Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Joanne Kennedy
  • 5.0 (16)
  • Alternative Health
  • Updated Weekly

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

  1. 4d ago

    Q&A. Why Do I Feel Depressed On Calcium-D-Glucarate?

    Have you noticed low mood or sadness after taking calcium D-glucarate? If you’re using it to support oestrogen detoxification or address high beta-glucuronidase on a gut test, your stage of life and hormone levels deserve consideration. In this short Q&A episode of The Histamine Well, Joanne explores why calcium D-glucarate may not suit everyone, particularly during perimenopause and menopause. She discusses the potential connection between oestrogen clearance and mood, and shares her own experience of feeling unusually sad while taking the supplement. If a supplement leaves you feeling worse, that experience deserves attention. Listen to hear why Joanne encourages a closer look at your hormones, symptoms and treatment plan. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  2. 6d ago

    60. The Gut and Immune System: The Histamine Connection

    Could your gut help explain why you’re reacting to foods you once tolerated? In this episode of The Histamine Well, Joanne explores the connection between gut health and histamine intolerance, explaining how the microbiome, intestinal lining, immune system, and nervous system interact. A low histamine diet may help reduce symptoms, but what happens when the gut itself is contributing to your histamine burden? Joanne discusses SIBO, dysbiosis, histamine-producing bacteria, mast cells, and the DAO enzyme—and why understanding the underlying contributors matters. What you’ll learn: How the intestinal barrier and secretory IgA help protect your gut.Why microbial diversity, butyrate and immune tolerance matter.How SIBO, dysbiosis and intestinal inflammation may contribute to histamine symptoms.How mast cells and certain gut bacteria produce histamine.Why intestinal health matters for DAO, the enzyme that helps break down dietary histamine.How stress, the nervous system, and gut motility can influence digestive symptoms.Why gut support needs to be personalised to your symptoms and tolerance.Whether you’re navigating histamine intolerance yourself or supporting patients in clinical practice, this episode offers a clearer understanding of the gut–immune connection. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  3. Sep 30 ·  Bonus

    Q&A. Why Do I Feel More Bloated on a Low FODMAP Diet?

    A low FODMAP diet is often used to reduce bloating, so why might your symptoms get worse after starting one? In this short Q&A episode, Joanne explores three possibilities: eating more sulfur-rich foods, replacing wheat with higher-oxalate ingredients, and changes in gut motility, including the migrating motor complex. She explains why it’s worth looking at what has changed in your diet instead of simply pushing through worsening bloating. In this episode: How food swaps on a low FODMAP diet may increase your sulfur or oxalate intakeSymptoms Joanne suggests watching for alongside bloatingWhy the migrating motor complex may matter when bloating persistsWhy a SIBO test can help clarify what may be going on✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  4. Sep 28

    59. Circadian Rhythm: How Your Body Clock Affects Sleep, Hormones, Gut Health & Histamine

    In this episode of The Histamine Well, Joanne is joined by clinical nutritionist Melanie Peers to explore circadian rhythm: the daily cycle that helps coordinate sleep, energy, hormones, digestion and immune activity. They also discuss why histamine symptoms may feel worse at certain times of the day or night. Joanne and Melanie talk about the signals that can disrupt your body clock, from spending the day indoors to bright lights, screens and late meals at night. They share practical ways to support a more consistent rhythm, including morning daylight, time outdoors during the day and a darker evening routine. In this episode, you’ll learn: What circadian rhythm is and why it matters beyond sleepHow light and darkness influence cortisol and melatoninWhy meal timing may matter for digestion and gut motilityHow histamine activity follows a daily patternSimple ways to support your body clock within your routineIf you’re navigating histamine intolerance, sleep difficulties, hormone concerns or persistent gut symptoms, this conversation offers another piece of the picture to discuss with your healthcare practitioner. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  5. Sep 23 ·  Bonus

    Q&A. Why Do I Feel Sick from Taking N-Acetylcysteine?

    NAC can support glutathione production, respiratory health and biofilm disruption—but some people experience nausea, headaches, brain fog, fatigue or bloating after taking it. In this Q&A episode, Joanne explains how reactions to NAC may be connected to sulfur intolerance, hydrogen sulfide production, gut dysbiosis, biofilm disruption and sensitivity to its mucolytic effects. You’ll also learn why feeling worse doesn’t necessarily mean NAC is working—and why a lower dose, slower introduction or different approach may be needed. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  6. Sep 21

    58. Biofilms: Why SIBO, Candida & Gut Infections Keep Coming Back

    Why do SIBO, Candida, and other gut infections sometimes return—even after treatment initially seems successful? In this episode of The Histamine Well Podcast, Joanne explains how biofilms may contribute to persistent bacterial and fungal overgrowths. Biofilms are organised microbial communities surrounded by a protective matrix that can help microorganisms survive antimicrobial treatment and resist immune defences. Joanne explores the role biofilms may play in recurring SIBO, Candida overgrowth, gut dysbiosis, chronic sinus infections and MARCoNS. She also explains how bacteria and fungi can communicate, share resources and coexist within mixed-species biofilms. You’ll discover: What biofilms are and why microorganisms create themWhy SIBO, Candida and gut infections may keep returningHow biofilms can protect bacteria and fungiThe connection between biofilms, chronic sinus infections and MARCoNSHow Candida and Aspergillus form fungal biofilmsThe difference between mould, mycotoxins and biofilmsWhat the biofilm matrix is made fromHow enzymes and N-acetylcysteine may support biofilm disruptionWhy biofilm support should be introduced gradually during antimicrobial treatmentIf you’re dealing with recurring digestive symptoms or want to better understand persistent microbial overgrowths, this episode offers a clear and practical introduction to biofilms and their potential role in gut and sinus health. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  7. Sep 16 ·  Bonus

    Q&A. Why Do I Feel Sick From Having an Epsom Salt Bath?

    Do you feel nauseous, dizzy, exhausted, or brain foggy after an Epsom salt bath? If a bath you hoped would help you relax leaves you feeling worse, you might wonder whether you’re experiencing a “detox reaction,” reacting to the heat or struggling to tolerate the Epsom salts themselves. In this short Q&A episode of The Histamine Well Podcast, Joanne explores possible reasons for feeling sick after an Epsom salt bath, including bath temperature, changes in blood pressure, histamine intolerance, mast cell activation and sensitivity to sulfur compounds. Epsom salts are magnesium sulfate. Joanne explains the role of sulfate in a detoxification pathway called sulfation and discusses why people use Epsom salt baths as part of their detox routines. She also shares why feeling unwell afterwards should not automatically be interpreted as a sign that a treatment is working—or a reason to push through. If you’ve been searching for answers about Epsom salt bath side effects, feeling dizzy after a hot bath, or the possible connection between histamine intolerance and Epsom salts, this episode offers a starting point for understanding your reaction and discussing it with your practitioner. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  8. Sep 14

    57. Gut Microbiome & Hydrogen Sulfide SIBO | Intestinal Sulfide Overgrowth Explained

    Do eggs, garlic, onions or broccoli leave you feeling bloated, fatigued or foggy-headed? In episode 57 of The Histamine Well Podcast, Joanne explores hydrogen sulfide SIBO and intestinal sulfide overproduction (ISO), discussing how sulfur-producing gut bacteria may contribute to these symptoms. Discover: The connection between sulfur intolerance and the gut microbiome.Why hydrogen sulfide production and clearance both matter.The uses and limitations of stool and breath testing.Joanne’s clinical approach to low sulfur diets, oregano, molybdenum and digestive support.Joanne also discusses where the evidence remains limited and why symptoms alone cannot confirm the cause. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

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5
out of 5
16 Ratings

About

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

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