Health Optimization Medicine Podcast

Health Optimization Medicine and Practice
  • 5.0 (188)
  • LIFE SCIENCES
  • UPDATED WEEKLY

The Health Optimization Medicine Podcast is dedicated to offering one-cent solutions to life's $64,000 questions across health optimization, decision-making, consciousness, performance, and human potential. Produced by Health Optimization Medicine & Practice (HOMeHOPe) and Smarter Not Harder, Inc., the makers of Troscriptions, this podcast bridges rigorous science with real-world clinical application. Each episode features in-depth conversations with leading researchers, clinicians, and original thinkers, including Karl Friston, Donald Hoffman, Anna Lembke, Adam Robinson, and Dominic D'Agostino. Together, they explore how small, precise interventions can create meaningful and lasting impact. Hosted by: + Dr. Ted Achacoso, founding pioneer of HOMeHOPe and Smarter Not Harder, Inc. + Dr. Scott Sherr, COO of HOMeHOPe and Smarter Not Harder, Inc. + Boomer Anderson, CEO of HOMeHOPe and Smarter Not Harder, Inc. + Jodi Duval, principal naturopath, formulator at Revital Health in Perth, Australia, and CEO of HOMeHOPe Australia New episodes every Wednesday. Previously published as the Smarter Not Harder Podcast (SNH Podcast).

  1. 1D AGO

    The Cell Danger Response Explained (Why You're Not Healing) | HOMe Podcast #006

    In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Dr. Ted Achacoso, and Jodi Duval as they break down one of the most important frameworks in Health Optimization Medicine — the Cell Danger Response (CDR). Originally developed by Dr. Robert Naviaux, the Cell Danger Response explains how cells respond to threat, adapt for survival, and either resolve or become "stuck" — leading to chronic disease. This episode walks through the three stages of the CDR, how mitochondria act as both sensors and signaling hubs, and why many modern conditions — from inflammation to chronic illness — are actually stalled healing processes. Most importantly, the team explains how clinicians and individuals can identify where the body is "stuck" and what to do (and NOT do) to support proper resolution. Join us as we delve into: What the Cell Danger Response (CDR) is and why it matters The 3 stages: defense, repair, and resolution How mitochondria act as sensors — not just energy producers Why inflammation is a protective response, not the problem How chronic disease reflects a "stalled" healing process This episode is for you if: You're dealing with chronic inflammation or unresolved health issues You want to understand the root cause of disease beyond symptoms You're a practitioner looking for a systems-based framework You want to optimize health by working with your biology, not against it You can also find this episode on… YouTube: https://youtu.be/NWEq32hlZrE Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/  Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

    37 min

  2. APR 8

    Microglia, Metabolism & the Future of Brain Health | HOMe Podcast #005

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia. Often overlooked, microglial cells are the brain's immune system and play a central role in determining whether the brain thrives or degenerates over time. Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer's, Parkinson's, and more. Most importantly, this episode highlights how everyday lifestyle choices — from diet and exercise to metabolic health — directly influence brain function and long-term cognitive resilience. Join us as we delve into: What microglia are and why they control brain health The difference between M1 (destructive) and M2 (protective) states How metabolism shapes the brain's immune response Why conditions like Alzheimer's are rooted in immune dysfunction The connection between blood sugar, insulin, and brain degeneration This episode is for you if: You want to protect your brain and prevent cognitive decline You're interested in the science of Alzheimer's and neurodegeneration You want actionable strategies to improve brain health You're curious about the future of brain optimization and longevity You can also find this episode on… Youtube: https://youtu.be/EMrlchMOZKk Find more from Dr. David Perlmutter Website: https://www.drperlmutter.com Book: https://braindefenders.com LinkedIn: https://www.linkedin.com/in/david-perlmutter-md/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMd/ Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

    59 min

  3. APR 1

    The Science of Chronobiology & Health Optimization | HOMe Podcast #004

    In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval as they explore chronobiology — and how modern life is disrupting the body's natural rhythms. From jet lag and shift work to late-night scrolling and irregular meals, the conversation dives into what Dr. Ted calls "circadian pollution" — the mismatch between our biology and the environments we've created. More importantly, the team breaks down simple, powerful tools to re-entrain your body clock using light, food timing, and movement — all foundational principles in Health Optimization Medicine. Join us as we delve into: What chronobiological re-entrainment actually means The difference between the brain clock and organ clocks How light, food, and movement act as biological time signals Why late-night eating creates "metabolic jet lag" How modern life creates circadian disruption This episode is for you if: You struggle with sleep, fatigue, or inconsistent energy You travel frequently or work irregular hours You want to optimize your circadian rhythm naturally You're looking for simple, zero-cost ways to improve health You can also find this episode on…  YouTube: https://youtu.be/WcheAJNzq2k Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

    24 min

  4. MAR 25

    Health vs Disease Markers: What Doctors Miss | HOMe Podcast #003

    In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Jodi Duval, Dr. Allen Bookatz, and Dr. Ted Achacoso as they explore the future of clinical intelligence — and why medicine must move beyond single biomarkers to understanding networks within the body. Rather than chasing isolated lab values like glucose, cholesterol, or testosterone, the conversation shifts toward a systems-based approach — where every biomarker is part of a dynamic network of relationships. From metabolomics to hormone balance, this episode explains why optimizing health requires understanding how different systems interact, adapt, and influence each other in real time. Join us as we delve into: Why single biomarkers are only "nodes" in a larger biological network The concept of nodes and edges in human physiology How glucose, thyroid, and metabolic systems are interconnected Why cholesterol, inflammation, and B vitamins must be viewed together The risks of optimizing one biomarker (like testosterone) in isolation This episode is for you if: You've been told to "fix" a single lab value but still feel off You want to understand your lab results in a deeper, systems-based way You're a practitioner looking to move beyond reductionist medicine You're interested in metabolomics and the future of health optimization You can also find this episode on… Youtube: https://youtu.be/CMbdZEnnuGo Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026:https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://www.homehope.org/ Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://www.troscriptions.com/

    24 min

  5. MAR 18

    The Biology of Comfort and Why We Need Stress | HOMe Podcast #002

    In this episode of the Health Optimization Medicine Podcast, join Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval as they explore the hidden cost of convenience and comfort in modern life.   From ultra-processed foods and low-fiber diets to sedentary lifestyles and technology-driven comfort, the conversation dives into how convenience is quietly reshaping our biology. The HOMeHOPe Faculty explains why small daily habits — like eating whole foods, moving regularly, and embracing mild discomfort — are essential for maintaining cellular health and resilience.   Rather than trying to "hack" health with quick fixes, the discussion emphasizes consistent lifestyle behaviors that support the microbiome, metabolic function, and long-term health optimization.   Join us as we delve into: • Why fiber is the fastest disappearing macronutrient in modern diets • The role of gut microbiota and short-chain fatty acids in health • Why habits like sleep, eating, and exercise cannot be "banked" • The physiological consequences of ultra-convenient lifestyles • Practical ways to introduce beneficial stress back into daily life   This episode is for you if: • You want to understand how convenience affects human physiology • You're interested in the role of fiber and gut health in disease prevention • You want practical ways to improve resilience and metabolic health • You're curious about the philosophy behind Health Optimization Medicine   You can also find this episode on… YouTube: https://youtu.be/6wLPUuLQgcY   Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://www.homehope.org/   Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://www.troscriptions.com/

    32 min

  6. MAR 11

    What Is Health Optimization Medicine? | HOMe Podcast #001

    In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty comes together for a roundtable conversation exploring the core philosophical framework behind Health Optimization Medicine. Dr. Scott Sherr, Boomer Anderson, and Dr. Allen Bookatz break down the three fundamental perspective shifts that redefine how we think about health, disease, aging, and the human body itself. Rather than focusing on disease management, this episode introduces the foundational principles behind building health from the cellular level up. Join us as we delve into: • The shift from pathogenesis (studying disease) to salutogenesis (creating health) • Why longevity alone isn't enough without vitality and morbidity compression • How neotenization focuses on restoring youthful biological function • The concept of the holobiont: humans as ecosystems of interconnected organisms This episode is for you if: • You want to understand the philosophy behind Health Optimization Medicine • You're curious why modern healthcare focuses on disease instead of health • You're interested in metabolomics, cellular health, and systems biology • You want a deeper framework for longevity, vitality, and resilience You can also find this episode on… Youtube: https://youtu.be/wuCXmT783_o Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026:https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://www.homehope.org/ Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://www.troscriptions.com/

    31 min

  7. MAR 4

    Dr. Helen Messier on AI, Epigenetics & the Future of Aging | SNH Podcast #165

    In this episode of the Smarter Not Harder Podcast, Dr. Helen Messier joins Dr. Scott Sherr for a wide-ranging and thought-provoking conversation about longevity, epigenetics, AI-powered medicine, and the real meaning of healthspan. From whole genome sequencing to digital twins and emotional resilience, this episode bridges cutting-edge science with deeply human healing in a way that challenges how we think about aging. Join us as we delve into: The difference between lifespan and healthspan — and why resilience matters more than years Whole genome sequencing, polygenic risk scores, and the limits of genetic hype Multi-omics medicine: genomics, metabolomics, proteomics, and systems biology AI in healthcare, digital twins, and the return of the "country doctor" model This episode is for you if: You're curious about biological age vs. chronological age You want to understand what genetic testing can (and can't) tell you You're fascinated by AI's role in the future of personalized medicine You want smarter, not harder ways to build resilience and optimize longevity You can also find this episode on… Youtube: https://youtu.be/QQ-kIH3XbF0 Learn more about Dr. Helen Messier: Fountain Life: https://www.fountainlife.com/ Instagram: https://www.instagram.com/fountainlife/ Website: https://www.ifm.org/educator/helen-messier LinkedIn: https://www.linkedin.com/in/helen-messier-phd-md/ Find more from Smarter Not Harder: Website: Smarter Not Harder Podcast Instagram: https://instagram.com/troscriptions/ HOMeHOPe Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Get 10% off your purchase of the Metabolomics module with code PODCAST10 at https://www.homehope.org/ Get 10% off your Troscriptions purchase with code POD10 at https://www.troscriptions.com/ Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

    1h 20m

  8. FEB 25

    52 Years in Nutritional Medicine with Dr. Alan Gaby | SNH Podcast #164

    In this episode of the Smarter Not Harder Podcast, Dr. Alan Gaby joins Jodi Duval to explore over five decades of clinical experience in nutritional medicine. From vitamin C and magnesium to hidden food allergies and the Myers' Cocktail, this conversation unpacks what actually works — and why much of it is still ignored by conventional medicine. Join us as we delve into: • Why magnesium may be the most overlooked nutrient deficiency • Folic acid vs. methylfolate — what the research really says • The truth about vitamin C, IV therapy, and immune resilience • Hidden food allergies as root causes of chronic disease • Niacinamide for osteoarthritis, skin cancer prevention, and glaucoma • How to break sugar addiction and stabilize blood sugar naturally This episode is for you if: • You want evidence-based nutritional medicine — not hype • You're curious about elimination diets and hidden food sensitivities • You've heard conflicting advice about methylated vitamins • You want simple, practical strategies to improve long-term health You can also find this episode on… YouTube: https://youtu.be/sTwlRtbCK-w Find more from Dr. Alan Gaby: Website: https://doctorgaby.com Nutritional Medicine (Textbook): https://doctorgaby.com/nutritional-medicine/ LinkedIn: https://www.linkedin.com/in/alan-gaby-44310721/ Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast Instagram: https://instagram.com/troscriptions/ HOMeHOPe Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Get 10% off your purchase of the Clinical Metabolomics module with code PODCAST10 at https://www.homehope.org/ Get 10% off your Troscriptions purchase with code POD10 at https://www.troscriptions.com/ Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

    1h 5m
See All (171)

Trailer

5
out of 5
188 Ratings

About

The Health Optimization Medicine Podcast is dedicated to offering one-cent solutions to life's $64,000 questions across health optimization, decision-making, consciousness, performance, and human potential. Produced by Health Optimization Medicine & Practice (HOMeHOPe) and Smarter Not Harder, Inc., the makers of Troscriptions, this podcast bridges rigorous science with real-world clinical application. Each episode features in-depth conversations with leading researchers, clinicians, and original thinkers, including Karl Friston, Donald Hoffman, Anna Lembke, Adam Robinson, and Dominic D'Agostino. Together, they explore how small, precise interventions can create meaningful and lasting impact. Hosted by: + Dr. Ted Achacoso, founding pioneer of HOMeHOPe and Smarter Not Harder, Inc. + Dr. Scott Sherr, COO of HOMeHOPe and Smarter Not Harder, Inc. + Boomer Anderson, CEO of HOMeHOPe and Smarter Not Harder, Inc. + Jodi Duval, principal naturopath, formulator at Revital Health in Perth, Australia, and CEO of HOMeHOPe Australia New episodes every Wednesday. Previously published as the Smarter Not Harder Podcast (SNH Podcast).

Information

You Might Also Like