Age of Aging

Penn Memory Center

Welcome to the Age of Aging, a podcast about living well with an aging brain. The Age of Aging is a podcast released every other Tuesday, covering a wide range of stories in aging research. Co-hosted by Jake Johnson and Terrence Casey from the Penn Memory Center communications team, each episode they will explore what it means to age with independence and dignity in the modern world. The Age of Aging is recorded and produced at the Michael Naidoff Communications Hub at the Penn Memory Center.

  1. MAY 19

    WHealthcare

    A longer lifespan is one of humanity’s greatest achievements. It also raises urgent questions about caregiving, financial security, and how we prepare for life after 65. On this episode of The Age of Aging, we take a look at the financial challenges that come with living longer.  First, Terrence Casey moderates a wide-ranging conversation with Surya Kolluri of the TIAA Institute and Dr. Mary Naylor of Penn Nursing’s NewCourtland Center for Transitions and Health about the financial realities of longevity in America. Later in the episode, financial experts Bode Hennegan and Christine Moriarty share practical strategies for planning ahead, avoiding common financial mistakes, and building long-term stability.  Inside this episode:   3:15 – A Different Life Structure: Surya Kolluri and Mary Naylor discuss the financial implications of an extended lifespan and why it will require fundamental changes on individual and societal level.  18:17 – The Sandwich Generation: Kolluri and Dr. Naylor Examine the growing pressures facing adults caring for both children and aging parents, and the policies needed to support them.  29:32 – 5 Financial Pitfalls: Bode Hennegan shares her top 5 most common pitfalls she sees older adults make when planning for later life.  35:24 – Money Peace: Christine Moriarty gives her top 5 financial planning tips for older adults.  41:24 – Start Saving and Communicating: Terrence Casey and Jake Johnson wrap up the episode by sharing the statistics that stayed with them most, and the changes they plan to make in their own lives.     Resources available on the episode webpage linked below  Visit the TIAA Institute’s website  Visit the NewCourtland Center for Transitions and Health’s website  More information on Surya Kolluri  More information on Mary Naylor   Learn more about Life Managers and Associates  Learn more about Money Peace    Special thanks this episode to Surya Kolluri, Mary D. Naylor, PhD, RN, FAAN, Bode Hennegan, and Christine Moriarty  The Age of Aging is a Penn Memory Center production, hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.  The show is made possible by generous support from the Michael Naidoff Communications Hub Fund.  Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, families across New Jersey and Pennsylvania receive guidance through every stage of the aging journey. Their team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind.  Rothkoff Law Group — your partner in elder care advocacy and senior care planning every step of the way. Visit RothkoffLaw.com for more information.

    48 min
  2. MAY 5

    Fragile Science

    The history of dementia research is a story of scientific progress stalled and derailed for nearly a century. 120 years ago, psychiatrist Alois Alzheimer made a groundbreaking discovery in the brain of a 55-year-old woman named Auguste Deter. Unfortunately, social and political turmoil would mean that his findings would not be widely understood until the end of the 20th century.   On this episode of The Age of Aging, Terrence Casey and Dr. Jason Karlawish reflect on Alzheimer’s discovery as well as the work of his colleague Oskar Fischer — a scientist on par with if not more consequential than Alzheimer in understanding the neuropathology of dementia — whose work was cut short by antisemitism and Nazi persecution. Together, they uncover how that finding was almost swallowed by the ideologies, politics, and global conflicts of the early 20th century — and the uncomfortable parallels between that time and our current moment.  Inside this episode:   0:48 – The First Case: Terrence Casey introduces the story of Auguste Deter, whose 1901 admission to a Frankfurt asylum would become the foundation of modern Alzheimer’s research.  4:34 – A Disease Without a Name: Why Deter’s symptoms didn’t fit existing diagnoses and how Alzheimer’s early observations challenged assumptions about aging and “senility.”  13:27 – A Revolutionary Idea: In 1911, Alzheimer proposed that “senile” and “presenile” dementia might be the same disease.  17:31 – Science Interrupted: How World War I, economic collapse, and political upheaval derailed progress in dementia research across Europe.  19:10 – The Forgotten Pioneer: How the contributions of Oskar Fischer to dementia research were nearly erased by antisemitism and Nazi persecution.  23:01 – The “Dark Ages” of Dementia: Why much of the 20th century viewed dementia as inevitable aging rather than disease.  30:48 – Lessons for Today: Why scientific progress depends on social, political, and economic stability — and what current global trends could mean for the future of dementia research.  32:41 – Rediscovery and Progress: The late 20th-century revival of Alzheimer’s research, including advances in diagnosis, biomarkers, and treatment.    Resources available on the episode webpage linked below  Learn more about the life and work of Alois Alzheimer   More information on the story of Alzheimer and Auguste Deter (PBS)  Read The Problem of Alzheimer's: How Science, Culture, and Politics Turned a Rare Disease into a Crisis and What We Can Do About It by Dr. Jason Karlawish  “Oskar Fischer and the study of dementia,” by Michel Goedert (National Library of Medicine)     Special thanks this episode to Jason Karlawish, MD.  The Age of Aging is a Penn Memory Center production, hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.  The show is made possible by generous support from the Michael Naidoff Communications Hub Fund.  Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, families across New Jersey and Pennsylvania receive guidance through every stage of the aging journey. Their team o...

    38 min
  3. APR 21

    Sprechstimme

    What does it mean to age well? For soprano Lucy Shelton, the answer may lie in music itself. At 82, Shelton recently made her debut at the Metropolitan Opera — performing in the world premiere of Innocence, a Finnish opera about a school shooting, sung in nine languages. On this episode of The Age of Aging, Dr. Jason Karlawish sits down with Shelton to explore her remarkable career, the relationship between music and the aging mind, and what it means to keep creating — and performing — well into the eighth decade of life.   Inside this episode:  0:00 – Shepherd on the Rock: Dr. Karlawish introduces Lucy Shelton with her recording of "Shepherd on the Rock" by Franz Schubert and shares why he wanted to interview her.  4:17 – Met Opera Debut at 82: Shelton and Dr. Karlawish discuss her debut at the Metropolitan Opera in Innocence, a Finnish opera performed in nine languages.  9:08 – A Musical Life: Shelton reflects on growing up in a musical family, discovering her voice, and building a career as a singer — not an opera singer.  15:23 – Singer vs. Opera Singer: Shelton explains what sets her apart from traditional opera singers, including the vocal techniques that have allowed her to keep performing into her eighties.  20:56 – Art Meets Life in Lucidity: Shelton describes performing Lucidity, a chamber opera written for her about a singer living with dementia — and what it meant to hold her score on stage, not just as a prop, but out of personal necessity.  26:34 – Bringing Lucidity to Philadelphia: Dr. Karlawish and Shelton discuss the possibility of bringing the opera to Philadelphia.  27:26– Music, Memory, and the Mind: Dr. Karlawish and Terrence Casey explore the connection between music and the aging brain, including PMC's partnership in the Community Voices Choir — a collaboration welcoming adults of all levels of cognition through music.  Resources available on the episode webpage linked below  Review of “Innocence,” in The Wall Street Journal   The New York Times Review of “Innocence.”  More information on “Innocence.” (The New York Times)  Visit Lucy Shelton’s website  Learn more about Shelton’s previous opera, “Lucidity.” (NPR)  Learn more about sprechstimme (Britannica)  More information on the Community Voices Choir  What Is the Association Between Music-Related Leisure Activities and Dementia Risk? A Cohort Study (International Journal of Geriatric Psychiatry)  Longitudinal effects of choir singing on aging cognition and wellbeing: a two-year follow-up study (Frontiers in Human Neuroscience)  Special thanks this episode to Jason Karlawish, MD, and Lucy Shelton.   The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terr...

    37 min
  4. APR 7

    "Make Way for the Masters"

    Exercise is one of the greatest things we can do for longevity and, according to Dr. Art Kramer, it’s never too late to start. On this episode of The Age of Aging, we look at one of the most accessible forms of exercise: running. We hear from competitive older runners about how they started, what keeps them going, and what running has given them over time.    Inside this episode:  4:13 – “Make Way for the Masters”: Masters athlete and Penn Relays coordinator Anthony Pugliese shares what makes the masters events at the Penn Relays so meaningful.  8:28 – Healthier Minds: Dr. Art Kramer explores how exercise benefits brain structure and function.  13:16 – A Half Hour Vacation: Masters runners reflect on how running helps them manage stress and clear their minds.  18:39 – Take it Slow: Bill McKenna and Anthony Pugliese offer advice for getting started with running and finding local track and field clubs.  Resources available on the episode webpage linked below  More information on Emily Largent   Visit the Penn Relays website  About the masters events at the Penn Relays  More information on Dr. Art Kramer  Study on Olga Kotelko’s brain  Fitness Effects on the Cognitive Function of Older Adults: A Meta-Analytic Study (Sage Journals)  Aerobic Exercise Training Increases Brain Volume in Aging Humans (The Journals of Gerontology)  Mental Health Benefits of Running (WebMD)  Visit Greater Philadelphia Track Club website  Learn more about track clubs and meets at usatf.org  Special thanks this episode to Emily Largent, PhD, JD, RN, Anthony Pugliese, Guy DeLillio, Art Kramer, PhD, Tom Jennings, Lauren Siegel, Claudia Simpson, Delvin Dinkins, and Bill McKenna.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.  The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund.  Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.

    30 min
  5. MAR 24

    Ambiguous Loss

    How do you grieve someone who is still standing in front of you? In this episode, we go beyond the medical diagnosis to explore Ambiguous Loss, the “long goodbye” that defines the dementia experience. It is a journey of grieving every day while the person you love is still living.    Inside this episode:  2:59 – "I Want to Go Home": Dr. Jason Karlawish uses poetry to dissect a fading mind.  12:01 – From Partner to Solo Parent: Eileen Ware’s journey with her husband Steve’s early-onset Alzheimer’s.  20:15 – Finding the Words: Dr. Cindy Weinstein on reclaiming her relationship with her father while grieving for 15 years.  31:30 – The Dual Process Model: Alison Lynn on why mourning in dementia is never linear.  Resources available on the episode webpage linked below  Learn more about Pauline Boss and ambiguous loss (Cleveland Clinic)  Read Dr. Karlawish’s poem, “Ambiguous Loss” in JAMA.  Learn more about Dr. Cindy Weinstein and her memoir, Finding the Right Words: A Story of Literature, Grief and the Brain  More information on Alison Lynn  More information on PMC’s support groups  The excruciating grief of watching a spouse become a stranger | STAT Special thanks this episode to Jason Karlawish, MD, Eileen Ware, Cindy Weinstein, PhD, and Alison Lynn, MSW, LCSW.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.  The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund.  Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.

    52 min
  6. MAR 10

    Getting Back to Life

    Nearly a year and a half ago, we released the Season 2 episode “In Sickness and in Health,” which explored new anti-amyloid therapies for Alzheimer’s disease, lecanemab and donanemab, known commercially as Leqembi and Kisunla.  After more than three years of lecanemab and nearly two years of donanemab in clinical use, how do patients, caregivers, and clinicians view these treatments today?  In this episode of The Age of Aging, we revisit the therapies reshaping Alzheimer’s care and hear from those experiencing them firsthand.  Inside this episode  Patients receiving anti amyloid therapy share reflections on treatment, uncertainty, and hope.  Dr. Justin Clapp discusses research on how patients, caregivers, and clinicians understand these therapies.  Dr. Kyra O’Brien reflects on prescribing the treatments and changes within clinical practice.  Dr. Jason Karlawish shares perspectives from patient conversations and clinical care.  Resources available on the episode webpage linked below  Listen to “In Sickness and in Health”  Learn more about Justin Clapp  Learn more about Kyra O’Brien  More information on anti-amyloid therapies  Special thanks this episode to Dave and Evelyn, Justin Clapp, PhD, MPH, Kyra O’Brien, MD, Joanne and Bruce Thomas, Sandy Shulan, and Jason Karlawish, MD.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.  The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund.  Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.

    35 min
  7. FEB 24

    The Miracle Kitchen

    We often think of dementia as an interior condition, one that happens within a person’s mind, independent of the outside world. However, as dementia and design experts note, we are in constant contact with our environments, and people with dementia are profoundly impacted by the spaces they occupy. How do we design a world for people with cognitive change? And what do the environments traditionally designed for older adults say about their current role in society? In this episode of The Age of Aging, we look at how architecture and design can both benefit those with dementia or become a detriment to their longevity.   Inside this episode:  The Miracle Kitchen: Dr. Jason Karlawish discusses the Greenhouse Project and alternative approaches to dementia care design.   The History of Concealment: Architectural historian Annmarie Adams explains how concealment has historically defined spaces for the sick and the elderly.   Inclusive Design: Dementia Design Specialists Greg and Fiona Walsh share how they implement inclusive designs to reduce stress and promote independence.  Resources available on the episode webpage linked below  Learn more about the Greenhouse Project  Read “Concealment and Compassion” by Shannon Mattern  Listen to Sally Chivers’ podcast, “Wrinkle Radio”   Read “Deception and Design: The Rise of the Dementia Village”   Explore the Alzheimer’s Foundation of America’s “The Apartment”  Learn more about Shannon Mattern  Learn more about Annmarie Adams  Visit Fiona Kenney’s website  Visit the Dementia Design Specialist Architects website  Special thanks this episode to Jason Karlawish, MD, Shannon Mattern, PhD, Annmarie Adams, PhD, Sally Chivers, PhD, Fiona Kenney, Greg Walsh, and Fiona Walsh.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson. Contributors include Dalia ElSaid, Jason Karlawish, Emily Largent, and Alison Lynn.  The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund.    Today’s episode is sponsored by The TIAA Institute, a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.    Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.

    40 min
  8. FEB 10

    A MINDful Diet

    Being intentional about our diet is one of the best things we can do for the health and longevity of our brain. But what exactly is a healthy brain diet—and how do we make it realistic?    In the season 5 premiere of the Age of Aging, we break down the science and strategy behind the MIND diet and what it looks like to shop and eat for cognitive longevity.    Inside this episode:  Terrence sits down with Dr. Jason Karlawish to discuss the results and implications of the U.S. POINTER study for healthy brain aging.  Dr. Karlawish explains the science behind the MIND diet and how he implements it in his daily life.   Registered dietitian nutritionist (and Terrence’s sister) Trish St. Ledger shares how to create nutritious meals that are both simple and affordable. St. Ledger provides an overview of a what typical day of breakfast, lunch, and dinner might look like following the MIND diet.   Resources available on the episode webpage linked below  More information on the MIND Diet (Cleveland Clinic)  More information on healthy eating and longevity (National Institute on Aging)  Learn more about Trish St. Ledger  Special thanks this episode to Jason Karlawish, MD and Trish St. Ledger, MS, RD, LDN.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.  The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund.

    54 min

Trailers

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About

Welcome to the Age of Aging, a podcast about living well with an aging brain. The Age of Aging is a podcast released every other Tuesday, covering a wide range of stories in aging research. Co-hosted by Jake Johnson and Terrence Casey from the Penn Memory Center communications team, each episode they will explore what it means to age with independence and dignity in the modern world. The Age of Aging is recorded and produced at the Michael Naidoff Communications Hub at the Penn Memory Center.

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