Biohacking Beauty: The Anti-Aging Skincare Podcast

Young Goose
  • 4.8 (187)
  • Fashion & Beauty
  • Updated Weekly

Welcome to Biohacking Beauty, the definitive exploration of skin health through the lens of longevity medicine and cellular biology. Hosted by the founders of Young Goose, Amitay Eshel and Anastasia Khodzhaeva, this podcast moves beyond "single-molecule" trends to uncover the multi-mechanism protocols required to optimize the body’s largest organ. We bridge the gap between systemic longevity research and topical application. By hosting world-renowned experts in mitochondrial health, epigenetic signaling, and regenerative medicine, we translate complex research into actionable strategies for biological recalibration. From the 12 Hallmarks of Aging to the latest in bio-harmonizing lifestyle shifts, Biohacking Beauty provides the molecular tools and insights needed to align your skin’s appearance with your body’s peak biological potential.

  1. 6d ago

    276. Skincare Routine by Age: The Science-Backed Protocol for Your 20s, 30s, 40s and 50s

    Most skincare routines are built by accumulation: a serum that went viral, a cream a friend swore by, whatever promised firmer skin that month. But what drives skin aging at 25 is not what drives it at 45, so a routine that never changes its priorities can spend years working on the wrong problem. And your birthday is only part of the picture. Some people's skin is running a decade ahead of their age, perimenopause can change what skin needs years before the 40s arrive, and the routine you will actually stick with is usually shorter than the one you think you need. So before you add another product, it is worth knowing what changes in your skin from one decade to the next and what each stage should prioritize. In this Biohacking Beauty Class, we walk through a skincare protocol for every decade, from protection in your 20s to correction in your 30s and recovery in your 40s, 50s, and beyond. We get into the research tying sun exposure to 80% of visible facial aging, why NAD+ declines in aging skin, what makes many exosome formulas questionable, how to tell if your skin is aging ahead of your age, and the red light specs that actually matter. What’s Discussed: (02:17) Why your skin's age matters more than the number on your birthday. (03:09) The "attention budget" and why a shorter routine often gets better results. (04:44) The research linking sun exposure to 80% of visible facial aging. (06:20) What happened when adults used sunscreen every day for four and a half years. (12:06) Why NAD+ declines in aging skin and what changes after 30. (15:03) How spermidine and autophagy help skin clear out what has expired. (22:08) Why exosomes cannot survive alongside vitamin C, acids, and peptides in the same formula. (24:04) The part of aging in your 40s that sunscreen cannot fully cover. (26:10) Why perimenopause and menopause mean moving up a stage, whatever your age. (31:22) A first look at the Youth Activating Ampoule and why some actives have to stay freeze-dried. (42:05) What to use at home in the weeks around microneedling and laser treatments. (45:25) What the research says about red light therapy and the specs worth paying for. (51:53) How to find out if your skin is aging ahead of your age. Listen to this episode of Biohacking Beauty before you add another product to your routine, so you know what your skin needs at the stage it is actually in. Resources Mentioned: Skincare by Age protocol: https://www.younggoose.com/pages/science Decade-by-Decade Skincare Field Guide Young Goose AI Facial Scanner SkinOS™ Longevity Test Find a Young Goose Professional Previous Episodes Mentioned: Anastasia and Amitay with Dave Asprey on The Human Upgrade Find more from Young Goose: Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com Instagram: @young_goose_skincare

  2. Oct 14

    275. Dave Asprey: The Uncomfortable Conversation About Aging Naturally vs. Biohacking

    There is an interesting contradiction in the way we talk about aging. We celebrate using technology to improve sleep, metabolism, cognition, recovery, and longevity, but when the same mindset is applied to appearance, the conversation can suddenly become much more judgmental. In this episode of Biohacking Beauty, we sit down with Dave Asprey to explore that tension. We get into why he chose a facelift after major weight loss, whether cosmetic procedures belong in the biohacking conversation, and why wanting to look younger is often treated differently from wanting the rest of your body to function younger. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, CEO of Upgrade Labs, host of The Human Upgrade, and co-founder of Unlimited Life. We also talk about how he prepares his body before procedures, what he thinks people misunderstand about peptides, and his takes on GLP face, collagen supplements, Botox, stem cells, and the other tools people are using to change how they age. What’s Discussed: [13:02] Why Dave ultimately chose a facelift after major weight loss. [15:24] Where non-surgical skin treatments reached their limit for the amount of excess skin he wanted to address. [18:58] Why copying someone else’s longevity or supplement stack can backfire. [28:59] Where to start when your biological-age markers look good but you still do not like what you see in the mirror. [30:07] Why sleep, recovery, HRV, and other foundational markers still matter when thinking about aging. [37:52] The stigma around cosmetic procedures in biohacking and why Dave questions where that line is drawn. [44:56] Why he believes fear around aging and medical procedures can affect the body’s stress response. [54:25] GLP-1s, muscle loss, and the changes people notice in facial appearance after weight loss. Listen to this episode of Biohacking Beauty for a conversation about where “aging naturally” ends, where biohacking begins, and why that line becomes much more complicated when appearance enters the picture. Find more from Young Goose: Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off atyounggoose.com Instagram: @young_goose_skincare Find more from Dave Asprey: Website:daveasprey.com LinkedIn: Asprey Instagram:@dave.asprey Facebook: Daveaspreyofficial YouTube: DaveAspreyBPR TikTok: @daveaspreyofficial Book: “Heavily Meditated”: https://daveasprey.com/heavily-meditated/

  3. Oct 7

    274. The Peptide Skincare Boom: Separating Skin Science From Marketing

    Peptides are everywhere in skincare right now. They are in serums, moisturizers, lip products, cleansers, body washes, and even shampoos, all promising some version of smoother skin, more collagen, or fewer visible signs of aging. But seeing “peptides” on a label tells you very little about whether the product can actually deliver those results. Which peptide is being used? Is there research behind that specific ingredient? Is there enough of it in the formula? Can it get through the skin barrier? And what happens when it is combined with everything else inside the bottle? So before you buy another peptide serum because the ingredient sounds impressive, it is worth knowing what actually makes a peptide useful for your skin and how formulation, delivery, concentration, and the rest of your routine can affect whether it works at all. In this Biohacking Beauty Class, we are separating the science from the marketing around topical peptides. We get into which ones have more evidence behind them, what “Botox in a bottle” gets wrong, why some peptide products make more sense than others, and what to look for if your goal is supporting collagen, softening fine lines, and keeping your skin functioning well as it ages. What’s Discussed: (01:47) Do peptides actually belong in everything from serums to body wash? (05:17) The biggest red flag when a skincare product uses peptides as the main selling point. (08:26) What should actually back up an anti-aging peptide claim. (11:11) Which topical peptides have more evidence behind them. (13:01) Why neuropeptides are not really “Botox in a bottle.” (15:54) What to know about using peptide products with vitamin C, retinoids, and other actives. (17:46) Why pH, concentration, and the other ingredients in a formula can affect peptide stability. (21:14) What actually makes a topical peptide product more likely to work. (22:45) Why healthy skin function still matters when you are trying to support collagen and repair. (25:09) If you could only add one peptide product to your routine, which type should it be? Listen to this episode of Biohacking Beauty before another peptide claim on a skincare label convinces you to spend more without knowing what is actually inside the formula. Previous Episodes Mentioned: Nathalie Niddam: Peptides, Bioregulators, and the Truth About Skin Longevity https://podcasts.apple.com/us/podcast/nathalie-niddam-peptides-bioregulators-and-the/id1552026927?i=1000736397042 Nathalie Niddam: The Potential of Peptides in Skin Health and Anti-Aging https://podcasts.apple.com/au/podcast/nathalie-niddam-the-potential-of-peptides-in-skin/id1552026927?i=1000642759851 Peptides episodes to watch: Peptides, Bioregulators & The Truth About Skin Longevity | Nathalie Niddam:: https://www.youtube.com/watch?v=2AoqcXJ_MMc Why Peptides Are Not the Shortcut Biohackers Think They Are with Chris Duffin: https://www.youtube.com/watch?v=UNPhDZXY6kw Peptides, Hormones, and the Anti-Aging Protocol Most Women Start Too Late: https://www.youtube.com/watch?v=b_CTcFjeyqQ&t=428s GHK-Cu Explained: The Copper Peptide That Signals Collagen Repair: https://www.youtube.com/watch?v=qGDNyVtZjl4 Find more from Young Goose: Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com Instagram: @young_goose_skincare

  4. Sep 30

    273. Dr. Staci Whitman: The Surprising Oral Causes Behind Facial Asymmetry and How Your Face Ages | Part 2

    You probably know which side of your face you prefer in photos. One jawline may look sharper. One cheek may sit differently. One under-eye may look darker. And while some facial asymmetry is completely normal, the way you use your mouth can also influence how the two sides of your face function over time. In Part 2 of our conversation with Dr. Staci Whitman, we look at facial aging from inside the mouth. We get into how one-sided chewing, bite patterns, tongue function, palate width, airway health, and jaw structure can influence facial symmetry and the way changes become visible in the face. We also explore what adults can realistically do when the issue is structural rather than purely cosmetic. Dr. Staci breaks down the conversations happening around mastic gum, myofunctional therapy, palate expansion, MARPE, oral appliances, and tongue-tie releases, including why changing the way the mouth functions is much more complicated than trying the latest jawline trend online. Dr. Staci Whitman is a board-certified pediatric dentist and Functional Medicine Certified Practitioner whose work focuses on functional dentistry, airway health, craniofacial development, the oral microbiome, and the mouth-body connection. She is the co-founder of the Institute for Functional Dentistry and founder of Bloom + Brighten. What’s Discussed: [1:37] Why persistent dark under-eyes may sometimes point to airway issues, inflammation, and facial structure rather than pigmentation alone. [3:32] What happens to the jaw and the bones supporting the face as we age. [6:44] How chewing predominantly on one side may contribute to differences between the two sides of the face. [10:55] What your chewing patterns, saliva, and cavities may reveal about how you are using your mouth. [17:09] Whether mastic gum and jaw exercises can actually change the appearance of an adult face. [20:00] How tongue function, swallowing, and breathing are addressed through myofunctional therapy. [21:50] Why a narrow palate may require more than simply changing your tongue position. [22:30] What adults should know about palate expansion, MARPE, and oral appliances. [31:26] Why finding a tongue tie does not automatically mean releasing it is the first step. [40:49] Who to see when you suspect your bite, tongue, airway, or jaw function may be affecting your face. Listen to this episode of Biohacking Beauty to learn why facial asymmetry may be giving you clues about what is happening inside your mouth. Find more from Young Goose: Website: www.younggoose.com/ Use code PODCAST10 to get 10% OFF your first purchase, and if you are a returning customer use code PODCAST5 to get 5% OFF. Instagram: @young_goose_skincare Find more from Dr. Staci Whitman: Website: doctorstaci.com Instagram: @doctor_staci TikTok: @doctor_staci YouTube: youtube.com/channel/ Book: SPIT: Why Your Mouth-and Its Microbes-Are the Secret to Whole-Body, Lifelong Health Read Dr. Staci’s newsletter: substack.com/@doctorstaci ResourcesFind an oral-systemic health practitioner through AAOSH: aaosh.org/find-a-practitioner Search the IAOMT directory for a biological dentist or health professional: iaomt.org/for-patients/Search/?ppage=dashboard Find an airway-focused practitioner through AAPMD: aapmd.org/find-aapmd-professional Search The Breathe Institute provider directory: breatheops.com/directory/the-breathe-institute Learn more about the Institute for Functional Dentistry: functionaldentistry.org/

  5. Sep 23

    272. Dr. Staci Whitman: The “Harmless” Oral Habits That Could Be Reshaping Your Face and Aging Your Skin | Part 1

    You can invest in your skincare, protect your collagen, and do everything you can to age well, while completely overlooking something that sits only a few inches away from your skin: your mouth. The way you breathe, chew, swallow, care for your gums, and support your oral microbiome can influence far more than your teeth. In this episode of Biohacking Beauty, we sit down with Dr. Staci Whitman to explore how oral health connects to facial structure, airway health, under-eye darkness, inflammation, blood flow, and the appearance of your skin. We also get into the everyday oral habits that may be working against you, what actually matters in an oral routine, and the facial signs that can make Dr. Staci suspect something deeper is going on. Dr. Staci Whitman is a board-certified pediatric dentist and Functional Medicine Certified Practitioner who specializes in the mouth-body connection, airway development, craniofacial growth, and the oral microbiome. She is the co-founder of the Institute for Functional Dentistry and founder of Bloom + Brighten, bringing functional medicine and systems biology into a part of health that is still often treated separately from the rest of the body. What’s Discussed: (01:17) Why humans chew dramatically less today and what that can mean for facial development. (05:57) How mouth breathing, narrow airways, and modern eating habits can show up in the face. (11:23) The oral bacteria involved in nitric oxide production and why blood flow matters for skin. (13:02) Why saliva is one of the most overlooked parts of oral health and what happens when your mouth stays dry. (16:50) Why Dr. Staci believes dentistry is missing a major piece of the longevity conversation. (24:20) What actually matters in an oral-health routine, from meal timing and nasal breathing to flossing and microbiome testing. (31:40) How hormones, pregnancy, perimenopause, and menopause can change oral health. (40:52) What tongue scraping actually does and what your tongue may reveal about your health. (46:02) What Dr. Staci notices about your face, eyes, lips, posture, and breathing before she even looks at your teeth. Listen to this episode of Biohacking Beauty to learn why the way your face looks may be influenced by habits you have never considered part of your beauty routine. Find more from Young Goose: Website: www.younggoose.com/ Use code PODCAST10 to get 10% OFF your first purchase, and if you are a returning customer use code PODCAST5 to get 5% OFF. Instagram: @young_goose_skincare Find more from Dr. Staci Whitman: Website: doctorstaci.com Instagram: @doctor_staci TikTok: @doctor_staci YouTube: youtube.com/channel/ Book: SPIT: Why Your Mouth-and Its Microbes-Are the Secret to Whole-Body, Lifelong Health

  6. Sep 16

    271. Dr. Mamina Turegano: What Your Skin Reveals About Your Health, Aging & Hormones

    Most of us assume that if something serious was happening inside our body, we would know. We would feel sick. Something would hurt. A blood test would catch it. But some health problems can develop quietly for years, and sometimes the clue that finally gets your attention is sitting right where you can see it: on your skin. In this episode of Biohacking Beauty, we get into the skin changes that can point to something happening beyond the surface, from psoriasis and multiple skin tags to persistent rashes, hair loss, and subtle signs of skin cancer. We also talk about what makes a dermatologist look deeper, how long sun damage can build before it becomes visible, and when a skin concern deserves more than another product or treatment. Dr. Mamina Turegano is a triple board-certified dermatologist, internist, and dermatopathologist, giving her a unique perspective that connects what is happening on the skin with what may be happening throughout the body. Her background in internal medicine and dermatopathology allows her to look beyond the appearance of a skin change and consider the metabolic, autoimmune, inflammatory, and systemic conditions that may be connected to it. What’s Discussed: (01:25) Why you can feel perfectly healthy while something is already changing internally. (02:48) Why psoriasis can warrant looking at cardiovascular and metabolic health too. (04:49) What multiple skin tags may tell you about insulin resistance. (16:07) When an unexplained rash or chronic itching deserves a deeper workup. (19:18) The skin cancer signs people may overlook and when hair loss needs more attention. (23:14) How sugar, alcohol, stress, sleep, and circadian disruption can accelerate skin aging. (35:31) Why Dr. Mamina is comfortable with topical peptides but not injectable peptides yet. (45:24) Whether Google, AI skin scanners, and self-diagnosis are helping or hurting. (48:53) How long sun damage may be building before you finally see it. Listen to this episode of Biohacking Beauty to learn which skin changes are worth paying closer attention to, and why treating what you see is not always the end of the conversation. Resources mentioned: Want to find out more about Autophagy? Listen here: The Overlooked Side of Autophagy Causing Aging - Part 1 The Overlooked Side of Autophagy Causing Aging - Part 2 Find more from Young Goose: Website: younggoose.com Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use code PODCAST5 to get 5% OFF. Instagram: @young_goose_skincare Find more from Dr. Mamina Turegano: Website: DrMamina.com Instagram: @dr.mamina TikTok: @dr.mamina YouTube: @dr.mamina

  7. Sep 9

    270. Your Most-Asked Skincare Questions, Answered With Science

    Social media has made skincare information easier to access than ever. One video can convince you to increase your retinol. Another influencer can tell you an ingredient is “toxic.” Then someone else swears your skin has stopped responding because you have used the same product for too long. But think about what that can do to your skin when you follow every new rule without understanding what the product is actually doing. More stimulation is not always better. “Clean” does not automatically mean effective. A rosacea flare is not always something another soothing serum can fix. And moving to a stronger retinol just because your current one feels less intense may be the wrong move entirely. In this Biohacking Beauty Class, we are answering the skincare questions our community keeps asking and unpacking the advice that sounds simple online but becomes much more complicated once you understand how skin actually responds. We also get into collagen supplements and share a few of the new Young Goose products and technologies we have been working on behind the scenes. What’s Discussed: (02:25) Can your skin actually get used to skincare products? (07:44) Why “clean skincare” does not automatically mean better skincare. (16:20) What may be driving rosacea when nothing seems to help. (19:09) Why stronger retinol is not always the smarter next step. (25:29) Do collagen supplements actually help your skin? (30:10) The new cleanser and eye product coming to Young Goose. (34:28) The new skincare technology we are testing in ampule form. Listen to this episode of Biohacking Beauty before the next skincare tip on your feed convinces you to change something that may not need changing at all. And before you go, we have a little listener bonus. If you want to receive a product from us, leave us a review on Apple Podcasts. That is all you have to do. If we read your review out loud on the podcast, we will send you a product in the mail. So leave us a review, make it cute, make it honest, and you might hear it in an upcoming Biohacking Beauty Class episode. Find more from Young Goose: Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com Instagram: @young_goose_skincare

  8. Sep 2

    269. Cynthia Thurlow: What Midlife Gut Changes Have To Do With Your Skin

    When your skin starts changing in midlife, it is easy to assume the products that used to work suddenly stopped working. And when changing the routine does not fix it, hormones usually get the blame. But there is another shift happening at the same time that rarely gets brought into the skin conversation: your gut. In this episode of Biohacking Beauty, we get into what starts changing in the gut through perimenopause and menopause, the surprising ways those changes can show up far beyond digestion, and why some of the health strategies women swear by before 40 may need to be reconsidered later. Cynthia Thurlow is a nurse practitioner, host of the Everyday Wellness podcast, author of The Menopause Gut, and an international speaker with more than 25 years of experience in women’s health, metabolic health, perimenopause, menopause, and intermittent fasting. What’s Discussed: (04:01) The health crisis that changed the way Cynthia understood midlife health. (19:12) The gut-hormone connection most women do not know exists. (23:14) What changes when estrogen, immunity, and the gut start shifting together. (29:13) The early signs that progesterone may be changing. (35:49) What your gut may have to do with ovarian and mitochondrial aging. (41:46) The part of longevity Cynthia thinks we are seriously underestimating. (47:54) Why Cynthia changed her own approach to intermittent fasting after 40. Listen to this episode of Biohacking Beauty to learn what midlife gut changes may have to do with your skin, and why the answer may go much deeper than changing your skincare routine. Find more from Young Goose: Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com Instagram: @young_goose_skincare Find more from Cynthia Thurlow: Twitter: @_CynthiaThurlow Instagram: @cynthia_thurlow_ LinkedIn: cynthia-thurlow YouTube: cynthiathurlow Website: cynthiathurlow.com/ The Midlife Pause supplements: themidlifepause.com

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About

Welcome to Biohacking Beauty, the definitive exploration of skin health through the lens of longevity medicine and cellular biology. Hosted by the founders of Young Goose, Amitay Eshel and Anastasia Khodzhaeva, this podcast moves beyond "single-molecule" trends to uncover the multi-mechanism protocols required to optimize the body’s largest organ. We bridge the gap between systemic longevity research and topical application. By hosting world-renowned experts in mitochondrial health, epigenetic signaling, and regenerative medicine, we translate complex research into actionable strategies for biological recalibration. From the 12 Hallmarks of Aging to the latest in bio-harmonizing lifestyle shifts, Biohacking Beauty provides the molecular tools and insights needed to align your skin’s appearance with your body’s peak biological potential.

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