The Age Reversal Project

Orshi McNaughton
  • 5.0 (8)
  • Life Sciences
  • Updated Weekly

How close are we to actually reversing aging — and what will it take to get there? The Age Reversal Project goes inside the rapidly evolving world of longevity, age-reversal science and healthy aging to explore the breakthroughs that could help us live longer, healthier and more capable lives. Host Orshi McNaughton talks with the scientists, researchers, biotech founders, physicians and pioneers working at the edge of human longevity — from regenerative medicine, cellular reprogramming and gene therapy to AI, longevity therapeutics, emerging medications, advanced diagnostics and human trials. We follow the technologies moving from the laboratory into the real world, the companies trying to turn longevity science into medicine, and the experiments testing what's possible in humans today. We also explore the interventions available now — from health optimization and biohacking to new approaches designed to extend healthspan, slow biological aging and potentially reverse aspects of aging itself. The Age Reversal Project is your front-row seat to the longevity frontier — and the race toward longevity escape velocity. If you're fascinated by longevity, age reversal, biotechnology, AI, anti-aging science, regenerative medicine, healthspan and the future of human lifespan, this is where you'll meet the people building that future and follow the breakthroughs that could change how we age.

  1. Sep 14

    Hormone Therapy, GLP-1s & Peptides for Women’s Longevity | Dr. Shoma Datta-Thomas

    Description Hormone replacement therapy, testosterone, GLP-1 medications and peptides are changing how women approach menopause, metabolic health and longevity. Dr. Shoma Datta-Thomas explains how declining hormones can affect brain fog, sleep, insulin resistance, visceral fat, muscle mass and cardiovascular health, and why hormone health extends far beyond reproductive health. We explore the evolving science of HRT after the Women’s Health Initiative, testosterone therapy for women, GLP-1s for metabolic optimization, resistance training, peptides, supplements, advanced lab testing and the growing role of AI in personalized longevity medicine. LET'S CONNECT Guest: Dr. M. Shoma Datta-Thomas, MD, FACOG Website: https://www.next-health.com/team/dr-shoma-datta-thomas Instagram: https://www.instagram.com/shomadatamd/ Host: Orshi McNaughton Website: https://orshimcnaughton.com/ Instagram: https://www.instagram.com/orshimcnaughton Substack: https://substack.com/@orshimcnaughton Enjoying the podcast? ⭐⭐⭐⭐⭐ Don’t forget to subscribe and leave a review to help spread the word!

    Hormone Therapy, GLP-1s & Peptides for Women’s Longevity | Dr. Shoma Datta-Thomas

  2. Aug 19

    Can We Reverse Human Aging? Inside the $101M XPRIZE | Rabbit Hole #1

    Can we actually reverse human aging? XPRIZE has put $101 million behind that question, challenging scientists to demonstrate something far more meaningful than a younger biological-age score: measurable improvements in muscle function, cognition, and immune resilience. In the first episode of The Rabbit Hole, I dig into the science behind the XPRIZE longevity competition and some of the approaches now being tested—from repurposed drugs and multimodal protocols to stem cells, gene therapy, extracellular vesicles derived from plants, and cellular reprogramming. We explore why XPRIZE is shifting the conversation from biomarkers to actual human function, what the latest human data tells us, and the critical difference between longevity therapies you can access today and those that have actually been proven to work. Read the full article + explore my writing: https://orshimcnaughton.substack.com/ https://www.instagram.com/orshimcnaughton/ https://www.linkedin.com/in/orshimcnaughton/ AI Disclosure: Portions of this episode feature AI-generated voices used to turn my original reporting and research into a conversational format. The underlying research, sources, editorial direction, and final review are my own. This podcast is for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider.

    Can We Reverse Human Aging? Inside the $101M XPRIZE | Rabbit Hole #1

  3. Jul 15

    Microdosing GLP-1s: Can Less Actually Work Better? | Dr. Karen Mann

    Microdosing GLP-1s is quickly becoming one of the most talked-about topics in obesity medicine, but can taking less actually produce better long-term results for some people? In this episode, Dr. Karen Mann shares how personalized GLP-1 dosing, food noise, behavior change, and identity-based habits may be the missing pieces to sustainable weight management. We also discuss preserving muscle, optimizing protein intake, resistance training, menopause, hormone replacement therapy, and why lasting health depends on changing who you become—not just what you weigh. #GLP1 #Microdosing #FoodNoise #WeightLoss TIMESTAMPS [00:00] Why discomfort is the key to lasting behavior change [00:43] Welcome to The Optimized Woman [01:15] Dr. Karen Mann's personal journey into obesity medicine [02:51] Why weight management requires a personalized approach [04:18] Why standard GLP-1 dosing isn't right for everyone [08:08] Why behavior change matters more than motivation [10:45] Finding your "why" and building identity-based habits [14:56] Becoming the person you want to become [16:32] Coaching, accountability and habit formation [18:46] What microdosing GLP-1s actually means [22:09] New oral GLP-1 medications explained [26:15] Food noise, emotional eating and impulse control [29:43] Ultra-processed foods and why we're still hungry [34:16] Can you lose weight eating unhealthy foods? [36:10] Protein, muscle loss and resistance training [39:42] Why strength training becomes essential with age [42:21] Hormone replacement therapy and healthy aging [47:49] Self-talk, self-compassion and changing your mindset [50:56] Redefining discomfort as an act of self-love LET'S CONNECT Guest: Dr. Karen Mann, MD Instagram: https://www.instagram.com/drkarenmann/ Host: Orshi McNaughton Podcast: https://optimized-women.captivate.fm/listen Website: https://www.optimizedwomen.com/ YouTube: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton Substack: https://substack.com/@orshimcnaughton

    Microdosing GLP-1s: Can Less Actually Work Better? | Dr. Karen Mann

  4. Mar 4

    Methylene Blue for Brain Fog, Anxiety and Low Energy | Dr. Scott Sherr, MD

    Methylene blue is one of the most talked-about tools in biohacking for mitochondrial function, brain fog, and energy—and the nuance is in dosing, quality, and context. In this episode, Dr. Scott Sherr explains how chronic stress and hormone shifts can trap women in a “wired but tired” state, why HRV drops when your nervous system can’t recover, and how sleep architecture, minerals, and mitochondrial support may help restore resilience. You’ll also learn the red flags of low-quality methylene blue, why low-dose and high-dose effects are different, and how to think about redox balance without making your stress physiology worse. KEY TOPICS Methylene blue benefits dosing and quality concerns Mitochondrial dysfunction behind brain fog fatigue and anxiety HRV and nervous system resilience in midlife women Sleep architecture REM sleep and why waking at night happens Minerals electrolytes cortisol and the wired but tired stress loop TIMESTAMPS [00:00] Metabolic health crisis and why mitochondrial dysfunction is so common [01:06] Show introduction and what this episode will help you fix [01:37] Scott Sherr’s integrative path and Health Optimization Medicine approach [03:57] The Sympathetic Spiral of Doom and what it looks like in real life [05:10] Why midlife hormones reduce stress tolerance and recovery capacity [06:45] How chronic vigilance and modern stress keep you stuck in fight or flight [08:10] HRV trends over time and why “doing everything right” still isn’t enough [09:54] What HRV measures and how to use it for real-world experiments [11:40] The cell danger response and how mitochondria downshift energy production [12:55] Why “wired but tired” signals mitochondrial and nervous system overload [14:35] Why mood changes and irritability show up when the brain lacks energy [16:34] GABA vs glutamate and the neurochemistry of anxiety and insomnia [18:20] Why SSRIs don’t map cleanly to “low serotonin” in depression [19:55] Short-term calming tools vs medium-term nutrient and gut foundations [21:08] Sleep architecture explained deep sleep REM sleep and recovery biology [22:55] Why waking at night happens and why progesterone alone may not solve it [24:10] Sleep starts in the morning sunlight meals timing and daytime stress [26:05] Why REM sleep is mitochondrially demanding and easier to disrupt [27:37] Minerals under stress why magnesium sodium and potassium get depleted [28:55] Personalizing electrolytes for travel training and high-stress periods [30:05] Cortisol rhythm and why late exercise and late meals can tank recovery [31:20] Why minerals and antioxidants matter for energy production and detox [32:14] Your methylene blue Goldilocks dose and how to cycle it [33:27] What methylene blue does for mitochondria energy and detox together [34:50] Low-dose vs high-dose methylene blue and when higher doses get stressful [36:10] Hydrogen peroxide production at higher doses and why antioxidants matter [37:20] Redox balance explained energy production plus detox capacity [38:20] Quality risks heavy metals potency issues and why liquids are risky [40:02] Why redox-active compounds can backfire if your nervous system is dysregulated [43:40] Breaking the stress loop support mitochondria first then downregulate stress [45:10] The parasympathetic edge why “calmer performs better” is real physiology [48:03] Where health optimization is heading mitochondrial medicine and healthspan [50:25] Organ-level thinking vs cellular-level optimization holobiont framework [52:30] N-of-1 tracking wearables and why personalization beats population advice [53:09] AI caution why models can mislead and why human clinical context matters [54:18] Where to find Dr. Scott Sherr and related work LET'S CONNECT Guest: Dr. Scott Sherr, MD Website: https://drscottsherr.com Instagram: https://www.instagram.com/drscottsherr Host: Orshi McNaughton Podcast: https://optimized-women.captivate.fm/listen Website: https://www.optimizedwomen.com/ YouTube: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton Enjoying the podcast? ⭐⭐⭐⭐⭐ Don’t forget to subscribe and leave a review to help spread the word!

    Methylene Blue for Brain Fog, Anxiety and Low Energy | Dr. Scott Sherr, MD

  5. 12/30/2025

    Weight Loss Resistance in Midlife: What the Research Reveals I Dr. Bill Campbell, PhD

    If you’re strength training, eating “clean,” and still gaining fat or losing muscle after 40, it’s not just willpower—it’s physiology. In this episode we break down what actually changes during perimenopause and menopause (lean mass, central fat gain, estrogen shifts), plus the research-backed levers that still move the needle: resistance training intensity, protein targets, smart cardio, recovery, and when HRT may help. If you feel like the old playbook stopped working, this is your reset with a real framework. KEY TOPICS Why weight loss resistance shows up in midlife even for active women How menopause shifts body composition toward central fat gain and lean mass loss HRT and estradiol research for muscle gain and inconsistent fat loss outcomes Protein targets for midlife women and how to hit them consistently Training strategy that works: heavy lifting, cardio for VO2 max, power, agility, and recovery TIMESTAMPS [00:00] Why Bill Campbell shifted his research to menopause after his wife’s experience [00:24] Female physiology matters: women are not “small men” and body composition changes hit hard [00:57] First generation of strength-trained women entering menopause and why the research gap matters [01:40] What’s really happening: gaining fat and losing muscle isn’t just about effort after 40 [09:13] Menopause vs aging debate: what the SWAN data suggests about the transition [12:40] DEXA findings: lean mass loss begins and fat gain accelerates during the transition [14:10] Why fat shifts to the middle: central adiposity, FSH rise, and estradiol decline [15:00] HRT question: what changes when women use hormone therapy during training [16:46] Estradiol and muscle: why estrogen therapy may be anabolic in trained women [18:30] Estradiol and fat loss: why results are variable and not a guaranteed solution [20:28] Hormone balance and nuance: estradiol, progesterone, testosterone, and body fat context [22:55] Estradiol target ranges discussed for bone and muscle support [27:53] Progesterone vs progestins: why older research can be misleading [29:21] Protein targets: 0.75–1.0 g/lb ideal body weight and why most women under-eat protein [33:47] Practical protein strategy: distribute evenly across meals to hit your daily target [38:17] Protein timing around workouts: why pre vs post doesn’t matter much [40:39] Supplements that matter: creatine, whey/complete protein, omega-3s [43:22] Magnesium and vitamin D: common deficiencies and bone-health relevance [45:00] Strength training minimum effective dose: 1 day for maintenance, 2+ days for best results [47:16] Training doesn’t change by decade: intensity and proximity to failure are the difference [49:46] Benchmarks: squat bodyweight and deadlift ~1.25x bodyweight as aspirational goals [54:47] Cardio after menopause: VO2 max, HIIT, and why walking isn’t the same stimulus [58:41] Stress resiliency: when pulling back is smarter than pushing harder [01:00:16] Ideal weekly structure: resistance, aerobic fitness, power, agility, plus daily movement [01:03:16] BFR/Kaatsu for joint pain and training around injuries [01:05:02] What turned it around for Bill’s wife: progesterone first, then estradiol, plus patience [01:07:46] HRT isn’t one-and-done: adjust, track, and combine with training, sleep, and recovery [01:11:26] Where to follow Bill Campbell and his menopause fitness content [01:12:00] Support the show and join the free community at optimizedwomen.com Guest: Dr. Bill Campbell Website: https://billcampbellphd.com Instagram: https://www.instagram.com/billcampbellphd/ LET'S CONNECT Host: Orshi McNaughton Podcast Links: https://optimized-women.captivate.fm/listen Website: https://www.optimizedwomen.com/ YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton

    Weight Loss Resistance in Midlife: What the Research Reveals I Dr. Bill Campbell, PhD

  6. 12/02/2025

    Women’s Hormones & the Future of Longevity Medicine | Dr. Amy Killen

    This episode explores how women’s hormones, aging, regenerative therapies, and technology are shaping the next era of longevity medicine. Dr. Amy Killen shares her evolution from ER doctor to multi-company entrepreneur, her work in stem cells and full-body regenerative procedures, and the role of diagnostics, AI, and hormone optimization in midlife women’s health. You’ll get an inside look at the queen phase of perimenopause, the future of longevity clinics, and how women can stay proactive as they age. KEY TOPICS Estrogen, perimenopause and the queen phase of women’s midlifeDr. Killen’s shift from ER medicine to entrepreneurship in longevityStem cells, exosomes and whole-body regenerative therapiesReputable Health, Hop Box and Humanát Health’s tech-enabled clinical modelAI-driven care plans, advanced diagnostics and the future of preventive longevity careTIMESTAMPS [00:00] Estrogen as a forgotten longevity drug and the mental health impact of perimenopause [00:56] Show intro and framing women’s health, resilience and personal transformation [01:27] ER burnout, single motherhood and the moment everything shifted [03:23] Leaving the ER and confronting criticism around hormones and regenerative medicine [04:08] Partnering with Docere Clinics and developing the Full Body Stem Cell Makeover [06:33] Stacking stem cells, exosomes, peptides, light therapy and sound therapy [08:10] Transformations in pain, sexual health and functional recovery using stem cells [10:09] Musculoskeletal outcomes and delaying joint replacement surgeries [10:57] Skin quality improvements, subtle rejuvenation and hair restoration in women [13:33] Stem cells vs PRP and when each modality is most effective [13:51] Founding Reputable Health to modernize clinical trials using wearables [15:11] How biohackers join studies and test real supplements and devices [16:28] Using AI to extract insights from sleep, HRV and wearable data [16:57] Creating Hop Box as a simple, evidence-based female longevity stack [18:17] Supplements tailored to female physiology, insulin resistance and skin health [19:29] Why Hop Box is not a multivitamin and how ingredients like spermidine fit in [21:06] Defining the queen phase and why women lose hormonal protection [23:11] Men’s gradual testosterone decline vs women’s hormonal cliff in midlife [24:52] Stress load in midlife and why so many women struggle in their 40s and 50s [25:43] Hormone therapy as a foundational pillar for women’s longevity [26:18] Building Humanát Health as a next-gen longevity clinic franchise [28:21] Core pillars of longevity care: lifestyle, diagnostics and prevention [30:39] Comparing Humanát to other longevity and biohacking clinics [32:36] Evidence-based hormone protocols and training providers at scale [35:31] How Humanát uses advanced diagnostics and AI-generated care plans [39:45] Why the franchise model expands access to longevity medicine [42:54] Membership tiers, affordability and the future of nationwide rollout [43:41] Inside the Humanát gym: VO2 max, strength, balance and kinetic testing [44:34] Advice to clinicians entering longevity entrepreneurship [45:42] The next decade of regenerative medicine and the role of women [46:41] Balancing motherhood, procedures, multiple companies and travel [47:45] Where to find her clinics, supplements and platforms [49:14] Closing reflections on the women’s longevity revolution Guest: Dr. Amy Killen Website: https://dramykillen.com/ Instagram: https://www.instagram.com/dr.amybkillen/ LET’S CONNECT Host: Orshi McNaughton Podcast: https://optimized-women.captivate.fm/listen Website: https://www.optimizedwomen.com/ YouTube: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton Enjoying the podcast? ⭐️⭐️⭐️⭐️⭐️ Don’t forget to subscribe and leave a review to help spread the word!

    Women’s Hormones & the Future of Longevity Medicine | Dr. Amy Killen

  7. 11/11/2025

    A Female Bodybuilder’s Guide to Muscle & Metabolism Over 50 I Carol Covino

    Discover how to build lean muscle, balance hormones, and reignite metabolism after 50. In this episode, you’ll learn the science behind muscle as a metabolic organ, how to train smarter (not harder) through menopause, and why recovery and hormone balance are key for strength and longevity. Perfect for women who want to stay strong, lean, and vibrant at any age. Muscle as metabolic medicine for women in midlifeSmart strength training splits and recovery for hormone healthBalancing HIIT, Zone 2, and daily movement for longevityHormone replacement therapy and testosterone in womenProtein, creatine, and supplement strategies for women over 50 TIMESTAMPS [00:00] Why muscle is key to metabolic health and glucose control in midlife [00:44] Starting bodybuilding at 50 and transforming your body at any age [01:33] Perimenopause, insulin resistance, and how strength training helps [03:19] Common training mistakes: too much cardio and skipping a coach [05:44] How to find the right trainer for women 40–60+ [09:46] Bodybuilding lessons: muscle splits, compound lifts, and progression [12:37] The best full-body plan for busy women (2–3 days a week) [14:21] How to train with balance and recovery between workouts [15:14] Heavy lifting, volume, and tempo — finding your intensity sweet spot [17:55] Conditioning vs cardio: HIIT, Zone 2, and power training explained [19:07] The ideal weekly mix for fat loss, recovery, and stress control [22:30] Daily walking, HRV tracking, and training around your stress load [27:26] Injury prevention: knees, shoulders, hips, and posture correction [33:17] Midlife recovery tools: mobility, foam rolling, flexibility, and rest [34:12] Men vs women in training — why women won’t “bulk up” [35:04] Estrogen decline, sarcopenia, and how to preserve muscle in menopause [36:23] HRT and testosterone therapy — benefits, myths, and what to watch for [41:13] Protein goals and timing for women 40+ [42:54] Carbs, fats, and how to eat for energy and body composition [44:22] Creatine, protein shakes, and supplement stack for strength [46:47] Carol’s book, podcast, and where to connect with her online Guest: Carol Covino Website: https://carolcovino.com/ Instagram: https://www.instagram.com/carolcovinofitness/ LET’S CONNECT Host: Orshi McNaughton Website: https://www.optimizedwomen.com/ YouTube: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton

    A Female Bodybuilder’s Guide to Muscle & Metabolism Over 50 I Carol Covino

  8. 10/14/2025

    How AI Is Revolutionizing Longevity Medicine | Jim Donnelly

    Discover how precision diagnostics, regenerative therapies, and AI are redefining the future of personalized healthcare. In this episode, you’ll learn how data-driven medicine, early disease detection, and foundational lifestyle strategies are transforming longevity and empowering women to take control of their healthspan. 💡 KEY TOPICS 💡 AI and data-driven longevity medicineDemocratizing access to precision health careFoundations of health optimization and lifestyle medicineRegenerative therapies and therapeutic plasma exchangeWomen’s hormones, midlife vitality, and personalized care ⏰ TIMESTAMPS ⏰ [00:00] Adding 20 good years of life and redefining longevity [02:15] The story behind Restore Hyper Wellness and the birth of Humanot Health [07:31] Building the wellness franchise model and scaling innovation [12:03] From athlete recovery to chronic inflammation relief [19:40] Defining health optimization and the role of foundational habits [23:53] How Humanot bridges fragmented longevity solutions [28:08] Making advanced therapies more affordable and accessible [34:24] Standardizing longevity medicine and women’s hormone care [46:32] How AI is transforming diagnostics and personalized medicine [54:07] Cutting-edge therapies like therapeutic plasma exchange [59:54] Preventative and minimally invasive healthcare approaches [01:00:30] What health optimization means for women in midlife [01:06:45] Final insights and how to connect with Humanot Health 🌿 GUEST 🌿 Jim Donnelly | CEO & Founder, Humanot Health Website: https://www.humanauthealth.com Instagram: https://www.instagram.com/humanauthealth/ LinkedIn: https://www.linkedin.com/in/jimdonnellyhumanaut 💫 LET'S CONNECT 💫 Host: Orshi McNaughton Website: https://www.optimizedwomen.com Podcast: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton/ LinkedIn: https://www.linkedin.com/in/orshimcnaughton/

    How AI Is Revolutionizing Longevity Medicine | Jim Donnelly
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About

How close are we to actually reversing aging — and what will it take to get there? The Age Reversal Project goes inside the rapidly evolving world of longevity, age-reversal science and healthy aging to explore the breakthroughs that could help us live longer, healthier and more capable lives. Host Orshi McNaughton talks with the scientists, researchers, biotech founders, physicians and pioneers working at the edge of human longevity — from regenerative medicine, cellular reprogramming and gene therapy to AI, longevity therapeutics, emerging medications, advanced diagnostics and human trials. We follow the technologies moving from the laboratory into the real world, the companies trying to turn longevity science into medicine, and the experiments testing what's possible in humans today. We also explore the interventions available now — from health optimization and biohacking to new approaches designed to extend healthspan, slow biological aging and potentially reverse aspects of aging itself. The Age Reversal Project is your front-row seat to the longevity frontier — and the race toward longevity escape velocity. If you're fascinated by longevity, age reversal, biotechnology, AI, anti-aging science, regenerative medicine, healthspan and the future of human lifespan, this is where you'll meet the people building that future and follow the breakthroughs that could change how we age.

Information

  • Creator
    Orshi McNaughton
  • Years Active
    2024 - 2026
  • Episodes
    26
  • Rating
    Clean
  • Copyright
    © Copyright 2026 Orshi McNaughton
  • Show Website
    The Age Reversal Project

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