Around the Rheum with Drs. Daniel Ennis & Janet Pope

Canadian Rheumatology Association

Join hosts Dr. Janet Pope (Western University) and Dr. Daniel Ennis (UBC) for thoughtful, informed conversations, filled with clinical pearls with some of the leading rheumatologists from Canada and the world.

  1. 5D AGO

    Episode 57: Autoinflammatory Diseases with Adult Rheumatologist Dr. Jason An

    Autoinflammatory diseases are often considered rare — but, in clinical practice, they may be far more common than we think. In this episode of Around the Rheum, hosts Dr. Daniel Ennis and Dr. Janet Pope speak with Dr. Jason An, a Toronto rheumatologist with expertise in autoinflammatory disorders. Together, they explore how these conditions differ from classic autoimmune disease, why adult rheumatologists should be thinking about them more often, and how to approach diagnosis when the presentation doesn’t fit neatly into familiar categories. Dr. An also shares practical strategies for recognizing autoinflammatory patterns, interpreting genetic testing, and using targeted therapies both diagnostically and therapeutically. In this episode we discuss: The evolving definition of autoinflammatory disease and how it differs from autoimmune diseaseWhy these disorders are not just pediatric diseases and may present in adulthoodA practical cytokine-based framework for classifying autoinflammatory diseasesThe four major inflammatory “buckets”:IL-1–mediated diseasesIL-18-mediated diseasesTNF / NF-κB pathway disordersInterferonopathiesClinical pattern recognition in patients with recurrent fevers and systemic inflammationThe role and limitations of genetic testing in autoinflammatory diseaseWhy variants of uncertain significance (VUS) may still be clinically meaningful in adultsUsing targeted therapies as diagnostic tools (colchicine, IL-1 blockade, JAK inhibitors)When rheumatologists should consider referral to an autoinflammatory disease specialistRecommended reading: Dr. An’s review on autoinflammatory diseases in The Journal of Rheumatology: https://www.jrheum.org/content/51/9/848 Dr. Jason An, MD, MSc is an adult rheumatologist specializing in the diagnosis and treatment of autoinflammatory diseases who works in community practice in the Greater Toronto Area (GTA) Around The Rheum is produced by the CRA Communications Committee. A special thank you to the podcast team, Dr. Dax G. Rumsey (CRA Communications Committee Chair), Dr. Daniel Ennis (Host), Dr. Janet Pope (Host) David McGuffin (exploreproductions.ca), and Erin Stewart (CRA) for leading production. Our theme music was composed by Aaron Fontwell. For more on the work of the Canadian Rheumatology Association, visit rheum.ca

    41 min

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Join hosts Dr. Janet Pope (Western University) and Dr. Daniel Ennis (UBC) for thoughtful, informed conversations, filled with clinical pearls with some of the leading rheumatologists from Canada and the world.

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