74 episodes

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey.

Fundamental Health with Paul Saladino, MD Paul Saladino, MD

    • Medicine
    • 4.8, 852 Ratings

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey.

    What really causes metabolic dysfunction? Carbs, PUFA, or aliens?

    What really causes metabolic dysfunction? Carbs, PUFA, or aliens?

    Heart & Soil is now a reality! This is my passion company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand. Check us out at: www.heartandsoilsupplements.com 
     
    The second edition of The Carnivore Code is now live in print, ebook, and audiobook formats!  www.Thecarnivorecodebook.com to order! 

    Heart & Soil: www.heartandsoilsupplements.com

    • 27 min
    What does a carnivore diet do to the gut microbiome? Part 1 with Vincent Pedre, MD

    What does a carnivore diet do to the gut microbiome? Part 1 with Vincent Pedre, MD

    Heart & Soil is now a reality! This is my passion company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand. Check us out at: www.heartandsoilsupplements.com 
     
    The second edition of The Carnivore Code is now live in print, ebook, and audiobook formats!  www.Thecarnivorecodebook.com to order! 



    Dr. Vincent M. Pedre, Medical Director of Pedre Integrative Health and President of Dr. Pedre Wellness, is a Board-Certified Internist in private practice in New York City since 2004. His philosophy and practices are a blend of both Western and Eastern medical traditions. He is a Clinical Instructor in Medicine at the Mount Sinai School of Medicine, as well as certified in yoga and Medical Acupuncture.



    Time Stamps:
     
    0:10:46 Dr. Vincent Pedre’s background 
    0:13:17 The vastness of our microbiomes 
    0:18:31The effect of GMOs on the microbiome of the soil
    0:23:15 Reversing climate change through healing the soil
    0:28:41 Healing the microbiome through reconnecting with nature. 
    0:33:41 Saving the planet through creating ecosystems 
    0:34:32 Observations of the gut microbiome of the Hadza
    0:39:24 Fiber does not increase microbiome diversity 
    0:40:44 Diet rapidly and reproducibly alters the human gut microbiome
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957428/
    0:43:35 Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets
    https://academic.oup.com/ajcn/article/71/3/682/4729121
    0:45:23 The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy
    https://www.nature.com/articles/s41522-018-0073-2?fbclid=IwAR1q7BKu4IN1-9g1E7PGBpwfvzVPu7Xe2g4omFEMR7B8HfBMKrd2kIHMCVw
    0:45:50 Reduced Mass and Diversity of the Colonic Microbiome in Patients with Multiple Sclerosis and Their Improvement with Ketogenic Diet
    https://www.frontiersin.org/articles/10.3389/fmicb.2017.01141/full
    0:47:36 How to build gut bacteria diversity 
    0:52:09 No fiber? No butyrate? No problem
    0:57:48 The metabolic inefficiency of plant nutrition
    1:03:30 Genetics and varying tolerances 
    1:06:59 Metabolic flexibility 
    1:13:55 The circadian rhythm of the gut microbiome 
    1:16:39 Seasonality and the microbiome 
    1:17:58 What wrecks your biodiversity 
    1:24:37 Where to find Dr. Vincent Pedre
     
     
     
    Heart & Soil: www.heartandsoilsupplements.com 
     
    Nutrisense (Continuous Glucose Monitor- CGM): www.Nutrisense.io, use the code CarnivoreMD for 20$ off. 
     
    BluBlox: www.blublox.com use the code CarnivoreMD for 15% off your order
     
    White Oak Pastures: Use the code CARNIVOREMD at www.whiteoakpastures.com for 10% off your first order!



    JOOVV: www.joovv.com/paul




    To subscribe to my newsletter visit: carnivoremd.com
     
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    email: drpaul@carnivoremd.com

    • 1 hr 34 min
    The Carnivore Code AMA (Ask Me Anything) from Ben Greenfield Episode!

    The Carnivore Code AMA (Ask Me Anything) from Ben Greenfield Episode!

    The second edition of The Carnivore Code is now live in print, ebook, and audiobook formats!  www.Thecarnivorecodebook.com to order! 
     
    Heart & Soil is also now a reality! This is my passion company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand. Check us out at: www.heartandsoilsupplements.com 



    In this AMA episode I answer questions from Ben Greenfield about my book, The Carnivore Code. It’s a deep dive into much of the science of an animal-based way eating. Prepare to learn a ton!



    Time Stamps:
     
    8:03 Carnivore diet background, framework
     
    18:25 Is there a magic ratio of fat to protein we should aim for? What is rabbit starvation?
     
    25:53 A Review of Issues of Dietary Protein Intake in Humans
    https://pdfs.semanticscholar.org/4f00/4c6ff9159de2753b060df2ea1aab936db9ec.pdf
     
    33:01. Is the decline in height and health fully attributable to plant agriculture or could it be due to industrialization?
     
    38:43 Why do present day hunter-gatherers have no access to wild game?
     
    42:54 How do we know that our high stomach acidity was driven by the consumption of animals? 
     
    45:09 The Evolution of Stomach Acidity and Its Relevance to the Human Microbiome https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134116
     
    50:51 How do herbivores detoxify plant toxins?
     
    56:34 Coevolution of poisonous plants and large herbivores on rangelands 
    https://journals.uair.arizona.edu/index.php/jrm/article/view/6858/6468
     
    1:02:09 What are the studies of isothiocyanates in humans?
     
    1:04:39  Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892312/
     
    1:07:03  Why molecular hormesis is bad news
     
    1:14:42  Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change: a randomised trial  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060837/ 
     
    1:18:03 Green tea extract only affects markers of oxidative status postprandially: Lasting antioxidant effect of flavonoid-free diet   https://www.researchgate.net/publication/11310865_Green_tea_extract_only_affects_markers_of_oxidative_status_postprandially_Lasting_antioxidant_effect_of_flavonoid-free_diet
     
    1:20:08 Uric acid and glutathione levels during short-term whole body cold exposure https://pubmed.ncbi.nlm.nih.gov/8063192/
     
    1:21:14 Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans https://www.nature.com/articles/ncomms14337
     
    1:22:58  Is there an acceptable dose of isoflavones? 
     
    1:23:53  Goitrogenic and Estrogenic Activity of Soy Isoflavones https://www.jstor.org/stable/3455387?seq=1
     
    1:25:32 Isoflavones: estrogenic activity, biological effect and bioavailability  https://www.researchgate.net/publication/233538635_Isoflavones_Estrogenic_activity_biological_effect_and_bioavailability
     
    1:26:48 Low Dietary Soy Isoflavonoids Increase Hippocampal Spine Synapse Density in Ovariectomized Rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330193/
     
    1:29:56 Is resveratrol really something we should avoid?
     
    1:31:09  David Sinclair’s work on Resveratrol https://www.ncbi.nlm.nih.gov/pmc/?term=sinclair%2C+david+resveratrol
     
    1:32:02 Resveratrol reduces the levels of circulating androgen precursors but has no effect on, testosterone, dihydrotestosterone, PSA levels or prostate volume. A 4‐month randomised trial in middle‐aged men https://pubmed.ncbi.nlm.nih.gov/25939591/#:~:text=Conclusion%3A%20In%20this%20population%20of,PSA%2C%20

    • 2 hr 16 min
    Bonus episode: How to live like your ancestors in 2020, with Dr. Anthony Gustin.

    Bonus episode: How to live like your ancestors in 2020, with Dr. Anthony Gustin.

    Heart & Soil is now LIVE! I couldn't be more excited to share the message of nose to tail nutrition and help more people include organs in their diet. Check us out at www.heartandsoilsupplements.com! 
     
    The second edition of The Carnivore Code (new cover and index!) is available for pre-order now!  www.Thecarnivorecodebook.com release date is August 4th 2020 in ebook, print, and audiobook formats. 
     
    Founder and CEO of Perfect Keto & Equip Foods, host of The Natural State Podcast, author of the best-selling Keto Answers. Former sports rehab clinician turned entrepreneur, trained in functional medicine and ordered labs and set treatment plans for hundreds of patients.
     
    Time Stamps:
     
    3:52  Being in touch with your environment bolsters human health
    9:29 Why regenerative agriculture is the only way forward
    16:00 On a mission to get people eating real food
    17:00 Using business to force [positive] change upon the system
    18:50 The importance of respecting complex systems
    20:35 Chronic disease is a genetic and environmental mismatch 
    21:23 Returning animals to their natural environment
    23:34 Lab-grown meat, and other carbon giants
    28:00 Nature’s carbon cycle unnatural carbon introduction
    31:31 Seasonality and diversity diminishes toxic load
    40:00 Genetic adaptation takes thousands of generations
    48:10 The value of learning the survivalist lifestyle
    55:13 The best use of social media
    1:00:20 How Anthony Gustin stays centered
    1:04:30 Where to find Anthony Gustin
     
    Heart & Soil: www.heartandsoilsupplements.com 
     
    Nutrisense (Continuous Glucose Monitor- CGM): www.Nutrisense.io, use the code CarnivoreMD for 20$ off. 
     
    BluBlox: www.blublox.com use the code CarnivoreMD for 15% off your order
     
    White Oak Pastures: Use the code CARNIVOREMD at www.whiteoakpastures.com for 10% off your first order!
     
    Belcampo: Use the Code CarnivoreMD for 20% off! 
     
    JOOVV: www.joovv.com/paul




    To subscribe to my newsletter visit: carnivoremd.com
     
    My contact information:
     
    Book: www.thecarnivorecodebook.com
     
    PATREON: https://www.patreon.com/paulsaladinomd
     
    SOCIAL MEDIA 
    Instagram: @carnivoremd
    Website: carnivoremd.com
    Twitter:@carnivoremd 
    Facebook: Paul Saladino MD
    email: drpaul@carnivoremd.com
     

    • 1 hr 16 min
    Part 2: How not to die of chronic disease or COVID (aka how to avoid insulin resistance), with Tommy Wood, MD/PhD

    Part 2: How not to die of chronic disease or COVID (aka how to avoid insulin resistance), with Tommy Wood, MD/PhD

    The second edition of The Carnivore Code (new cover and index!) is available for pre-order now!  www.Thecarnivorecodebook.com release date is August 4th 2020 in ebook, print, and audiobook formats. 
     
    Tommy Wood MD, PhD is an elite-level professional nerd who has coached world class athletes in a dozen sports.  He has an undergraduate degree in biochemistry from the University of Cambridge, a medical degree from the University of Oxford, and a PhD in physiology and neuroscience from the University of Oslo. Tommy is a Research Assistant Professor at the University of Washington, a Research Scientist at the Institute for Human and Machine cognition, and is on the scientific advisory board of Hintsa Performance. He is also CSO (Chief Snake Officer) at the Costa Rican Center for Bro Research. Tommy lives in Seattle with his wife Elizabeth and their two goofy boxers. In his spare time he can usually be found cooking, reading, or lifting something heavy.
     
    Time Stamps:
     
    10:15 Tommy on Coronavirus.
    13:00 Why it's okay to be wrong as a scientist.
    15:00 Where are we now with Coronavirus? (12:24) (14:20-14:59)
     
    22:17 Boris Johnson Moves To Ban Junk Food Discount Deals To Fight Obesity
    https://www.independent.co.uk/news/uk/politics/boris-johnson-junk-food-ban-buy-one-get-one-free-obesity-coronavirus-a9611766.html
     
    24:45. Tommy’s article on metabolic health and pandemics.
    Metabolic health and lifestyle medicine should be a cornerstone of future pandemic preparedness Metabolic health and lifestyle medicine should be a cornerstone of future pandemic preparedness https://onlinelibrary.wiley.com/doi/full/10.1002/lim2.2  
    27:45  COVID-19 severity is predicted by earlier evidence of accelerated aging
    https://www.medrxiv.org/content/10.1101/2020.07.10.20147777v1
     
    37:10 Is there an ideologically ‘’perfect’’ diet.
     
    40:25 How does metabolic health affect our immune system? (38:44)
     
    FIGURE


    41:47  An elastic-net logistic regression approach to generate classifiers and gene signatures for types of immune cells and T helper cell subsets
    https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-019-2994-z
     
    42:55 The NLRP3 inflammasome: Role in metabolic disorders and regulation by metabolic pathways
    https://pubmed.ncbi.nlm.nih.gov/29339210/

    45:15   Analysis and modulation of the TH1/TH2 cytokine balance
    https://www.imd-berlin.de/en/subject-information/diagnostics-information/th1th2-cytokine-balance.html
     
    46:57  Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357061/
     
    56:10. Are ethnic populations at greater risk?
     
     
    59:10  Impact of obesity and metabolic syndrome on immunity
    https://academic.oup.com/advances/article/7/1/66/4524061
     
    60:15. Insulin Resistance. 
     
    1:14:50 What causes pathologic insulin resistance?
     
    1:19:07 Polyunsaturated fatty acids (1:19:30) 
     
    1:19:29  Increase of Adipose tissue little lake acid in US adults in the last half century
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642429/
     
    1:32:29   Tissue levels of polyunsaturated fatty acids during early human development
    https://pubmed.ncbi.nlm.nih.gov/1532827/
     
    1:31:52  Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets
    https://pubmed.ncbi.nlm.nih.gov/15070924/
     
    1:35:52   Dietary a little lake acid elevates endogenous 2-AG anandamide and induces obesity
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458187/
     
    1:37:10 Saturated fatty acids (studies) (1:50:20)
     
    1:37:33  Effects of step-wise increase in dietary carbohydrate on circulating saturated fatty acids and palmitoleic acid in adults with metabolic syndrome
    https://pubmed.ncbi.nlm.nih.gov/25415333/
     
    1:46:14. Dietary stearic aci

    • 2 hr 39 min
    How Not to Die of Chronic Disease (aka how to avoid insulin resistance), Part 1 of 2 with Tommy Wood, MD/PhD

    How Not to Die of Chronic Disease (aka how to avoid insulin resistance), Part 1 of 2 with Tommy Wood, MD/PhD

    The second edition of The Carnivore Code (new cover and index!) is available for pre-order now!  www.Thecarnivorecodebook.com release date is August 4th 2020 in ebook, print, and audiobook formats. 
     
    Tommy Wood MD, PhD is an elite-level professional nerd who has coached world class athletes in a dozen sports.  He has an undergraduate degree in biochemistry from the University of Cambridge, a medical degree from the University of Oxford, and a PhD in physiology and neuroscience from the University of Oslo. Tommy is a Research Assistant Professor at the University of Washington, a Research Scientist at the Institute for Human and Machine cognition, and is on the scientific advisory board of Hintsa Performance. He is also CSO (Chief Snake Officer) at the Costa Rican Center for Bro Research. Tommy lives in Seattle with his wife Elizabeth and their two goofy boxers. In his spare time he can usually be found cooking, reading, or lifting something heavy.
     
    Time Stamps:
    8:07 Start of Podcast 8:52 The mechanism of caffeine/other compounds found in coffee/tea/chocolate in the human body. 11:27 Paul’s thoughts on coffee.  15:42 Tommy’s thoughts on coffee. 21:37 Human detoxification of plant toxins.  24:22 Regional differences in genetics. 26:00 Benefits of  Elimination diet. 27:37 Tommy’s issues with low carb diets. 29:52 Is insulin anabolic?  36:07 Protein requirements  37:17 Physiologic insulin resistance.  51:47 What Causes insulin resistance?  58:12 Digestion of processed fat and carbohydrate  59:47 What is the fastest way to fix insulin resistance? 1:01:47 How the processing of food changes your physiology.  1:04:22 Insulin resistance in asian populations. 1:06:32 The bagel study. 1:08:37 Low-carb-high fat vs. low fat-high carb.  1:12:07 Electrolyte balance on low carb diet.  1:17:47 Where to find Tommy online? 1:19:57 The most radical thing Tommy has done recently.
    References: 
    https://www.researchgate.net/publication/235366395_Addition_of_Carbohydrate_or_Alanine_to_an_Essential_Amino_Acid_Mixture_Does_Not_Enhance_Human_Skeletal_Muscle_Protein_Anabolism



    Nutrisense (Continuous Glucose Monitor- CGM): www.Nutrisense.io, use the code CarnivoreMD for 20$ off. 
     
    BluBlox: www.blublox.com use the code CarnivoreMD for 15% off your order
     
    White Oak Pastures: Use the code CARNIVOREMD at www.whiteoakpastures.com for 10% off your first order!
     
    Belcampo: Use the Code CarnivoreMD for 20% off! 
     
    JOOVV: www.joovv.com/paul




    To subscribe to my newsletter visit: carnivoremd.com
     
    My contact information:
     
    Book: www.thecarnivorecodebook.com
     
    PATREON: https://www.patreon.com/paulsaladinomd
     
    SOCIAL MEDIA 
    Instagram: @carnivoremd
    Website: carnivoremd.com
    Twitter:@carnivoremd 
    Facebook: Paul Saladino MD
    email: drpaul@carnivoremd.com

    • 1 hr 25 min

Customer Reviews

4.8 out of 5
852 Ratings

852 Ratings

I Love Snow!!!! ,

He follows the evidence!

This is my fav podcast because Dr Saladino digs into the medical literature and science with the attitude that he’s going to follow where the evidence leads. I greatly appreciate that! I always learn a lot from his podcasts.

TayMC$ ,

SO RAD!

This is by far my favorite and most listened to podcast in my library. I so appreciate Dr. Paul Saladino for questioning the norm and providing EVIDENCE based science and facts for the listener. Yes, his episodes are freaking long! But I really don’t care because I know I’m going to learn so much. This guy is RADICAL!

Nomdska ,

My favorite podcast

Truth seekers; unlearning of the agricultural, sedentary mistake. The only class I liked in high school was anthropology. I’ve always questioned this crazy civilization. Dr. Paul Saladino is doing this too, in order to allow us to live better lives and to help our ailing planet.

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