialThanks for listening. Find more info about Clearly Hormonal on the website or Instagram.

  3. Oct 7

    Perimenopause Is Not a Lab Value: How to Recognize It and Get the Right Care

    📱 Send Us a Text Message! We’d love to hear from you! Please include your name and email address so we can reply. Don’t worry — this won’t sign you up for our email list. We’ll only use your info to respond to your question. Perimenopause is often missed because the most common symptom is vague (“I just don’t feel like myself”) and hormone tests can look normal. In this episode of Clearly Hormonal, Dr. Komal Patil-Sisodia walks through how perimenopause is actually recognized: from your age, your menstrual pattern, and your symptoms over time. This is Episode 1 of our Menopause Awareness Month series. In this episode you will learn Why a normal hormone result does not rule out perimenopauseThe three things Dr. Komal focuses on: age, periods, and symptomsHow cycles differ in early and late perimenopause, using the STRAW+10 frameworkWhat can make perimenopause harder to recognize: birth control, hysterectomy, and PMOS (formerly PCOS)Why FSH and estradiol are a snapshot, and when blood tests do helpWhy pregnancy testing should be one of the first tests if you miss a periodFour symptom groups: sleep, mood and thinking, physical comfort, and sexual and urinary healthOther conditions to rule out: thyroid disease, anemia, sleep apnea or insomnia, medication effects, and worsening anxiety or depressionWhat a useful perimenopause appointment includes, and how to prepare for itTimestamps 00:00 | Could This Be Perimenopause? 01:06 | Why Labs Miss It 02:16 | Three Diagnosis Clues 03:45 | Cycle Changes Explained 04:49 | Early vs. Late Transition 06:36 | When Cycles Mislead 07:32 | Hormone Testing Myths 08:50 | When Bloodwork Helps 10:12 | Symptom Categories 11:53 | Rule Out Other Causes 13:02 | Differences Across Women 15:38 | What a Good Visit Includes 16:52 | Three Key Takeaways 17:26 | Prep for Your Appointment 18:17 | Series Wrap and Course Announcement Course announcement The PMOS Conversation You Deserve is Dr. Komal’s patient course on understanding PMOS and advocating for yourself in the doctor’s office. It includes three months of access plus a monthly live Q&A webinar with Dr. Komal. Introductory pricing runs through October 13, with regular pricing beginning October 14. Monthly webinar calls begin October 21, 2026.  Details and enrollment: The Perimenopause Conversation You Deserve Connect Instagram and TikTok: @drpatilsisodiaWebsite: eastsidemm.comQuestions about the course: send a message through the website or DM on socialThanks for listening. Find more info about Clearly Hormonal on the website or Instagram.

  4. Sep 30

    You Deserve More Than a Diagnosis: Turning PMOS Knowledge Into Better Care

    📱 Send Us a Text Message! We’d love to hear from you! Please include your name and email address so we can reply. Don’t worry — this won’t sign you up for our email list. We’ll only use your info to respond to your question. About one in eight women lives with PMOS, polyendocrine metabolic ovarian syndrome, formerly called PCOS. It is one of the most common hormone conditions there is, and still one of the most misunderstood, by patients and by many clinicians. In this final episode of September PMOS Awareness Month, Dr. Komal Patil-Sisodia explains why the name changed, why the condition is about far more than ovarian cysts, and why the metabolic and cardiovascular pieces so often get missed when a visit stays focused on periods, acne, or hair growth. She also shares what the data shows about diagnosis delays and disparities, and a piece of her own story. Then she moves from the science to the practical: what to ask, what to track, and what to do when you raise a reasonable concern and do not get a useful answer. She introduces her new six-module course, The PMOS Conversation You Deserve, built to help you walk into your next appointment better informed and better prepared. IN THIS EPISODE Why PMOS stands for polyendocrine metabolic ovarian syndrome, and why the change from PCOS was more than a rebrandHow PMOS can show up across the lifespan, from adolescence through the reproductive years, perimenopause, and beyondThe metabolic side of PMOS: insulin resistance, blood sugar, cholesterol, blood pressure, and long-term cardiovascular riskWhat one large international study found about diagnostic delays: about one in three women waited more than two years, and nearly half saw at least three healthcare professionalsDisparities in who gets diagnosed, including findings in a safety net health system study for Black women and patients on Medicaid or charity careWhy knowing the science is not the same as knowing how to use it in an appointmentA first look at The PMOS Conversation You Deserve, including the pushback module, the workbook, and three months of live Q&ATIMESTAMPS 00:00  Welcome to Clearly Hormonal 01:08  PMOS: Why It Matters 02:22  PMOS Name Change Explained 02:57  Symptoms and Lifespan Impact 04:04  Diagnosis Delays and Disparities 05:51  Turning Knowledge Into Care 07:17  Course: The Conversation You Deserve 08:53  Enrollment Dates and Details 09:45  Final Takeaways and Wrap Up COURSE DATES Pre-order opens: October 7Introductory pricing through: October 13Regular price begins: October 14First live Q&A: October 21LINKS AND RESOURCES The PMOS Conversation You Deserve (pre-order opens October 7): Sign up here to get on the list.Eastside Menopause & Metabolism: eastsidemm.comFollow Dr. Patil-Sisodia on Instagram and TikTok: @drpatilsisodiaDISCLAIMER This podcast is for education and is not personalized medical advice. Please discuss what resonates with your own healthcare team. Thanks for listening. Find more info about Clearly Hormonal on the website or Instagram.

  5. Sep 23

    The Long Road to Diagnosis: PMOS and Mental Health

    📱 Send Us a Text Message! We’d love to hear from you! Please include your name and email address so we can reply. Don’t worry — this won’t sign you up for our email list. We’ll only use your info to respond to your question. In the final episode of PMOS Awareness Month, I focus on something that does not get talked about enough: the mental health toll of PMOS and the harm caused by waiting years for a diagnosis. We walk through what weight-matched studies show about depression, anxiety, and eating disorders, why so many people carry these burdens long before anyone connects them to PMOS, and what real care should look like. In this episode Why people with PMOS are about four times more likely to have depression and more than five times more likely to have anxietyWhy a PMOS diagnosis often comes before a new diagnosis of depression, anxiety, or sleep problemsHow eating disorder risk rises with PMOS, and why it is not limited to larger bodiesHow years of scattered symptoms and "it is just stress" responses make things worseWhy body image distress from visible symptoms is a real pathway to disordered eatingWhat good care includes: screening at diagnosis, CBT as a first step, careful medication choices, treating physical symptoms, and mind-body approaches Timestamps 00:00 Welcome to Clearly Hormonal 01:01 PMOS Series Finale Setup 02:04 Mental Health Stats in PMOS 03:24 Eating Disorders and PMOS 04:00 Why Diagnosis Takes Years 05:37 Body Image and Visible Symptoms 06:56 What Good Care Looks Like 08:50 What This Means for You 09:51 Series Wrap Up and Resources 11:02 PMOS Mini Course Announcement Key numbers from the episode About 4 times more likely to have depression with PMOS, in weight-matched studiesMore than 5 times more likely to have anxiety with PMOSAbout 1 in 3 people with PMOS have moderate to severe depression; more than 4 in 10 have real anxiety symptoms; well under 15 percent without PMOSAbout 1.5 times more likely to have an eating disorder, with the biggest increases in binge eating disorder and bulimia The full PMOS Awareness Month series Episode 1: What happens in PMOS after your childbearing yearsEpisode 2: Why PMOS gets missed in people with a normal BMI (lean PMOS)Episode 3: Where GLP-1 medications fit into PMOS treatmentEpisode 4: PMOS and mental health (this episode) A note on support If anything in this episode brought up something personal for you, especially around food, body image, or how you have been feeling emotionally, please do not sit with that alone. Talk to your doctor or a mental health professional. If you are in crisis in the US, you can call or text 988 at any time. Connect Instagram and TikTok: @drpatilsisodiaeastsidemm.comThis episode is for education and is not a substitute for individual medical advice. Thanks for listening. Find more info about Clearly Hormonal on the website or Instagram.

  6. Sep 21

    Why We Withdrew From the ADA Webinar, and Why Peer & Lived Experience Must Be Central to Obesity Care

    📱 Send Us a Text Message! We’d love to hear from you! Please include your name and email address so we can reply. Don’t worry — this won’t sign you up for our email list. We’ll only use your info to respond to your question. Dr. Komal Patil-Sisodia, obesity advocate Michael Donnelly-Boylen, and Dr. Matthea Rentea explain why they withdrew from a planned ADA-hosted webinar in support of a broader boycott, after an ADA Scientific Sessions keynote by a MAHA representative and the removal of peacefully protesting scientists were followed by an organizational response the three of them found unsatisfying. They still share the content they had planned to present: integrating peer and lived experience into obesity care, to address a trust gap driven by weight stigma, shaming language, and oversimplified messaging that can delay or derail care, including preventive screening and procedures. They talk through curiosity, person-first language, motivational interviewing, and acknowledging medical trauma, along with practical solutions such as moderated peer support groups, credible online resources, and comprehensive programs that combine lifestyle foundations, medications, bariatric pathways, and clinic infrastructure shaped by patient input. Timestamps 00:00  Why This Episode Changed 00:47  ADA Boycott Context 02:15  Meet The Panel 03:26  Inside The Keynote Fallout 06:41  Protest And Conference Mood 10:01  Choosing To Withdraw 11:18  Webinar Topic And Roadmap 13:47  Trust Gap And Weight Stigma 18:37  Language That Builds Safety 23:23  Peer Support And Community 25:09  Social Media And Group Coaching 27:19  Why I Started Posting 28:43  Building a Comprehensive Program 30:32  Three Pathways of Care 33:32  Designing for Real Bodies 35:54  Practical Clinician Changes 37:48  Mountain Dew Lesson 41:30  Trauma and Safe Spaces 42:25  Peer Support Communities 44:20  Insurance and Advocacy 46:27  Fighting Wellness Misinformation 47:55  How to Build Support Groups 50:53  Wrap Up and Where to Find Us Connect Dr. Komal Patil-Sisodia: Instagram and TikTok @drpatilsisodia. Podcast: Clearly Hormonal. Dr. Matthea Rentea: Instagram, TikTok, and YouTube. Podcast: The Obesity Guide with Matthea Rentea, MD, at renteaclinic.com. Michael Donnelly-Boylen: Instagram and TikTok as Mike On A Mission. Podcast: Weight and Measure with Mike and Zach, at weightandmeasurepod.com. Thanks for listening. Find more info about Clearly Hormonal on the website or Instagram.

  7. Sep 16

    Beyond the Buzz: Where GLP-1s Really Fit in PMOS Care

    📱 Send Us a Text Message! We’d love to hear from you! Please include your name and email address so we can reply. Don’t worry — this won’t sign you up for our email list. We’ll only use your info to respond to your question. Dr. Komal Patil-Sisodia continues the PMOS Awareness Month series by walking through where GLP-1 medications, like semaglutide and tirzepatide, fit into PMOS treatment. She explains what GLP-1s actually do in the body, who is likely to benefit, who they are not built for, and why they are never a stand-alone treatment plan for PMOS. In This Episode What a GLP-1 is and the three main effects these medications have on the bodyWhy insulin resistance sits at the center of PMOS for so many patients, and how that connects to androgen levels and symptoms like acne and excess hair growthWho is the clearest fit for a GLP-1: patients with insulin resistance or higher body weight, and those who haven't seen enough improvement from metformin or lifestyle changes aloneWho GLP-1s are not built for: lean PMOS patients without insulin resistance, and anyone trying to conceive soonWhy GLP-1s only work well alongside lifestyle change, and the real risks of low protein and fiber intake while on these medicationsWhat a GLP-1 does not replace: ongoing metabolic monitoring, fertility treatment, and androgen-targeted treatments like birth control pills or spironolactoneThe four questions Dr. Patil-Sisodia asks herself before recommending a GLP-1 for a PMOS patient Timestamps 00:00 Podcast Intro01:01 Series Setup02:13 GLP-1 Basics02:45 Why It Matters03:28 Who Benefits04:32 Who Should Avoid05:27 Lifestyle and Safety06:15 What GLP-1s Don't Replace07:40 How I Decide08:29 Wrap Up and Next Week09:36 Mini Course Promo Links Mentioned Newsletter sign-up: eastsidemm.com/newsletterFollow Dr. Patil-Sisodia: @drpatilsisodia on Instagram and TikTokThanks for listening. Find more info about Clearly Hormonal on the website or Instagram.

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About

Have you ever wondered why your body feels like it's falling apart just as you're hitting your stride in other areas of your life? Join Dr. Komal Patil-Sisodia as she explores women’s metabolic health changes that start in perimenopause. The episodes center around educating and empowering women to have open dialogue with their doctors so that they can achieve their best metabolic health. Dr. Patil-Sisodia is board certified in Endocrinology,  Obesity Medicine and Internal Medicine. She is also a Menopause Society Certified Practitioner. Any medical discussion on this podcast is purely for educational purposes and is not individualized medical advice. Please consult with your doctor to discuss any health concerns you may have.

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