The Longevity Show with Dr. Hillary Lin

Hillary Lin, MD

The Longevity Show with Dr. Hillary Lin breaks down complex medical concepts into easy-to-understand, actionable advice. We explore cutting-edge topics in preventative medicine, nutrition, metabolic health, exercise, and mental wellness - all aimed at helping you live a longer, healthier life.

  1. 1D AGO

    The Oral Longevity Blind Spot: Detecting the Silent Killer in Your Mouth

    You probably track your sleep, HRV, and blood work, yet the second-largest microbiome in your body is quietly driving systemic aging. In fact, 57 major systemic diseases—including Alzheimer's, cardiovascular disease, and autoimmune conditions—are directly linked to oral inflammation.Traditional dentistry waits for symptoms—cavities, bleeding gums, or severe pain—before treating the problem. Dr. Jonathan Levine argues this is like waiting for a massive heart attack before ever checking your cholesterol.In this episode, we dismantle the 1840 "Grand Rebuke" that dangerously separated dentistry from medicine. We explain why standard basic cleanings fail to detect early pathogenic risk and why the equivalent of a preventative full-body scan for your mouth—AI-enabled 3D Mouth Mapping—is the only way to truly visualize your risk. We also dive deep into advanced longevity protocols, including airway expansion for deep sleep, point-of-care salivary omics, and the high-performance oral hygiene regimen you need to adopt immediately.Topics Covered:• The Failure of the "Gold Standard": Why standard 2D x-rays and basic cleanings completely miss dangerous pathogens.• Leaky Gums & Systemic Disease: Understanding how the P. gingivalis bacteria travels from your mouth to build arterial plaque and drive Alzheimer's.• Advanced Imaging: How 3D Mouth Mapping and AI visualize hidden airway obstructions and structural breakdown.• Protocols for Prevention: The role of pH-raising rinses, tongue scraping, and why you must throw out alcohol-based mouthwashes.• Airway Health & Sleep: The connection between mouth breathing, nitric oxide depletion, and how structural jaw expansion can cure disrupted sleep.• The Nuance of Fluoride: Protecting your enamel without neurotoxic risks through dose-specific applications.About Dr. Jonathan Levine:Dr. Jonathan Levine is a preventative prosthodontist, clinical innovator, and pioneer in oral-systemic health based in New York City. He is the inventor of GLO Science technology and the co-founder of Smile House, the Center for Dental Longevity. He has dedicated his 35-year career to bridging the gap between medicine and dentistry, utilizing advanced diagnostics to detect and stop systemic inflammatory diseases at their source.Website: https://www.drjonathanlevine.com/Instagram:   / drjonlevine  JBL New York City: @jblnewyorkcitySmile House Tribeca: @smilehousetribecaGLO Science: @gloscienceGLO Science Pro: @gloscienceproGLO Good Foundation: @glogoodfoundationChapters 00:00 The Overlooked Role of Oral Health in Longevity03:10 Rebuilding the Dental Care Model06:19 The Center for Dental Longevity & Smile House11:14 The Oral-Systemic Connection14:33 Integrating Dentistry with Overall Health20:07 The Tech-Enabled Dental Exam22:28 Airway Health, Nitric Oxide, & Sleep29:51 The Future of Salivary Diagnostics31:12 Mission Work in Dental Deserts34:06 High-Performance Oral Protocols36:48 The Role of Fluoride in Dental Health39:17 Epigenetics vs. Genetics in Decay46:04 Top Takeaways for Oral Longevity

    49 min

  2. FEB 12

    The Heart Attack You Won't See Coming (Even With 'Good' Stats).

    50% of people who die of a heart attack have zero prior symptoms. They have no chest pain, no shortness of breath, and often, "normal" cholesterol on a standard panel. In Part 1 of 𝘛𝘩𝘦 𝘔𝘰𝘥𝘦𝘳𝘯 𝘓𝘪𝘱𝘪𝘥 𝘗𝘭𝘢𝘺𝘣𝘰𝘰𝘬, I break down why the standard of care is failing to detect the world's #1 killer until it’s too late. I share the science on why atherosclerosis is actually a pediatric disease, the "cumulative exposure" math that proves early prevention is 3x more effective, and the specific blood markers you need to look at instead of just LDL-C. 📩 𝐆𝐞𝐭 𝐖𝐞𝐞𝐤𝐥𝐲 𝐋𝐨𝐧𝐠𝐞𝐯𝐢𝐭𝐲 𝐔𝐩𝐝𝐚𝐭𝐞𝐬: https://www.hillarylinmd.com/subscribe 𝐎𝐍 𝐓𝐇𝐈𝐒 𝐄𝐏𝐈𝐒𝐎𝐃𝐄: We dismantle the "plumbing" model of heart disease and replace it with the latest science on lipidology and longevity. • 𝐓𝐡𝐞 "𝐒𝐢𝐥𝐞𝐧𝐭" 𝐊𝐢𝐥𝐥𝐞𝐫: Why your body is evolutionarily designed to hide heart disease from you. • 𝐓𝐡𝐞 𝐏𝐞𝐝𝐢𝐚𝐭𝐫𝐢𝐜 𝐄𝐯𝐢𝐝𝐞𝐧𝐜𝐞: Autopsy data showing plaque in 20-year-olds (Korean War & PDAY studies). • 𝐓𝐡𝐞 𝐌𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦: How ApoB particles get trapped in the artery wall (The "Response to Retention" model). • 𝐓𝐡𝐞 𝐌𝐚𝐭𝐡 𝐨𝐟 𝐑𝐢𝐬𝐤: Why "Cholesterol-Years" matter more than your current numbers. • 𝐋𝐢𝐟𝐞𝐬𝐭𝐲𝐥𝐞 𝐅𝐚𝐜𝐭𝐨𝐫𝐬: How sleep debt and stress physically damage your endothelium. 𝐂𝐇𝐀𝐏𝐓𝐄𝐑𝐒: 01:47 One Disease, Three Addresses: Heart Attack, Stroke, and Aneurysm 03:09 The Pediatric Bombshell: This Is a Childhood Disease 09:14 The Mechanism: What's Actually Happening Inside Your Arteries 15:20 The Math of Cumulative Exposure: Why When You Start Matters More Than What You Do 22:17 The Evolutionary Paradox: Why Our Bodies Betray Us 27:41 The Invisible Damage: What's Happening While You Feel Fine 32:27 The Information War: Why You’re Confused 41:12 What This Means For You: The Stakes, The Opportunity

    43 min

  3. JAN 17

    Stop Cooking With These: A Longevity Physician’s Guide to Seed Oils & Saturated Fat

    We’ve been told the same story for 50 years: "Saturated fat is bad, vegetable oil is heart-healthy." But if that’s true, why are we in a global energy crisis of chronic fatigue and metabolic stalling?As a longevity physician, I look at the body like an engineer looks at a high-performance machine. When the engine stalls, I don't blame the driver—I look at the fuel. In this masterclass, we dismantle the "Fat Wars" with clinical nuance. I explain why the Seed Oil debate is often missing the most dangerous variable: Oxidation. We explore the "Two-Hit Theory" of heart disease, how unstable fats create "zombie" membranes in your mitochondria, and why your Air Fryer might be an oxidation accelerator. Most importantly, I provide a practical kitchen protocol to help you rebuild your biology from the cell membrane out.In this episode, we cover:• The Two-Hit Theory: Why LDL volume is only half the problem (and why oxidation is the match that lights the fire).• The Membrane Theory: How Linoleic Acid creates "fragile" cells that leak toxic waste (4-HNE) into your brain.• The Migraine Connection: New NIH data on how specific oils chemically activate your pain receptors (TRPV1).• The Smoke Point Lie: Why "high smoke point" oils can still rot your DNA.• The Official Protocol: My Tier 1, 2, and 3 hierarchy for the longevity-focused kitchen.Chapters00:00 The Energy Crisis Within Us01:47 The Two-Hit Theory: Why "Healthy" Oils May Be Driving Heart Disease04:34 Cellular Sabotage: How Unstable Fats Break Mitochondria & Trigger Pain07:54 Cooking Myths Debunked: Smoke Points, Olive Oil, & Air Fryer Risks09:50 The Return of Solid Fats: Why Tallow Wins & Crisco Kills11:37 The Official Protocol: Tier 1, 2, and 3 Oils for Your Kitchen

    14 min

  4. 12/30/2025

    “Normal” Labs but Still Exhausted? Mitochondrial Series (Pt 1): Mitophagy + 4-Step Protocol

    If you’re sleeping well, eating clean, exercising—and still exhausted—this may be an engine problem, not a fuel problem.This is Part 1 of my Mitochondrial Health Series, where I start with the foundation: mitophagy—your body’s ability to clear damaged mitochondria.In longevity medicine, I call this mitophagy failure: damaged mitochondria (“zombie batteries”) stop producing clean energy and leak signals that can trigger inflammation, brain fog, and that 2 p.m. crash.In this video, I break down:• Why zombie mitochondria can keep you stuck in “sickness behavior”• The key biology: PINK1 + Parkin (how your cells tag and remove broken mitochondria)• My 4-step energy protocol: 14–16 hr overnight fasting, Zone 2 cardio, heat (sauna/hot bath), and urolithin A + spermidine• The NAD+ trap: why NMN/NR can backfire if you “fuel” before you “clean”Chapters: 00:00 The "Zombie Battery" Cause of Fatigue 01:54 Why Your Cells Think They Are Dying04:43 The Cleanup Crew: PINK1 & Parkin07:02 Protocol 1: The "Janitor" Fast (AMPK vs. mTOR)08:44 Protocol 2: Why HIIT Might Be Making You Tired09:59 Protocol 3: Heat Shock Proteins & Sauna11:30 Protocol 4: Supplements (Urolithin A, Spermidine) & The NAD+ Mistake15:18 Summary: The 4-Step Energy Protocol

    16 min

  5. 12/20/2025

    The "Normal" Cholesterol Myth: Detecting the Widowmaker Before It Strikes

    Heart disease is still the #1 killer worldwide, yet 50-75% of people who suffer a heart attack have "normal" cholesterol levels.Traditional cardiology waits for symptoms—chest pain, shortness of breath, or cardiac arrest—before treating the problem. Dr. John Osborne, MD, PhD, argues this is like waiting for Stage 4 cancer before ordering a screening.In this episode, we dismantle "20th Century Cardiology." We explain why standard EKGs and stress tests fail to detect early plaque and why the "Cardiac Colonoscopy"—AI-enabled CCTA—is the only way to truly visualize your risk. We also dive deep into advanced reversal protocols, including the use of Colchicine for inflammation, the "Keto Paradox," and the genetic biomarkers (Lp(a) and ApoB) that you need to request immediately.*Topics Covered:*• The Failure of "Gold Standards": Why stress tests miss 30-40% of dangerous blockages.• Soft Plaque vs. Hard Plaque: Understanding the difference between stable calcium and the "lava" that causes sudden death.• Advanced Imaging: How AI CCTA visualizes the vessel wall (the "donut") rather than just the hole.• Protocols for Reversal: The role of Colchicine, PCSK9 inhibitors, and statins in shrinking plaque.• The Keto Paradox: Can you have healthy arteries with high cholesterol?• Genetics: Why everyone needs to test for Lipoprotein(a) once in their life.About Dr. John Osborne:Dr. John Osborne is a Preventative Cardiologist and Lipidologist based in Dallas. He holds an MD and PhD in cardiovascular physiology and founded State of the Heart Cardiology. He is the Co-Founder and Chief Medical Officer of Clear Cardio, pioneering the use of AI in cardiac imaging to detect and reverse heart disease before it becomes fatal. Chapters: 00:00 Introduction to Heart Disease and Its Impact 04:46 Why Your "Normal" Cardiology Workup Is Useless 13:08 The Cardiac Colonoscopy: AI Imaging vs. Blind Blood Work 16:24 Cardiac CT + AI: The 20-Second Scan That Changes Everything 31:08 The Blood Tests That Actually Matter 36:36 Cholesterol vs. Sticky Vessels: The Two-Factor Model  40:45 The Debate on Diets: Cholesterol and Inflammation 44:13 Reversing Heart Disease: Colchicine, Statins, and New Protocols 54:14 Exploring Stem Cell Therapy in Cardiology 57:00 The Future of Preventative Cardiology

    1 hr

  6. 12/09/2025

    Healthspan vs Lifespan: The Real Reason We Age Poorly

    When most people imagine living to 100, they don’t picture joy, movement, or independence. They picture decline. Years spent in medical offices. A body that can’t keep up with the life they still want to live.That reaction reveals something important. The real problem isn’t how long we live. It’s how well we live those added years.In this episode, we explore the gap between lifespan (how long you live) and healthspan (how long you live well), and why so many people spend the last decade or two of life surviving instead of thriving. You’ll see why this gap exists, how modern healthcare and society make it worse, and what can be done to change the trajectory.Here’s what we cover:⭐ Why the healthspan–lifespan gap exists⭐ The forces inside the healthcare system that work against prevention⭐ Societal pressures that quietly undermine long-term health⭐ The biological wiring that makes healthy choices harder than they should be⭐ Practical steps to help close the gapFor anyone who has seen a parent or grandparent lose their independence too early, or anyone who wants their later decades to be full of movement, purpose, and connection, this conversation matters.“In the end, it’s not the years in your life that count. It’s the life in your years.”If this episode helps reframe what aging can look like, tap like, share your biggest insight in the comments, and send it to someone you want to grow old well with. Chapters 01:28 Why the Healthspan-Lifespan Gap Exists05:06 Economic and Systemic Barriers to Healthspan10:49 Societal Barriers to Healthspan Extension14:00 Biological Barriers to Healthspan Extension

    25 min

  7. 11/28/2025

    This Genetic Cholesterol Particle Drives Heart Attacks. Why Doctors Miss It

    20% of the population has high Lipoprotein(a), yet most doctors don't test for it until it’s too late. Lp(a) is an independent genetic risk factor that triples your risk of heart attack and stroke. If you've never had this specific blood test, this video is a must-watch. I explain exactly what it is and how to ask for the test.In this episode, we cover what Lp(a) is, why it is strongly inherited, and which groups are most affected. You will learn how to test for it, what levels mean, and why new RNA based treatments could change cardiovascular care in the next few years. If you have a family history of heart disease or “normal” cholesterol with lingering symptoms, this is essential viewing.What you will learn:• Why Lp(a) is missed on standard cholesterol tests• How genetics set your Lp(a) level for life• Ethnic differences in Lp(a) and who should test today• Why Lp(a) promotes plaque, inflammation, and clots• Current options. PCSK9 inhibitors, apheresis, and lifestyle strategy• New RNA based therapies that may drop Lp(a) by up to 90 percentIf heart disease runs in your family, ask your clinician for an Lp(a) test. This one number can change your prevention plan.#lipoproteina #lpa #cholesterol #heartdisease #strokeprevention #cardiovascularhealth #heartattack #cardiologist #cholesteroltest #preventivemedicine #genetics #atherosclerosis #pcsk9 #rnatherapy #hillarylinmd

    32 min

  8. 11/26/2025

    Catch Silent Killers Early with a 30-Minute MRI

    What if your biggest risk isn’t food or fitness. It’s the tumor or aneurysm no one is looking for. Dr. Alan Alexander shows how a 30-minute whole-body MRI is already saving lives. Former team physician for the Lakers and Dodgers. NIH longevity researcher. Now CEO of CoreViva. Dr. Alexander explains why proactive imaging matters, how thin-slice MRI can find early cancers and aneurysms, and why “know your body” beats waiting for symptoms. We also dig into caloric restriction, intermittent fasting done right, the 3-2-1 sleep rule, tech-neck epidemic, pricing and insurance realities, and a bold 2035 vision for preventive care.Key takeaways:• Why standard screening leaves gaps. What MRI can catch across organs• Intermittent fasting works when calories actually drop. Not when you cram meals• The 3-2-1 sleep rule for better melatonin release• Tech-neck is everywhere. Here is what thin-slice imaging reveals• Immediate results with physician consult. Then a detailed report and CoreViva Score• Pricing, false positives, and when insurance could follow the data• How proactive care shifts outcomes and cost curves by 2035 Chapters 00:57 What Caloric Restriction Taught Us About Aging07:57 How Elite Athletes Master Longevity Habits10:25 How CoreViva Was Created to Save Lives12:59 Inside A CoreViva Scan: What Patients Experience16:32 What the Scans Are Revealing About Modern Health25:23 The Future of Prevention and Longevity Medicine39:17 The 3 Habits That Outlive Us All#WholeBodyMRI #EarlyCancerDetection #LongevityPodcast #PreventiveMedicine #ProactiveHealth #CoreViva #MRIScreening #BrainAneurysmScreening #VisceralFatMRI #MusculoskeletalAge #IntermittentFastingScience #CaloricRestrictionPrimate #BlueZonesLongevity #Sleep321Rule #TechNeck #AthleteLongevity #LakersDoctor #DodgersDoctor #AIinRadiology #AnnualHealthScreening #PreventiveImaging #CancerScreeningOptions #HillaryLinMD #CareCore

    44 min
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Ratings & Reviews

5
out of 5
3 Ratings

About

The Longevity Show with Dr. Hillary Lin breaks down complex medical concepts into easy-to-understand, actionable advice. We explore cutting-edge topics in preventative medicine, nutrition, metabolic health, exercise, and mental wellness - all aimed at helping you live a longer, healthier life.

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