Endgame with Amanda Cassatt

Serotonin
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The world is changing at an accelerating pace—Endgame is here to make sense of it. Hosted by Amanda Cassatt, founder of Serotonin, this podcast brings you conversations with the visionaries driving breakthrough technologies and shaping the future. Join Amanda as she unpacks the trends, innovations, and paradigm shifts defining our time. Where is this all going? Let’s figure it out together. Subscribe now on Apple Podcasts, Spotify, YouTube, and wherever you listen.

  1. 3d ago

    Britain Threatened 4chan With £18 Million and Prison. Its Lawyer Sent a Hamster

    “Thanks very much for several dozen pages of legally void correspondence. It will make excellent bedding for my pet hamster.” That’s how Preston Byrne, the lawyer representing 4chan, responded to Britain’s internet regulator, Ofcom. The dispute began after Ofcom targeted 4chan under the UK’s Online Safety Act. The regulator ultimately imposed £520,000 in additional penalties in March 2026, following an earlier £20,000 fine. Preston says the enforcement correspondence also threatened penalties of up to £18 million and potential imprisonment — against an American internet company with no presence, operations, or infrastructure outside the United States. 4chan and Kiwi Farms took Ofcom to U.S. federal court. On September 15, 2026, the case was dismissed on sovereign-immunity grounds because the court found it lacked jurisdiction. The ruling did not decide the underlying constitutional dispute over whether Ofcom’s orders could ultimately be enforced against protected activity in the United States. In this episode of Endgame, Amanda Cassatt and Preston Byrne unpack what the UK’s Online Safety Act would require platforms like 4chan to change, why U.S. and British free-speech law diverge so sharply, and what happens when a foreign regulator claims authority over an American website. They also discuss Brexit and tech regulation, why Preston tells founders to think carefully about where they build AI, crypto, and internet companies, and the GRANITE Act legislation introduced in the U.S. House aimed at limiting the domestic enforcement of foreign censorship orders. The bigger question: can an open internet survive when governments around the world increasingly claim jurisdiction over what happens online? Timestamps  00:00 Why Preston Byrne Represents 4chan 02:44 The UK Online Safety Act and Ofcom 06:11 Can UK Rules Reach U.S. Websites? 10:44 Why Preston Replied With a Hamster 15:33 What Happened in 4chan vs. Ofcom? 19:35 How U.S. Companies Respond to Ofcom 21:58 What Ofcom Wanted 4chan to Change 26:22 Free Speech in the U.S. vs. UK 31:19 Is There a Case for the UK Approach? 34:02 Why the Fight Became Personal 36:32 Is Preston Byrne a Free Speech Absolutist? 38:48 Who Tries to Control Online Speech? 43:42 Brexit, Europe and Tech Regulation 47:44 Where Should Tech Founders Build? 48:56 The GRANITE Foreign-Speech Shield 55:50 Can the Open Internet Survive? 🌐 Follow Preston https://x.com/prestonjbyrne?lang=en https://www.linkedin.com/in/prestonjbyrne #4chan #Ofcom #OnlineSafetyAct #OpenInternet #FreeSpeech #InternetLaw #TechPolicy #FirstAmendment #AI #Crypto #PrestonByrne #Endgame

    Britain Threatened 4chan With £18 Million and Prison. Its Lawyer Sent a Hamster

  2. Sep 9

    Are Humans Being Replaced? The Truth About AI | Malcolm & Simone Collins

    Malcolm and Simone Collins became known as prominent voices in the pronatalist movement. But today, much of their work is focused on a different question: what happens to humans, culture, education, and future generations as artificial intelligence transforms society? In this episode of Endgame, Amanda Cassatt sits down with Malcolm and Simone to explore how AI is reshaping internet culture, why they believe the next major culture war is forming around artificial intelligence, and what it means to raise children in a world where machines may outperform humans at increasingly general tasks. They discuss how they are preparing their own children for a post-AI economy, why specialization may become more valuable than being a generalist, and whether humans will remain economically necessary as AI agents become more capable. The conversation also explores the evolution of internet subcultures, the rise of AI-generated media, effective altruism and “stellar humanism,” genetic technology, pronatalism, demographic decline, and the question at the center of it all: what kind of people and what kind of civilization will thrive in the future? Malcolm and Simone also discuss their work with rfab.ai and how they think AI tools can expand individual creative and technological capabilities. Timestamps  00:10 — Introduction 04:46 — From Tech and VC to Pronatalism 09:04 — Genetic Screening and the Origins of Their Movement 12:55 — How Internet Media Creates Celebrity 15:30 — Why Pronatalism Went Mainstream 20:10 — How Internet Subcultures Become Mainstream Culture 25:30 — Is AI the Next Culture War? 28:21 — Could AI Art Become Bigger Than Memes? 32:26 — Effective Altruism vs. Stellar Humanism 39:06 — Are Humans Being Replaced by AI? 43:24 — What Happens When Humans Lose Their Economic Advantage? 45:23 — Raising Children in the Age of AI 50:01 — Teaching Kids How to Use Technology Safely 52:29 — Should AI Uncertainty Change the Decision to Have Kids? 57:16 — Can Pronatalism Reverse Falling Birth Rates? 58:42 — Building Culture for a Post-AI Future 1:02:57 — Their Alternative to Modern Dating 1:03:00 — Building rfab.ai and an AI-Native Community Stay Connected https://x.com/amandacassatt https://x.com/serotonin_hq Apple Podcasts & Spotify  https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Simone & Malcolm Collins https://www.instagram.com/simonehcollins/?hl=en

    Are Humans Being Replaced? The Truth About AI | Malcolm & Simone Collins

  3. Sep 2

    Who Wins the 2027 Crypto Bull Market | Santiago R. Santos, Inversion

    Santiago R. Santos of Inversion was investing in DeFi before “DeFi” was even a widely used term. As a former partner at ParaFi and an early investor in projects including Aave, Arbitrum, and Polymarket, he watched Ethereum evolve from an experimental smart contract platform into the foundation of a massive onchain economy. But the growth of crypto has also changed his investment thesis. In this episode of Endgame, Amanda Cassatt and Santiago R. Santos examine whether Ethereum can succeed while ETH captures less of the value created on top of it, why he expresses his long-term Ethereum thesis through Robinhood stock, and why he believes crypto is increasingly becoming a distribution race. They also explore what Santiago learned from betting on Western Union over Solana, why adding stablecoins to legacy businesses is harder than it looks, whether AI agents actually need crypto-native money, and how autonomous agents could choose between blockchains without the tribal loyalties humans bring to crypto. Finally, they discuss the evolution of prediction markets, why Santiago believes market integrity matters as platforms like Polymarket grow, and how prediction markets and 24/7 crypto markets could evolve beyond speculation into tools for insurance, hedging, and real-time risk management. Timestamps  00:00 - Can Ethereum Win While ETH Loses? 00:36  - Investing in Aave Before DeFi Summer 05:06 - What Changed Santi’s Ethereum Thesis 10:30 - Can Ethereum Win While ETH Loses? 11:40  - Hyperliquid vs. Ethereum 13:44 - Is ETH Properly Valued Today? 18:16 -  Where Crypto Networks Actually Capture Value 21:10 - Why Santiago R. Santos Owns Robinhood Instead of ETH 24:02 - Crypto Is Becoming a Distribution Race 27:37 - Why Santiago R. Santos Bet on Western Union Over Solana 30:30 - Why Adding Crypto to Legacy Businesses Is Hard 35:47 - Do AI Agents Actually Need Stablecoins? 40:42 - How AI Agents Will Choose Blockchains 45:27 - Why 24/7 Crypto Markets Matter 47:59 - AI Agents, Prediction Markets and Insurance 51:26 - Does Polymarket Need Insider Trading Rules? 59:15 - Prediction Markets Beyond Speculation 🎧Stay Connected https://x.com/amandacassatt https://x.com/serotonin_hq Apple Podcasts & Spotify  https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Santiago R. Santos https://x.com/santiagoroel?lang=en  https://mc.linkedin.com/in/santiago-rs

    Who Wins the 2027 Crypto Bull Market | Santiago R. Santos, Inversion

  4. Aug 19

    The Worst Outcome Is a High IQ Psychopath | Jonathan Anomaly

    What if we could select the optimal genetic traits for our children? In this episode of Endgame, Amanda Cassatt sits down with bioethicist and philosopher Jonathan Anomaly to explore the cutting edge of reproductive biotechnology. They dismantle the social and political taboos surrounding genetic curation, tracing everything from the uncomfortable reality of cognitive capacities and human success to the macro ethical implications of advanced embryo selection. Jonathan argues why denying genetic influence is an intellectually dangerous myth and details how decentralized biotechnology will soon allow humanity to shift from being passive victims of natural selection to becoming its active architects. This is a raw, unfiltered conversation about modern inequality, human cognitive potential, and the existential risks of trying to optimize our own species. Timestamps 00:00 Intro 04:59 What Does “Eugenics” Mean Today? 09:13 IQ, Personality & Cognitive Diversity 15:47 Are Intelligence and Personality Genetic? 18:11 Nature vs. Nurture: How Much Is Genetic? 20:35 Is IQ Really 70% Heritable? 22:50 Why IQ Matters for Embryo Selection 27:21 How Much Can Embryo IQ Actually Differ? 29:43 The Risks of Maximizing Intelligence 32:08 Should We Genetically “Optimize” Humans? 34:26 How Genetic Selection Could Change Dating 36:47 Sperm Donors, Genetics & the Future of Reproduction 39:07 Do Polygenic Embryo Scores Actually Work? 41:24 How Herasight Predicts Genetic Traits 43:46 The Genetic Data Gap Across Ancestries 46:06 IVG, Artificial Wombs & the Future of IVF 48:26 When Could “Babies From a Blood Draw” Arrive? 50:23 CRISPR, Gene Editing & Its Biggest Risks 52:52 Are We Going Too Far With Human Genetics? 55:07 Should Parents Prevent Genetic Disabilities? 56:29 The Ethics of Selecting Against Disease 57:45 The Hidden Risks of Genetic Selection 58:08 Should Genetics Be Left to the Free Market? 58:28 The Coming “Polygenic Revolution” 59:00 Can We Make Human Nature Better? Stay Connected  Amanda on X:  https://x.com/amandacassatt    Serotonin on X: https://x.com/serotonin_hq  Spotify https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg    Endgame on Apple Podcasts  https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Follow Jonathan Anomaly https://x.com/JonathanAnomaly Don’t forget to subscribe!

    The Worst Outcome Is a High IQ Psychopath | Jonathan Anomaly

  5. Aug 12

    The Man Who Built the Metaverse Explains Why Meta Failed | Philip Rosedale

    Corporate metaverses failed the moment big tech tried to turn human connection into a closed retail space. In this episode of Endgame, Second Life creator Philip Rosedale joins Amanda Cassatt to explain why corporate giants spent $80 billion and still couldn't build a functional virtual world. Moving far beyond the surface-level hype of Silicon Valley, Philip exposes how algorithmic feeds and centralized interfaces are stripping away genuine human sovereignty, leaving us with a cheap illusion of agency.  They dive deep into the high-stakes ethics of emerging technology, explaining why corporate LLMs risk breeding digital demons if we continue to treat artificial entities as enslaved tools for profit rather than digital offspring. Discover why true digital freedom requires localized artificial life and persistent pseudonymity rather than surveillance state biometric scans. Timestamp 0:00 – Welcome 3:01 – What did Second Life know 20 years ago that Meta still doesn't? 5:07 – The COVID-era logic that convinced everyone we'd all end up in the metaverse 7:17 – Why virtual worlds still can't replicate meeting a stranger in person 9:30 – Who actually stays in Second Life: repressive regimes and long-term escape 11:13 – Is staying in a virtual world for life a good thing? 13:19 – Do shooter video games actually teach transferable skills? 15:13 – Why women used Second Life more effectively than men 17:13 – Roblox, Minecraft, and the ethics of monetizing kids 19:13 – Why Second Life deliberately stores nothing about you: the case for pseudonymity 21:27 – Did Second Life become what Rosedale actually wanted? 23:24 – The night the community blew up his own nightclub 25:16 – Is technology pulling people together or tearing them apart? 27:42 – From Wikipedia optimism to "big tech has done nothing but harm" 30:03 – Are AI models conscious? Defining consciousness itself 32:21 – Marc Andreessen says there's no path to AI consciousness — does Rosedale agree? 34:45 – Will machines start demanding rights? 39:25 – "Awakening the Angels": should AI be unstoppable and unowned? 41:50 – "Machines are our children": raising AI as independent offspring 44:12 – What he's building at New Theory, beyond LLMs 46:23 – Artificial life, cellular automata, and the other path to AGI 48:41 – Fusing atoms and bits — and why crypto's obsession with "sovereignty" might be an illusion 50:15 – Closing case for nuance over Silicon Valley's binary thinking Stay Connected Amanda on X:  https://x.com/amandacassatt   Serotonin on X: https://x.com/serotonin_hq  Spotify https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg    Endgame on Apple Podcasts  https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Follow Philip Rosadale https://x.com/philiprosedale https://www.linkedin.com/in/philiprosedale

    The Man Who Built the Metaverse Explains Why Meta Failed | Philip Rosedale

  6. Jul 29

    Sui's Kostas Chalkias: I Told Them to Freeze the $163 Million

    As chief cryptographer of Sui and Mysten Labs, Kostas Chalkias helped design a blockchain built on more than 100 published cryptography papers and an object-based architecture fast enough to let AI agents chain dozens of transactions into a single intent, without skipping the security research most "fast chains" leave out entirely. In this episode of Endgame, Amanda Cassatt sits down with Kostas to break down why validators froze $163 million after the Cetus hack, why post-quantum migration can't wait for a crisis to force it, and why he thinks cryptographers now have exactly one place left to do their best work. But the most unexpected part isn't the tech; it's the path. Chalkias was lecturing cryptography at universities in Dubai before spending three years building Facebook's ill-fated Libra project. He walked away from Meta because, in his words, it was too slow for how fast cryptography actually moves. Now he's chief cryptographer at one of the most talked-about L1s in the space. Timestamp 0:00 – Is the quantum threat to Bitcoin and Ethereum real, or Sui's marketing wedge? 0:42 – Why every chain needs to start quantum migration now 2:32 – Why isn't a single top-40 blockchain quantum-safe yet? 7:52 – Why leave Facebook's Libra project to build another L1? 9:05 – Bitcoin, Ethereum, Solana already won  so why build Sui? 21:06 – Why has Sui gone down more than once? 24:33 – The Cetus hack: why validators froze $163M 27:01 – What can only be built on Sui's object-based architecture? 30:14 – Is Sui's confidential-transactions push just Tornado Cash with extra steps? Stay Connected  Amanda on X:  https://x.com/amandacassatt    Serotonin on X: https://x.com/serotonin_hq   Spotify https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg    Endgame on Apple Podcasts  https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Follow Kostas Chalkias  https://www.linkedin.com/in/chalkiaskostas https://x.com/kostascrypto?lang=en

    Sui's Kostas Chalkias: I Told Them to Freeze the $163 Million

  7. Jul 22

    Open Source AI Is How America Loses | Diogo Mónica

    Diogo Mónica co-founded Anchorage Digital, the first federally chartered crypto bank in the US, and now argues for a position most of Silicon Valley won't say out loud: America should be building closed AI, not open source. In this episode of Endgame, Amanda Cassatt sits down with Diogo, Co-Founder of Anchorage Digital and General Partner at Haun Ventures, to break down why he thinks open-sourcing AI just hands China a free ride, why he calls AI "the ultimate weapon," and why he considers defending US AI intellectual property "perfectly legitimate." They also discuss his board seat at Erebor, Palmer Luckey's new bank for crypto, AI, and defense companies; why stablecoins bridge crypto anarchism and financial regulation; and why he calls building in crypto an act of American patriotism. Timestamp 0:56 – Kicking off with Katie Haun and Haun Ventures  2:13 – Reconciling his crypto-anarchist roots with his own philosophy 3:15 – Founding a regulated bank: Anchorage Digital  4:18 – Stablecoins: centralized control on decentralized rails  5:26 – Would a crypto anarchist say regulation just protects incumbents?  6:38 – Is building in crypto an act of American patriotism?  8:11 – Can crypto be "American-made" if it was born borderless?  13:25 – Introducing Palmer Luckey and the US-China AI/crypto landscape  14:21 – Is America on the right side of technology history?  15:39 – Why he believes America should build closed AI, not open source  16:31 – Does intellectual property even make sense in the AI age?  17:55 – Is the "China competition" narrative a political red herring? 18:18 – AI as "the ultimate weapon" and the end of mutually assured destruction 19:46 – Turning the protectionism question back on China (Google, Gmail, Twitter)  20:21 – Building Erebor: Palmer Luckey's bank for crypto, AI, and defense  22:55 – Toward a left-wing and right-wing version of every business? 24:14 – Crypto's real legacy: financial education for an entire generation Stay Connected ● Amanda on X:  https://x.com/amandacassatt   ● Serotonin on X: https://x.com/serotonin_hq  ● Spotify https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg    Endgame on Apple Podcasts https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Follow Diogo Monica https://www.linkedin.com/in/diogomonica https://x.com/diogomonica?lang=en Don’t forget to subscribe! #EndGame #AI #crypto  #bitcoin  #fintech

    Open Source AI Is How America Loses | Diogo Mónica

  8. Jul 15

    Why Robinhood Built on Ethereum Instead of Launching Its Own L1

    Robinhood is evolving far beyond commission-free trading. In this episode of Endgame, Amanda Cassatt sits down with Johann Kerbrat, SVP & GM of Robinhood Crypto, for an in-depth conversation about how Robinhood is using blockchain, AI, and tokenization to reshape investing. Johann explains why Robinhood built its own Layer 2 on Ethereum, how tokenized stocks work in Europe, why Robinhood believes financial markets should operate 24/7, and how AI is changing the future of investing. They also discuss crypto regulation, DeFi, prediction markets, Ethereum vs. Solana, Robinhood Wallet, self-custody, and Robinhood’s long-term vision for bringing traditional financial assets onchain. If you’re interested in crypto, fintech, investing, AI, or the future of financial markets, this conversation offers a rare look inside one of the world’s largest retail investing platforms. In this episode: • Why Robinhood built on Ethereum and Arbitrum • Tokenized stocks explained (EU vs. US) • The future of on-chain ownership • Robinhood’s vision for 24/7 financial markets • AI’s role inside Robinhood • How AI agents could transform investing • DeFi made simple • Robinhood Wallet and self-custody • Ethereum vs. Solana • Prediction markets vs. gambling • Robinhood’s acquisition of WonderFi • The future of global investing Timestamps:  00:00 Introduction 00:20 What Makes Robinhood Different 02:10 Crypto Fees and Accessibility 04:06 Crypto’s Role at Robinhood 05:06 Tokenized Stocks Explained 09:38 What Investors Actually Own 10:57 Putting Real Stocks Onchain 12:31 The Case for 24/7 Markets 15:48 Why Robinhood Chose Ethereum 18:12 KYC and Decentralization 20:12 Are L2s Good for Ethereum? 21:27 Ethereum vs. Solana 22:45 How Robinhood Uses AI 24:22 AI, DeFi and WonderFi 25:32 Trading vs. Gambling 29:39 What’s Next for Robinhood? Stay Connected Amanda on X:  https://x.com/amandacassatt   Serotonin on X: https://x.com/serotonin_hq  https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg    Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Follow Johann Kerbrat https://x.com/JohannKerbrat?lang=en https://www.linkedin.com/in/johann-kerbrat #EndGame #Robinhood #Tokenization #DeFi #Web3

    Why Robinhood Built on Ethereum Instead of Launching Its Own L1
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The world is changing at an accelerating pace—Endgame is here to make sense of it. Hosted by Amanda Cassatt, founder of Serotonin, this podcast brings you conversations with the visionaries driving breakthrough technologies and shaping the future. Join Amanda as she unpacks the trends, innovations, and paradigm shifts defining our time. Where is this all going? Let’s figure it out together. Subscribe now on Apple Podcasts, Spotify, YouTube, and wherever you listen.

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