Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Joanne Kennedy
  • 5.0 (16)
  • Alternative Health
  • Updated Weekly

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

  1. 1d ago

    50. Is PMDD a Histamine Problem? H1 and H2 Blockers Explained

    Could histamine be contributing to Premenstrual Dysphoric Disorder (PMDD)? In this episode of The Histamine Well Podcast, Joanne explores the growing interest in the connection between PMDD, histamine intolerance, mast cell activation, and hormonal fluctuations. As more women report improvements in PMDD symptoms with antihistamines, the question is gaining attention: could histamine be a missing piece of the PMDD puzzle? Joanne breaks down the science behind the estrogen-histamine feedback loop, explains how histamine interacts with estrogen and progesterone throughout the menstrual cycle, and discusses why some women experience worsening mood symptoms during the luteal phase. You'll learn about the role of mast cells, neurotransmitters, neuroinflammation, and hormone sensitivity in PMDD, as well as the potential benefits and limitations of H1 and H2 antihistamines. Joanne also shares her clinical observations on histamine-related hormone symptoms and why addressing underlying drivers of histamine excess may be essential for long-term symptom improvement. In This Episode You'll Learn: What PMDD is and how it differs from PMSThe relationship between histamine and women's hormonesHow estrogen can increase histamine levelsThe role of progesterone in histamine regulationMast cell activation and hormone-related symptomsWhy histamine may worsen anxiety, irritability, and mood swingsThe science behind H1 and H2 blockersPotential risks of long-term antihistamine useHistamine's effects on neurotransmitters including serotonin and dopamineThe connection between PMDD, MCAS, and histamine intoleranceWhy methylation may play a role in PMDD symptomsCommon root causes of histamine excess, including SIBO, mold exposure, oxalates, and gut dysfunctionNatural strategies for addressing histamine-related hormone symptoms✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    23 min

  2. Jun 8

    49. Mould & Mitochondria: Why You're Still Exhausted (and What's Really Driving It)

    Persistent fatigue is one of the most common—and most frustrating—symptoms experienced by people with mould illness. Many find that despite sleeping more, resting, pacing themselves, and trying countless supplements, the exhaustion simply doesn't improve. In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould illness and mitochondrial dysfunction, revealing why fatigue can persist long after mould exposure has been identified. You'll learn how three key factors often work together to impair cellular energy production: Mycotoxins and their direct toxic effects on mitochondriaSulfur depletion and reduced glutathione productionOxalate accumulation and mitochondrial stressJoanne explains how these mechanisms can disrupt ATP production, increase oxidative stress, and contribute to symptoms such as chronic fatigue, brain fog, muscle weakness, exercise intolerance, post-exertional malaise, pain sensitivity, and temperature dysregulation. This episode also explores the important relationship between mould exposure, gut dysbiosis, SIBO, sulfur metabolism, and oxalate overload—factors that are frequently overlooked when addressing ongoing fatigue and recovery from mould illness. Whether you're a practitioner, student, or someone navigating chronic health challenges, this episode provides valuable insights into the biological processes driving fatigue and what may need to be addressed for meaningful recovery. In this episode, you'll discover: How mould toxins damage mitochondrial functionWhy fatigue often persists despite rest and sleepThe critical role of sulfur in energy production and detoxificationHow oxalates can contribute to mitochondrial dysfunctionCommon signs of mould-related mitochondrial impairmentWhy addressing mould exposure alone may not be enough for recovery✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    12 min

  3. Jun 1

    48. How Mould Mycotoxins Cause SIBO

    In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould mycotoxins and Small Intestinal Bacterial Overgrowth (SIBO) — and why so many people with chronic digestive symptoms may be missing the true root cause of their gut dysfunction. If you’ve been struggling with bloating, reflux, constipation, diarrhea, histamine intolerance, food sensitivities, nausea, fatigue, or recurring SIBO that never fully resolves, this episode explains how mould exposure may be contributing to ongoing nervous system and digestive dysfunction. Joanne breaks down the mechanisms behind mould-related gut issues, including how mycotoxins impact the vagus nerve, gut motility, stomach acid production, bile flow, pancreatic enzymes, inflammation, and the migrating motor complex. She also discusses why chronic SIBO cases are often difficult to treat when mould toxicity is not properly addressed. In this episode, you’ll learn: Why mould illness and SIBO commonly occur togetherHow poor vagal tone affects digestion and bacterial overgrowthThe connection between mould, histamine intolerance, and mast cell activationWhy low stomach acid and sluggish bile flow can worsen gut symptomsHow chronic inflammation disrupts gut motility and digestive functionWhy antibiotics and herbal antimicrobials may not fully resolve SIBOThe importance of mould testing in chronic gut health conditions#SIBO #MouldIllness #HistamineIntolerance #GutHealth #Mycotoxins #MCAS #FunctionalMedicine #DigestiveHealth #MoldToxicity #VagusNerve ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    15 min

  4. May 25

    47. The Bile-Histamine Connection: SIBO, Estrogen, Mold & Oxalates Explained

    What if your histamine symptoms aren’t just about food? In this episode of the The Histamine Well Podcast, Joanne explores the overlooked connection between bile flow, histamine intolerance, SIBO, estrogen dominance, mold exposure, oxalates, methylation, and chronic inflammation. Bile plays a critical role in digestion, detoxification, hormone clearance, and microbial balance in the gut. When bile flow becomes sluggish, it can contribute to bacterial overgrowth, poor fat digestion, impaired estrogen detoxification, oxalate accumulation, and worsening histamine symptoms. In this episode, Joanne explains: How poor bile flow contributes to histamine intoleranceWhy mold toxicity and mycotoxins affect the liver and gallbladderThe vicious cycle between SIBO and bile dysfunctionHow estrogen dominance impacts bile flow and histamineWhy oxalates can worsen inflammation and histamine symptomsThe role of methylation and phosphatidylcholine in healthy bile productionHow vagus nerve dysfunction affects digestion and bile releaseCommon signs and symptoms of poor bile flowThis episode is essential listening for anyone struggling with histamine intolerance, MCAS, gut health issues, bloating, hormone imbalances, mold illness, chronic inflammation, food sensitivities, or unexplained digestive symptoms. 🎧 Subscribe to The Histamine Well Podcast for evidence-based conversations on histamine intolerance, methylation, SIBO, mold illness, women’s hormones, and functional medicine. #HistamineIntolerance #SIBO #GutHealth #MoldIllness #EstrogenDominance #Oxalates #Methylation #FunctionalMedicine #BileFlow ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    11 min

  5. May 4

    46. High Homocysteine: Histamine, Methylation & Why You Might Not Tolerate Methylated B Vitamins

    Can methylated B vitamins make your symptoms worse instead of better? In this episode of The Histamine Well Podcast, Joanne explains the connection between high homocysteine, histamine intolerance, methylation, and why some people react poorly to methylated nutrients. High homocysteine is associated with cardiovascular disease, cognitive decline, inflammation, and neurological health concerns — yet lowering it isn’t always simple. Many people experience headaches, anxiety, insomnia, digestive issues, skin flare-ups, or worsening histamine symptoms when taking methylfolate or methyl B12. Joanne breaks down the methylation cycle in simple terms, explains the role of histamine in nutrient tolerance, and explores how genetics such as the MTHFR gene mutation and COMT enzyme activity may influence how your body responds to methylated supplements. In this episode, you’ll learn:  • What high homocysteine means and why it matters  • The connection between homocysteine and methylation  • Why methylated B vitamins can trigger symptoms  • Histamine intolerance and supplement sensitivity  • The role of MTHFR, COMT, and methylation pathways  • Overmethylation vs undermethylation explained  • Practical clinical insights for improving tolerance to methyl nutrients Whether you're a practitioner, student, or navigating your own health journey, this episode offers practical education on histamine, methylation, gut health, and root-cause healing. Subscribe to The Histamine Well Podcast for expert discussions on histamine intolerance, women’s hormones, functional medicine, gut health, methylation, and integrative wellness. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    12 min

  6. Apr 29

    Q&A. Should I Take Calcium-D-Glucarate Whilst On HRT Oestrogen?

    Can you take Calcium-D-Glucarate while on HRT estrogen during menopause? In this short Q&A episode of The Histamine Well Podcast, Joanne explores the relationship between estrogen detoxification, hormone replacement therapy (HRT), menopause, gut health, and histamine-related symptoms. Many women are advised to take supplements that support estrogen detox, but is this always the right approach when using bioidentical hormones or estrogen therapy? Joanne explains why Calcium-D-Glucarate may not be beneficial for menopausal women on HRT, how estrogen balance works during menopause, and why understanding your hormone dose matters for symptom relief and long-term wellbeing. This episode also covers:  The role of estrogen during menopause and HRT  Why over-detoxifying estrogen may worsen symptoms  The connection between beta-glucuronidase, the estrobolome, and gut microbiome health  Histamine intolerance, hormone imbalance, and menopause symptoms  Natural considerations for estrogen metabolism and hormone support  Why gut health may be more important than estrogen detox supplements If you're navigating menopause, hormone replacement therapy, estrogen dominance symptoms, histamine intolerance, or gut-related hormone imbalance, this episode offers practical clarity backed by clinical naturopathic insight.  Subscribe to The Histamine Well Podcast for expert conversations on histamine intolerance, methylation, gut health, hormones, mold illness, MCAS, menopause, and functional medicine approaches to healing. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    5 min

  7. Apr 27

    45. Case Study: SIBO, Histamine Intolerance & Hormonal Imbalance

    In this episode of The Histamine Well, Joanne shares a powerful clinical case study exploring the connection between SIBO (Small Intestinal Bacterial Overgrowth), histamine intolerance, hormonal imbalance, estrogen dominance, gut health, bloating, acne, fatigue, and PMS symptoms. This episode follows the journey of a 37-year-old woman who experienced rapid body changes over two years — including unexplained weight gain, chronic bloating, severe PMS, hormonal acne, headaches, fluid retention, breast tenderness, digestive discomfort, and low energy. Through functional testing and a naturopathic treatment approach, Joanne uncovers how gut dysfunction, histamine overload, and hormone imbalance can work together to drive chronic symptoms. You’ll discover how SIBO contributes to nutrient malabsorption, inflammation, estrogen dominance, histamine intolerance, and digestive dysfunction, along with why symptoms such as bloating, fatigue, skin issues, and menstrual changes are often connected. In this episode, Joanne discusses: The link between SIBO, histamine intolerance, and hormonal imbalanceWhy bloating, PMS, headaches, and acne may stem from gut dysfunctionThe difference between hydrogen and methane SIBOHow nutrient deficiencies affect hormones, mood, and energyWhy is bowel motility essential for successful SIBO treatmentThe role of biofilms in persistent gut symptomsFunctional medicine strategies for improving gut and hormone healthWhether you are a practitioner, student, or someone navigating digestive and hormone-related symptoms, this episode offers practical insight into the deep connection between gut health, histamine, hormones, and systemic inflammation. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    17 min

  8. Apr 22 ·  Bonus

    Q&A. How Do Epsom Salt Baths Work & Why Are They Good For Me?

    Can something as simple as an Epsom salt bath support detoxification, gut health, and nervous system regulation? In this Q&A episode of The Histamine Well Podcast, Joanne breaks down the clinical benefits behind Epsom salt baths (magnesium sulfate)—and why they’re often recommended for patients dealing with histamine intolerance, sulfur issues, chronic fatigue, and food sensitivities. You’ll learn how magnesium and sulfate work together in the body, how they’re absorbed through the skin, and why this gentle therapy can support everything from sleep and muscle relaxation to liver detox pathways and gut lining integrity. 🎧 In this episode, you’ll learn:  What Epsom salt (magnesium sulfate) actually is  How transdermal absorption supports magnesium levels  The role of sulfate in liver detoxification (sulfation pathway) Why sulfate is essential for gut lining, skin, and connective tissue health How Epsom salt baths support the nervous system and stress response Why they’re helpful for people with histamine intolerance, sulfur sensitivity, mold illness, and oxalate issues How to safely start Epsom salt baths (especially if sensitive) Epsom salt baths aren’t just about relaxation—they’re a powerful, low-cost tool to support detox pathways, reduce stress, and restore key nutrient levels without burdening the digestive system. This makes them especially beneficial for those who struggle to tolerate supplements or are dealing with complex chronic symptoms. If you’ve ever wondered whether Epsom salt baths actually “do anything”—this episode will give you a clear, science-backed answer and practical guidance. Tune in to learn how to use this simple therapy effectively and safely. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    5 min
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5
out of 5
16 Ratings

About

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

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