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California's cannabis producers are not seeing the windfalls predicted, amid regulations and a robust black market that are cutting into legal pot profits. Sharyn Alfonsi reports. A letter written by Christopher Columbus, describing his discovery of the Americas, became the world's first best seller more than 500 years ago. As Jon Wetheim reports, the surviving copies are so rare and valuable, they're being stolen and replaced with forgeries. And Ethiopian pilgrims have been trekking to this mysterious holy site for centuries. Scott Pelley has the story on this week's "60 Minutes."

An NIH clinical trial is ushering in a genetic revolution as an innovative type of gene therapy is used to attempt to cure sickle cell anemia. Dr. Jon LaPook reports. The International Rescue Committee and Sesame Workshop are teaming up on a major new effort to help young Syrian refugee children, including a new Sesame show in Arabic. Lesley Stahl reports. And Sharyn Alfonsi introduces us to Matthew Whitaker, a blind pianist whose so good, scientists are studying him. Those stories on this week's "60 Minutes."

On this week's "60 Minutes," Scott Pelley tells the story of a Yazidi woman who survived a genocide. Hungary's populist government is spending billions to encourage woman to have more children to solve its demographic problem. At the same time it has built fences to keep immigrants out. Critics of the right wing government are outraged.Jon Wertheim has the story. And Bill Whitaker profiles a family of Southern Utah, a clan sporting nine professional cowboys with five world rodeo titles among them, who live a lifestyle straight out of the old west.

Scott Pelley investigates the evidence and speaks to victims' relatives and prosecutors of the Malaysia Flight 17 -- which was shot down over eastern Ukraine. Public monuments to the Confederacy have been generating controversy and sometimes violence over what critics consider their racist symbolism. Anderson Cooper examines the national debate. And Bill Whitaker gets unprecedented access to rehearsals of the modernized vision of this classic of the American musical theater "West Side Story." Those stories on this week's "60 Minutes."

Sharyn Alfonsi reportson the ongoing water crisis in Flint, Michigan. Lesley Stahl shares the remarkable story of architect Chris Downey, who lost his sight, found a way to keep working and believes blindness has made him a better architect.And the world's number 1 tennis player, Rafael Nadal, takes Jon Wertheim back to his hometown on the Spanish island of Mallorca. Those stories on this week's "60 Minutes."

The pandemic has forced election officials to explore ways to keep the public safe at the polls and offer alternatives to in-person voting. A three-month investigation reveals federal officials failed to immediately stop the distribution of many COVID-19 antibody tests they knew were flawed, leading to inaccurate data about the spread of the virus. Those stories on this week's 60 Minutes.