Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Joanne Kennedy
  • 5.0 (16)
  • Alternative Health
  • Updated Weekly

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

  1. 2d ago ·  Bonus

    Q&A. Why Do I Feel Sick From Having an Epsom Salt bath?

    Do you feel nauseous, dizzy, exhausted, or brain foggy after an Epsom salt bath? If a bath you hoped would help you relax leaves you feeling worse, you might wonder whether you’re experiencing a “detox reaction,” reacting to the heat or struggling to tolerate the Epsom salts themselves. In this short Q&A episode of The Histamine Well Podcast, Joanne explores possible reasons for feeling sick after an Epsom salt bath, including bath temperature, changes in blood pressure, histamine intolerance, mast cell activation and sensitivity to sulfur compounds. Epsom salts are magnesium sulfate. Joanne explains the role of sulfate in a detoxification pathway called sulfation and discusses why people use Epsom salt baths as part of their detox routines. She also shares why feeling unwell afterwards should not automatically be interpreted as a sign that a treatment is working—or a reason to push through. If you’ve been searching for answers about Epsom salt bath side effects, feeling dizzy after a hot bath, or the possible connection between histamine intolerance and Epsom salts, this episode offers a starting point for understanding your reaction and discussing it with your practitioner. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  2. 4d ago

    57. Gut Microbiome & Hydrogen Sulfide SIBO | Intestinal Sulfide Overgrowth Explained

    Do eggs, garlic, onions or broccoli leave you feeling bloated, fatigued or foggy-headed? In episode 57 of The Histamine Well Podcast, Joanne explores hydrogen sulfide SIBO and intestinal sulfide overproduction (ISO), discussing how sulfur-producing gut bacteria may contribute to these symptoms. Discover: The connection between sulfur intolerance and the gut microbiome.Why hydrogen sulfide production and clearance both matter.The uses and limitations of stool and breath testing.Joanne’s clinical approach to low sulfur diets, oregano, molybdenum and digestive support.Joanne also discusses where the evidence remains limited and why symptoms alone cannot confirm the cause. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  3. Sep 9 ·  Bonus

    Q&A. What Should I Do if I'm Constipated on the Low-FODMAP Diet?

    Struggling with constipation on the low-FODMAP diet? If your bloating has improved but your bowel movements have slowed down, what should you consider next? In this short Q&A episode of The Histamine Well Podcast, naturopath Joanne Kennedy shares how she approaches constipation in patients following a low-FODMAP diet. She discusses fibre intake, hydration, digestive support, and the role of the nervous system in bowel regularity. If you’re navigating constipation, SIBO, bloating or histamine intolerance, this episode offers practical topics to discuss with your treating practitioner. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  4. Sep 7

    56. Can Gut Dysbiosis Cause Anxiety & Depression? What the Science Actually Says

    Can an imbalanced gut microbiome contribute to anxiety and depression? We often think of mental health conditions as beginning solely in the brain. However, growing research suggests that the gut microbiome may also influence mood through the gut–brain axis. In this episode of The Histamine Well, Joanne explores what gut dysbiosis is and how the gut communicates with the brain through the vagus nerve, immune signalling, inflammation, stress hormones, short-chain fatty acids and neurotransmitter precursors. Joanne also examines what the research actually says about probiotics, intestinal permeability, depression and anxiety—without overstating the evidence or promising a simple cure. In this episode, you’ll learn: What gut dysbiosis means and what can disrupt the gut microbiomeHow the vagus nerve connects the gut and brainWhy short-chain fatty acids are important for inflammation and brain healthHow gut bacteria may influence the stress response and serotonin productionWhat studies have found about the microbiome and depressive symptomsWhy the evidence for depression is currently stronger than the evidence for anxietyWhat “psychobiotics” are and why probiotic benefits are strain-specificWhy gut health interventions should complement—not replace—appropriate mental health treatmentPractical ways to support microbial diversity and the gut–brain axisWhy fermented foods and some prebiotic fibres may not suit everyone with histamine intolerance or SIBOThe science supports a genuine connection between gut health and mental health, but the relationship is complex. There is no single probiotic, diet or supplement proven to resolve anxiety or depression on its own. Supporting the gut through a diverse, fibre-rich diet, appropriate prebiotic or fermented foods, regular movement, sufficient sleep and stress management may form one valuable part of a broader approach to mental wellbeing. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  5. Aug 31

    55. Bile & Digestion: Ox Bile, TUDCA, Taurine & Phosphatidylcholine Explained

    Could sluggish bile be affecting your digestion, gut health and histamine symptoms? In this episode of The Histamine Well Podcast, Joanne Kennedy explains the essential role bile plays in fat digestion, nutrient absorption, liver detoxification and microbial balance. She also explores how poor bile flow may contribute to SIBO, histamine intolerance and increased oxalate absorption. Joanne breaks down four popular bile-support supplements—ox bile, TUDCA, taurine and phosphatidylcholine—including how each works, when it may be considered and why they are not interchangeable. In This Episode, You’ll Learn: Common symptoms of sluggish or inadequate bile flowWhat happens to digestion after gallbladder removalHow poor bile flow may contribute to SIBO and histamine intoleranceThe connection between fat malabsorption and oxalatesHow ox bile supports fat digestionHow TUDCA supports liver health and bile flowWhy taurine is needed to produce functional bile saltsHow phosphatidylcholine supports bile quality and methylationImportant supplement precautions involving gallstones and bile duct obstructionListen now to understand how bile affects digestion—and how targeted support may benefit your liver, gallbladder and gut health. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  6. Aug 24

    54. Stress, Cortisol & Histamine: The Hidden Loop

    In this episode of The Histamine Well, Joanne explores the powerful connection between stress, cortisol, mast cell activation, and histamine intolerance. She explains how chronic stress can keep the nervous system trapped in fight-or-flight mode, trigger histamine release, and contribute to symptoms such as itching, flushing, headaches, sinus congestion, digestive issues, and skin reactions. You’ll learn how the HPA axis responds to stress, why cortisol is helpful in the short term, and what can happen when the body becomes less responsive to cortisol’s anti-inflammatory effects. Joanne also discusses how reduced vagal tone may affect inflammation, mast cell reactivity, and the body’s ability to return to a calm, regulated state. In this episode, you’ll discover: How stress activates the HPA axis and sympathetic nervous systemThe connection between cortisol, mast cells, and histamineWhy chronic stress may worsen histamine intolerance and MCAS symptomsHow stress-signalling molecules can trigger histamine releaseWhat glucocorticoid resistance is and how it may affect inflammationThe role of the vagus nerve in immune and nervous-system regulationWhy antihistamines may not address the upstream causePractical ways to improve vagal tone and support nervous-system regulationJoanne also shares simple strategies to help the body shift from fight-or-flight into rest-and-repair mode, including breathwork, humming, singing, gentle neck massage, and other vagus nerve exercises. If your histamine symptoms seem to flare during periods of stress, this episode will help you understand why—and what you can do to begin breaking the stress–histamine cycle. Resources mentioned: The Secret Language of the BodyThe Workout Witch nervous-system programs✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  7. Aug 17

    Are Oxalates Fueling Your Histamine Intolerance? (with Melanie Peers) [Replay]

    Could oxalates be the hidden reason your histamine intolerance symptoms aren’t improving? In this popular podcast replay, Joanne is joined by Melanie Peers to explore the often-overlooked connection between oxalates, histamine intolerance, inflammation, gut health, and nervous system dysregulation. Oxalates are naturally occurring compounds found in many foods—including some commonly considered healthy. For sensitive individuals, a high oxalate load may contribute to pain, digestive problems, urinary symptoms, fatigue, and increased reactions to foods and supplements. In this episode, Joanne and Melanie discuss: What oxalates are and how they can affect the bodyThe connection between oxalates, histamine, and inflammationCommon high-oxalate foods that may be contributing to symptomsSigns and symptoms associated with oxalate overloadHow gut health may influence oxalate absorptionThe impact of oxalates on minerals, sulfur, and important detoxification pathwaysWhy some people develop multiple food and supplement intolerancesThe role of methylation and transsulfuration pathwaysWhy nervous system regulation is an important part of recoveryWhy oxalates should be reduced carefully rather than eliminated too quickly✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  8. Aug 11

    How Histamine Works (and What Happens When It's Too High) [Replay]

    What is histamine, and why does it cause so many frustrating symptoms?  In this replay of one of our most popular episodes, Joanne explains the science of histamine intolerance in a simple, practical way. Learn how histamine affects your immune system, gut health, hormones, brain, and skin, why histamine levels become too high, and the common symptoms of histamine intolerance—including migraines, anxiety, insomnia, hives, eczema, reflux, bloating, and more.  Discover why a low-histamine diet alone isn't enough and why identifying the root cause is the key to lasting relief.  Whether you're new to histamine intolerance or revisiting this episode, this is the perfect place to start your healing journey. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

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5
out of 5
16 Ratings

About

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

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