Decoding Longevity

Raghav Sehgal

A podcast dedicated to unraveling the mysteries of aging through the lens of cutting-edge science. Each episode breaks down the latest research papers in the field of geroscience, offering clear, insightful discussions on longevity, biological aging, and the quest for extending healthspan. Perfect for scientists, enthusiasts, and anyone curious about the science behind living longer and healthier lives.

  1. What Can Hibernating Squirrels Teach Us About Aging, Disease, and Human Health?: A Conversation With Dr. Ashley Zehnder

    3 days ago

    What Can Hibernating Squirrels Teach Us About Aging, Disease, and Human Health?: A Conversation With Dr. Ashley Zehnder

    What can hibernating squirrels teach us about aging, disease, and human health? In Episode 28 of Decoding Longevity, we sit down with Dr. Ashley Zehnder, Co-Founder and CEO of Fauna Bio, to explore how evolution-driven drug discovery is uncovering new therapeutic opportunities for some of humanity’s most challenging diseases. Ashley explains how animals that naturally withstand oxygen deprivation, prevent fibrosis, rebuild tissues, and resist neurodegeneration may hold the key to future treatments for heart failure, metabolic disease, and age-related decline. We discuss hibernation biology, comparative genomics, AI-powered drug discovery, regenerative medicine, and how nature’s most resilient species are helping scientists identify novel therapeutic targets. Key topics include: • Hibernation as a model for regeneration and tissue repair • Comparative biology and longevity science • AI, genomics, and evolution-driven drug discovery • Brain resilience and neurodegenerative disease • Heart failure therapeutics inspired by nature • The future of biotechnology and healthy aging Guest: Dr. Ashley Zehnder Co-Founder & CEO, Fauna Bio Hosts: Dr. Raghav Sehgal & Dr. Macsue Jacques Fauna Bio: https://www.faunabio.com/ Ashley’s Talks https://www.youtube.com/watch?v=WX-ulloH08whttps://www.youtube.com/watch?v=kmowQzL_VjYhttps://www.youtube.com/watch?v=C9cy7vyTUGs

    27 min
  2. Metabolism, Immunity & the Biology of Aging: A Conversation with Dr. Eric Verdin

    27 May

    Metabolism, Immunity & the Biology of Aging: A Conversation with Dr. Eric Verdin

    What if aging is not just damage — but a biologically regulated process shaped by metabolism, inflammation, and gene expression? In this episode of Decoding Longevity, Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging, joins us for a wide-ranging conversation on the molecular biology of aging. We explore how metabolism influences epigenetics, why immune aging may be central to healthspan, and what today’s longevity science actually tells us about extending healthy human life. From NAD+ and ketone bodies to inflammaging, biomarkers, rapamycin, metformin, and epigenetic reprogramming, this episode breaks down some of the most important ideas shaping the future of longevity research. We also discuss the growing hype surrounding longevity medicine — and why rigorous science, clinical trials, and evidence still matter. Featuring:Dr. Eric VerdinHosted by Dr. Raghav Sehgal & Dr. Macsue Jacques Follow Decoding Longevity for more conversations on aging biology, longevity science, AI, and the future of medicine. Buck Institute of Aging: https://www.buckinstitute.org/ Eric Verdin's LinkedIn: https://www.linkedin.com/in/eric-verdin-490212/

    50 min
  3. Resetting Cells Without Rewinding Identity: A Conversation with Janine Sengstack, Ph.D.

    13 May

    Resetting Cells Without Rewinding Identity: A Conversation with Janine Sengstack, Ph.D.

    Can aging cells be reset — without turning them into stem cells? In Episode 26 of Decoding Longevity, Dr. Janine Sengstack explains how Genevity is using AI, human data, and RNA therapeutics to identify the master regulators of aging and restore cells to healthier states. This episode explores the intersection of aging biology, transcription factors, siRNA therapeutics, and precision longevity medicine. 🔗 Junevity: https://www.junevity.com/

    24 min
  4. Redesigning Aging: Ethics, Economics, and the Narrative of Longevity — A Conversation with Raiany Romanni-Klein, Ph.D.

    29 Apr

    Redesigning Aging: Ethics, Economics, and the Narrative of Longevity — A Conversation with Raiany Romanni-Klein, Ph.D.

    What if the biggest barrier to healthy longevity isn’t scientific—but philosophical, economic, and ethical? In this episode of Decoding Longevity, Raghav Sehgal and Macsue Jacques are joined by Dr. Raiany Romanni-Klein to explore how our beliefs about aging, death, and human value shape the future of longevity science. From the idea that “natural is good” to the economic incentives holding the field back, this conversation challenges how we think about aging—and what it will take to change it. 🔗 Resources & Links: Silver Linings : https://silverlinings.bio/Raiany’s TEDx Talk: https://www.youtube.com/watch?v=kB1IFGYaYXo

    20 min
  5. The First Cellular Rejuvenation Therapy in Clinical Trials with Michael Ringel, Ph.D., J.D.

    15 Apr

    The First Cellular Rejuvenation Therapy in Clinical Trials with Michael Ringel, Ph.D., J.D.

    Aging might not be inevitable. In this episode of Decoding Longevity, Dr. Michael Ringel (COO, Life Biosciences) explains how scientists are learning to “reset” the biological age of cells—without changing what they are. From reversing vision loss in preclinical models to launching one of the first human trials, this conversation explores a future where we don’t just treat diseases of aging—we target aging itself. 🔗 Show notes: Life Biosciences: https://www.lifebiosciences.com/ Clinical pipeline: https://www.lifebiosciences.com/pipeline/ Michael Ringel talks: https://www.youtube.com/watch?v=XC31N9KbOEs / https://www.youtube.com/watch?v=OycGR-03S8A / https://www.youtube.com/watch?v=EZUBjXv5wIw

    28 min
  6. Mobility, Metabolism, and Resilience: Translating Geroscience into Function — A Conversation with Steve Kritchevsky

    1 Apr

    Mobility, Metabolism, and Resilience: Translating Geroscience into Function — A Conversation with Steve Kritchevsky

    What if aging isn’t defined by disease — but by how much function we preserve over time? In this episode of Decoding Longevity, Raghav Sehgal and Macsue Jacques sit down with Stephen Kritchevsky to explore how mobility, metabolism, and physiological resilience shape the aging process. From walking speed as a powerful integrative biomarker… to why muscle quality may matter more than muscle mass… to what long-term trials like Look AHEAD reveal about bending aging trajectories — this conversation reframes longevity around function, not just lifespan. We also dive into the trade-offs of weight loss in older adults, the connection between brain and physical aging, and what it will take to measure — and truly slow — aging in humans.

    45 min
  7. From Science to Strategy: How Policy Will Shape the Future of Longevity — A Conversation with Dylan Livingston

    18 Mar

    From Science to Strategy: How Policy Will Shape the Future of Longevity — A Conversation with Dylan Livingston

    What if the biggest barrier to extending healthy human lifespan isn’t the science — but policy? In this episode of Decoding Longevity, hosts Raghav Sehgal and Macsue Jacques speak with Dylan Livingston, founder of the Alliance for Longevity Initiatives. Together, they explore why public policy may be one of the most important — and overlooked — drivers of progress in longevity science. From building support for aging research funding to launching the Congressional Longevity Science Caucus and expanding access to investigational therapies, Dylan shares how advocacy and legislation could shape the future of preventative medicine and healthy aging. Learn more: Alliance for Longevity Initiatives (A4LI) → https://a4li.org/ LongeviPAC → https://www.longevipac.org/

    31 min
  8. Turning Biology of Aging into Medicines: A Conversation with James Peyer, Ph.D.

    5 Mar

    Turning Biology of Aging into Medicines: A Conversation with James Peyer, Ph.D.

    What if the future of medicine is preventing aging-related disease before it begins? In this episode of Decoding Longevity, Raghav Sehgal and Macsue Jacques speak with James Peyer, CEO of Cambrian Biopharma, about turning aging biology into real therapeutics. We explore exercise-mimetic drugs, metabolism reset therapies, mTOR inhibition, and the path to the first approved gerotherapeutics.

    39 min
See All (28)

About

A podcast dedicated to unraveling the mysteries of aging through the lens of cutting-edge science. Each episode breaks down the latest research papers in the field of geroscience, offering clear, insightful discussions on longevity, biological aging, and the quest for extending healthspan. Perfect for scientists, enthusiasts, and anyone curious about the science behind living longer and healthier lives.

Information

  • Creator
    Raghav Sehgal
  • Years Active
    2k
  • Episodes
    28
  • Rating
    Clean
  • Copyright
    © Raghav Sehgal
  • Show Website
    Decoding Longevity

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