The Longevity Loop Podcast

Brent Wallace
  • 5.0 (3)
  • Alternative Health
  • Updated Weekly

The Longevity Loop with Brent Wallace is for dads who want to still be playing with their kids, and their grandkids, in their 80s and 90s.Not the guy with a $50,000 budget and a full-time coach. The guy with a job, a family, and 45 minutes a day.Brent's been running experiments on himself since 2018. Nutrition degree, 20-plus biomarkers tracked, too many supplements on the counter, and a kid who does not slow down. He's spent real money finding out what works and what's a waste, and he'll tell you which is which.Every week he talks with docs, scientists, founders, and coaches, and asks what you'd ask. Does this actually work? What does it cost? What would you do if it were your own body?We call out the hype, skip the noise, and get to what actually works in the real world.This is education, not medical advice, so talk to your own doc before you change anything.Watch the video version: youtube.com/@TheLongevityLoopBrent runs Spannr.com, a vetted directory of longevity clinics and practitioners, and founded LongevityClinicMarketing.com. 

  1. Oct 21

    Why Everything You Know About Aging Is Wrong

    Dr. Michael J. Hall: What Actually Earns a Spot in Your Protocol Episode Summary Brent Wallace speaks with Miami Beach longevity physician Dr. Michael J. Hall, author of *Infinite Youth: Solving the Aging Equation*, about what deserves a place in a longevity protocol. They examine supplement hype, rapamycin, methylene blue, growth hormone, resveratrol, and why sleep, nutrition, and movement come first. What You'll Hear - How Dr. Hall weighs clinical evidence and before-and-after labs over trends, and why he considers many supplements a waste. - Vitamin D dosing and sun exposure. Note: Adult RDA is 600 IU (800 IU over 70); 400 IU applies to infants. - Rapamycin's possible biomarker effects, with no proven human lifespan extension. - His "heliotropic" approach: light breakfast, protein at midday, root vegetables at dinner; plus 10–12 deep squats before meals. - Why he cautions against refined white flour, sugar, and rice. - His personal COVID experience with methylene blue, not a treatment recommendation. - His "Aging Funnel": foundational habits before peptides or supplements, plus managing wearable anxiety, longevity fatigue, and recovery. - How an ophthalmology residency dispute led him toward family medicine, New Zealand's health system, and preventive care. - His top three: sleep, nutrition, movement. Meet the Guest Dr. Michael J. Hall, MD, MSc, is a board-certified physician, Senior FAA Aviation Medical Examiner, and founder of Hall Longevity Clinic in Miami Beach (established 2006). His background includes ophthalmology training at New York Hospital/Cornell, a master's in healthcare management and law from NYU, and family medicine. His patients have included entertainers and professional athletes. He is developing WellSkor, a dashboard combining labs and wearable data. Guest Links - Clinic: https://hallongevity.com - Bio: https://hallongevity.com/about - Book (paperback): https://www.amazon.com/Infinite-Youth-Solving-Aging-Equation/dp/B0H486YDD3 - Book (Kindle): https://www.amazon.com/Infinite-Youth-Solving-Aging-Equation-ebook/dp/B0H9JPFM75 - WellSkor: [Sign-up link to verify] - Contact: michael@hallongevity.com | 866-937-4255 [Verify] Research and Context - TRIIM, Fahy et al. (2019), growth hormone/DHEA/metformin and thymus/epigenetic-age findings in a small trial: https://onlinelibrary.wiley.com/doi/10.1111/acel.13028 [Verify zinc mention] - PEARL, low-dose rapamycin (2025), 48-week safety and selected functional outcomes, not lifespan: https://www.aging-us.com/article/206235/text [Confirm this is Dr. Hall's study] - NIH vitamin D guidance: https://ods.od.nih.gov/factsheets/vitamind-consumer/ - Consumer Reports, phthalates in kids' snacks: https://action.consumerreports.org/nb-20260826-anniescheddarbunnies [Find main article] - Calorie restriction: CALERIE and NIA/Wisconsin primate studies [Add sources]. Human lifespan extension is not established. - Methylene blue and light for COVID [Research link needed]. Evidence is limited; interactions are possible. - Resveratrol/Sirtris: GSK bought Sirtris for $720M in 2008; its site closed in 2013. https://www.fiercebiotech.com/biotech/gsk-buys-sirtris-for-720m | https://newrepublic.com/article/112706 Other Mentions XYMOGEN: https://www.xymogen.com Also discussed: Thorne, Pure Encapsulations, Ortho Molecular Products, GI-MAP, CellCore, Oura Ring, WHOOP, David Sinclair, Peter Attia [name to verify], the French paradox, Blue Zones, Hippocrates' disputed "food is medicine" quote, and Wills Eye Hospital [name to verify]. Films: Forever Young (2025): https://tv.apple.com/us/movie/umc.cmc.4t1561uviumw4ofcri0ufql7v ; Elysium (2013). Spannr.com Find a vetted longevity practitioner: https://spannr.com — owned and published by Brent Wallace. Disclaimer The Longevity Loop is for education and entertainment, not medical advice. Brent is not a physician. Experiences, opinions, studies, and protocols discussed are not diagnoses, prescriptions, or guarantees of results. Consult a qualified healthcare professional before changing medications, supplements, diet, or exercise. Individual outcomes vary. Affiliate links or sponsored, gifted, or paid placements may appear; commissions may be earned at no extra cost. Opinions are those of the speakers, not necessarily The Longevity Loop, Longevity Clinic Marketing, or Spannr. You are responsible for your health decisions. Share this with someone in their 40s or 50s, and subscribe for weekly episodes. Think you're ready to revolutionize your clinic's first impression? Let's chat about some strategy! Visit https://longevityclinicmarketing.com for a friendly, no-pressure talk about boosting your clinic's marketing and reputation. We're here to help you shine from the moment patients reach out!

    Why Everything You Know About Aging Is Wrong

  2. Oct 14

    Why You're Not Optimizing Your Health and How to Fix It

    Sanjiv Lal spent twenty years building pharmaceutical, diagnostic, and laboratory companies. Then at forty, he became the patient, and the system he helped build told him to manage his decline. In this episode, Brent talks with Sanjiv about what happened next, and about the peptide boom nobody is explaining honestly. They get into what peptides actually are, why the FDA is reconsidering its restrictions on roughly nineteen of them, and what's really inside the vials people buy online. You'll hear about: - What it's like to become a patient inside the industry you built your career in - Why the future of regenerative medicine might be the signals cells send, not the cells themselves - Which peptides have real evidence and which ones people are taking on faith - The honest risk of gray-market "research use only" compounds - How a clinic decides what goes on its menu, and the red flags to walk out on - What to do about all of this on a normal budget Guest: Sanjiv Lal, pharmaceutical scientist, co-founder of RegenTherapy and Cell Factors, and Chief Innovation Officer at Beverly Hills Rejuvenation Center. Links: cell.health regentherapy.com linkedin.com/in/sanjiv-lal-456985149 Spannr.com, find vetted longevity clinics and practitioners Disclaimer: This podcast is for educational purposes only and is not personal medical advice, diagnosis, or treatment. Nothing in this conversation creates a clinician-patient relationship. Always work with your own licensed clinician before making decisions about your health. If this helped you think differently, share it with one person in their 40s or 50s who needs to hear it. Subscribe so you never miss a loop. Subscribe for weekly longevity, biohacking, and health optimization content. 🌐 Website: https://spannr.com #longevity #biohacking #antiaging #healthoptimization Think you're ready to revolutionize your clinic's first impression? Let's chat about some strategy! Visit https://longevityclinicmarketing.com for a friendly, no-pressure talk about boosting your clinic's marketing and reputation. We're here to help you shine from the moment patients reach out!

    Why You're Not Optimizing Your Health and How to Fix It

  3. Oct 5

    Why You're Failing at Recovery (And How to Fix It)

    Episode summary Dr. Quinto Pauletti joins Brent Wallace to discuss a challenge he sees in high-performing executives: some have neglected their health for years, while others have accumulated mountains of health data without knowing what it means. His approach starts with the fundamentals, then looks for missing pieces through health history, testing, wearables, lifestyle, oral health, and other tools. For people in their 40s and 50s trying to optimize everything at once, the takeaway is simple: more testing and more biohacks are not always the answer. Sometimes the next step is rebuilding the foundation first. What you'll hear in this episode The two high-performer profiles Dr. Pauletti commonly sees: the burned-out executive and the health optimizer overwhelmed by data.Why adding cold plunges, saunas, hard training, and other stressors can backfire when someone is already depleted.Why sleep, diet, exercise, hydration, stress management, sunlight, prayer, and meditation remain foundational.How Biostrap, HRV, Oura, WHOOP, and CGMs can add useful context without letting data become noise.Why oral health, biological dentistry, CBCT imaging, root canals, extraction sites, and amalgam fillings enter the longevity conversation.Dr. Pauletti's “Triad of Health”: structure, chemistry, and emotional stress.His Missing Link Protocol: calm, clear, then challenge/optimization.His take on full-body MRI screening, cold plunges, CGMs, and executive physicals in Brent's “Loop Filter.”Guest Dr. Quinto Pauletti, DC, is a chiropractor and executive health practitioner based in Pennsylvania. He holds a BS in Human Nutrition, Foods, and Exercise from Virginia Tech and a Doctor of Chiropractic degree from Palmer College of Chiropractic. His work focuses on executives and entrepreneurs using health history, testing, lifestyle assessment, and wearable data. Credential note: Public professional sources identify Dr. Pauletti as a DC, Doctor of Chiropractic, rather than an MD or DO. Links and resources mentioned Doc-Q — Dr. Pauletti's executive health practice: https://doc-q.com/ Running on Empty at the Top — Dr. Pauletti's upcoming book: https://runningonemptybook.com/ Biostrap — wearable and HRV monitoring platform: https://biostrap.com/ Oura Ring: https://ouraring.com/ WHOOP: https://www.whoop.com/ Function Health: https://www.functionhealth.com/ Bryan Johnson / Blueprint: https://blueprint.bryanjohnson.com/ Dr. Daniel Pompa: https://drpompa.com/ IABDM biological dentist directory: https://iabdm.org/location/ Dr. Dominik Nischwitz (“Dr. Dome”): https://linktr.ee/dr.dome Applied Kinesiology: https://www.icak.com/ Neuro Emotional Technique: https://www.netmindbody.com/ Quantum Neurology: https://www.quantumneurology.com/ Root Cause Protocol: https://therootcauseprotocol.com/ John Wooden’s “basics first” story: https://newsroom.ucla.edu/magazine/john-wooden-tie-shoes-teaching-basketball Evidence notes Dr. Pauletti discusses jaw “cavitations” or NICO as possible hidden sources of chronic infection. Evidence in this area remains disputed, with reviews noting limited-quality evidence and a lack of accepted diagnostic standards. He also discusses CBCT imaging and amalgam fillings. Current dental guidance recommends CBCT based on clinical need rather than routine use. The FDA does not recommend removing intact amalgam fillings solely to prevent disease when there is no decay or medical reason for removal. Whole-body MRI screening also comes up in the Loop Filter. Research suggests it can detect abnormalities in asymptomatic people, but incidental findings, inconsistent protocols, and limited long-term outcome data remain important limitations. Spannr.com Looking for a vetted longevity clinic or practitioner? Spannr.com is a longevity directory owned and published by Brent Wallace. https://spannr.com/ Disclaimer The Longevity Loop is for educational and entertainment purposes only and does not constitute medical advice. Brent Wallace is not a physician. Nothing shared should be taken as a diagnosis, treatment, or prescription. Always consult a qualified healthcare professional before changing your diet, supplements, medications, exercise, or health protocols. This channel may contain affiliate links, sponsorships, gifted products, or paid promotions. Guest opinions are their own and do not necessarily reflect those of the host, The Longevity Loop, Longevity Clinic Marketing, or Spannr.com.  Watch the video version: youtube.com/@TheLongevityLoop Think you're ready to revolutionize your clinic's first impression? Let's chat about some strategy! Visit https://longevityclinicmarketing.com for a friendly, no-pressure talk about boosting your clinic's marketing and reputation. We're here to help you shine from the moment patients reach out!

    Why You're Failing at Recovery (And How to Fix It)

  4. Sep 28

    Breaking Down the Barriers to a Longer Life

    We talk with Dr Ron Primas about what actually improves healthspan when you strip away expensive hype and focus on the basics that work. We dig into prevention, training, testing, and the social support that helps people stay resilient as they age.  • Lessons from caring for ultra-wealthy patients, including why money does not replace sleep, exercise, nutrition, and fasting  • Why social support and built-in care teams can extend functional years in extreme old age  • The Manhattan bubonic plague case, how it presented, and why catching it early matters  • Health literacy in Harlem, food deserts, and the Good Food in the Hood approach to changing what stores stock  • The three Es of preventive medicine: engineering, education, enforcement  • Why concierge medicine grew from insurance reimbursement pressures and the need for time-intensive prevention  • How longevity medicine overlaps with preventive medicine and why safety and fall prevention still count  • Intrinsic capacity as a real-world measure: grip strength, sit-to-stand, walking tests, cognition, mood  • Epigenetic clocks and other aging tests as motivation tools, plus which basic labs matter most  • Strength training as the key lever, with zone 2 and HIIT to support VO2 max  • Dr Primus’ routine: full-spectrum light, training split, Norwegian 4x4, lactate-guided zone 2, fasting adjustments  • Ancestral eating, fiber-rich tubers, and the role of organ meats in nutrient density  • Where to learn more: drprimus.com and a4li.org  share it with someone else, you know, especially if someone's in their 40s, 50s. subscribe so you don't miss your next longevity loop, and we'll see you there.  Watch the video version: youtube.com/@TheLongevityLoop Think you're ready to revolutionize your clinic's first impression? Let's chat about some strategy! Visit https://longevityclinicmarketing.com for a friendly, no-pressure talk about boosting your clinic's marketing and reputation. We're here to help you shine from the moment patients reach out!

    Breaking Down the Barriers to a Longer Life

  5. Sep 22

    Can We Invest Our Way to Longer Lives?

    You can buy a “longevity stack” in 30 seconds, but you can’t buy your way around biology. Today we sit down with Sergei Yakimov, a longevity-focused VC who has reviewed thousands of companies and only funded a handful, to unpack what actually earns conviction when real money and real outcomes are on the line. We dig into the difference between evidence-based biotech and consumer longevity hype: why clinics, stem cell storefronts, peptide trends, and easy app plays often fail the defensibility and data test, and why serious teams obsess over focus, endpoints, and a realistic FDA and clinical trials roadmap. Sergei also explains why venture capital is still educated guesswork, why “smart money” can be an absurd label, and how “fake it till you make it” collapses once new data packages have to survive external scrutiny. Then we go bigger: the influencer marketing engine and the human craving for shortcuts, why “aging is a disease” works as a catchy narrative but breaks down under measurement and trial design, and a more practical framework for longevity that targets the barriers that cause premature death disease by disease. We also get hands-on with what helps right now, from biomarker tracking to at-home blood testing that removes friction, plus a rapid-fire filter on resveratrol, NMN, senolytics, and plasma exchange. If you care about healthspan, biotech investing, and cutting through longevity misinformation, hit subscribe, share this with one person who loves a shortcut, and leave a review with the single idea you’re changing after listening.  Watch the video version: youtube.com/@TheLongevityLoop Think you're ready to revolutionize your clinic's first impression? Let's chat about some strategy! Visit https://longevityclinicmarketing.com for a friendly, no-pressure talk about boosting your clinic's marketing and reputation. We're here to help you shine from the moment patients reach out!

    Can We Invest Our Way to Longer Lives?

  6. Aug 31

    Biohacking for Longevity - The Truth They Don't Tell You

    Biohacking for longevity often hits a wall because critical pieces are missing from your daily routine. Learn to identify the silent gaps stalling your progress. Most people approach health optimization with a incomplete checklist. Dr. Thomas and Brent examine why standard wellness protocols frequently fail to deliver the expected results. By analyzing the overlooked factors in physical and mental performance, this conversation highlights exactly why your current habits might not be yielding the vitality you expect. Whether you are a newcomer or a dedicated biohacker, this session provides a practical framework to audit your lifestyle. We focus on the nuance of healthy aging, moving past surface-level advice to address the foundational elements required for true system efficiency. Subscribe for weekly longevity breakdowns, and let us know in the comments which health optimization topic you want us to cover next. #longevity #biohacking #antiaging #healthoptimization Subscribe for weekly longevity, biohacking, and health optimization content. 🌐 Website: https://spannr.com Want to go deeper into the science behind these conversations? David Donnelly's new course The Long Game covers 21 modules of longevity science with a real-world toolkit for better health decisions. Use code SPANNR for 25% off (brings it from $295 to $221):  https://foreveryoung.thinkific.com/products/courses/thelonggame?ref=137f61  Watch the video version: youtube.com/@TheLongevityLoop Think you're ready to revolutionize your clinic's first impression? Let's chat about some strategy! Visit https://longevityclinicmarketing.com for a friendly, no-pressure talk about boosting your clinic's marketing and reputation. We're here to help you shine from the moment patients reach out!

    Biohacking for Longevity - The Truth They Don't Tell You

  7. Aug 11

    How Hospitals Miss Early Warning Signs And What Families Can Do

    We talk with Dr. Jean Huddleston about what actually goes wrong in hospitals and why the biggest risks are often the quiet “misses,” not the dramatic mistakes. We also share practical ways to spot deterioration early, ask better questions, and advocate for the care we would want for our own family.  • why “commission” errors are a small slice of patient harm  • the “nurse worry factor” and why bedside intuition predicts decline  • two simple deterioration rules to trigger escalation  • why Mayo built a 100% mortality review and what it changed  • raw mortality versus adjusted metrics and why the difference matters  • AI-assisted case review that saves human time without replacing judgment  • the iceberg of omissions: missed diagnoses, delayed tests, untreated symptoms  • stopping the “freight train” with goals-of-care conversations  • full code, DNR, and using plain language for informed consent  • the Loved One Lens as a reality check for “oh but” excuses  • family advocacy tactics: bring meds, record talks, correct handoff errors  • when asking for a second opinion helps and when it backfires  • rapid response teams and whether families can call them  • what longevity data is useful in an acute admission and what is not  • preparing to advocate for parents before the crisis hits  Share it with someone.  Subscribe to the podcast just so you don’t miss the next loop episode.   Watch the video version: youtube.com/@TheLongevityLoop Think you're ready to revolutionize your clinic's first impression? Let's chat about some strategy! Visit https://longevityclinicmarketing.com for a friendly, no-pressure talk about boosting your clinic's marketing and reputation. We're here to help you shine from the moment patients reach out!

    How Hospitals Miss Early Warning Signs And What Families Can Do

  8. Aug 3

    How To Use Ozempic And Mounjaro Safely For Long-Term Results

    We challenge the biggest misconceptions about GLP-1 medications and explain why many “side effects” are really caused by dosing, behavior, and lack of guidance. We connect semaglutide and tirzepatide to metabolic health, dopamine, and longevity, then lay out a practical framework for using them with better results and less shame. • why GLP-1 side effects often come from misuse and poor education • how Bracca pivots from emergency medicine to IV Drips and then HelloDose • what “food noise” feels like and why quieting it changes behavior • the reward system, dopamine, and the pause between craving and action • why Bracca calls GLP-1s “longevity drugs” through insulin and glucose control • metformin comparison and why GLP-1s feel like a newer tool • microdosing for longevity goals and using a CGM for feedback • the DROP method: dose, real-time feedback, own habits, pause factor • sex drive concerns and why extreme cutting is the real risk • why people regain weight, body set point, and why tapering matters • muscle loss myth and why resistance training and creatine matter • how HelloDose works: virtual consults, shipped prefilled syringes, coaching support Share it with someone who might be curious about this or curious about longevity in general.  Watch the video version: youtube.com/@TheLongevityLoop Think you're ready to revolutionize your clinic's first impression? Let's chat about some strategy! Visit https://longevityclinicmarketing.com for a friendly, no-pressure talk about boosting your clinic's marketing and reputation. We're here to help you shine from the moment patients reach out!

    How To Use Ozempic And Mounjaro Safely For Long-Term Results
See All (31)

Ratings & Reviews

5
out of 5
3 Ratings

About

The Longevity Loop with Brent Wallace is for dads who want to still be playing with their kids, and their grandkids, in their 80s and 90s.Not the guy with a $50,000 budget and a full-time coach. The guy with a job, a family, and 45 minutes a day.Brent's been running experiments on himself since 2018. Nutrition degree, 20-plus biomarkers tracked, too many supplements on the counter, and a kid who does not slow down. He's spent real money finding out what works and what's a waste, and he'll tell you which is which.Every week he talks with docs, scientists, founders, and coaches, and asks what you'd ask. Does this actually work? What does it cost? What would you do if it were your own body?We call out the hype, skip the noise, and get to what actually works in the real world.This is education, not medical advice, so talk to your own doc before you change anything.Watch the video version: youtube.com/@TheLongevityLoopBrent runs Spannr.com, a vetted directory of longevity clinics and practitioners, and founded LongevityClinicMarketing.com. 

Information

  • Creator
    Brent Wallace
  • Years Active
    2025 - 2026
  • Episodes
    31
  • Rating
    Explicit
  • Copyright
    © 2026 The Longevity Loop Podcast
  • Show Website
    The Longevity Loop Podcast

You Might Also Like