Transcatheter tricuspid valve replacement is quickly becoming a real option for patients with severe symptomatic TR, but the decision-making is still nuanced. In this MurmurMD discussion, Dr. Aidan Raney speaks with Dr. Sameer Gafoor, about a Septuagenarian female with severe non-rheumatic tricuspid regurgitation, NYHA class III symptoms, prior mechanical mitral valve replacement, persistent AFib on warfarin, prior stroke, EF around 44%, RV dilation, moderately reduced RV function, TAPSE 1.1, and severe TR. The case focuses on why Dr. Gafoor's team favored transcatheter tricuspid valve replacement over edge-to-edge repair, how they approached CT and echo sizing, and how they moved their program from TEE-guided TTVR toward ICE-only TTVR, including a pathway from general anesthesia with TEE and ICE to conscious sedation with ICE. The discussion also covers key questions every TTVR program has to answer: surgical risk scoring, RV dysfunction, anticoagulation, pacemaker risk, working room, valve sizing, procedural imaging, fluid status matching, and what patients should expect after intervention. KEY TOPICS • Severe symptomatic non-rheumatic TR • TTVR vs edge-to-edge repair decision-making • Surgical risk vs tricuspid-specific risk scores • RV dysfunction, TAPSE, and when to say no • CT sizing vs TEE and ICE measurements • Annular and basal RV oversizing • Working room, RA height, RV height, and RV depth • ICE-only TTVR workflow development • Anchor position, commissures, and deployment assessment • Matching fluid status between CT and procedure • Anticoagulation requirements after TTVR • Pacemaker risk and lifetime management questions 🔔 Subscribe for more insights from interventional experts and real-world program builders.📱 Download the app: https://apps.apple.com/app/apple-store/id1586692687📺 Follow us on YouTube: https://www.youtube.com/channel/UCfrLYhAhliQ2ZvXinkDCZvA CHAPTERS 00:00 – Introduction: TTVR case from Swedish Hospital 00:32 – Patient presentation: severe TR, AFib, MVR, stroke, and RV dysfunction 01:22 – Surgical consult, CT, TEE, and risk scoring 02:52 – Choosing intervention: repair vs replacement 03:52 – CT sizing, TEE discrepancy, and oversizing 04:53 – Working room: RA height, RV depth, and delivery space 05:35 – Moving from TEE-guided to ICE-only TTVR 07:54 – ICE setup, MPR views, and valve orientation 09:11 – Deployment assessment and anchor position 10:34 – Final result and key lessons learned 12:06 – Q&A: surgical risk scores and tricuspid-specific tools 13:56 – RV dysfunction and when to avoid TTVR 15:35 – Post-procedure support and Swan discussion 15:59 – ICE workflow as primary imaging strategy 17:28 – Closing thoughts #TTVR #TricuspidValve #TricuspidRegurgitation #StructuralHeart #CardiacImaging #ICE #TEE #ValveReplacement #RightHeartFailure #TranscatheterValveReplacement #MurmurMD