Paper Talk

淼淼Elva

Sharing research articles, tracking the latest developments

  1. −1 H

    493-Commensal TMCM Lipids Protect the Ocular Surface

    Research shows the commensal bacterium Corynebacterium mastitidis uses the lipid TMCM to trigger protective ocular immunity. TMCM activates IL-17+ γδ T cells through TCR and IL-1R1 signaling. This microbial factor strengthens barrier defenses and prevents bacterial infections.References: Xu X, Rigas Y E, Mattapallil M J, et al. Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity[J]. Immunity, 2025.

    13 min

  2. −1 H

    492-ECS-dependent polytubey block in Arabidopsis

    In Arabidopsis, egg-cell proteins SDN1–3 prevent polyspermy by degrading specific miRNAs (miR833a, miR395a/f, miR827). This turnover ensures the expression of ECS1/2 endopeptidases, which establish a polytubey block post-fertilization to maintain genomic integrity.References: Shen K, Qu M, Zhou X, et al. Degradation of detrimental microRNAs safeguards the fertilized egg cells to establish an ECS-dependent polytubey block in Arabidopsis[J]. Developmental cell, 2025.

    17 min

  3. −2 H

    491-Enhanced Stem Cell Differentiation

    Yu et al. mapped human pancreatic gene co-expression networks (GCNs) to improve stem cell-derived β cell induction. Existing protocols fail to mimic in vivo GCNs, but a new 19-day strategy restores this architecture. This approach yields 70% functional β cells that reverse diabetes.References: Yu X X, Wang X, Yang L, et al. Reconstructing human pancreatic gene networks enhances stem cell-derived β cell induction[J]. Developmental Cell, 2025.

    17 min

  4. −1 D

    490-Peroxisome-Mediated Intestinal Repair in Long COVID

    SARS-CoV-2 reservoirs in the gut cause long COVID gastrointestinal issues by disrupting the VLCFA-PPAR-peroxisome axis. This impairment halts intestinal stem cell differentiation and epithelial repair. Treatments like fenofibrate restore regeneration and alleviate symptoms.References: Wang M, Chen Y, Guo M, et al. Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID[J]. Developmental Cell, 2026.

    17 min

  5. −1 D

    489-MYRF: Regulator of Lung Mesothelium Fate and Plasticity

    Luna et al. found that Myrf is essential for mesothelium function and lung development. Deleting Myrf causes lung hypoplasia and congenital diaphragmatic hernia (CDH). Without Myrf and Yap/Taz, mesothelial cells transform into ectopic smooth muscle, mimicking adult PPFE.References: Luna G, Verheyden J M, Tan C, et al. MYRF controls mesothelium specification, signaling, and plasticity in lung development[J]. Developmental Cell, 2026.

    15 min

  6. −1 D

    488-Neddylation: Link Between Neuronal Aging and Alzheimer's

    Researchers used CRISPR screening to identify neddylation as a vital regulator of neuronal aging. Blocking this pathway in stem cell-derived neurons triggers senescence, DNA damage, and proteostasis failure. These age-related hallmarks drive Tau pathology and cell death.References: Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration Saurat, Nathalie et al.Cell Stem Cell, Volume 31, Issue 8, 1162 - 1174.e9

    16 min

  7. −2 D

    487-Peripheral Glia Orchestrate Early Immune Responses

    Injury-activated peripheral glia form a pro-reparative niche essential for skin healing. These repair glia recruit macrophages via the CCL2-CCR2 axis, which in turn drive fibroblast proliferation and myofibroblast transition. Glial depletion impairs this immune-fibrotic crosstalk.References: Stierli S, Salas-Bastos A, Micheli S, et al. A peripheral glial niche orchestrates the early stages of skin wound healing[J]. Cell Stem Cell, 2026.

    16 min

  8. −2 D

    486-3D Nichoids Enhance Gene Therapy

    Nichoid-based 3D culture improves gene therapy by preserving hematopoietic stem cell (HSPC) functionality. This nanoengineered substrate regulates cytoskeletal architecture and metabolism to reduce DNA damage and oxidative stress, ensuring superior engraftment and clonal output.References: Midena F, Alessandrini L, Conci C, et al. Nanoengineered 3D culture substrate enables superior persistence and polyclonal engraftment of genetically engineered hematopoietic stem cells[J]. Cell Stem Cell, 2026.

    18 min
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Sharing research articles, tracking the latest developments

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  • Skapad av
    淼淼Elva
  • Aktiva år
    2025 - 2026
  • Avsnitt
    480
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    Barnvänligt
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