The Feldman Protocol

Dave Feldman
  • 4.7 (31)
  • Science
  • Updated Weekly

Dave Feldman hosts the Feldman Protocol, a long form, in-person podcast largely covering science, nutrition, and technology – with a lot of personal stories, interests and pop culture mixed in.

  1. 2d ago

    Isabella Cooper – Part 1 – The Chemical Removed From Tampons Is Still in Most Diapers

    In this episode of The Feldman Protocol, what does beta-hydroxybutyrate between meals actually reveal about a person's insulin state — and why might that matter for understanding chronic disease risk? Dave sits down with Isabella Cooper (PhD), a biochemistry and pathophysiology scientist whose research spans assay quality control, hyperinsulinemia detection, ketone thresholds, mitochondrial function, and the lipid energy model, making the case that personalized insulin thresholds — not population-wide cutoffs — may be key to identifying subclinical metabolic dysfunction.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/48` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & intro1:06 – Isabella's background & credentials3:05 – East-meets-West medicine upbringing5:43 – Ballet, modeling & low-carb insights6:36 – Industrial design degree & lab thinking8:58 – Assay quality problems in undergrad lab12:08 – Coefficient of variation explained17:01 – Standardizing vortex & sample handling27:30 – Back to timeline: the 15-year gap39:52 – Pregnancy, diapers & toxicology deep dive53:06 – Old physiology papers vs modern science1:00:05 – Osteocalcin hypothesis & being wrong1:06:48 – Ben Bikman, mitochondria & insulin1:19:40 – Headwinds for low-carb research1:34:19 – Personalized insulin threshold concept1:41:28 – Beta-hydroxybutyrate as insulin surrogate1:51:44 – Leptin, IGF-1 & multi-marker detection2:09:09 – Subclinical hyperinsulinemia marker cluster2:14:20 – Fasting, lipid dynamics & VLDL traffic#FeldmanProtocol #DaveFeldman #IsabellaCooper #Hyperinsulinemia #Ketosis #Mitochondria #MetabolicHealth #InsulinResistance #BetaHydroxybutyrate #LowCarb #ChronicDisease #LipidEnergyModel #AssayQuality #KetoneThreshold #LaboratoryScience #Bioenergetics #BloodTesting #Inflammation

  2. 6d ago

    Dr Scott Murray – Is IVUS Plaque ‘Regression’ Just Measurement Noise?

    In this episode of The Feldman Protocol, how much does metabolic health shape cardiovascular risk beyond what standard lipid markers can reveal? Dave Feldman sits down with Scott Murray (MD), a UK-based interventional cardiologist, to explore plaque imaging and its limitations, the role of visceral and perivascular fat in heart disease, the lipid energy model and lean mass hyper-responders, cardiac fuel metabolism and heart failure with preserved ejection fraction, and the challenges of conducting and interpreting cardiovascular trials. 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/47` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & Scott's intro 14:21 – Scott's cardiology practice 17:28 – Invasive vs. CT angiography 24:49 – Collaterals & microvascular function 34:31 – Glycocalyx & endothelial health 40:28 – Perivascular fat & imaging 51:14 – Imaging, CAC, and plaque noise 1:00:04 – Lipid hypothesis & population context 1:07:05 – CT plaque measurement variability 1:19:42 – Perivascular inflammation & Caristo scoring 1:29:07 – Lipid energy model discussion 1:49:43 – LP(a), acute-phase markers & reverse causation 2:05:01 – LMHR study timeline & next scans 2:22:57 – Heart fuel preference & HFpEF 2:39:08 – PCSK9 trials & all-cause mortality 2:52:06 – Run-in periods & trial design concerns 3:05:00 – Context, guidelines & patient conversations 3:17:35 – GLP-1 peptides & obesity biology 3:26:28 – Where to find Scott & closing thoughts #FeldmanProtocol #DaveFeldman #ScottMurray #PreventiveCardiology #HeartHealth #LipidHypothesis #LeanMassHyperResponder #CTAngiography #PlaqueImaging #CardiovascularResearch #MetabolicHealth #LipidEnergyModel #HeartFailure #LPa #GLP1 #TrialDesign #Cardiology #LowCarb #BloodWork

  3. Sep 1

    Darius Sharp – Pt 2 – What Happens to Your Lipids After 2,000 Calories of Fat?

    In this episode of The Feldman Protocol, what actually drives cardiovascular disease in a metabolically healthy, lean individual — and is elevated LDL the most important variable to consider? Darius Sharpe (ER nurse and lean mass hypersponder community member) discusses his unexpected CAC score at age 38, his theory on postprandial glucose and vascular damage, a personal episode of atrial fibrillation, the Keto CTA study's Clearly data controversy, and what ER nurses observe firsthand about metabolic illness. 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/43` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & CAC score reveal 4:51 – Darius's CAC scan background 9:07 – First-phase insulin response explained 15:47 – CAC result context & vessel findings 22:09 – Darius investigates his own cardiac risk 33:43 – Atrial fibrillation episode & AFIB physiology 43:28 – Electrolytes, magnesium, and sodium discussion 51:04 – Stress tests vs. imaging: a patient case 58:01 – Metabolic syndrome underdiagnosis in hospitals 1:03:09 – Dave's diet experiments & LMHR data 1:09:18 – Fat bomb experiment: NMR findings 1:20:53 – Lipid energy model & structural hypothesis 1:30:37 – Keto CTA: plaque associations & progressors 1:39:41 – Clearly data controversy & scientific transparency 1:51:55 – Glucose, hyperglycemia, and plaque theory 2:05:22 – Raw data release & cards on the table 2:15:01 – ER realities & medication safety 2:29:07 – Lifestyle, habits, and the ER patient perspective 2:39:10 – Where to find Darius & closing thoughts #FeldmanProtocol #DaveFeldman #DariusSharpe #LeanMassHypersponder #KetoCTA #CACScore #AtrialFibrillation #PostprandialGlucose #MetabolicSyndrome #LipidEnergyModel #CardiovascularHealth #CGM #LDL #InsulinResponse #ERNurse #BloodTesting #HeartHealth #NMRPanel

  4. Aug 31

    Dr. Malcolm Kendrick – The Country With the Lowest Cholesterol and the Highest Heart Disease Rate

    In this episode of The Feldman Protocol, how well does the prevailing understanding of LDL and cardiovascular disease hold up under close scrutiny? Dave sits down with Malcolm Kendrick (MD) — author, researcher, and longtime cardiovascular disease skeptic — who challenges key assumptions across trial methodology, observational data, Mendelian randomization, clinical trial blinding, nitric oxide's role in vascular health, and the response-to-injury model of atherosclerosis.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/46` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Introduction & cold open1:11 – Malcolm Kendrick's background6:02 – Early contrarian tendencies in medicine16:48 – International cholesterol skeptic network22:13 – Shifting LDL targets over decades39:05 – FH, heterozygous vs. homozygous49:35 – Examining pharmaceutical trial evidence57:00 – Clinical trial blinding & composite endpoints1:07:27 – Data transparency & CTT access questions1:23:11 – Statins, nitric oxide & plausible mechanisms1:37:34 – Mendelian randomization discussed1:54:43 – Audience questions: ApoB & endothelial injury2:05:24 – Kendrick's cardiovascular disease model2:19:44 – Shared models: vascular repair & hemostasis2:38:39 – The Daily Mail lawsuit: origins2:47:32 – Five-year legal battle & court proceedings3:00:01 – CTT emails & trial methodology concerns3:17:29 – LMHR study update & CLEARLY retraction3:33:23 – Where to find Malcolm Kendrick#FeldmanProtocol #DaveFeldman #MalcolmKendrick #CardiovascularDisease #LDLCholesterol #LipidHypothesis #ClinicalTrials #NitricOxide #Atherosclerosis #StatinResearch #HeartHealth #LeanMassHyperresponder #CholesterolDebate #ApoB #MetabolicHealth #EvidenceBasedMedicine #TrialMethodology #Cholesterol

  5. Aug 21

    Sugar Is Wiring Kids' Brains for Lifelong Addiction – Dr. Jen Unwin

    In this episode of The Feldman Protocol, what does it take to recognize and address a compulsive relationship with food — and why does that recognition matter so much? Jen Unwin (clinical and health psychologist) joins Dave to explore the psychology of hope in medical settings, her personal history with carbohydrate-driven food behaviors, the evidence behind ultra-processed food addiction as a proposed clinical category, the WHO/ICD recognition process, GLP-1 medications as one potential tool, and why social context and proximity to trigger foods shape outcomes for so many people.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/45` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Introduction & cold open1:13 – Jen's background in psychology5:44 – Path to clinical training in Manchester12:47 – Hope as a clinical concept21:28 – Positive psychology & the nun study27:02 – Hope's influence on David Unwin's practice35:23 – Jen's personal food history43:02 – Discovering low-carb & the turning point52:22 – Food addiction: Dave's french fry story1:02:47 – Seeking official recognition of food addiction1:09:01 – Building expert consensus on terminology1:15:55 – Treatment outcomes & published research1:27:47 – Comparing food addiction to tobacco history1:36:05 – Proximity, social pressure & behavior change1:47:08 – Behavioral vs. substance-based framing1:54:52 – Prevalence data & retired athlete findings2:02:23 – Audience questions & GLP-1 medications2:33:39 – Nutrient density, protein, and food as fuel2:39:41 – Where to find Jen & closing remarks#FeldmanProtocol #DaveFeldman #JenUnwin #FoodAddiction #UltraProcessedFood #HopeInMedicine #PositivePsychology #LowCarb #BehaviorChange #DSM #FoodAddictionRecognition #CarbohydrateAddiction #GLP1 #NutrientDensity #MentalHealth #SolutionFocused #MetabolicHealth #Keto

  6. Aug 14

    Dr. David Unwin: Low Carb, Diabetes & Food Addiction

    In this episode of The Feldman Protocol, how does one family doctor's decades-long frustration with a "progressive, incurable" disease lead to a fundamentally different approach to patient care? Dave Feldman and David Unwin (MD) explore the pivotal 2012 patient encounter that reshaped Unwin's practice, the psychology of behavior change and food addiction, real-world data from a 10,000-patient NHS cohort, collaborative medicine versus authoritarian care, GLP-1 drugs as a last resort, and AI's emerging role in clinical decision-making. 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/44` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Introduction & cold open 1:24 – David Unwin's background 13:07 – Generational health trends observed 20:19 – Conventional medicine & early career 39:14 – The art vs. science of medicine 52:28 – The ACCORD study discussed 1:04:45 – The 2012 pivotal patient encounter 1:17:13 – Publishing the first 18-patient audit 1:30:06 – Unexpected behavioral changes on diet 1:45:09 – Collaborative medicine & patient partnership 2:02:32 – Evolutionary context for modern diet 2:13:06 – Food addiction & maintenance challenges 2:35:12 – GLP-1 drugs: a nuanced discussion 2:47:23 – Questions from the desk 3:09:27 – Unwin's real-world remission data 3:16:03 – AI in medicine & society 3:44:36 – Technology, freedom & human adaptability 3:59:46 – Closing & where to find David Unwin #FeldmanProtocol #DaveFeldman #DavidUnwin #LowCarb #MetabolicHealth #Type2Diabetes #DiabetesRemission #BehaviorChange #FoodAddiction #CollaborativeMedicine #NHSData #GLP1 #NutritionalScience #InsulinResistance #RealWorldData #PublicHealthCollaboration #LowCarbGP #AIInMedicine #FamilyMedicine

  7. Aug 5

    Darius Sharpe – From Treating Heart Attacks to Almost Becoming One

    Part 1 of 2In this episode of The Feldman Protocol, what can a quarter-century of emergency medicine experience reveal about the everyday habits quietly shaping metabolic health outcomes? Darius Sharpe (ER nurse and former paramedic with 24 years in emergency medicine) makes the case that postprandial glucose excursions deserve far more clinical attention, discusses his personal glucose experiments after a low-carb reintroduction of fast food, shares observations on hospital nutrition practices, and weighs in on the calories-in/calories-out vs. carbohydrate-insulin debate.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/42` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & introduction1:10 – Darius introduces himself3:42 – Path from EMT to ER nurse12:09 – Recognizing atypical heart attack symptoms16:07 – Time is tissue: stroke & MI urgency24:33 – Patterns Dave saw responding to 911 calls40:25 – Darius's personal health & family history54:44 – Early lipid labs and what they showed1:01:11 – Nursing school glucose discovery1:13:32 – The In-N-Out glucose experiment series1:21:42 – Joining the LMHR community1:31:40 – Metabolic illness observations during 2020–20221:45:43 – First CGM and self-experimentation1:51:14 – Keto week vs. high-carb week: OGTT comparison1:59:39 – Defining low-carb, keto, and net vs. total carbs2:19:36 – Calories vs. insulin: what both sides get right2:30:58 – Hospital food, juice, and postprandial glucose2:44:29 – Bedside patient education and CGM advocacy#FeldmanProtocol #DaveFeldman #DariusSharpe #MetabolicHealth #BloodSugar #PostprandialGlucose #LeanMassHyperResponder #LMHR #LowCarb #KetogenicDiet #CGM #ContinuousGlucoseMonitor #EmergencyMedicine #ERNurse #InsulinResistance #Cholesterol #HeartHealth #StrokeAwareness #HospitalNutrition

  8. Jul 14

    LIVE with Ken Berry MD – Reversing Diabetes With a Carnivore Diet

    In this episode of The Feldman Protocol, can a practicing family physician's personal health crisis reshape the dietary advice he gives to thousands of patients? Ken Berry (MD) makes the case for low-carbohydrate approaches in managing metabolic conditions, shares his path from rural Tennessee to family medicine, discusses founding the American Diabetes Society as an alternative institution, explores the debate around long-term ketosis and fasting insulin, and joins Dave and audience members in examining how to rebuild trust in medical and scientific institutions. 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/40` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & introduction 1:51 – Ken Berry's background in medicine 8:08 – Path from rural Tennessee to med school 16:03 – Ken's health during his early career 23:01 – Shifting away from standard dietary guidelines 33:42 – Patient signals and expanding the practice 42:17 – Starting a YouTube channel 54:21 – "Lies My Doctor Told Me" and colleague pushback 1:00:18 – Founding the American Diabetes Society 1:05:00 – Audience Q&A begins 1:08:53 – Discussion of long-term ketosis markers 1:18:31 – Talking to loved ones about diet 1:29:14 – Nutrition education in medical schools 1:39:47 – Restoring trust in medical institutions 1:47:00 – Semmelweis, paradigm shifts & patience 1:55:40 – Long-term ketosis safety & ketone measurement 2:09:10 – Blood work as a snapshot: context matters 2:30:28 – Dietary flexibility, travel, and glucose spikes 2:51:05 – Closing remarks & where to find Ken Berry #FeldmanProtocol #DaveFeldman #KenBerry #LowCarbDiet #KetogenicDiet #CarnivoreDiet #MetabolicHealth #BloodSugar #InsulinResistance #DiabetesManagement #FamilyMedicine #NutritionScience #ProperHumanDiet #CGM #CholesterolCode

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4.7
out of 5
31 Ratings

About

Dave Feldman hosts the Feldman Protocol, a long form, in-person podcast largely covering science, nutrition, and technology – with a lot of personal stories, interests and pop culture mixed in.

Information

  • Creator
    Dave Feldman
  • Years Active
    2025 - 2026
  • Episodes
    47
  • Rating
    Explicit
  • Copyright
    © Dave Feldman
  • Show Website
    The Feldman Protocol

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