If you've ever walked into a room and forgotten why you went there, lost your train of thought mid-sentence, or felt like your brain just isn't working the way it used to, this episode is for you. In this conversation, I sit down with Lauren Dewsbury, who is currently completing her PhD in brain health and dementia risk reduction, to unpack the emerging research on creatine for brain fog, mood, sleep, and cognitive resilience in midlife women. Most of us have only ever heard creatine spoken about in the context of the gym to support muscle, strength and performance. But the science Lauren is exploring goes far beyond that. We talk about why menopause is not just a hormonal shift, but a major neurological transition, and how changes in oestrogen can alter the way the brain produces and uses energy. That's where creatine becomes so interesting. Lauren shares how this simple, accessible supplement may help support memory, word recall, emotional regulation, sleep-deprived cognition, and the mental sharpness so many women feel slipping during perimenopause and post-menopause. We also go deep into her Australia-wide clinical trial currently studying creatine in post-menopausal women with subjective cognitive decline and elevated dementia risk. CHAPTERS 00:00 – Why creatine for the brain, not just muscle 01:31 – How creatine supports cognitive function and ATP production 04:11 – Why menopause is a neurological transition 08:24 – Is HRT enough for brain fog and cognition? 10:15 – Why post-menopausal women with cognitive decline are the focus 11:45 – Can creatine help reduce future dementia risk? 13:14 – The global impact of menopause-related brain fog 16:02 – Why workplaces need to better support midlife women 18:16 – Inside Lauren's clinical trial: what cognition markers she's measuring 20:48 – Creatine for emotional regulation and mood 22:20 – How creatine helps after a bad night's sleep 23:59 – Why women may respond better to creatine than men 26:52 – Why midlife women may benefit more than younger women 28:40 – The brain-muscle longevity connection 30:22 – What to look for in a creatine supplement 32:02 – The biggest creatine myths: kidneys, bloating, and "gym bros" 34:30 – Brain health dosing: 5g vs 10g vs 20g 38:09 – How participants qualify for the trial 40:26 – Why the study is Australia-wide and fully remote 42:21 – What positive findings could change for women's healthcare 43:24 – What women can do right now for brain fog 49:11 – Final thoughts: should every midlife woman try creatine? CONNECT WITH LAUREN DEWSBURY Instagram: @menocogtrial & @lauren_dewsburyphd JOIN OUR LIVE WELL LONGER WOMEN'S BIOHACKING RETREAT 1–6 May 2026 | Revīvō Wellness Resort, Bali Live Well Longer Retreat has been named Group Retreat of the Year 2025 by the prestigious Destination Deluxe Awards. Following this global recognition, we're thrilled to return to Revīvō Wellness Resort in Bali, 1–6 May 2026, for a deeply personalised, science-led retreat created exclusively for women ready to reclaim their vitality and redesign their future. Co-founded by renowned biohacking experts Azra Alagic and Camilla Thompson this award-winning women-only experience blends cutting-edge biohacking with soulful rituals and ancient practices to deliver lasting transformation. At this intimate retreat, limited to just 16 women, you'll experience: Daily biohacking workshops tailored to women's health Private coaching, DNA testing, and optional hormone/gut diagnostics with naturopath Hot/cold therapy, hydrotherapy, meditation and MOVEŌ movement classes A curated, functional medicine-inspired gourmet menu Spa treatments, traditional Balinese blessings, full moon ceremony 1:1 consult with Cocoon medical Dr Whether you're curious about biohacking or already on your longevity path, this retreat delivers the clarity, support, and practical tools to thrive at every stage of life. Spaces are extremely limited — and this retreat will sell out so get in quick :) Find out more here www.livewelllongerretreats.com Contact Revivo Retreat directly with any questions or to book directly (deposit required) reservation-nusadua@revivoresorts.com HELP US SPREAD THE WORD! If you found this conversation valuable, interesting or inspiring I'd love you to share the pod and leave a review! Great reviews will help me to continue to bring you interviews with experts in longevity, and health and wellness. I would be so grateful if you could take a few minutes to submit a review on the podcast platform you listen from. WANT TO LEARN MORE? If you're keen to get started on your biohacking journey to optimise your health and live well longer please join me on my socials: Instagram: https://www.instagram.com/biohackher_official Facebook: https://m.facebook.com/people/Biohackher Website: www.biohack-her.com YouTube: https://www.youtube.com/@biohackherpodcast