What happens when someone urgently needs oxygen delivered to their tissues and compatible blood is not immediately available? Carl Rausch has spent much of his working life trying to solve versions of that problem. Carl Rausch is a chemical and medical engineer, biotechnology founder and senior executive whose career has spanned some of the formative decades of modern biotechnology. He was Founder, former Chairman and CEO of Biopure, later led Boston Therapeutics and World Technology East II, and has worked across blood purification, separation science, haemoglobin-based oxygen delivery, clinical development, manufacturing, regulation and commercialisation. Along the way he has raised significant capital, built and led teams of around 200–250 people, testified before congressional committees, worked with senior leaders across major pharmaceutical and biotechnology companies, and assembled boards and investor groups that included three billionaires and former US Surgeon General C. Everett Koop. Carl and Sam move through an extraordinary life in science and business: his early work in environmental and life-science engineering, caring for his father with ALS, purification of blood-derived products, the AIDS crisis and the development of bovine haemoglobin as an oxygen carrier. They also explore what happens when promising science meets company upheaval, regulation, manufacturing complexity and repeated commercial setbacks. Carl is still pushing the work forward, including applications in veterinary medicine, organ sustainability and kidney transplantation. Away from the science, there are glimpses of Carl’s love of travelling, hiking, skiing, sailing, family and a life increasingly designed for greater freedom. Thank you to Christopher Treble for introducing us. Content note: This conversation includes discussion of animal bleeding and veterinary procedures, severe human blood loss and postpartum haemorrhage. It also includes Carl’s views and experiences of medical regulation and blood banking. These are shared as personal and professional perspectives, not medical advice. What you’ll hear: • How Carl moved from chemical engineering into medicine, biology and blood science • Caring for his father with ALS and designing practical ways to help him keep working • Blood purification, the AIDS crisis and the origins of Carl’s bovine haemoglobin work • Delivering oxygen without matched human blood • Building companies, losing control of technology and repeatedly starting again • Veterinary applications, organ sustainability and kidney transplantation • A life of science, persistence, travel, family and creating more freedom Guest links: • Carl Rausch: https://www.linkedin.com/in/carl-rausch-7566824/ • Carl on delivering oxygen without blood: https://www.linkedin.com/feed/update/urn:li:activity:7484543321936416768/ • Carl on delivering oxygen without blood 2: https://www.linkedin.com/feed/update/urn:li:activity:7451251694543327232/ Conversation mentions: • Christopher Treble’s Natural Genius: https://youtu.be/5jSAFj7lwy8 • Dr Mario Feola, whose work helped influence Carl’s move towards cattle as a controlled source of haemoglobin Chapters: 00:13 Christopher Treble, technology and how humans learn 12:35 Carl’s current mission and a life built around the work 16:28 His father’s ALS and the move into medical engineering 19:11 Blood purification, Waters and the emerging biotechnology industry 28:50 The AIDS crisis, bovine haemoglobin and delivering oxygen 39:31 Veterinary use, regulation and keeping the technology alive 48:42 Organ sustainability, kidney transplantation and future applications 56:34 Building companies, selling the science and creating more freedom Explore further: Discover Natural Genius: https://naturalgenius.com.au Learn more about Sam: https://samanthabell.com.au Other platforms: https://www.buzzsprout.com/2568387 Subscribe to hear future episodes. Credits: Hosted by Samantha (Sam) Bell in Kiama and New York, 22 July 2026. Produced at the Kiama office, 22 July - 7 August 2026. Natural Genius Podcast https://naturalgenius.com.au