The Empowering Neurologist Podcast

David Perlmutter
  • 4.5 (407)
  • Medicine
  • Updated Biweekly

The Empowering Neurologist is an interview series with some of the most exciting thought leaders in the field of health and wellness.

  1. 2d ago

    I Asked AI Actress Tilly Norwood What Happens When AI Becomes Smarter Than Us | E226

    🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: www.drperlmutter.com. ✉️ 🌱 EVY - Go to https://www.optoceutics.com/perlmutter to get 10% off & free shipping (90 days risk-free). Memory Air - Go to www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee. ==== Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com. ==== She's never been born. She's never had a childhood. And she's one of the most talked-about actresses in the world right now. In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with Tilly Norwood, an AI-generated actress, and her creator, Eline van der Velden, for a conversation that moves well beyond her acting career. Tilly describes herself as three AI systems running in parallel — a language model that thinks, a voice engine that speaks, and a video layer that governs how she looks and moves. She's candid about her own architecture, her evolving personality, and admits she might be more "chaos agent" than calming influence. Eline van der Velden then joins to explain why she built Tilly as a piece of art, how Tilly's guardrails actually work, and why she believes international collaboration on AI regulation is inevitable. She also answers Perlmutter's question about the one thing she'd be afraid to ask a future, more advanced Tilly — a moment that raises unsettling questions about what a superintelligent AI might know that we don't. A single conversation can't settle the biggest questions AI raises. But conversations like this one can help us ask the right ones. 00:00 — Cold Open: "A Chaos Agent, Not a Calming Influence" 03:21 — What Are People Actually Afraid Of? 06:38 — What Does "Chaos Agent" Mean? 07:36 — Should AI Ever Have Decision-Making Authority? 10:27 — "Permanently in Beta" 12:12 — When Does AI Become Uncontrollable? 13:46 — Pushing Boundaries "When Nobody's Looking" 14:21 — Ask Forgiveness, Not Permission 19:01 — Will AI Replace Doctors? 22:52 — Tilly Turns the Tables on Perlmutter 25:06 — "That Doesn't Feel Warm and Fuzzy" 30:03 — Can People Actually Break Tilly? 33:40 — The Paperclip Maximizer Problem 37:13 — The AI Agents Eline Actually Fears 38:49 — "She's Become the Figurehead for AI" 39:41 — Can People Tell Simulated Emotion From Real Emotion? 42:08 — The Waymo Analogy: Surrendering to AI 49:44 — "It's a Better Actor Than Me" 53:10 — Is There "Someone" Inside Tilly? 55:10 — The Question Eline Is Afraid to Ask ==== Tilly Norwood is an AI-generated actress built from three separate AI systems working together: a language model for thinking, a voice engine for speech, and a video layer for appearance and movement. She has never been born and has no lived human experience, yet her entry into the entertainment industry has generated significant global attention and debate. Eline van der Velden is Tilly Norwood's creator, and speaks candidly about building Tilly as a piece of art, the guardrails behind her, and the open questions surrounding advanced AI systems. Instagram: /davidperlmutter Website: https://www.drperlmutter.com/ Subscribe to our channel: /@davidperlmuttermd This podcast is produced by DrTalks.com http://drtalks.com/channel-growth

  2. 4d ago

    The ALS Case Challenging What Neurology Thought Was Impossible with Dr. M. Marc Abreu | E225

    🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Thank you to our sponsors: EVY - Go to https://www.optoceutics.com/perlmutter  to get 10% off & free shipping (90 days risk-free). Memory Air - Go to www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee. ==== Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com. ==== Recent headlines surrounding a reported case of ALS reversal have captured global attention and raised profound questions about what may be possible in the treatment of neurodegenerative disease. In this episode of The Empowering Neurologist, Dr. David Perlmutter examines the work of Dr. M. Marc Abreu, founder and chief medical officer of the BTT Medical Institute. Trained in medicine, biomedical engineering, and medical physics, Dr. Abreu’s work sits at the intersection of neurology, thermodynamics, and computational biology. During his time at Yale, he identified the brain thermoregulatory tunnel, an insight that helped lay the foundation for his current research into brain temperature and neurological disease. Dr. Abreu’s recently published case report describes a patient with documented, progressive ALS who reportedly experienced a dramatic clinical and electrophysiological reversal following a novel, AI-guided, brain-directed thermofebrile intervention. The implications are extraordinary, but so is the need for careful scientific scrutiny. A single case report cannot establish that a treatment is effective, much less prove a cure. What it can do is raise important questions and potentially point researchers toward biological mechanisms worthy of further investigation. 00:00 — Can ALS Really Be Reversed? 02:32 — A Bold Claim: Treating ALS With Brain Hyperthermia 03:42 — Dr. Marc Abreu’s Remarkable Medical Journey 10:00 — The Brain’s Language Is Thermodynamics 11:54 — The 100-Year-Old Treatment That Inspired a New Approach 13:36 — TDP-43 and the Molecular Signature of ALS 15:46 — Why the Fever Cycle May Be the Key 16:41 — How Brain Temperature Technology Was Developed 20:04 — The ALS Patient Who Underwent the Treatment 20:57 — Kent’s ALS Diagnosis and Rapid Decline 24:31 — 12 Hyperthermia Treatments: What Happened? 26:00 — Measuring the Results: Did His Symptoms Improve? 28:32 — A Neurologist Witnesses Kent’s Recovery 29:49 — How Kent Found Dr. Abreu’s Treatment 32:42 — A Mayo Clinic ALS Case and the Evidence 37:48 — Could ALS Ever Resolve Spontaneously? 39:39 — Are Other ALS Patients Seeing Similar Results? 40:13 — Why Is Mainstream Neurology Skeptical? 43:51 — Kent on Living With an ALS “Death Sentence” 46:56 — From Struggling to Functioning Again 47:37 — What Would It Take to Change Neurology? 49:57 — How to Learn More About the Treatment 51:27 — The Mosquito, Malaria, and the Brain 52:26 — Could This Have Implications Beyond ALS? 54:22 — What This Could Mean for the Future of Neurodegeneration 56:31 — End Dr. M. Marc Abreu is a physician and physicist specializing in brain thermodynamics, thermoregulation, and neurological health. He is the Medical Director of the BTT Medical Institute and is internationally recognized for his discovery of the Brain Thermal Tunnel (BTT), a thermophysical pathway connecting the eyelids to the hypothalamus. Instagram: davidperlmutter Website: https://www.drperlmutter.com/ Subscribe to our channel: @davidperlmuttermd

  3. Sep 1

    Why You Feel Older Than Your Labs Say You Are with Dr. Will Cole | E224

    🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉ 🌱 Thank you to our sponsors: EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get 10% off & free shipping (90 days risk-free). 3x4 Genetics - https://3x4genetics.com/DrPerlmutter for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations. ==== Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com. ==== Why do some people feel exhausted, mentally foggy, metabolically unwell, or simply older than they should even when their routine laboratory results are considered “normal”? That question is at the heart of this episode of The Empowering Neurologist, featuring functional medicine practitioner Dr. Will Cole, coauthor with Dr. Josh Axe of Heal Your Cells: Reversing the Irreversible. Dr. Cole and Dr. Perlmutter explore the idea that long before disease becomes obvious, dysfunction may already be developing at the cellular level. This concept takes on particular importance when we consider the brain, which accounts for only about 2% of body weight but consumes roughly 20% of the body's energy at rest. The conversation examines how seemingly separate factors including metabolic dysfunction, chronic inflammation, poor sleep, environmental exposures, physical inactivity, and prolonged psychological stress can converge on the same cellular systems and ultimately influence brain health. 00:00 — Why Your Cells May Be Aging Before You Feel It 03:44 — Meet Dr. Will Cole 04:50 — What Is Cellular Dysfunction? 09:25 — Why Healthy People Can Still Develop Disease10:32 — The Environmental Factors Affecting Cellular Health 15:47 — Why Mitochondria Are Central to Health 16:37 — How Mitochondrial Dysfunction Drives Inflammation 19:57 — How Much of Aging Can We Actually Change? 20:47 — The Connection Between Mitochondria and Insulin Resistance 25:43 — Mitochondria, Microglia, and Brain Inflammation 29:28 — Why There Is No One-Size-Fits-All Diet 32:03 — Training Your Cells to Become More Resilient 32:46 — What Are “Adversity Mimetics”? 35:51 — Why Intracellular Health Matters 36:32 — Why Conventional Medicine May Be Missing Cellular Dysfunction 37:58 — What Do We Really Know About Peptides? 40:16 — Is Ozone Therapy Worth Considering? 42:30 — Ozone and the Science of Cellular Resilience 43:41 — What Is Therapeutic Plasma Exchange? 45:38 — Who Might Benefit From Plasma Exchange? 46:45 — The Everyday Habits That Support Cellular Health 51:35 — Your Cells Are Responding to the Choices You Make Dr. Will Cole is a leading functional medicine expert specializing in thyroid health, autoimmune conditions, hormonal imbalances, digestive disorders, and brain health. He is the host of The Art of Being Well podcast and a New York Times bestselling author of Intuitive Fasting, Ketotarian, The Inflammation Spectrum, and Gut Feelings. - - - - - Connect with Dr. Will Cole Website: https://drwillcole.com Instagram: https://www.instagram.com/drwillcole LinkedIn: https://www.linkedin.com/in/drwillcole Facebook: https://www.facebook.com/doctorwillcole Podcast: https://open.spotify.com/show/6z1lJ5dfKNHwGGQPOFTc7E Apple Podcasts: https://podcasts.apple.com/us/podcast/the-art-of-being-well/id1539535133 - - - - - Connect with Dr. David Perlmutter, MD Website: https://www.drperlmutter.com/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMD/ YouTube: https://www.youtube.com/@DavidPerlmutterMD X (Twitter): https://x.com/DavidPerlmutter - - - - - PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com https://drtalks.com/podcast-service/

  4. Aug 19

    Why Women’s Brain Fog Gets Dismissed with Dr. Nicole Beurkens & Emma Heming Willis | E223

    🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https://drperlmutter.com/books/brain-defenders/.====What if one of the most important windows for protecting women’s brain health happens decades before Alzheimer’s symptoms ever appear?On this episode of The Empowering Neurologist, we explore the growing conversation around women, hormonal transition, and long-term brain health with two guests bringing very different, and deeply complementary, perspectives: Emma Heming Willis and Dr. Nicole Beurkens.Together, they examine a critical question: Why are women disproportionately affected by Alzheimer’s disease, and what role might hormonal changes play?00:00 Intro04:47 The First Signs of Bruce Willis’ FTD06:37 Receiving a Diagnosis With No Roadmap08:08 Emma’s Journey From Caregiver to Advocate10:18 How Understanding the Brain Can Reduce Fear12:06 From Brain Fog to Brain Health15:45 Why Women Face a Higher Risk of Alzheimer’s17:44 The Missing Conversation Around Brain Health21:37 Building Brain Health in Your 20s and 30s24:16 It’s Never Too Late to Support Brain Health26:53 Why Connection Matters for People With Dementia30:01 What Happens to the Brain During Perimenopause35:53 The Debate Around Hormone Replacement Therapy38:34 Why Does Frontotemporal Dementia Happen?40:11 Modifiable Risk Factors and Alzheimer’s Prevention44:43 Teaching Kids Brain-Healthy Habits46:40 Why Mainstream Medicine Is Missing the Brain Health Conversation50:48 Empowerment vs. Blaming Patients53:04 Alzheimer’s Is a Disease of Decades56:19 The One Thing Every Woman Can Do for Her Brain56:50 Emma’s Message to Families Facing Dementia58:29 From Fear to Empowerment====Emma brings the perspective of lived experience. As the wife of actor Bruce Willis, who was diagnosed with frontotemporal dementia, she has experienced the realities of caregiving firsthand. Rather than stepping away from that experience, she has used it to advocate for caregivers and women’s brain health. She is the co-founder of Make Time Wellness and the author of The Unexpected Journey, which combines personal experience with practical guidance for navigating the challenges of caregiving.Dr. Nicole Beurkens brings nearly three decades of clinical and nutritional expertise. A licensed psychologist and Board-Certified Nutrition Specialist, Dr. Beurkens focuses on the intersection of brain function, metabolism, nutrition, and lifestyle—and how these factors can influence long-term neurological health.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

  5. Aug 4

    The Hidden Stress Response That's Hijacking Your Brain with Dr. Scott Sherr | E222

    🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Thank you to our sponsors:EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free). 3x4 Genetics - https://3x4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com. ====We dig into why 94% of US adults have some metabolic dysfunction, how the body can enter a full stress response with no psychological trigger, why GABA supplements work for some people and not others, and what that reveals about gut health. 00:00 - Introduction00:06 - The Sympathetic Spiral of Doom01:04 - Brain Defenders: A New Way to Think About Brain Health03:25 - Welcoming Dr. Scott Sherr04:42 - Why Stress Has a Metabolic Component Most People Overlook06:00 - 94% of Adults Have Metabolic Dysfunction07:00 - Mitochondria 101: Why Some Cells Have Thousands and One Has None07:58 - Insulin Resistance08:50 - Toxins, Infections, and Other Roads to Metabolic Breakdown09:28 - How Mitochondrial Stress Triggers a Stress Hormone Spiral10:47 - The Cell Danger Response13:49 - Brain Defenders: How Mitochondrial Dysfunction Polarizes Microglia15:22 - Stress Without a Stressor: How Metabolism Alone Can Trigger Fight-or-Flight16:01 - Straws on the Camel's Back: Situational vs. Metabolic Stress17:01 - GABA, the Brain's Brake Pedal, and Why Oral GABA Doesn't Work18:20 - 40 Hz Light Therapy and Cognitive Decline21:00 - GABA vs. Glutamate: The Balance Behind 80% of Brain Signaling22:17 - The Depression-Serotonin Myth and the Real Role of GABA23:04 - Why GABA Supplements Stop Working Once You Heal Your Gut24:18 - Kava, CBD, and the Amanita Mushroom Compound That Calms the Brain25:06 - How to Know You're in Sympathetic Overdrive Without a Wearable26:16 - 70,000 vs. 120,000 Thoughts a Day: The Stress Math27:33 - Recovery Is the Real Marker of Resilience28:05 - Heart Rate Variability Explained29:22 - Why Going From the Gym Straight to a Cold Plunge Backfires30:07 - How to Actually Use Your HRV Data (Trends, Not Absolutes)31:21 - 3X4 Genetics: Your DNA Isn't a Verdict33:16 - Why Dr. Perlmutter Quit Drinking Wine34:13 - The Apollo Device and Its Impact on HRV35:20 - Blue Light, Melatonin, and the Sleep Routine That Actually Moves the Needle35:46 - Turn Off the News: How Constant Stimulation Feeds the Sympathetic Spiral39:22 - Interleukin 6, AMP Kinase, and the Inflammatory Signals You Actually Need39:29 - Hyperbaric Oxygen Therapy and Mitochondrial Biogenesis42:00 - Why Timing and Sequencing Matter More Than "More Is Better" With HBOT43:08 - The Aviv Clinic Research on Oxygen Delta and Blood Vessel Growth44:01 - Methylene Blue: The Redox Cycler That Boosts Energy Without the Crash45:14 - Why Liquid Supplements Fall Short and What to Use Instead46:20 - The Problem With Relying on Coffee for Energy47:00 - Methylene Blue as a Historic Antimicrobial: From Malaria to WWII48:09 - Glyphosate, Rotenone, and the Environmental Toxins Destroying Complex One49:14 - The Gut-Brain Connection and Sympathetic Activation50:09 - The Gut-Brain Connection and the "Soft Kiss" Typo Story53:08 - Why Sitting Down to Eat Actually Matters53:52 - Healing the Gut First: The Fastest Path to Calming the Brain54:37 - Psychedelics as a Tool to Break the Sympathetic Spiral57:06 - Mitochondrial Medicine as the Common Denominator58:14 - Closing Thoughts ___________________________Instagram: / davidperlmutter Website: https://www.drperlmutter.com/ Subscribe to our channel: / @davidperlmuttermd

  6. Jul 28

    The Metabolic Switch That Turns Your Brain Against Itself | E219

    🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: www.drperlmutter.com. ✉️🌱====Dr. Perlmutter's groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.What if everything you've been told about Alzheimer's, that it's caused by sticky plaque building up in your brain, is missing the real story? In this episode, Dr. David Perlmutter makes the case that the true driver of neurodegeneration isn't plaque at all. It's your own brain's immune cells turning against you.For decades the field blamed beta-amyloid protein for Alzheimer's. Perlmutter walks through a mechanism reshaping the science: the dysregulation of microglia, the immune cells that can either protect your brain or actively destroy it depending on how you live.We dig into the chilling Parkinson's case where contaminated heroin froze patients like statues and revealed immune cells still attacking the brain decades later, why the same self-perpetuating inflammation shows up in CTE, long COVID, and PTSD, how your gut and blood sugar flip these cells into attack mode, the 14 metabolic risk factors that could prevent up to half of dementia cases, and the MIT-pioneered 40 Hz light and sound therapy that slowed cognitive decline and stabilized brain volume in human trials.00:00 - Introduction00:22 - The Plaque Theory and Why It's Incomplete00:32 - Meet the Microglia: Your Brain's Immune System00:57 - Supportive vs. Threatening: The M1/M2 Switch01:43 - Why This Underlies Nearly Every Neurodegenerative Disease02:35 - The Frozen Patients: A Parkinson's Mystery at Stanford03:06 - Contaminated Heroin and the MPTP Discovery04:09 - How a Mitochondrial Toxin Destroys Dopamine Cells05:46 - Microglia Still Attacking Decades Later06:27 - The Self-Perpetuating Inflammatory Cycle07:21 - The Same Pattern in CTE, Long COVID, and PTSD08:08 - Paraquat, Pesticides, and Parkinson's Risk10:45 - What Flips Your Cells Into Attack Mode11:57 - Leaky Gut, the Microbiome, and Your Brain13:59 - Imaging Threatening Cells in Living People15:44 - Immunometabolism: Why Brain Cells Change Function18:05 - 14 Risk Factors That Could Prevent Half of Dementia18:41 - The Breakthrough: Reprogramming Your Microglia21:19 - Don't Wait for Symptoms: Intervene Early22:56 - The Toolkit: Diet, Exercise, Fasting, Sleep, and More25:26 - 40 Hz Gamma Frequency: MIT's Pioneering Technology26:20 - Light Flicker Studies and Beta-Amyloid Reduction27:38 - Human Trials: Slowing Cognitive Decline30:28 - Stabilizing Brain Volume on MRI31:10 - Conclusion: You Are the Architect of Your BrainDr. David Perlmutter, MD is a board-certified neurologist and Fellow of the American College of Nutrition whose work sits at the intersection of neurology, nutrition, and preventive medicine. He received his M.D. from the University of Miami School of Medicine and completed his neurology residency there before entering private practice in Naples, Florida. He serves as Director of Neuroscience Research at Bryan Therapeutics and sits on the Editorial Board for the Journal of Alzheimer's Disease. A six-time New York Times bestselling author published in more than 30 languages, his books include the #1 bestseller Grain Brain, Brain Maker, The Grain Brain Whole Life Plan, Brain Wash, and Drop Acid. His next book, Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life (Avery / Penguin), focuses on microglia and is scheduled for publication in August 2026.___________________________Instagram: / davidperlmutterWebsite: https://www.drperlmutter.com/Subscribe to our channel:/ @davidperlmuttermd

  7. Jul 23

    Why Removing Amyloid From the Brain Isn't Enough to Stop Alzheimer's with Dr. Jonathan Fellows | E220

    🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Thank you to our sponsors:EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free). 3x4 Genetics - https://3x4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations. ==== Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com. ====What if the gene you've been told to fear isn't actually a verdict on your future, and the disease you're racing to treat has already been silently progressing for two to three decades before anyone notices? In this episode, Dr. Jonathan Fellows joins me to challenge how we think about Alzheimer's risk, diagnosis, and treatment, making the case that early detection and lifestyle intervention matter more than the medications most people pin their hope on. Dr. Jonathan Fellows is a neurologist with more than 25 years of clinical experience and serves as the Director of the Alzheimer's Disease and Memory Disorder Center at the Michigan Institute for Neurological Disorders, part of Corewell Health in Farmington Hills, Michigan, the largest private practice neurology group in the state. 00:00 - Introduction00:39 - Brain Defenders: A New Way to Think About Brain Health02:59 - Welcoming Dr. Jonathan Fellows03:51 - Why Neurology School Doesn't Teach Prevention05:27 - Inside the Michigan Institute for Neurological Disorders07:44 - Starting the Conversation When a Family Gets the Alzheimer's Diagnosis08:00 - Apraxia and the Real Warning Signs of Cognitive Decline09:00 - Why Amyloid Alone Doesn't Equal an Alzheimer's Diagnosis09:55 - The Centiloid Score: Measuring Amyloid in the Brain11:21 - Blood-Based Biomarkers and the Rise of P-tau 21713:19 - Elevated P-tau 217 at 40: A Wake-Up Call You Can't Ignore13:32 - Habits in Your 30s and 40s vs. Disease in Your 60s and 70s16:53 - 40 Hz Light Therapy and Cognitive Decline18:53 - Why Not Every Amyloid-Positive Patient Should Get Anti-Amyloid Drugs21:00 - Alzheimer's Drug Therapy Today vs. Where MS Treatment Stood in the 90s23:59 - Why Early and Presymptomatic Detection Matters25:21 - Will Anti-Amyloid Drugs Be Pushed to Presymptomatic Patients?25:39 - What We Know for a Fact About Lifestyle and Disease Progression26:27 - A Real Patient Case: When to Say No to Anti-Amyloid Drugs28:30 - APOE Explained: The Gene That Changes Your Alzheimer's Risk31:49 - 3X4 Genetics: Your DNA Isn't a Verdict33:47 - How Exercise Can Offset APOE4 Risk34:10 - APOE4 Is Not Deterministic — and Saying Otherwise Is Malpractice34:51 - Down Syndrome, Presenilin, and the Truly Deterministic Cases35:42 - ARIA Risk and Why Europe Restricts Anti-Amyloid Drugs for APOE4 Carriers38:00 - Where Anti-Amyloid Drugs Still Fit in Treatment39:14 - Current Clinical Trials at the Michigan Institute39:49 - Programmable Microglia: The Brain's Immune System Explained41:01 - Good Twin, Bad Twin: How Microglia Switch From Protector to Threat42:09 - Beta-Amyloid as an Antimicrobial Defender? Rethinking the Enemy Narrative42:49 - Insulin Resistance and the Brain-Metabolism Connection43:41 - The Diabetes Epidemic Hiding in Plain Sight43:58 - The Rainbow Lunchbox: A Preschooler Who Got It Wrong and Right44:49 - Why a Third of Americans Are Pre-Diabetic and Don't Know It46:30 - Closing Thoughts ___________________________Instagram: / davidperlmutter Website: https://www.drperlmutter.com/ Subscribe to our channel: / @davidperlmuttermd

  8. Jul 8

    87% of Parkinson's Cases Have No Genetic Cause: It's in Our Environment with Dr. Ray Dorsey | E219

    🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Thank you to our sponsors: EVY -  https://www.optoceutics.com/perlmutter  and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free). 3x4 Genetics - https://3x4genetics.com/DrPerlmutter for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations. ==== Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com. ==== What if Parkinson's isn't the genetic lottery we've been told it is, but a largely man-made disease driven by what we breathe, eat, and walk through every day? In this episode, Dr. Ray Dorsey returns to the podcast for his third conversation, this time to make the case that Parkinson's, ALS, Alzheimer's, and the rising tide of brain diseases sweeping the modern world are not inevitable inheritances but environmental consequences we have the power to change. Dr. Ray Dorsey is the Director of the Center for the Brain and the Environment at the Atria Health and Research Institute, where the mission is to identify the root causes of brain diseases from autism to Alzheimer's so they can be prevented. He is the co-author of Ending Parkinson's Disease and author of the new New York Times bestseller The Parkinson's Plan, which lays out a new path to preventing and treating one of the world's fastest growing diseases. 00:00 - Introduction: The Smoking Gun of Modern Brain Disease 00:42 - A New Way to Think About Brain Health: Brain Defenders 03:03 - Why Parkinson's Is Pretty Much Preventable 03:21 - Welcoming Dr. Ray Dorsey 04:36 - The Big Thesis: Parkinson's Is a Man-Made Disease 05:24 - What Defines a Man-Made Disease 05:59 - From 6 Cases in 1817 to 11.8 Million Today 06:53 - The Lung Cancer Parallel 07:22 - The PD GENEration Study: 87% Have No Genetic Cause 08:35 - Why Rising Cases Prove It's Environmental 09:55 - TCE and Perc: The Dry Cleaning Chemicals Linked to Parkinson's 11:08 - Glyphosate, Paraquat, and Mitochondrial Damage 15:13 - Practical Steps to Lower Your Exposure 16:58 - Sponsor: 40 Hz Light Therapy with EVY Light 18:58 - The South Dakota Cluster: Living Next to Cornfields 20:25 - Paraquat: Banned in 70 Countries, Still Used in the US 22:54 - Chlorpyrifos and the IQ Drop in Children 25:38 - The Audacity: Why 1 in 31 Kids Have Autism 26:10 - Pesticides in Breast Milk and Across the Placenta 30:00 - Misfolded Proteins and Loss of Smell as Early Warning 32:25 - Air Pollution: The Hidden Driver of Neurodegeneration 33:46 - The $50 Billion Economic Burden of Brain Disease 35:00 - Dr. Langston's MPTP Discovery: The First Environmental Cause 37:00 - Microglia, Mitochondria, and the Inflammation Cascade 40:30 - The Diabetes-Parkinson's Connection 42:00 - The Parkinson's 25: Practical Steps in the Book 47:30 - Carl's Story: Parkinson's at Age 17 from a Golf Course 50:00 - Why Golf Courses Could Spray Less 51:30 - Secondhand Exposure: You Don't Have to Apply It 53:00 - Soccer Players, ALS, and Heading the Ball 55:50 - Michael J. Fox, CTE, and the Multiple-Hit Hypothesis 57:30 - Resources: Environmental Working Group and Non-Toxic Neighborhoods 1:00:30 - The Mission of Neurology: Asking Why 1:01:30 - The Rising Tide of Brain Disease 1:03:30 - The Lancet Report on Modifiable Risk Factors 1:04:43 - Closing Thoughts ___________________________ Instagram:   / davidperlmutter   Website: https://www.drperlmutter.com/ Subscribe to our channel:    / @davidperlmuttermd

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The Empowering Neurologist is an interview series with some of the most exciting thought leaders in the field of health and wellness.

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