The Big Unlock

Rohit Mahajan & Ritu M. Uberoy

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Technology
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THE BIG UNLOCK PODCAST is a Healthcare Digital Transformation Podcast. Stay Updated on Healthcare’s Digital Transformation Trends. Featuring C-suite Leaders and Insights on Digital Health Innovation. Explore Emerging Healthcare Technologies with Rohit Mahajan and Ritu M. Uberoy.

20h ago

Episode 225 – Moving Healthcare AI from Conversation to Execution

The Big Unlock · Shailu Verma, Chief Executive Officer, Co-founder, Mila Health In this episode, Shailu Verma, CEO and Co-founder of Mila Health, explores how healthcare AI is moving beyond patient engagement and conversational tools toward AI agents that execute care coordination workflows. He explains that many critical tasks across the patient journey remain manual, creating an opportunity for AI to improve access, engagement, operational efficiency, and outcomes. Shailu emphasizes that scaling AI requires more than another point solution. AI must integrate seamlessly into existing clinical technology, remain configurable and governable, deliver consistent responses, and bring humans into the loop when needed. He sees LLMs becoming increasingly commoditized, making the last mile of execution, governance, and workflow integration critical differentiators. Shailu urges healthcare leaders to start with measurable problems where AI can demonstrate real ROI. His message is clear: move AI from conversation to execution, automate manual coordination, and focus on getting meaningful work done. Take a listen.
Sep 1

Episode 224 – AI Can Augment Clinical Judgment Without Replacing It

The Big Unlock · Dr. Ami Bhatt, Chief Medical Officer, WHOOP In this episode, Dr. Ami Bhatt, Chief Medical Officer at WHOOP and former Chair of the FDA Digital Health Advisory Committee, explores how healthcare can embrace AI without losing the clinical judgment, human connection, and context essential to patient care. She sees AI as a powerful source of compute that can surface knowledge, identify patterns, and help clinicians navigate growing volumes of health data, while clinical acumen remains central to decision-making. Dr. Bhatt emphasizes that digital health and Agentic AI must start with the patient, incorporate individual preferences, and establish clear guardrails for when human intervention is required. She also highlights wearables as an important bridge between community-based monitoring and clinical care. Dr. Bhatt highlights the need for post-deployment monitoring and real-world evidence as AI systems continuously evolve, and calls for closer collaboration among patients, clinicians, technology companies, and regulators. She urges healthcare leaders to prepare for constant technological change, develop stronger digital infrastructure, and focus innovation on unmet patient needs rather than technology for its own sake. Take a listen. This episode was recorded in July 2026. Dr. Bhatt is now Chief Medical Officer at WHOOP.
Aug 25

Episode 223 – From Legacy Systems to AI-Native Healthcare in Rural America

The Big Unlock · Michael Archuleta, Chief Information Officer, Mt. San Rafael Hospital and Clinics In this episode, Michael Archuleta, Chief Information Officer at Mount San Rafael Hospital, explores how technology can help rural health systems deliver high-quality, patient-centered care regardless of geography. He discusses the hospital’s transition to an AI-native Oracle Health platform and emphasizes that digital transformation should follow the patient journey, reduce clinician burden, improve interoperability, and enable better outcomes. Michael sees AI, ambient technology, remote patient monitoring, and interoperability as important tools for improving clinical outcomes, reducing administrative burden, expanding access in rural communities, and giving clinicians more time to focus on patients. He also emphasizes that cybersecurity is fundamentally a patient safety issue, requiring continuous testing, workforce awareness, strong identity management, and a “human firewall” to counter increasingly sophisticated AI-enabled threats. Michael believes rural healthcare can leapfrog legacy limitations by strategically investing in digital transformation and emerging technologies. He also sees the CIO role evolving from technology management to business and strategic leadership, with greater responsibility for automation, operational performance, workforce well-being, and patient outcomes. His message is clear: technology must matter, and it must ultimately improve care. Take a listen. This guest appearance was facilitated through conversations initiated at HIMSS.
Aug 20

Episode 222 – AI is Moving Drug Discovery From Prediction to Generation

The Big Unlock · Alex Zhavoronkov, Founder, CEO and CBO, Insilico Medicine In this episode, Alex Zhavoronkov, Founder, CEO and CBO of Insilico Medicine, explores how generative AI is reshaping drug discovery and opening new possibilities in longevity research. He explains how AI can move pharmaceutical R&D from searching for promising molecules toward generating molecules with desired properties, while orchestrating specialized models and agents across the drug development lifecycle. Insilico combines AI models across biology, chemistry, and clinical development to move from target identification to drug candidates faster, with multiple programs now in clinical trials. Alex argues that AI can dramatically expand the number of experiments researchers can conduct, but the complexity of biology means failure remains inevitable and real-world validation is essential. He discusses the industry’s shift from predictive AI to generative and agentic systems capable of orchestrating thousands of drug discovery tasks, while emphasizing the importance of rigorous validation. Alex believes the strongest competitive advantages will come from proprietary drugs, scientific infrastructure, capital, and the ability to turn ideas into validated products. He cautions against AI hype and emphasizes benchmarking, peer-reviewed evidence, and clinical results. His ultimate ambition is to use AI-driven drug discovery to extend human lifespan and give people more years of life. Take a listen. This guest appearance was facilitated through conversations initiated at Ai4 2026.
Aug 18

Episode 221 – Making Human Movement Measurable with AI

The Big Unlock · Zaw Thet, CEO and Co-Founder, Exer AI In this episode, Zaw Thet, CEO and Co-founder of Exer AI, explores how AI-powered computer vision can make human movement measurable and transform the delivery of musculoskeletal and movement health. He explains how Exer uses ordinary cameras and AI to assess movement across orthopedics, neurology, rehabilitation, telehealth, and at-home care, providing clinicians with objective insights while improving clinical efficiency and access. The conversation highlights how AI can improve patient outcomes and help clinicians deliver more personalized care at scale. Zaw also discusses the growing role of continuous monitoring, combining movement data with signals from wearables to identify risks earlier, particularly for older adults and fall prevention. He emphasizes that scaling healthcare AI requires clinical validation, regulatory compliance, proprietary data, and patience to move from innovation to real-world adoption. Zaw expects AI to create a more efficient healthcare system but cautions against removing humans from clinical decision-making too quickly. As generative AI expands, human oversight, accountability, and patient safety will remain essential to scaling AI responsibly. Take a listen.
Aug 11

Episode 220 – Cloud and AI Are Reshaping Healthcare Transformation

The Big Unlock · Dr. Angela Shippy, Senior Physician Executive and Clinical Innovation Lead, Amazon Web Services (AWS) In this episode, Dr. Angela Shippy, Senior Physician Executive and Clinical Innovation Lead at Amazon Web Services (AWS), shares how cloud and AI are reshaping healthcare by helping organizations move from experimentation to enterprise-scale transformation. She explains that successful AI adoption requires more than powerful models – it demands secure cloud infrastructure, responsible governance, workforce upskilling, and trusted partnerships. Dr. Shippy explains how leading health systems are moving beyond isolated AI pilots by solving well-defined organizational and clinical challenges first. Through purpose-built services like Amazon Connect Health, institutions are streamlining patient engagement, reducing administrative burden, and improving access to care. From antimicrobial resistance surveillance to genomics research and health equity programs, she illustrates how cloud-based platforms are helping healthcare organizations generate insights faster and improve patient outcomes at scale. Dr. Shippy believes that scaling enterprise AI requires upskilling healthcare workforces, establishing strong security guardrails, and embracing agentic workflows. She envisions a future driven by multimodal AI, ambient listening, and automated task execution that accelerates drug discovery, reduces burnout, and enables clinicians to focus on direct patient care. Dr. Shippy encourages health systems to start small, think big, and never lose sight of improving patient and workforce experiences. She believes agentic technologies will augment clinicians, accelerate innovation, and help build a more connected, efficient, and patient-centered healthcare ecosystem. Take a listen. This guest appearance was facilitated through conversations initiated at ViVE.
Aug 4

Episode 219 – Health Literacy is Key to Better Patient Outcomes

The Big Unlock · Greg O’Neill, Director, Patient & Family Health Education, ChristianaCare In this episode, Greg O’Neill, Director of Patient & Family Health Education at ChristianaCare, explores why effective communication is one of the most overlooked drivers of better healthcare outcomes. Drawing on his experience as an ICU nurse and health system leader, Greg explains that health literacy is not simply about providing information, it is about ensuring patients truly understand their care and feel confident acting on it. Greg shares how ChristianaCare is embedding health literacy into patient education, medication management, and clinical workflows by using plain language, personalized content, and technology that supports rather than disrupts caregivers. He also discusses AI’s potential to break down fragmented care by connecting information across systems, reducing cognitive burden for patients, and guiding them through increasingly complex healthcare journeys. Greg encourages healthcare leaders to adopt a health literacy lens when evaluating digital tools and transformation initiatives. He argues that the greatest value comes when technology strengthens human connection, builds trust, and helps patients achieve better outcomes through clearer communication. Take a listen. This guest appearance was facilitated through conversations initiated at HIMSS.
Jul 28

Episode 218 – Using Multimodal Foundations and Ambient AI to Scale Clinical Impact

The Big Unlock · Umesh Rustogi, General Manager, HLS Dragon & Platform, Microsoft In this episode, Umesh Rustogi, General Manager, Healthcare & Life Sciences Dragon & Platform at Microsoft, explains that meaningful AI outcomes depend on combining unified multimodal data foundations with clinician-centered design to achieve healthcare’s quadruple aim: improving care quality, patient experience, operational efficiency, and workforce well-being. Addressing the severe nursing shortage and turnover driven by administrative burnout, Umesh details how Microsoft co-innovated with nine major health systems to deploy Dragon Copilot for Nursing, a clinical assistant that works alongside nurses. By leveraging ambient AI on mobile devices, the solution helps nurses capture flow sheet documentation for their review and maintains a running cognitive memory across shifts, significantly lowering cognitive load and enabling nurses to be truly present with their patients. Umesh also emphasizes that enterprise-scale success requires far more than model selection. It demands responsible AI governance, transparent audit capabilities, deep workflow customization, and robust change management, including nurse leader sponsorship and dedicated unit champions. He envisions smart hospital rooms, multimodal AI, wearable integration, and agentic workflows transforming clinical operations by delegating non-patient-facing tasks so caregivers can focus on delivering better care. Take a listen. This guest appearance was facilitated through conversations initiated at HIMSS.

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THE BIG UNLOCK PODCAST is a Healthcare Digital Transformation Podcast. Stay Updated on Healthcare’s Digital Transformation Trends. Featuring C-suite Leaders and Insights on Digital Health Innovation. Explore Emerging Healthcare Technologies with Rohit Mahajan and Ritu M. Uberoy.

Creator

Rohit Mahajan & Ritu M. Uberoy
Years Active

2018 - 2026
Episodes

197
Rating

Clean
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© 2025 The Big Unlock Podcast
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