NRTGE | No Reason to Get Excited

Dr. Aaron Winkler
  • 5.0 (1)
  • Chemistry

No Reason to Get Excited is a curiosity-driven podcast built around one simple idea: smart people talking about interesting things.Hosted by Dr. Aaron Winkler, the show features thoughtful, unscripted conversations with researchers, clinicians, scientists, and creators exploring the ideas that shape how the world works.It’s a space for real conversations, where people can think out loud, follow ideas wherever they go, and occasionally stumble into something genuinely fascinating.If you enjoy learning, asking better questions, and hearing how people actually think, you’ll feel at home here.

Episodes

  1. 3d ago

    Living Drug Factories: Bioelectronics, Wireless Power, and the Implantable Future of Medicine | Siddharth Krishnan

    Send us Fan Mail What if curing a chronic disease looked less like a daily pill and more like a tiny, wireless implant of living cells that quietly produces your medicine on demand? In this episode of No Reason to Get Excited (NRTGE), Dr. Aaron Winkler sits down with Siddharth Krishnan, Assistant Professor of Electrical Engineering at Stanford University, to explore the rapidly evolving frontier of bioelectronic medicine. From his grandfather's soldering iron in Chennai, to a New Yorker article on John Rogers that changed his life, to a battery-free implant that has cured diabetes in mice for months, Siddharth walks through how his lab is engineering devices that combine living cells with thin-film electronics to deliver biologic drugs continuously, sense biomarkers in real time, and reshape what treatment for chronic disease can even look like. Along the way, he and Aaron dig into why oxygen is the hardest problem in implantable cell therapy, why the solution borrows physics from fuel cells, RFID credit cards, and photosynthesis, and why the future of medicine might involve all of us walking around with our own tiny bioreactors under the skin. About the Guest Siddharth Krishnan is an Assistant Professor of Electrical Engineering at Stanford University and a Terman Faculty Fellow, with a courtesy appointment in Bioengineering. His lab develops bioelectronic devices for sensing and therapeutics, with a particular focus on battery-free, wirelessly powered implants that combine inorganic electronics with living cells (so-called "living drug factories") to treat chronic diseases such as type 1 diabetes. He received his BS and MS degrees in mechanical engineering from Washington University in St. Louis, earned his PhD in materials science and engineering from the University of Illinois at Urbana-Champaign in the lab of Prof. John Rogers, and was a K99/R00 Research Scientist in the labs of Profs. Daniel Anderson and Robert Langer at the Koch Institute at MIT and Boston Children's Hospital before joining Stanford. He is also a co-founder of Rhaeos Inc., a medical device company translating his graduate work on wireless wearable diagnostic tools for neurological surgery, and has been recognized on the Forbes 30 Under 30 list and MIT Technology Review's Innovators Under 35. Connect with Siddharth https://siddharthrkrishnan.wordpress.com LinkedIn: https://www.linkedin.com/in/siddharth-krishnan-b2a79a8/  Chapters 00:00 – Cold Open: Wireless Power and Magnetic Fields 00:30 – Meet Siddharth Krishnan 01:08 – From Chennai to the Midwest 04:52 – The Light in Olin Library: From Humanities to Engineering 07:09 – A Grandfather, a Soldering Iron, and a Homemade Guitar Amp 10:47 – The New Yorker Article That Changed Everything 15:23 – Living Drug Factories: Engineering Cells Inside Implants 19:30 – Pancreatic Islets, Glucagon, and Type 1 Diabetes 24:24 – The Real Bottleneck: Solving the Oxygen Problem 27:38 – Borrowing Physics from Fuel Cells and Silicone Membranes 34:34 – Engineering Photosynthesis Inside the Body 36:18 – Wireless Power Harvesting and the RFID Trick 40:00 – Building a Bioelectronic Artificial Pancreas 46:44 – Why Life Stays Small Without Blood Supply 49:05 – From Drug Delivery to Living Biosensors 52:42 – Real-Time Inflammation Tracking and Long COVID 54:42 – Curing Mouse Diabetes for Months If you enjoyed this episode of No Reason to Get Excited, make sure to follow the show, leave a rating or review, and share this episode with someone who loves deep conversations about science, physics, and the mysteries of the universe. Connect with Dr. Aaron Winkler Website: www.aaronwinklermd.comLinkedIn: @NRTGEPODInstagram @NRTGEPOD

    58 min

  2. May 26

    Building Brains on Chips: Carbon Nanotubes, Lipid Nanoparticles, and Engineering the Frontier of Neurodegeneration | Rebecca Pinals

    Send us Fan Mail What if the most powerful tools for understanding the human brain are the very tiny particles we're learning to build, atom by atom? In this episode of No Reason to Get Excited (NRTGE), Dr. Aaron Winkler sits down with Rebecca Pinals, Assistant Professor of Chemical Engineering at Stanford University and Institute Scholar at Sarafan ChEM-H, to explore the frontier where nanotechnology, neuroscience, and chemical engineering collide. From carbon nanotubes that glow in the near-infrared, to the "protein corona" that makes biological systems so beautifully unpredictable, to lipid nanoparticles that may one day flush the brain clean of disease, Rebecca walks through how her lab is engineering microscopic tools to crack one of medicine's hardest problems: Alzheimer's disease. Along the way, Aaron and Rebecca dig into why almost everything we know about the brain comes from animals that aren't quite us, how a handful of cells can self-assemble into a working capillary inside a hydrogel, and why the long-overlooked story of lipids may be the missing piece in our understanding of neurodegeneration. About the Guest Rebecca Pinals is an Assistant Professor of Chemical Engineering at Stanford University and an Institute Scholar at Sarafan ChEM-H. The Pinals Lab engineers neuro-models and nano-tools to uncover mechanisms of neurodegenerative disease, with a particular emphasis on the blood–brain barrier, the vascular interface that serves as the molecular gateway into the brain. Rebecca trained as a chemical engineer at Brown University, completed her PhD in Chemical and Biomolecular Engineering at UC Berkeley with Professor Markita Landry as an NSF Graduate Research Fellow, and pivoted into neuroscience as a Schmidt Science Fellow during her postdoc at MIT's Picower Institute, working with Professors Li-Huei Tsai and Bob Langer. Her lab combines induced pluripotent stem cell–based 3D brain models with the rational design of nanoparticles to study, intervene in, and ultimately treat diseases like Alzheimer's. Connect with Rebecca LinkedIn: https://www.linkedin.com/in/rebeccapinals/  Chapters  00:00 – Cold Open: A Chemical Engineer at the Edge of Neuroscience 00:32 – Meet Rebecca Pinals 01:20 – From Conventional Catalysis to a Love of the Nanoscale 03:42 – Carbon Nanotubes That Glow in the Near-Infrared 09:55 – The Protein Corona Problem 12:30 – Lipid Nanoparticles, mRNA Vaccines, and a COVID Pivot 14:18 – Why Alzheimer's: The Forgotten Lipid Story 18:34 – APOE, Astrocytes, and Lipoproteins as Therapeutics 24:15 – Why We Need a Human Blood-Brain Barrier Model 33:35 – Endothelial Cells, Pericytes, and the Real Anatomy of the BBB 42:48 – When Cells Find Each Other: Self-Assembly Into Capillaries 50:51 – Microplastics, Prions, and What We Don't Know We're Doing 54:17 – The Moments a Scientist Lives For 57:40 – Becoming a PI: From the Bench to Big Science If you enjoyed this episode of No Reason to Get Excited, make sure to follow the show, leave a rating or review, and share this episode with someone who loves deep conversations about science, physics, and the mysteries of the universe. Connect with Dr. Aaron Winkler Website: www.aaronwinklermd.comLinkedIn: @NRTGEPODInstagram @NRTGEPOD

    1h 12m

  3. May 19

    Life at the Edge of Equilibrium: Non-Equilibrium Physics, Machine Learning, and the Molecular Machinery of Life | Grant Rotskoff

    Send us Fan Mail What if the secret to understanding life lies in the mathematics of systems that can never sit still? In this episode of No Reason to Get Excited (NRTGE), Dr. Aaron Winkler sits down with Grant Rotskoff, Assistant Professor of Chemistry at Stanford University, to explore the breathtaking frontier where statistical physics, computation, and biology collide. From the unsolved mystery of how ATP, the "spark of life," actually hydrolyzes, to the way muscle tissue self-assembles from molecular ratchets, Grant unpacks what it means to study living systems that are, by their very nature, perpetually far from equilibrium. Along the way, Aaron draws striking parallels between the molecular machinery of cells and the deepest questions of consciousness, attention, and emergence. About the Guest Grant Rotskoff is an Assistant Professor of Chemistry at Stanford University. His research sits at the intersection of theoretical chemistry, statistical physics, and machine learning, with a focus on understanding the non-equilibrium dynamics of biological systems. He trained as a mathematician at the University of Chicago before turning to biophysics, and his lab uses cutting-edge computational methods, including machine-learned interatomic potentials and importance sampling, to study problems ranging from ATP hydrolysis to the self-assembly of muscle tissue. Connect with Grant LinkedIn: https://www.linkedin.com/in/grant-rotskoff-47427a31b Chapters 00:00 – Why Great Research Questions Live in the Gaps 01:07 – Meet Grant Rotskoff 01:49 – What It Means for Life to Be Far From Equilibrium 08:17 – Why Biology Is Too Complex to Brute-Force 18:01 – How Machine Learning Is Changing Molecular Simulation 28:02 – ATP Hydrolysis: The Spark of Life 35:40 – ATP Synthase, Kinases, and Molecular Motors 38:20 – Why Biology Works Like a Ratchet at the Nanoscale 42:06 – How Organisation Emerges From Energy 55:32 – Muscle Tissue, Sarcomeres, and Self-Assembly 56:49 – The Mathematics of Emergence 01:08:33 – Use the Tools You Have If you enjoyed this episode of No Reason to Get Excited, make sure to follow the show, leave a rating or review, and share this episode with someone who loves deep conversations about science, physics, and the mysteries of the universe. Connect with Dr. Aaron Winkler Website: www.aaronwinklermd.comLinkedIn: @NRTGEPODInstagram @NRTGEPOD

    1h 10m

  4. May 15

    The Price of Power: Campaign Finance, Press Coverage, and the Polarization of American Politics | Andrew Myers

    Send us Fan Mail What happens when you apply machine learning and rigorous data analysis to the "Wild West" of American campaign finance? In this episode of No Reason to Get Excited (NRTGE), Dr. Aaron Winkler sits down with Andrew Myers, a PhD candidate at Stanford University and incoming Assistant Professor at MIT, to pull back the curtain on how money, media, and institutional rules shape our democracy. From the surprising ways donors "punish" extremist candidates to the hidden consequences of term limits, Andrew shares insights from his dissertation that challenge standard political assumptions. Along the way, Aaron draws fascinating parallels between the circulatory system of the human body and the systematic flow of modern civilization. About the Guest Andrew Myers is a political scientist and PhD candidate at Stanford University specializing in American politics and political methodology. His research focuses on polarization in legislatures, campaign finance, and election administration. After completing a fellowship at the Hoover Institution, he will join the faculty at MIT as an Assistant Professor. Connect with Andrew Website: www.andrewcwmyers.com Chapters  00:00 – The "Block Power" of Parliamentary Systems 02:00 – Meet Andrew Myers: From Stanford to MIT 04:00 – The Role of Money: Analyzing Citizens United and Direct Contributions 07:20 – Machine Learning in Politics: Mapping Contributions to Voting Records 12:20 – Why "Coin Flip" Elections are a Social Scientist's Dream 15:15 – Aaron’s Lessons from the Obama 2004 Senate Campaign 22:10 – The "Uncontested" Victory: How Obama Won His First Election 33:00 – The Press Coverage Problem: Why Down-Ballot Races Suffer in the Dark 40:00 – Conclusion #1: Do Donors Punish Extremists? 41:30 – Conclusion #2: How Strengthening Local Press Moderates Legislatures 48:00 – Access-Seeking vs. Ideological Donors 53:00 – "Why Is There So Little Money in Politics?" 58:00 – The Chipping Away of Campaign Finance Reform 1:01:00 – The Lack of Competition in State Legislatures 1:06:00 – The Dark Side of Term Limits: Why They May Actually Increase Polarization 1:09:00 – Redistricting and Strategic Residing 1:31:00 – "Dialing for Dollars": The Fundraising Quotas of New Representatives 1:38:00 – The Body Politic: O’Hare Airport as a Heart and the ATP Synthase of Cities 1:46:00 – Blood Pressure and Political Compromise: The Kidney-Lung Connection If you enjoyed this episode of No Reason to Get Excited, make sure to follow the show, leave a rating or review, and share this episode with someone who loves deep conversations about science, physics, and the mysteries of the universe. Connect with Dr. Aaron Winkler Website: www.aaronwinklermd.comLinkedIn: @NRTGEPODInstagram @NRTGEPOD

    1h 53m

  5. May 12

    The Chemistry of Creativity, Light, and High-Energy Molecules | Noah Burns

    Send us Fan Mail What does it actually mean to create a molecule that has never existed before? In this episode of No Reason to Get Excited (NRTGE), Dr. Aaron Winkler sits down with Stanford organic chemist Noah Burns for a wide-ranging conversation about chemistry, creativity, photochemistry, molecular design, and the strange beauty hidden inside organic reactions. What begins as a discussion about bromination and halogenation quickly expands into something much bigger: the relationship between science and imagination, the role of intuition in research, and how chemists develop entirely new reaction pathways capable of creating highly strained molecular structures. Noah explains how his lab designs reactions that selectively create one molecular “handedness” over another, why chirality matters in medicine and biology, and how light can be used to drive reactions that would otherwise be energetically impossible. Along the way, Aaron connects chemistry to psychology, creativity, consciousness, traffic systems, human relationships, and even the metaphorical power of molecules like porphyrin. This is not a technical lecture disguised as a podcast. It’s an intellectually playful conversation about discovery, emergence, energy, and the deeply human side of scientific work. About the Guest Noah Burns is an associate professor of chemistry at Stanford University specializing in synthetic organic chemistry. His research focuses on developing new chemical reactions, photochemistry, halogenation strategies, strained molecular systems, and the total synthesis of complex natural products. His lab explores how novel molecular transformations can enable discoveries in biology, medicine, and materials science. Connect with Noah Website: https://chemistry.stanford.edu/people/noah-burns Chapters  00:00 – Introduction to Noah Burns and Organic Chemistry 01:20 – Columbia, New York City, and Academic Training 03:00 – Teaching, Curiosity, and Scientific Enthusiasm 04:30 – What Synthetic Organic Chemists Actually Do 06:00 – Primary vs. Secondary Metabolites 08:30 – Natural Products and Drug Discovery 10:00 – Halogenation, Bromination, and Chemical Reactivity 12:30 – Why Bromine Is Both Beautiful and Dangerous 14:00 – Chirality and Why Molecular Handedness Matters 16:00 – Enantioselective Catalysis Explained 18:30 – Nobel Prize-Winning Chemistry and Selective Reactions 21:00 – Designing New Reaction Pathways 24:00 – Titanium Catalysts and Chiral Ligands 28:00 – The Creativity and Trial-and-Error of Organic Chemistry 32:30 – Building Four-Membered Carbon Rings 34:30 – Using Light and Copper to Create Cyclobutanes 38:00 – Photochemistry and High-Energy Molecular States 40:00 – Porphyrins, Photosynthesis, and Human Systems 44:30 – Redox Reactions and the “Vital Spark” of Life 46:00 – Why Life Is Controlled Oxidation 48:00 – Evolution, Energy, and Reactive Systems 51:00 – Translating Ideas Into Physical Reality 54:00 – Traffic Theory, Systems Thinking, and Flow States 57:00 – DARPA, High-Energy Molecules, and Closing Thoughts If you enjoyed this episode of No Reason to Get Excited, make sure to follow the show, leave a rating or review, and share this episode with someone who loves deep conversations about science, physics, and the mysteries of the universe. Connect with Dr. Aaron Winkler Website: www.aaronwinklermd.comLinkedIn: @NRTGEPODInstagram @NRTGEPOD

    58 min

  6. May 12

    Can We Actually Detect Gravitational Waves with Atoms? | Peter Graham

    Send us Fan Mail What happens when a psychiatrist sits down with a Stanford physics professor to talk about gravitational waves, dark matter, quantum mechanics, and atoms existing in two places at once? In this episode of No Reason to Get Excited (NRTGE), Dr. Aaron Winkler talks with Stanford Physicist Peter Graham about the strange and fascinating world of modern physics. What starts as a conversation about gravitational wave detection quickly turns into a deep exploration of quantum mechanics, atom interferometry, atomic clocks, dark matter, and the bizarre reality of particles behaving like waves. Peter explains how researchers are building tabletop experiments capable of measuring incredibly small distortions in space-time, why gravity is surprisingly weak compared to electromagnetism, and how a single atom can exist in two places at once. Along the way, Aaron asks the kinds of questions many listeners are probably thinking themselves, leading to a conversation that feels less like a formal interview and more like two curious minds trying to make sense of the universe together. This episode is not a simplified science lecture. It’s an intellectually alive conversation about uncertainty, experimentation, physics, and the limits of human intuition. About the Guest Peter Graham is a professor of physics at Stanford University whose research focuses on fundamental physics, dark matter, gravitational waves, and precision measurement techniques using atomic systems. His work often bridges theoretical physics and experimental collaboration, helping develop new ways to probe some of the deepest unanswered questions in modern science. Connect with Peter: Website: https://physics.stanford.edu/people/peter-graham Chapters  00:00 – Introduction to Peter Graham and Stanford Physics 03:20 – Why Collaboration Matters in Modern Physics 05:10 – The Problem with Dark Matter and Fundamental Physics 06:00 – Building New Experiments Instead of Bigger Colliders 07:00 – How LIGO Detects Gravitational Waves 09:30 – Why Gravity Is Surprisingly Weak 11:20 – Gravitons, Dark Matter, and Unanswered Questions 15:15 – Atom Interferometry Explained 18:00 – Quantum Mechanics and Probability Waves 24:40 – Using Lasers to Manipulate Atoms 29:20 – The History of Particle Physics and Scientific Discovery 33:00 – What Quantum Waves Actually Mean 41:00 – Vacuum Chambers, Cooling Atoms, and Laser Physics 47:00 – How Laser Cooling Works 55:00 – Creating an Atomic Interferometer 1:00:30 – Measuring Time with Atomic Clocks 1:08:00 – Using Atoms to Detect Gravitational Waves 1:15:00 – Earth’s Gravity, Potential Energy, and Quantum States 1:20:00 – Why Vertical Mine Shafts Matter 1:24:00 – Measuring Acceleration with Atomic Systems 1:28:00 – Building the Future of Gravitational Wave Detection If you enjoyed this episode of No Reason to Get Excited, make sure to follow the show, leave a rating or review, and share this episode with someone who loves deep conversations about science, physics, and the mysteries of the universe. Connect with Dr. Aaron Winkler Website: www.aaronwinklermd.comLinkedIn: @NRTGEPODInstagram @NRTGEPOD

    1h 30m
  • 6 Episodes

About

No Reason to Get Excited is a curiosity-driven podcast built around one simple idea: smart people talking about interesting things.Hosted by Dr. Aaron Winkler, the show features thoughtful, unscripted conversations with researchers, clinicians, scientists, and creators exploring the ideas that shape how the world works.It’s a space for real conversations, where people can think out loud, follow ideas wherever they go, and occasionally stumble into something genuinely fascinating.If you enjoy learning, asking better questions, and hearing how people actually think, you’ll feel at home here.

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