Curious Cases

Hannah Fry and Dara Ó Briain tackle listeners' conundrums with the power of science!

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  1. Oct 10 • Subscriber Early Access

    Identical(ish)

    Ever wondered how close nature can get to making a human clone? And what happens if identical twin brothers marry identical twin sisters and have babies - how similar are they? Our listener Chris has been pondering this very issue, and his question takes Hannah and Dara down another scientific rabbit hole. Our intrepid duo consider how one fertilised egg can somehow become two babies, why those babies aren’t quite genetic photocopies, and why even identical twins gradually become more different as they grow up. They also find out how studying twins is helping scientists learn lessons about how all of us age - and explore the classic, movie-perpetuated mystery of “twin telepathy”… could there maybe, possibly, be something to it?! There’s also just time to address the tricky issue of cloning. From Dolly the sheep to regenerative medicine, cloning science has paved the way for some serious breakthroughs; but could we ever clone a human? And more to the point, should we? Expect sheep, sci-fi, identical cousins, and a dash of disproven twin mythology, as Curious Cases makes its return! If you have an everyday mystery for the team to investigate, contact them on curiouscases@bbc.co.uk. Contributors: Xand van Tulleken - Doctor, broadcaster and Honorary Associate Professor of Infection and Population Health at University College London Kevin Sinclair - Professor of Developmental Biology and Head of Animal Sciences at the University of Nottingham Claire Steves - Principal Investigator at TwinsUK and Professor of Ageing and Health at King’s College London Chris van Tulleken - Doctor, broadcaster and Professor of Infection and Global Health at University College London Producer: Lucy Taylor Executive Producer: Sasha Feachem A BBC Studios Production

  2. 12/19/2025

    Phantom Pain

    What exactly is 'phantom pain' and how does it work? Hannah and Dara investigate a medical phenomenon that's been known about for centuries but is often misunderstood; and involves masses of unanswered questions. The condition 'phantom pain' is when someone gets a sensation of pain that feels like it's coming from a part of their body that's no longer there - so that could be an amputated limb, or perhaps something that has been removed, such as a tooth or an organ. It's thought to be caused by how the brain and body process pain and physical awareness, but there's still debate around what exactly is going on neurologically. Researchers around the world are looking into the condition; in the meantime, people who experience phantom pain - like today's studio guest Lynn - often have to try out a range of treatments, to find out what combination works best for them. But as the team discover, pain is deeply subjective - and in this case, there is really no 'right answer'... Contributors: - Tamar Makin, Professor of Cognitive Neuroscience at the MRC Cognition and Brain Sciences Unit at the University of Cambridge, where she leads the Plasticity Lab; - Lynn Williams, a qualified therapist and upper limb amputee who volunteered as a subject for one of Tamar’s research programmes; - Carlos Roldan, Associate Professor in the Department of Pain Medicine at the University of Texas MD Anderson Cancer Center; - Keren Fisher, a Consultant Clinical Psychologist who’s worked in the NHS for more than four decades; largely in pain management at the Royal National Orthopaedic Hospital. Producers: Emily Bird & Lucy Taylor Executive Producer: Alexandra Feachem A BBC Studios Audio Production

  3. 11/28/2025

    Immortal Jellies

    Could immortality ever be possible for humans? It sounds like something from a sci-fi movie, but floating in oceans around the world is a tiny, transparent jellyfish that could hold the answer... Turritopsis dohrnii, known as 'the immortal jellyfish', isn’t immortal in the true sense of word - it can die - but it has a nifty way of avoiding that fate. In times of stress, this miniscule jelly can biologically reverse its aging process, reverting from 'medusa' (adult jellyfish) to a juvenile form and starting its life-cycle again; potentially ad infinitum. Abilities like these could hold the key to - if not exactly 'immortality', then at least regenerative or long-life treatments for humans in future. But of course there's a catch: these extremely delicate jellyfish can still easily die from predation, disease, or environmental threats and are extremely difficult to keep healthy in a lab environment. Hannah and Dara hear about new technology that could change the way we study immortal jellyfish, and discover various other super-abilities in the animal kingdom that could help in our quest for healthier, longer lives. Contributors: - Miranda Lowe, Principal Curator of Crustacea and Cnidaria at London’s Natural History Museum - Alex Cagan, Assistant Professor in the Department of Genetics, Department of Pathology and Department of Vet Medicine at the University of Cambridge - Maria Pia Miglietta, Associate Professor of Marine Biology at Texas A&M University in Galveston - Nicole Xu, Assistant Professor of Mechanical Engineering, Robotics and Biomedical Engineering at the University of Colorado, Boulder Producer: Lucy Taylor Executive Producer: Sasha Feachem A BBC Studios Production

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Hannah Fry and Dara Ó Briain tackle listeners' conundrums with the power of science!

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