Hump Day Hormones

Dr. Jill Jennings & Kortney Spann, APRN
  • 5.0 (40)
  • MEDICINE
  • UPDATED WEEKLY

This is a podcast about all things hormones! Dr. Jill Jennings and Kortney Spann, APRN are so excited to share their knowledge and expertise about menopause, perimenopause, and hormone imbalances.

  1. Vitamin D — Better Bones, Less Groans, and Psychiatric Overtones. Why Vitamin D is the Unsung Hormone Helper in Perimenopause; Menopause

    6D AGO

    Vitamin D — Better Bones, Less Groans, and Psychiatric Overtones. Why Vitamin D is the Unsung Hormone Helper in Perimenopause; Menopause

    “I already take vitamin D.” “It’s just for bones, right?” “My labs were normal.” Before you tune this one out, stay with us. Vitamin D is not just a vitamin. It acts like a hormone. It binds to receptors, enters the nucleus of your cells, and turns genes on and off. In fact, research shows it influences about 5 percent of our genome and impacts roughly 1,000 genes. And deficiency is incredibly common. If optimal is considered 40 to 60 ng/mL, up to 60 to 90 percent of people fall below that range depending on the population and season. In this episode, we break down why vitamin D matters even more in perimenopause and menopause, when hormone fluctuation, sleep disruption, anxiety, bone loss, muscle decline, and insulin resistance are already in play. We walk through: 🦴 Bone Health • How vitamin D supports calcium absorption and bone mineralization • Why bone loss accelerates in the first 5 to 7 years after menopause • What the fracture data actually shows 🌸 Hormone Signaling • How vitamin D supports follicle development and ovulation • Its role in progesterone production • Why low vitamin D is associated with worse PMS and heavier cycles • How it improves hormone receptor sensitivity 🧠 Mood & Brain Health • Why vitamin D receptors are all over the brain • Its role in serotonin and dopamine signaling • The association between low levels and depression, anxiety, fatigue, and brain fog • What supplementation studies show 🏋️ Metabolism & Insulin Resistance • How vitamin D supports insulin secretion and receptor function • The bi-directional relationship between visceral fat and vitamin D • The link between low vitamin D and metabolic syndrome, fatty liver, and type 2 diabetes 🦠 Inflammation & Immune Function • How vitamin D modulates inflammatory cytokines • Its role in autoimmune risk, gut health, and healing 🎗 Breast Cancer & Long-Term Risk • What observational data suggests about higher vitamin D levels and improved outcomes • Why this is about immune surveillance and cell regulation, not “prevention” claims We also cover practical guidance: • What level is actually considered optimal in hormone medicine • How sunlight production works and why modern life makes deficiency common • Who may need higher doses • Why D3 is preferred • Why magnesium and K2 matter • Why taking it with fat improves absorption If you are dealing with fatigue, low mood, body aches, frequent illness, bone concerns, or stubborn metabolic changes, vitamin D may be one of the most foundational pieces of your hormone puzzle. It is not hype. It is not trendy. It is basic physiology. Share this with the friend who says, “I’m exhausted but my labs are normal.”

    51 min
  2. Why Are My Periods Doing This? Understanding Perimenopause Bleeding Changes

    MAR 4

    Why Are My Periods Doing This? Understanding Perimenopause Bleeding Changes

    “My periods have changed… and I don’t understand what’s happening.” “They’re heavier than ever.” “They’re closer together.” “I’m skipping months.” “I feel terrible before my period now.” And the only explanation you’re given is: “That’s just perimenopause.” Which is true — but wildly incomplete. In this week’s episode of Hump Day Hormones, we’re breaking down why bleeding changes happen in perimenopause — and what’s actually driving them hormonally. Because periods are not controlled by estrogen alone. They are controlled by ovulation. In this episode, we walk through: • Why perimenopause is about inconsistent ovulation — not just “low estrogen” • The progesterone gap — and why progesterone declines first • Why you can still bleed regularly even when you’re not ovulating • Why heavy bleeding, shorter cycles, and worse PMS are so common • Why anxiety, sleep disruption, and migraines often worsen in this phase We also explain why perimenopause often feels harder than menopause itself. Hormones aren’t necessarily low — they’re unpredictable. And the brain, nervous system, blood sugar, and sleep cycles don’t like unpredictability. Then we get into what to actually do about it: • What needs to be ruled out first (fibroids, polyps, thyroid dysfunction, structural causes) • Why most bleeding in your 40s is hormonal but still deserves evaluation • How progesterone support can stabilize the lining and calm the nervous system • Why treatment is not one-size-fits-all • Why birth control isn’t the only solution If your cycles feel heavier, closer together, more chaotic — or you just don’t feel like yourself before your period anymore — this episode will help you understand why. Your body isn’t failing. Your ovaries are changing how they signal. And understanding that opens the door to real strategy. Share this with the friend who keeps saying, “Something feels off… but I don’t know what.”

    52 min
  3. When Does Menopause End? (And What’s Actually Happening in Your Body Along the Way)

    FEB 25

    When Does Menopause End? (And What’s Actually Happening in Your Body Along the Way)

    “Just get through menopause.” “It’ll pass.” “Your hormones will settle down.” But what if that framing is completely wrong? In this week’s episode of Hump Day Hormones, we’re answering one of the most common questions we hear: When does menopause actually end? Here’s the truth: Menopause isn’t a moment. It’s not a finish line. And it doesn’t “end” the way most women have been led to believe. Instead, menopause is a biologic transition that affects every major organ system — and those effects evolve over time. In this episode, we walk through: • The phases of menopause — premenopause, perimenopause, menopause, and postmenopause • What’s happening hormonally in each stage • Why progesterone declines early • How testosterone has been declining quietly since your 20s • Why perimenopause often feels chaotic and unpredictable We also break down how menopause shows up in different systems of the body: 🧠 The Brain ❤️ The Heart 🦴 Bones 🦠 The Gut 🏋️ Metabolism & Muscle 🩺 Pelvic Floor & Bladder If you’ve ever been told: “This is just aging.” “You’ll have to live with it.” “Menopause is over — you shouldn’t still feel this way.” This episode is for you. Because menopause isn’t something to “get through.” It’s a new physiologic era — and you deserve to understand what’s happening in your body. Share this with the friend who keeps asking, “When will this end?”

    58 min
  4. I Just Started HRT… So Why Am I Bleeding?!

    FEB 18

    I Just Started HRT… So Why Am I Bleeding?!

    You finally did it. You survived perimenopause. You found a provider who listens. You started hormone therapy… And then you started bleeding. And suddenly the questions spiral: Did I break something? Is this cancer? Should I stop HRT immediately? Take a breath. In today’s episode of Hump Day Hormones, we’re breaking down bleeding on HRT — why it happens, when it’s completely expected, and when it needs evaluation — without panic or fear-based advice. We start with a real patient story that perfectly captures how scary this experience can feel, especially when no one warned you it might happen. Then we get into the science. We break down: • How common unscheduled bleeding is after starting HRT (spoiler: very common) • Why 30–50% of women experience spotting or bleeding in the first 3–6 months • Why this is usually a normal adjustment — not a complication • What The Menopause Society actually says about bleeding on hormone therapy • Why bleeding does not automatically mean something is wrong We explain why bleeding happens, including: • How estrogen stimulates the uterine lining (that’s part of its job) • Why progesterone dose, timing, and consistency matter — a lot • How missed doses can lead to breakthrough bleeding • Why the route of estrogen (oral vs transdermal vs pellets) changes bleeding risk • Why perimenopause itself is hormonally chaotic and unpredictable We also clarify: • What bleeding is considered normal early on • When bleeding should be evaluated • What a typical work-up looks like (and why evaluation doesn’t mean danger) • Why most cases are solved with simple, boring adjustments — not stopping HRT Most importantly, we want you to hear this: Bleeding on HRT does not mean you failed. It does not mean your body “can’t tolerate hormones.” It means your uterus is responding — and that response can be managed. If you’re bleeding on HRT and spiraling, pause. Talk to your provider. Adjustments are part of the process, not a sign that something has gone wrong. If this episode helps, share it with the woman who just texted you: “Is this normal?!” Menopause care should come with information — not fear.

    37 min
  5. BRCA Mutations, Breast Cancer Risk & Hormone Therapy: What Women Deserve to Know

    FEB 11

    BRCA Mutations, Breast Cancer Risk & Hormone Therapy: What Women Deserve to Know

    If you carry a BRCA mutation, chances are you’ve been told two terrifying things: Your cancer risk is higher. And hormones are dangerous. But here’s the question women are almost never given a straight answer to: If you remove your ovaries early to reduce cancer risk… are hormones truly off the table — or are we harming women by withholding them? Today on Hump Day Hormones, we’re breaking down BRCA mutations, breast cancer risk, and hormone therapy — with data, nuance, and clarity instead of fear and headlines. This episode is a natural follow-up to our conversation on surgical menopause, because for many BRCA carriers, risk-reducing surgery means abrupt, early menopause. We break down: 🔥 Why BRCA1 and BRCA2 carriers are often advised to remove ovaries in their 30s–40s 🔥 Why surgical menopause is not the same as natural menopause 🔥 How sudden estrogen loss increases risk for heart disease, bone loss, cognitive changes, sexual dysfunction, and overall mortality 🔥 The real fear driving hormone avoidance — and where it came from 🔥 Why older hormone studies don’t apply to young women thrown into menopause overnight 🔥 Why BRCA carriers are biologically different from average-risk populations Then we get into what the science actually shows. We walk through: 🔬 Landmark studies showing hormone therapy does not undo the breast cancer risk reduction from ovary removal 🔬 Why estrogen-only therapy appears most reassuring when possible 🔬 Why progesterone type matters — and why “not all progesterone is created equal” 🔬 What large cohort and meta-analysis data really say about breast cancer risk 🔬 Why context matters: age, timing, dose, route, and duration We also cover: ✔ What ACOG and international menopause societies actually recommend ✔ Why short-term hormone therapy after early or surgical menopause may be appropriate — and protective ✔ How symptom control, bone, heart, and brain health factor into the decision ✔ What we still don’t know — and why individualized counseling is essential Hormone therapy in BRCA carriers is not: ❌ An automatic “no” ❌ One-size-fits-all ❌ A decision driven by fear alone It is: ✅ Nuanced ✅ Evidence-based ✅ About balancing risk, quality of life, and long-term health For women with BRCA mutations, the real danger isn’t hormones — it’s oversimplified advice. If this episode helps bring clarity where there’s been fear, share it with the woman who’s been told “you just can’t” — without ever being told why.

    35 min
  6. Ep: 58: Hysterectomy & Menopause: What Really Happens to Your Hormones - Truth, Timing, and Treatment?

    FEB 4

    Ep: 58: Hysterectomy & Menopause: What Really Happens to Your Hormones - Truth, Timing, and Treatment?

    If you’ve ever been told, “Once you have a hysterectomy, you’ll go straight into menopause,” this episode is for you — because that statement is not always true. Today we’re breaking down one of the most misunderstood topics in women’s health: hysterectomy, surgical menopause, and what actually happens to your hormones — without fear, confusion, or outdated advice. This episode was inspired by a powerful listener story and tackles the questions women are rarely given clear answers to: • Does removing the uterus automatically cause menopause? • Do ovaries still make hormones after hysterectomy? • What’s the difference between surgical menopause and natural menopause? • Why do symptoms after ovary removal feel so intense — and why are they often undertreated? We explain why hysterectomy is not one single surgery, and why lumping all procedures together causes unnecessary fear and misinformation. We break down: • What menopause actually is (hint: it’s about ovaries, not periods) • Why losing your period does NOT automatically mean menopause • The difference between hysterectomy with ovaries left in place vs ovaries removed • Why surgical menopause feels more abrupt and severe than natural menopause • How sudden estrogen loss affects the brain, joints, sleep, mood, sex, and metabolism • Why many women in surgical menopause are excellent candidates for hormone therapy • What “replacement-level” estrogen really means for younger women • Why “lowest dose for the shortest time” doesn’t make sense for everyone • How labs, symptoms, and history should guide care — not fear We also talk honestly about: • Why hormone needs after surgical menopause are different • Why underdosing is so common — and so harmful • What major medical societies actually recommend • How to know if you’re truly in menopause when you no longer have periods If you’ve had a hysterectomy… If you’re facing ovary removal… Or if you’ve been told “this is just how it is now” after surgery… This episode is here to remind you: Your uterus is not the hormone factory — your ovaries are. Surgical menopause is real. And your symptoms deserve real treatment. Fear should never replace facts — and menopause care should never stop at dismissal. If this episode helps you, share it with a woman who’s been given more warnings than answers.

    44 min
  7. Ep: 57: Joint Pain and Sarcopenia in Perimenopause and Menopause – Why Everything Hurts and What Helps

    JAN 28

    Ep: 57: Joint Pain and Sarcopenia in Perimenopause and Menopause – Why Everything Hurts and What Helps

    If your joints ache when you get out of bed… If your hands hurt opening jars that never used to be a problem… If your muscles feel weaker, softer, or harder to maintain — even though you’re trying… You’re not imagining it. You’re not broken. And no — this is not “just aging.” Today on Hump Day Hormones, we’re talking about joint pain and sarcopenia — two of the most common (and dismissed) complaints in perimenopause and menopause. This episode is part of our Head-to-Toe Menopause Series, and it tackles what’s now being recognized as the musculoskeletal syndrome of menopause. We break down: 🔥 Why up to 70% of midlife women experience new or worsening joint and muscle pain 🔥 Why perimenopause is a uniquely vulnerable time for musculoskeletal symptoms 🔥 How fluctuating and declining estrogen affects bones, joints, cartilage, tendons, and muscle 🔥 Why inflammation increases — and recovery slows 🔥 Why muscle loss accelerates in menopause (and why that matters for metabolism and insulin resistance) 🔥 Why symptoms often worsen with poor sleep, stress, or under-fueling 🔥 How to tell hormone-related pain from red flags that need further workup If your knees, hips, hands, shoulders, or feet suddenly hurt — this is a real, recognizable pattern. And then we get practical about what actually helps. We talk about: ✔ Why resistance training is non-negotiable in menopause ✔ How much protein women actually need to preserve muscle ✔ Why even distribution of protein matters more than total grams ✔ Creatine and collagen — what the evidence actually shows ✔ How estrogen therapy can reduce joint pain for some women ✔ The role of testosterone in preserving lean mass (and why it’s not magic on its own) ✔ Why thyroid, vitamin D, iron, and inflammation labs matter ✔ When pain is not hormonal — and should not be ignored Joint pain and muscle loss in menopause are not: A personal failure A lack of motivation Something you should “just get used to” They are: A physiologic transition Influenced by hormones, inflammation, sleep, nutrition, and stress Highly responsive to the right, layered strategy If you’ve been told, “This is just aging,” that’s outdated medicine. Your body isn’t betraying you. It’s asking for a different approach. And the good news? This is a season where small, consistent changes make a big difference — in strength, function, and how you feel in your body.

    59 min

  8. JAN 22

    Ep: 56: GSM — The Menopause Symptom Nobody Warned You About

    This episode is part of our Head-to-Toe Menopause Series, and it tackles one of the most underdiagnosed and undertreated menopause conditions out there — GSM. This is a menopause symptom that’s incredibly common, highly treatable, and somehow still whispered about like it’s a secret. If you’ve ever thought: “Why does sex suddenly feel like sandpaper?” “Why am I peeing all the time?” “Why do I feel irritated down there for no reason?” You’re not broken. You’re not “just getting older.” You may have Genitourinary Syndrome of Menopause (GSM) — and today, we’re talking all about it. We break down: • What GSM actually is (and why it replaced the outdated term “vaginal atrophy”) • Why symptoms often persist and worsen without treatment • How low estrogen changes vaginal, vulvar, and urinary tissue at a structural level • Why this is about collagen, blood flow, pH, and microbiome — not “just dryness” • Why GSM can affect sex, bladder control, UTIs, irritation, and pelvic floor health • Why common doesn’t mean normal — and why we should be talking about this more And then we get very clear about what actually helps. We talk about: • The difference between lubricants and vaginal moisturizers • Why vaginal estrogen is not a lubricant — and why that matters • Why low-dose vaginal estrogen is the gold standard for GSM • What the research really says about systemic absorption and safety • Vaginal estrogen vs DHEA — and why “not estrogen” doesn’t mean safer • What ACOG, AUA, and menopause societies actually recommend • When pelvic floor physical therapy can be a game changer • Why lasers and energy-based devices deserve a cautious conversation GSM is not: • Rare • A personal failure • Something you just have to live with It is: • Common • Progressive without treatment • One of the most treatable menopause conditions we see If you’re dealing with dryness, irritation, pain with sex, urinary urgency, or recurrent UTIs — bring it up. If your clinician doesn’t ask, you can. And if your symptoms are dismissed, it’s okay to get a second opinion. Menopause symptoms don’t need to be miserable — and this one is especially fixable.

    1h 9m
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5
out of 5
40 Ratings

About

This is a podcast about all things hormones! Dr. Jill Jennings and Kortney Spann, APRN are so excited to share their knowledge and expertise about menopause, perimenopause, and hormone imbalances.

Information

  • Creator
    Dr. Jill Jennings & Kortney Spann, APRN
  • Years Active
    2024 - 2026
  • Episodes
    91
  • Rating
    Clean
  • Show Website
    Hump Day Hormones

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