NYU Langone Insights on Psychiatry

NYU Langone Health Department of Psychiatry
  • 4.8 (20)
  • LIFE SCIENCES
  • UPDATED WEEKLY

Conversations about complex psychiatric cases and evolving treatments. Host Charles Marmar, MD, Chair of Psychiatry at NYU Grossman School of Medicine, speaks with NYU Langone faculty about diagnostic reasoning, treatment decisions, and the ethical questions that arise in clinical practice.

  1. Rethinking Treatment Goals in Bipolar Depression and Mixed Episodes

    JAN 2

    Rethinking Treatment Goals in Bipolar Depression and Mixed Episodes

    Bipolar depression and mixed episodes remain among the most difficult—and highest-risk—conditions in psychiatry. Even when mood symptoms improve, many patients continue to experience significant cognitive and functional impairment. On NYU Insights on Psychiatry, Dan Iosifescu, MD, explains why standard treatment approaches so often fall short. Dr. Iosifescu argues that symptom suppression is frequently mistaken for recovery, that short-term improvement does not equal durable treatment, and that bipolar mixed episodes expose the limits of one-size-fits-all care. The discussion focuses on the clinical dangers of mixed episodes, the challenge of recognizing them, and the importance of acute stabilization followed by a deliberate transition to sustainable long-term treatment. Dr. Iosifescu also explores how emerging biological research—including metabolic interventions and personalized experimental models—may eventually help clinicians better match patients to treatments. Rather than offering quick fixes, this conversation reframes how clinicians think about success, recovery, and personalization in the treatment of bipolar depression. Guest: Dan Iosifescu, MD, Director of Clinical Research at the Nathan Kline Institute and Director of the Mood Disorders Clinical and Research Program at NYU Langone Health. Watch Insights on Psychiatry on YouTube Senior Producer: Jon Earle

    23 min
  2. Interventional Approaches to Treatment-Resistant Mood Disorders

    12/26/2025

    Interventional Approaches to Treatment-Resistant Mood Disorders

    Joshua Berman, MD, PhD, discusses how careful evaluation, patient priorities, and risk-benefit tradeoffs guide the use of interventional treatments when conventional approaches fall short. Dr. Berman also explains how tools such as ketamine, TMS, ECT, and neurofeedback can be used strategically—sometimes in sequence or combination—to address different vulnerabilities within mood-related brain circuits. Dr. Berman is Associate Professor of Psychiatry and Director of Interventional Psychiatry at NYU Langone Health. Topics Evaluating patients who have not improved with medications or psychotherapyThe limitations of existing treatment guidelines for complex casesWhen and why sequencing or combining interventions may be appropriateEmerging approaches such as EEG-guided neurofeedback and focused ultrasoundBuilding a comprehensive, patient-centered interventional psychiatry programThis episode offers a clinician-level perspective on how interventional psychiatry is practiced today, and how new technologies may expand options for patients with the most challenging presentations. Chapters 00:00 Introduction: Caring for Patients Who Don’t Respond to Standard Treatment 00:47 What Is Interventional Psychiatry? 02:33 Evaluating Treatment-Resistant Presentations 06:31 Precision, Patient Priorities, and Clinical Judgment 09:35 Sequencing and Combining Interventions 10:40 Limits of Treatment Guidelines 12:18 The Future of Interventional Psychiatry 13:23 Emerging Technologies: Neurofeedback and Focused Ultrasound 17:15 Building a Comprehensive Interventional Program 18:13 Tools vs. Understanding Brain Circuits Watch Insights on Psychiatry on YouTube Senior Producer: Jon Earle

    19 min
  3. Complex Cases: The State of Precision Psychiatry

    12/19/2025

    Complex Cases: The State of Precision Psychiatry

    To kick off Season 4, Charles Marmar, MD, explains how precision psychiatry is reshaping the way clinicians and researchers think about diagnosis, treatment selection, and the underlying biology of psychiatric disorders. This conversation is a overview of where the field stands today—including emerging molecular markers, biologically informed subtypes, and new translational approaches inspired by oncology and other precision-based specialties. Dr. Marmar is Chair of Psychiatry at NYU Grossman School of Medicine, and Director of the Center for the Study of Alcohol Use Disorder and Traumatic Stress. In this episode, he outlines current work on: Molecular and genomic signatures that may distinguish patient subtypesClinical trials examining targeted treatments for alcohol use disorderThe development of proxy “brain biopsy” methods such as exosomal analyses and iPSC-derived organoidsHow converging biological data could eventually support more individualized treatment planningThis discussion reflects ongoing efforts at NYU Langone Health to move psychiatry toward a more mechanism-based, biologically grounded model of care, while acknowledging the complexity and early stage of the work. For clinicians, scientists, and trainees, the episode provides a clear snapshot of the major directions shaping precision psychiatry today. CHAPTERS 00:00 Introduction: The Challenge in Psychiatry00:34 Meet the Experts01:07 Understanding PTSD: Types and Subtypes04:47 Current Research and Innovations06:19 The Future of Psychiatry: Precision Medicine09:34 Case Study: Personalized Treatment Success11:33 Conclusion: The Path ForwardWatch Insights on Psychiatry on YouTube Senior Producer: Jon Earle

    13 min
  4. The Next Big Breakthrough

    05/21/2025

    The Next Big Breakthrough

    What if mental health care worked more like cancer treatment—tailored to the individual, informed by biology, and driven by data? Charles Marmar, MD, Chair of Psychiatry at NYU Grossman School of Medicine, takes us through the latest advances in precision psychiatry. From brain imaging to digital phenotyping, Dr. Marmar outlines the tools shaping a future where treatment is fully customized. He also shares stories from the front lines: a patient whose depression was treated with the help of a brain biopsy, why PTSD and depression aren’t one-size-fits-all, and how quantum computing could radically accelerate psychiatric research. 🔍 Topics Covered 00:00 Introduction 02:24 Personalized Treatment Approaches 05:13 Challenges in Precision Psychiatry 11:12 The Role of Genomics and Brain Imaging 23:35 Digital Psychiatry and AI 25:57 Quantum Computing in Psychiatry 33:04 Future of Precision Psychiatry 37:22 Conclusion 📚 Related Resources Charles Marmar, MD – NYU Faculty Profile NYU Langone Psychiatry Adriana Heguy, PhD – NYU Faculty Profile Javad Shabani, PhD – NYU Faculty Profile 🙌 Support & Subscribe If this episode challenged your thinking, like, share, and subscribe to help bring smart, science-forward conversations to a wider audience. Watch Insights on Psychiatry on YouTube Senior Producer: Jon Earle

    44 min
  5. The Schizophrenia Puzzle is Solvable

    05/14/2025

    The Schizophrenia Puzzle is Solvable

    There’s a care model for schizophrenia that actually works—why isn’t it everywhere? On this episode, W. Gordon Frankle, MD, MBA, Vice Chair of Psychiatry at NYU Langone Health, shares how his team in Brooklyn is building a new model for treating serious mental illness—one rooted in long-term, relationship-driven, team-based care. From wraparound services to precision psychiatry, this conversation explores what happens when you bring humanity, structure, and innovation to a population too often left behind. Also discussed: The first novel schizophrenia drug in over 50 years (Cobenfy)Why clozapine is underused—and how that may finally changeThe potential of brain imaging and biomarkers in psychiatric treatmentWhat a real community mental health system looks likeWhy trust, not just treatment, is essential for recovery🔍 Topics Covered 00:00 Introduction 00:30 Dr. Frankle's Current Work 01:08 Advancements in Schizophrenia Research 02:29 Challenges and New Treatments in Schizophrenia 05:02 Precision Medicine in Psychiatry 05:59 PET Scans and Brain Energetics 09:46 Barriers to Effective Treatment 11:51 Clozapine and Treatment Access 13:38 Wraparound Services and Community Care 14:46 Early Screening and Public Health Interventions 18:32 Mandated Treatment and Patient Engagement 30:08 Homelessness and Mental Health 34:54 Future Directions in Schizophrenia Treatment 38:09 Conclusion 📚 Related Resources W. Gordon Frankle, MD, MBA Schizophrenia care at NYU Langone NYU Langone Hospital—Brooklyn 3 Things to Know About Cobenfy (Yale Medicine) 🙌 Support & Engage If you enjoyed this episode, please like, share, and subscribe to support real conversations about transforming mental health care. Watch Insights on Psychiatry on YouTube Senior Producer: Jon Earle

    39 min
  6. How Psychedelics Rewire the Brain

    05/07/2025

    How Psychedelics Rewire the Brain

    How could a single psychedelic treatment cause lasting change? Joshua Siegel, MD, PhD, is on a mission to find out. A leading expert on neuroimaging and neuropsychopharmacology at NYU Langone’s Center for Psychedelic Medicine, Dr. Siegel unpacks how psilocybin may spark neuroplasticity and reshape the depressed brain. He also gives us an inside look at the race to develop non-hallucinogenic psychedelic analogs.  Dr. Siegel is an assistant professor at NYU Grossman School of Medicine. 🔍 Topics Covered: 00:00 Introduction 00:15 Dr. Siegel's Current Work 01:01 Past Research and Human Psilocybin Imaging Study 02:39 Understanding Brain Changes and Biomarkers 06:13 Mechanisms of Action and Plasticity 12:51 Surprising Findings and Context Dependence 16:34 Challenges and Future Directions in Psychedelic Research 20:46 Advanced Imaging and Personalized Treatment Plans 24:15 Setbacks and Lessons in Psychedelic Medicine 28:40 Emerging Areas in Neuropsychopharmacology 31:46 Conclusion 📚 Related Resources: Joshua Siegel, MD, PhD  NYU Langone Health’s Center for Psychedelic Medicine The Multidisciplinary Association for Psychedelic Studies (MAPS) “Psychedelic and Dissociative Drugs as Medicines” (NIH)  🙌 Support & Engage: Enjoyed this episode? Like, comment, and share to support science-based conversations about mental health. 🔔 Don’t forget to subscribe for more interviews with top psychiatric researchers. Watch Insights on Psychiatry on YouTube Senior Producer: Jon Earle

    32 min
  7. Can AI Help Prevent PTSD?

    04/30/2025

    Can AI Help Prevent PTSD?

    What if a simple conversation in the emergency room could reveal who’s most at risk for PTSD before symptoms even begin? Katharina Schultebraucks, PhD, shares her innovative work on using machine learning to forecast mental health outcomes and explains how AI could revolutionize how we detect, prevent, and treat psychiatric disorders. Dr. Schultebraucks is Co-Director of the Computational Psychiatry Program and Associate Professor in the Department of Psychiatry and Population Health at NYU Grossman School of Medicine. 🔍 Topics Covered 00:00 Introduction 00:23 Current Work and Research Focus 01:29 Objective Measures in Psychiatry 02:50 Predicting PTSD Risk 04:28 Early Preventive Interventions 05:47 Machine Learning in Mental Health 09:49 Challenges and Surprises in Research 22:46 Burnout in Emergency Department Providers 27:17 Precision Psychiatry and Future Directions 29:35 Conclusion 📚 Related Resources -Katharina Schultebraucks, PhD -Computational Psychiatry Program in NYU Langone’s Department of Psychiatry -“Dissecting racial bias in an algorithm used to manage the health of populations” by Ziad Obermeyer, et al -PTSD Treatment at NYU Langone Health  🔔 Subscribe for more conversations at the intersection of mental health and innovation. 📢 Like, comment, and share if this episode sparked your thinking. Watch Insights on Psychiatry on YouTube Senior Producer: Jon Earle

    30 min
  8. ADHD at School: What Actually Helps

    04/23/2025

    ADHD at School: What Actually Helps

    How do you help a child with ADHD stay organized, on task, and confident in school? Richard Gallagher, PhD, a child and adolescent psychologist at NYU Langone Health, shares groundbreaking research on organizational skills training for children with ADHD—a behavioral treatment that’s changing lives and improving classroom performance. This episode dives into how executive functioning challenges manifest in real life, the strengths (and limits) of technology, and the power of parent training and therapeutic coaching to help children thrive. Dr. Richard Gallagher is Associate Professor in the Department of Child and Adolescent Psychiatry at NYU Grossman School of Medicine, and Director of the Organization Skills Program. 🔍 Topics Covered 00:00 Introduction 00:19 Current Research on Organizational Skills 01:06 Executive Functioning and Practical Interventions 02:37 Impact of Interventions on ADHD 04:41 Expanding Research and Brain Connectivity 05:08 Medication and Organizational Skills 08:11 Technology in ADHD Assessment 15:39 Effective Parenting Styles for ADHD 23:10 Non-Pharmacological Treatments and Future Research 25:58 Conclusion and Final Thoughts 📚 Related Resources 👨‍⚕️More about Dr. Richard Gallagher 🔬 NYU Child Study Center 📘 “Organizational Skills Training for Children with ADHD” by Richard Gallagher, Howard B. Abikoff, and Elana G. Spira  📝 CHADD Parent Training Resources 📈 CDC ADHD Parent Guide 🙌 Support & Engage If this episode was helpful, please like, share, and subscribe to support the series and spread awareness about evidence-based ADHD care. Watch Insights on Psychiatry on YouTube Senior Producer: Jon Earle

    30 min
See All (36)

4.8
out of 5
20 Ratings

About

Conversations about complex psychiatric cases and evolving treatments. Host Charles Marmar, MD, Chair of Psychiatry at NYU Grossman School of Medicine, speaks with NYU Langone faculty about diagnostic reasoning, treatment decisions, and the ethical questions that arise in clinical practice.

Information

  • Creator
    NYU Langone Health Department of Psychiatry
  • Years Active
    2023 - 2026
  • Episodes
    36
  • Rating
    Clean
  • Copyright
    © 2026 NYU Langone Health
  • Show Website
    NYU Langone Insights on Psychiatry

You Might Also Like