94 episodes

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey.

Fundamental Health with Paul Saladino, MD Paul Saladino, MD

    • Medicine
    • 4.8 • 1.1K Ratings

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey.

    Fertility, Pre-natal, Pregnancy, Breast Feeding and Peri-menopause with Jaime Seeman, MD

    Fertility, Pre-natal, Pregnancy, Breast Feeding and Peri-menopause with Jaime Seeman, MD

    Dr Jaime Seeman is a board certified  Obstetrician and Gynecologist practicing in Omaha, Nebraska. Born and raised in the state she played collegiate softball for the Cornhuskers. She has a Bachelor of Science degree in Nutrition, Exercise and Health Sciences. She then went on to graduate medical school and completed her OBGYN residency at The University of Nebraska Medical Center. She currently is in private practice at Mid City OBGYN offering a full range of services in obstetrics, gynecology, robotic surgery and primary care. She is a fellow in Integrative Medicine at The University of Arizona School of Medicine. She is one of the first board certified ketogenic nutrition
    Specialists in the country. She has a passion for fitness, preventative medicine and ketogenic therapy not only in her medical practice but in her own life. She is married to her husband Ben, a police Sargent and has three young daughters. Dr Seeman is also Mrs Nebraska 2020, will compete for Mrs America in January and appeared on NBC Titan games with Dwayne “The Rock” Johnson. 



    Time stamps:
    0:10:46   Jaimee Seeman on the Titan Games
    0:14:37   Infertility outlined
    0:25:01   The effect of vegetarianism on male fertility
    0:27:47   How high fiber diets tank estrogen levels
    0:36:46   How the omega 3:6 ratio influences ovarian and sperm health
    0:39:42   How to properly use birth control
    0:44:38Constructing a fertility-optimization diet
    0:51:22   Riboflavin Lowers Homocysteine in Individuals Homozygous for the MTHFR 677C→T Polymorphism   https://www.ahajournals.org/doi/full/10.1161/circulationaha.105.580332
    0:52:10   Why you should drop your prenatal supplement
    0:55:20   Should you worry about too much liver during pregnancy?  
    0:55:20   Should you worry about eating too much liver during pregnancy?   
    0:55:20   Should you worry about eating too much liver during pregnancy?
    0:58:31   The impossibility of proper vegetarian nourishment  
    1:03:10   Nutritional considerations for pregnancy 
    1:05:01       Nutritional Considerations for Pregnancy                                                                     5 min clip
    1:05:42  Hyperglycemia and Adverse Pregnancy Outcomes   https://www.nejm.org/doi/full/10.1056/nejmoa0707943
    1:07:00   Ketones, carbohydrates, and pregnancy
    1:14:57   Postpartum and breastfeeding
    1:14:57   Effect of dietary macronutrient composition under moderate hypocaloric intake on maternal adaptation during lactation   https://academic.oup.com/ajcn/article/89/6/1821/4596837
    1:26:12   Nutritional support for perimenopause 
    1:32:14   The details on hormone replacement therapy
    1:36:15   How men can best ward off prostate complications
    1:36:55   How polyphenols affect estrogen metabolism
    1:38:58   Getting enough magnesium
    1:40:13Glycine is vital in pregnancy (preventing stretch marks)
    1:42:07   Don't forget about fish!
    1:42:53   What about dairy?
    1:43:41   Where to find Jaime Seeman
    1:43:59   Jaimee Seeman, Miss Nebraska




    Sponsors:
     
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    Sacred Hunting: www.sacredhunting.com/paul
     
    Chilipad/ Ooler: https://www.chilitechnology.com//CarnivoreMD
     
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    • 1 hr 49 min
    Controversial Thoughts: When high cholesterol is GOOD!

    Controversial Thoughts: When high cholesterol is GOOD!

    Is high cholesterol always a bad thing? I say no! Context matters greatly here, as in are you metabolically healthy? Do you know how to assay this? Many people eating an ancestral type diet like carnivore, carnivore-ish, keto, paleo, etc.  (like me!) will see LDL rise, but I don't believe this is a bad thing if we are insulin sensitive/metabolically healthy- this is the importance of context. I discuss the importance of considering context in discussions of LDL, Lp (a), uric acid, and APOE4 in this video. Get ready for a wild ride.  #theremembering 
    Check out heartandsoil.co if you need more nose to tail nutrition in your life. The JRE show notes are there as well.
     

    • 27 min
    What does a mainstream cardiologist think of my cholesterol? With Nadir Ali, MD

    What does a mainstream cardiologist think of my cholesterol? With Nadir Ali, MD

    Dr. Nadir Ali is an interventional cardiologist with over 25 years of experience. He is also the chairman of the Department of Cardiology at Clear Lake Regional Medical Center. Before working as a cardiologist, he served as an assistant professor of medicine for eight years at Baylor College of Medicine in Houston, where he also received his medical training.
     
    Time Stamps:
    0:09:44  Podcast Begins
    0:11:00  Lifestyle change and the power of animal foods
    0:16:38  Is red meat killing us?  
    0:19:32  Humans are not hebivores 
    0:24:31  The problem with mainstream cardiology
    0:31:03  The full story of LDL [and oxidized LDL]
    0:38:22  Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a)  https://www.ahajournals.org/doi/10.1161/01.ATV.0000118012.64932.f4?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
    0:43:23  Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/ 
    0:43:50  Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients  https://www.sciencedirect.com/science/article/abs/pii/S0009308497000959?via%3Dihub
    0:44:44  Linoleic acid is at the root of heart disease  
    0:50:08  LDL and immune health
    0:58:06  Genetic Assessment of Potential Long-Term On-Target Side Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibitors  https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002196
    1:00:11  Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease  https://www.nejm.org/doi/full/10.1056/nejmoa1615664
    1:02:05  Serious adverse events and deaths in PCSK9 inhibitor trials reported on Clinical  Trials.gov: a systematic review  https://www.tandfonline.com/doi/full/10.1080/17512433.2020.1787832
    1:02:56  The dark truth of PCSK9 inhibitors
    1:05:12  Metabolic health is what matters  
    1:07:04  Metabolic health is what matters  
    1:08:07  Let' change the paradigm!
    1:13:21  Dr. Nadir Ali's health optimizaton advice
    1:18:12  Where to find Nadir Ali MD
    1:22:48  Binding and Partial Inactivation of Staphylococcus aureus a-Toxin by Human Plasma Low-Density Lipoproteinhttps://www.jbc.org/content/258/9/5899.long
    1:23:18  Why you should rethink your statin
    1:26:24  The Framingham Study
    1:26:56  High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study  https://www.amjmed.com/article/0002-9343(77)90874-9/pdf
    1:28:51  Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity  https://pubmed.ncbi.nlm.nih.gov/12951168/
    1:29:44  LDL size matters
    1:31:24  Clinical Effects of Cholesterol Supplementation in Six Patients With the Smith–Lemli–Opitz Syndrome(SLOS)  https://www.researchgate.net/publication/14184407_Clinical_effects_of_cholesterol_supplementation_in_six_patients_with_Smith-Lemli-Opitz_syndrome_SLOS
    1:32:56  Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005588/
    1:34:19  Determination of lipid oxidation products in vegetable oils and marine omega-3 supplementshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118035/
    1:34:29  Stop your omega-3 supplement!
     
    Heart & Soil is my passion based company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand and developing a US based supply chain. Check us out at: www.heartandsoil.co, @heartandsoilsupplements on Instagram 



    Belcampo: www.b

    • 1 hr 40 min
    Controversial Thoughts: Do organ meats cause Gout? What does?

    Controversial Thoughts: Do organ meats cause Gout? What does?

    Meat and Organs cause gout, right? Not so fast sea bass! In this controversial thoughts video, I break it all down and discuss how CONTEXT is again critical here and how Western Medicine is myopic in its view of gout. Hint: it's all about metabolic dysfunction, like so many other things!
    Check us out at Heart & Soil (www.heartandsoil.co) if you need more nose to tail nutrition in your life! Send me an email at drpaul@heartandsoil.co if you have questions about diet/organs!
     

    • 22 min
    Is it saturated fat or polyunsaturated fat that’s killing you? With Peter Dobromylskyj from Hyperlipid.

    Is it saturated fat or polyunsaturated fat that’s killing you? With Peter Dobromylskyj from Hyperlipid.

    Petro Dobromylskyj is a veterinarian, trained at the RVC, London University. He was fortunate enough to intercalate a BSc degree in physiology into his veterinary degree. He was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow him to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. He stumbled onto nutrition completely by accident. Once you have been taught to think, it's hard to stop.
     
    Time Stamps:
     
    0:08:42  Podcast Begins
    0:09:52  Peter's Background
    0:16:36  The Electron Transport Chain
    0:45:30  Insulin resistance is a cellular antioxidant defense mechanism   https://www.pnas.org/content/106/42/17787
    0:47:50 High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates   https://www.researchgate.net/publication/5929069_High_rates_of_superoxide_production_in_skeletal-muscle_mitochondria_respiring_on_both_complex_I-_and_complex_II-linked_substrates
    0:49:50  We need insulin resistance
    0:54:53  All about a1a
    1:00:37  How PUFAs affect mitochondria
    1:02:40  PUFAs and cellular lipid accumulation
    1:05:34  Pathological insulin sensitivity  
    1:07:52  Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4  https://www.sciencedirect.com/science/article/abs/pii/S1388198107002296?via%3Dihub
    1:12:34  The center of metabolic health: the adipocytes 
    1:14:08  PUFAs and tumor growth
    1:15:52  Eating the perfect ratio of fatty acids
    1:20:18  Differential Metabolic Effects of Saturated Versus Polyunsaturated Fats in Ketogenic Diets  https://academic.oup.com/jcem/article/89/4/1641/2844241
    1:20:18  How PUFAs break your metabolism
    1:23:20  Premature Atherosclerosis Associated With Monogenic Insulin Resistance  https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
    1:25:21  Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/
    1:30:16  Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/
    1:30:53  Context matters in interpreting lipids
    1:36:49  You might want to rethink your avocado and olive oil
    1:40:17  Plant are not benevolent
    1:47:55  How to find Peter Dobromylskyj
    1:51:01  Peter's radical running habits
    1:53:54  Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet   https://www.cambridge.org/core/product/identifier/S0007114502000673/type/journal_article
    1:55:42  The roots of the chronic disease epidemic
    1:58:23  Diet Fat Composition Alters Membrane Phospholipid Composition, Insulin Binding, and Glucose Metabolism in Adipocytes from Control and Diabetic Animals  jbc.org/content/265/19/11143.long
    1:59:29 Insulin-sensitive obesity   https://journals.physiology.org/doi/full/10.1152/ajpendo.00586.2009?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org




    Heart & Soil is my passion based company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand and developi

    • 2 hr 5 min
    Controversial Thoughts: How does bloodwork look on a nose to tail carnivore diet?

    Controversial Thoughts: How does bloodwork look on a nose to tail carnivore diet?

    What does bloodwork look like on a Nose to Tail Carnivore diet? Find out in this detailed video in which I review @KarnivoreKurt 's bloodwork with him and add detailed commentary. Spoiler alert: It looks amazingly good because animal-based diets are what humans are designed to eat! Check us out at www.heartandsoil.co if you need more nose to tail nourishment in your life! Welcome to The Remembering... 
     
    Firestarter and Gut & Digestion are out now in addition to Beef Organs and Bone Marrow & Liver. Blood Builder and Histamine & Immune are out now as well!  Yeehaw!
     

    • 33 min

Customer Reviews

4.8 out of 5
1.1K Ratings

1.1K Ratings

jamesallin90 ,

Awesome!

So glad to just happen to catch you on the JRE pod. So helpful and hopeful since I have troubles with my LDL and HDL and suffer from gout at the ripe age of 30. Keep it up!

P_hob ,

Paul is the best

He’s so detailed and thorough and he’s truly dedicated to providing guidance for humans to become better in totality.

Waltznight ,

Well-researched & essential listen

As a self-proclaimed veggie-holic, I was initially wary of the carnivore diet. Thankfully, I heard Dr. Saladino on Chris Kresser (even though I initially didn’t want to listen), and was blown away by his thoughtful, data-driven, respectful approach to diet and lifestyle. Although I’m far from full-blown carnivore, I appreciate the spectrum of plant toxicity that Dr. Saladino discusses, and love his female-centric content (more Jaime Seeman!). Keep up the great content! And please make a “stay radical” tank with just the front design on it and no back design :)

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