Below-the-knee disease remains one of the most difficult areas in vascular intervention: small vessels, severe calcification, acute recoil, aggressive restenosis, and patients who often present with CLTI, diabetes, CKD, wounds, and limited surgical options. In this MurmurMD discussion, Dr. Sameh Sayfo speaks with Dr. S Jay Mathews about the evolution of below-the-knee disease treatment — from plain balloon angioplasty to IVUS-guided therapy, laser, atherectomy, scoring and cutting balloons, IVL, drug therapy, and emerging scaffold technologies. The conversation focuses on why BTK intervention is different from other vascular beds, why durable outcomes have historically been difficult, and how newer calcium-modification tools may help operators achieve better acute results while setting up more effective definitive therapy. The discussion also includes real-world cases showing how IVL and combination therapy can be used across challenging vascular territories, including BTK disease, common femoral disease, profunda protection, and subclavian occlusion. KEY TOPICS • Why below-the-knee vessels are uniquely challenging • CLTI vs claudication indications for BTK intervention • Angiosome-directed revascularization and inline flow • IVUS for morphology, sizing, calcium, and device selection • Acute recoil, dissection, restenosis, and intimal hyperplasia • Evolution from PTA to atherectomy, laser, IVL, and scaffolds • When IVL is a standalone prep tool vs adjunctive therapy • Javelin, E8, M5 Plus, and other IVL platform considerations • Laser plus IVL in complex fibrocalcific disease • Common femoral IVL and profunda preservation • Subclavian occlusion, body floss, and focal stenting strategy • Future IVL platforms and the changing role of atherectomy 🔔 Subscribe for more insights from interventional experts and real-world program builders. 📱 Download the app: https://apps.apple.com/app/apple-store/id1586692687 📺 Follow us on YouTube: https://www.youtube.com/channel/UCfrLYhAhliQ2ZvXinkDCZvA CHAPTERS 00:00 – Introduction: evolution of below-the-knee disease treatment 00:52 – Why BTK vessels are so challenging 01:49 – CLTI vs claudication: when to treat below the knee 03:16 – Choosing the target vessel and angiosome strategy 05:28 – What IVUS has taught us about BTK disease 07:10 – Recoil, dissection, and why acute results may not last 08:32 – Evolution of tools: atherectomy, laser, balloons, and scaffolds 10:39 – Retrievable and drug-eluting scaffold concepts 12:23 – Matching lesion prep to definitive therapy 14:58 – Why IVL became attractive for BTK disease 15:56 – IVL adoption and platform differences 17:26 – Javelin, E8, and IVL as adjunctive therapy 19:28 – Case 1: CLTI, CKD, wounds, laser, and IVL 25:02 – Case 2: Common femoral disease and M5 Plus 28:58 – Case 3: Subclavian occlusion and IVL-assisted strategy 33:00 – Future IVL platforms and expanding applications 36:15 – How IVL is changing atherectomy use 36:55 – Conference discussion and closing thoughts #BelowTheKnee #BTK #CLTI #LimbSalvage #PeripheralIntervention #IVUS #IVL #IntravascularLithotripsy #Javelin #E8 #Atherectomy #PeripheralArteryDisease #MurmurMD