Lyme Insider by Dr. Tom Moorcroft Dr. Tom Moorcroft, Integrative Medicine Specialist

Summary
Dr. Ed Breitschwerdt discusses his interest in Bartonella research and the challenges associated with studying this bacteria. He explains the discovery of Bartonella and its unique aspects, including the various vectors and modes of transmission. The prevalence of Bartonella and the challenges in diagnosing the infection are also discussed. Dr. Breitschwerdt highlights the difficulties in testing and diagnosing chronic Bartonella infections and the use of digital PCR for more accurate detection. The chapter concludes with a discussion on the pathophysiology of chronic Bartonella infection. The conversation explores the challenges in accurately diagnosing Bartonella infections and the differences in results from different labs. It highlights the importance of using the correct isolates of the organism for testing and the prevalence of different strains. ThKe discussion also touches on the phenomenon of patients stopping the production of antibodies to Bartonella and the interplay between acute and chronic infections. The conversation emphasizes the need for better diagnostic tests and the development of a vaccine to protect animals and humans from Bartonella infections.
 
Takeaways
Bartonella is a complex bacteria with various vectors and modes of transmission.
Diagnosing Bartonella infection, especially chronic cases, can be challenging.
Digital PCR is a promising tool for more accurate detection of Bartonella.
Chronic Bartonella infection can lead to a range of symptoms and recrudescence. Different labs may use different isolates of Bartonella, leading to different results in testing.
Patients may stop producing antibodies to Bartonella, making serology testing less reliable.
Exposure to Bartonella species is common, and many individuals may be asymptomatic carriers.
Bartonella infections may contribute to a spectrum of neurologic and neuropsychiatric diseases.
The development of a diagnostic test and a vaccine for Bartonella are important goals for future research.
 
Chapters
00:00 Introduction and Background
00:42 Interest in Bartonella Research
05:38 Challenges and Unique Aspects of Bartonella
08:37 Transmission of Bartonella
11:11 Vectors and Transmission to Humans
14:58 Prevalence of Bartonella and Challenges in Diagnosis
29:35 Chronic Bartonella Infection and Recrudescence
32:20 Pathophysiology of Chronic Bartonella Infection
36:06 Diagnostic Challenges and Digital PCR
41:13 Challenges in Accurate Diagnosis
42:02 Different Results from Different Labs
42:16 Different Isolates of the Organism
43:42 Prevalence of Bartonella Henselae Strains
44:41 Patients Stop Making Antibodies
45:56 Interplay Between Acute and Chronic Infections
46:45 Serofast State in Bartonella Henselae
47:21 Exposure to Bartonella Species
48:19 Testing Blood Donors for Bartonella
49:47 Role of Bartonella in Neurologic Diseases
52:43 Symptoms of Bartonella Infection
54:03 Understanding Bartonella on a Cellular Basis
57:34 Developing a Diagnostic Test for Bartonella
01:00:09 Vaccine Target for Bartonella
01:11:44 Protecting the Human-Animal Bond
01:18:03 Future Goals: Diagnostic Test and Vaccine


Dr. Ed Breitschwerdt, DVM , DACVIM
Learn more about Dr. Breitschwerdt and his work at NC State University
Learn more about Dr. Breitschwerdt’s work at Galaxy Diagnostics
Donate to the NC State Bartonella/Vector Borne Research Fund
 
 Tom Moorcroft, DO
Learn more about Dr. Tom’s Lyme Disease Practitioner Training program.
 

Summary
In this conversation, I’m joined by Dr. Choukri Ben Mamoun and Dr. Tim Sellati to discuss Dr. Ben Mamoun’s recent study on the use of combination therapy for the treatment of Babesia infection entitled: Tafenoquine-Atovaquone Combination Achieves Radical Cure and Confers Sterile Immunity in Experimental Models of Human Babesiosis. 
We explore the key findings of the study, including the use of immunocompromised mouse models and the potential for long-lasting immunity. The conversation also delves into the importance of understanding the differences between tick-borne infections and the challenges of translating research findings into clinical practice. The discussion highlights the need for further research on dosing and the therapeutic index of different drugs.
Overall, the conversation provides valuable insights into the current understanding of Babesia treatment and the potential for future advancements. The conversation covers topics such as combination therapy and resistance, dormant parasites and relapse, terminology and immunocompromised, immune dysregulation and cold exposure, diagnostic testing for Babesia, improving diagnostic testing, and the goal of helping patients.
 
Key Takeaways
Combination therapy with tafenoquine and atovaquone has shown promising results in the treatment of Babesia infection.
Immunocompromised mouse models are valuable tools for studying the efficacy of different treatments.
Understanding the differences between tick-borne infections is crucial for accurate diagnosis and treatment.
Further research is needed to determine optimal dosing and the therapeutic index of different drugs for Babesia treatment.
Recrudescence and treatment failure are important considerations in Babesia treatment. 
Combination therapy can reduce the probability of resistance in parasites.
Dormant parasites may be responsible for relapse in Babesia infections.
The terminology used in scientific research may differ from the general public's understanding.
Factors like sleep, stress, and nutrition can contribute to immunocompromised states.
Diagnostic testing for Babesia needs improvement to reduce false negatives and false positives.
The ultimate goal is to help patients get better by finding the right diagnosis and treatment.
There is a need for collaboration between clinicians, researchers, and patients to advance the understanding and treatment of tick-borne infections.
 
Chapters
00:00 Introduction and Overview
03:00 The Study and Key Findings
06:35 Understanding the Research and Clinical Implications
11:56 The Importance of Animal Models
14:43 Immunocompromised Mouse Models
23:22 Differences Between Tick-Borne Infections
26:34 Combination Therapy: Tafenoquine and Atovaquone
32:26 Dosing and Therapeutic Index
36:48 Artemisinin as a Treatment Option
46:20 Recrudescence and Treatment Failure
48:23 Combination Therapy and Resistance
50:24 Dormant Parasites and Relapse
53:18 Terminology and Immunocompromised
56:15 Immune Dysregulation and Cold Exposure
59:14 Diagnostic Testing for Babesia
01:03:22 Improving Diagnostic Testing
01:12:12 The Goal of Helping Patients
01:20:22 Caring and Finding the Truth
 
Link to the paper we discussed:
Tafenoquine-Atovaquone Combination Achieves Radical Cure and Confers Sterile Immunity in Experimental Models of Human Babesiosis - https://pubmed.ncbi.nlm.nih.gov/38169301/
 
Learn More About My Guests:
Choukri Ben Mamoun, PhD - Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis; Affiliated Faculty, Yale Institute for Global Health https://medicine.yale.edu/profile/choukri-benmamoun/
 
Timothy Sellati, PhD - Chief Scientific Officer, Global Lyme Alliance https://www.globallymealliance.org/
 
Learn more about Dr. Tom’s Lyme Disease Practitioner Training program.
 

Why So Many Kids Are Picky Eaters and What to Do About It
Katie Kimball is an author, entrepreneur, teacher of a Wall Street Journal recommended online cooking class, and a mother of four. She explains how to deal with picky eaters, and get kids to willingly eat healthy foods. In conversation with Dr. Tom Moorcroft, Katie explains how to get kids to develop a healthy relationship with food, and in turn, grow into independent, resilient adults. Find the inspiration you need for your picky eater at home.
 
Top Tips
It is not the job of parents to get their kids to eat. By removing the stress and control over the whole process of eating, parents can help picky eaters eat healthy, whole foods. Sensory overload and environmental toxins around us are often the reasons why kids are so fussy about the food they will eat and not eat.  Give kids choice, control, and agency to help them develop a healthy relationship with food. Getting kids into the kitchen is a good way to get them interested in food. Let kids cook, and experiment with different foods and textures to get them invested in the process of cooking. Kids should be allowed to handle age-appropriate kitchen tools, even knives. It is especially important to get boys involved in the process of cooking, for parents to bring up healthy, independent, self-reliant individuals. Dr. Tom Moorcroft’s Full Cup Life Podcast has benefitted numerous people, helping them achieve greatness and supercharge healing. Don’t miss this enlightening and uplifting chat with Katie Kimball about kids, food, parenting, and all the associated challenges.
 
Need a guide on your journey to health and wellbeing? Contact Dr. Tom Moorcroft, specialist in treating mystery illnesses, to get on the path to holistic healing and happiness.
 
https://www.originsofhealth.com/
support@tommoorcroft.com
 
#drtommoorcroft #tommoorcroft #fullcuplife #foodissues #pickyeater #pickyeaters #katiekimball #sensoryprocessing #relationshipwithfood #foodsensitivities #experimentwithfood #criticalthinking #kidscooking #cookingclasses #healthykids
 
Katie Kimball
The national voice of healthy kids cooking, is a blogger, TEDx speaker, former teacher, and mom of 4 kids who founded the Kids Cook Real Food eCourse, recommended by The Wall Street Journal in 2020 as the best online cooking class for kids. Her blog, Kitchen Stewardship helps families stay healthy without going crazy, and she’s on a mission to connect families around healthy food and teach every child to cook as part of the Kids' Meal Revolution. 
 
More about Katie

Hack Yourself with Proven Culture Hacks: In Conversation with Robert Richman
In this episode of Full Cup Life, Dr. Tom Moorcroft speaks to Robert Richman who used to be the culture strategist at Zappos and co-founded Zappos Insights. Robert reveals some of the life mantras that have helped him grow and shares how he now inspires leaders to achieve greater success. Find out more about the Xpill Experience, about changing mindsets and achieving your goals. Listen now to get inspired to make the changes required to live your best life.
 
Top Tips
Robert Richman was the culture strategist at Zappos and co-founded Zappos Insights. He speaks to Dr. Tom Moorcroft about leadership, life, success, feedback, and about training leaders to achieve mindset changes and move beyond blockages. Xpill is something that Robert Richman came up with, essentially like an open-labeled placebo designed to help people find their passion and align their actions to their goals. A real leader is one who listens to others first and speaks last. This is the best way to understand the feelings and capabilities of people and to effectively assign work, and delegate. When we speak about going out of the comfort zone, this is about being uncomfortable with something unfamiliar but not to the point of being overwhelmed. That is the point where it can become counterproductive. Getting feedback isn't about hearing only positive things from people. It is about hearing what one doesn’t want to hear. Only when one expresses the negative can they communicate the positive effectively. Dr. Tom Moorcroft’s Full Cup Life Podcast has benefitted numerous people, helping them achieve greatness and supercharge healing. Don’t miss this enlightening and uplifting chat with Robert Richman about life, leadership, goals, success, and everything in between.
 
https://www.originsofhealth.com/
support@tommoorcroft.com 
 
the placebo effect
how does the placebo effect work
how to use the placebo effect
what is the placebo effect
Robert Richman
how to succeed in business
how to succeed in life
ways to succeed in life
how do I find my passion in life
find your passion
 
#fullcuplife #successgoals #successmindset #successformula #powerofplacebo #xpill #placeboeffect #empoweryourself #findyourpurpose #mindsetshift #comfortzone #goalsetting #abundancemindset #manifestingabundance
 
 

Robert Richman
https://robertrichman.com/
 
Robert Richman is a culture hacker and was Culture Strategist at Zappos. He co-created Zappos Insights, an innovative program focused on educating companies on the secrets behind Zappos’ amazing employee culture.
 
Together with CEO Tony Hsieh, Robert built Zappos Insights from a small website to a thriving multi-million dollar business teaching over 25,000 students per year. Through his work, Robert has been helpful in improving the employee culture at hundreds of companies.
 
As one of the world’s authorities on employee culture, Robert is a sought-after keynote speaker at conferences around the world and has been hired to teach culture in person at companies like Google, Toyota, and Eli Lilly. He has pioneered a number of innovative techniques to build culture, such as bringing improv comedy to the workplace.
 
Robert graduated from Northwestern University with a degree in film, as well as from Georgetown University’s Leadership Coaching Program. He is a member of the Transformational Leadership Council, and he is based out of San Diego (though he’s on the speaking tour most of the time).

Life, Love, Success
https://samara-health.mykajabi.com/offers/zrbgwLyS
Dr. Tom Moorcroft speaks to motivational and keynote speaker Norman Gräter in this episode of Full Cup Life. Check out this fascinating chat about the most effective ways to reach life goals and to enhance the experience of that journey. Find out why it’s important to be in the moment and to commit to it fully, and get inspired to never lower your standards, but to expect others to rise to the expectations and standards you set. Listen now!
 
Top Tips
 
The uncomfortable and unpleasant things in life are not necessarily bad or unnecessary. In fact, it is these things that give us a keener appreciation for all the good there is in life, and we benefit from understanding the contrast between the two.
 
Assumption determines experience. Our assumptions have the power to predict and even actualize goals. If you assume that which you desire, the future becomes the present and your assumption will be fulfilled.
 
We may think that the Universe failed to deliver the gifts that we expected from it, but the Universe will deliver. It may not deliver in the form you expect and it may not deliver exactly when you think it should, but it will deliver -- if only one can learn to recognize them.
 
One's focus should not be fixed on the result. The focus should be upon developing a reality we can inhabit and this will free us up to many results and many possibilities. Be in the moment and inhabit it fully.
 
Develop clarity about your goals and what you want from life. Don’t lower your standards and don’t compromise on what you know you deserve. It is up to others around to come up to the level that you inhabit. Raise others up, don’t let yourself down.
 
Dr. Tom Moorcroft’s Full Cup Life Podcast has benefitted numerous people, helping them achieve greatness and supercharge healing. Don’t miss this enlightening and uplifting chat with Norman Gräter about life, love, success, and everything in between.
 
Join Dr. Tom each Tuesday morning for your weekly dose of Limitless. Learn how to access your Limitless nature through the study of some of the most profound texts and exercises ever produced. Study what Dr. Tom is studying directly with him. Change Your Mind, Change Your Results, Change Your Life!
https://samara-health.mykajabi.com/offers/zrbgwLyS
 
-----
Norman Graeter / Gamechanger & Hero Creator 
Norman is a true celebrity whisperer. During his more than 25 years as an event manager, Norman started to ask the artists he was working with, what their key to success in life might be. What started as a small talk, ended in a self-experiment. Up to today, Norman has spoken to over 400 celebrities like Michelle Obama, Arnold Schwarzenegger, Hillary Clinton, and Sylvester Stallone about their success secret for life.
He took all their wisdom and tried it successfully on himself. 
Today, besides being a three-time European champion in public speaking, Norman is a multi award-winning motivational keynote speaker and mindset coach. Companies such as PayPal, DACHSER, Bosch, Viessmann, and many others trust his expertise when it comes to goal achievement and mindset. Norman also wanted to share his knowledge and experience in a life-changing arena show that he prepared for six years. 12 days before the premiere, COVID-19 hit, and everything had to be canceled. Out of this huge setback, Norman came out stronger than ever before. Currently, he is working with a multi award-winning Hollywood Producer to bring his inspirational journey onto the big screen very soon. Stay tuned for more of Norman Graeter, the hero creator. 
Receive your five free gifts for your own celebrity mindset at www.celebmindset.com or visit his German page at www.norman-graeter.com 
#fullcuplife #loveandfear #beingkind #beinthemoment #appreciatecontrast #dreamsbecomereality #fulfilldesire #openyourheart #visionboar

Trevor Hash, Elite Movement Coach, of Primal Athlete Talks to Dr. Tom Moorcroft About His Journey
 
In this episode of the Full Cup Life podcast, Dr. Tom Moorcroft catches up with Trevor Hash of Primal Athlete. We trace Trevor’s journey from pain and repeated injuries over ten years, to the path of corrective exercise and finding freedom in his own body. Trevor is a super-fit athlete, and a movement and lifestyle coach, who shares his mantras for making peace with one's own body, acknowledging stress, and not apportioning blame. Listen now!
 
Top Tips
The seeming setbacks we experience in life are actually learning opportunities. These are bits of information that help us move forward. How we interpret the ‘setbacks’ is the key to overcoming them. Fear can sometimes manifest in the body in physical ways. We may hamper progress simply because we are scared of how the body will react to a new therapy or a different approach. We need to take that leap of faith. We often shy away from doing things because the apprehension of being judged may be deeply and physiologically ingrained. However, overcoming that apprehension can be freeing and joyous, and could actually turn into one's passion. It is important to have a morning routine where one creates certain positive habits – some minutes of movement to start the day. Just a few minutes can have beneficial impacts and could feel as though one has meditated for half an hour. Very often, people don’t realize when they are stressed and how much that stress affects them. It is important to acknowledge that stress and to work at organizing one’s mental space accordingly. Dr. Tom Moorcroft’s Full Cup Life Podcast has benefitted numerous people, helping them achieve greatness and supercharge healing. Listen to this episode to hear his inspiring and transformative conversation with Trevor Hash. 
 
Need a guide on your journey to health and wellbeing? Contact Dr. Tom Moorcroft, a specialist in treating mystery illnesses, to get on the path to holistic healing and happiness.
 
https://www.originsofhealth.com/

support@tommoorcroft.com 
 
#FullCupLife #PrimalFitness #PrimalAthlete #MovingForward #FindingFreedom #CorrectiveExercise #EmbraceYourJourney #AcknowledgeStress #MovementPractice #MovementAsMeditation #FindYourFreedom #FindYourPath #NavigateYourDay #DontBlameYou #Synchronicity #StrengthSide
 
Trevor Hash is a movement coach like no other. There’s no better way to get to know him than with his own words: Do it right the first time. 
 
I spent years trying to figure everything out on my own.  I learned what works, and I learned what doesn’t. But more importantly, I wasted precious time learning the hard way that a coach can save you your precious time. There are plenty of great coaches out there.
 
Here’s what I can guarantee you that many other coaches cannot: an open conversation. I’ve used many online programs and worked with coaches who withhold their “why’s” for their closest disciples. I don’t want to keep my methods a secret. I will give you your program, and if you’re interested in the “why” behind anything in it, I’m all for discussing it. I want to help you understand your body better. It will speed up your own progress. And it elevates us all as a community and society. I want it to become common knowledge that moving your spine is not only safe but Necessary. And that your shoulder blades shouldn’t always be “back and down.” I want to spread quality knowledge to you in the hopes that you will spread the knowledge as well.
 
Check out Trevor online at:
https://www.TrevorHash.com
https://www.StrengthSide.com
YouTube at StrengthSide (link: https://www.youtube.com/user/strengthsidetrainer)