The Feldman Protocol

Dave Feldman

Dave Feldman hosts the Feldman Protocol, a long form, in-person podcast largely covering science, nutrition, and technology – with a lot of personal stories, interests and pop culture mixed in.

  1. 1d ago

    Sameer Dossani on Gut Health, Carnivore Transition, and Cholesterol Science

    In this episode of The Feldman Protocol, how should researchers and clinicians weigh insulin resistance against lipid markers when assessing cardiovascular risk? Dave Feldman sits down with Sameer Dossani (PhD, anthropology; health coach specializing in autoimmune and gut conditions) to explore human evolutionary dietary history, the origins of metabolic disease across ancient cultures, the lean mass hypersponder phenotype and ketone production, challenges in science communication, and the role of AI in personalized health. 📎 Mentioned in this episode: • 1:23:33 – Bradford Hill 1965 — 'Environment and Disease' (criteria paper): `https://pmc.ncbi.nlm.nih.gov/articles/PMC1898525/` • 1:33:20 – Ramsden 2015 re-analysis — Minnesota Coronary Experiment & Sydney Diet Heart Trial: `https://doi.org/10.1136/bmj.i1246` • 2:23:35 – Zero-fiber vs high-fiber constipation RCT (2012) — discussed by Nick Norwitz: `https://www.wjgnet.com/1007-9327/full/v18/i33/4593.htm` • 3:04:05 – Sameer Dossani's Linktree (all links): `https://linktr.ee/SameerDossani` • 3:04:07 – Sameer Dossani's YouTube channel — @meatheels: `https://www.youtube.com/@MeatHeals` 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/56` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open and introduction 1:05 – Sameer's background and credentials 3:42 – Human origins and migration out of Africa 9:20 – Career in international economics and NGOs 15:34 – Ancient medicine and carbohydrate restriction 22:31 – Food culture, comfort eating, and self-soothing 34:12 – Human evolutionary diet: specialist vs. generalist 43:23 – Persistence hunting, sweat glands, and melanin 55:29 – Platform suppression and content challenges 1:03:03 – Sameer's personal health journey and diet shift 1:14:10 – Reaven's insulin resistance study and LDL findings 1:23:30 – Bradford Hill criteria and epidemiological data 1:33:09 – Minnesota Coronary experiment and withheld data 1:43:58 – Ketogenic diets, euketonemia, and fad diet framing 1:54:34 – LMHR study: plaque progression and CLEARLY analysis 2:04:27 – Statin pleiotropic effects and pharmaceutical trade-offs 2:18:20 – Own Your Labs Q&A: protein, muscle, and gut health 2:32:01 – Gut health, sleep, fatigue, and meal timing 2:46:26 – LMHR ketone production explained by Dave 2:52:04 – Changing the narrative: data, science, and next steps #FeldmanProtocol #DaveFeldman #SameerDossani #LeanMassHyperResponder #InsulinResistance #MetabolicHealth #LDL #Cholesterol #HumanEvolution #AncestralDiet #LowCarb #Ketogenic #AutoimmuneHealth #GutHealth #CholesterolCode #BloodWork #Carnivore #EpidemiologyDebate #ScientificMethod #HealthCoaching

  2. Oct 16

    Bronson Dant – Keto and Athletic Performance: What the Studies Miss

    In this episode of The Feldman Protocol, can the principles of metabolic flexibility reframe how athletes — and everyday people — think about fueling exercise? Dave Feldman sits down with Bronson Dant (metabolic performance coach and doctoral candidate in health science), who makes the case that food is function, not fuel. Bronson discusses his Army nutrition research experience, his carnivore diet journey and its effect on longstanding IBS, the distinction between fitness and health, oxidative priority debates, and emerging research on ketogenic adaptation timelines. 📎 Mentioned in this episode: • 2:18:58 – Clinical audit of Dr. Mark Cucuzella's VA low-carb nutrition program: `https://journalofmetabolichealth.org/index.php/jmh/article/view/141` • 3:00:37 – Bronson Dant & colleagues — substrate-corrected VO2 / movement economy paper: `https://journalofexerciseandnutrition.com/index.php/JEN/article/view/212` • 3:02:58 – Coach Bronson's website / coaching hub (coachbronson.com): `https://coachbronson.com/` • 3:03:04 – Coach Bronson — YouTube channel: `https://www.youtube.com/@coach.bronson` 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/55` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & intro 1:15 – Bronson's background in fitness 6:36 – Decision to join the Army 11:04 – Army nutrition research at Natick Labs 20:57 – Transition from IT to CrossFit coaching 31:52 – Opening a gym: lessons learned 51:20 – Carnivore as an elimination approach 1:05:04 – IBS resolution and dietary change 1:21:56 – Coaching, identity & behavior change 1:34:22 – The 2020 disruption & rebuilding 1:46:43 – Systems thinking in nutrition science 1:56:37 – Metabolic flexibility: four components 2:04:06 – Ketogenic adaptation & performance research 2:18:09 – Virginia nutrition counseling audit findings 2:30:09 – Nutrition advice across training types 2:41:21 – Oxidative priority and food as function 2:50:26 – Glycogen storage, fat adaptation & RER 3:00:37 – Substrate-corrected VO2 research 3:02:53 – Where to find Bronson & closing thoughts #FeldmanProtocol #DaveFeldman #BronsonDant #MetabolicFlexibility #CarnivoreDiet #KetogenicDiet #SportsNutrition #LowCarbPerformance #FoodAsFunction #ExerciseScience #IBSRecovery #FatAdaptation #OxidativePriority #CrossFit #MetabolicHealth #NutritionCoaching #BloodWork #HealthOptimization

  3. Oct 9

    Zachary DiMattia and Dave Feldman Debate LDL, Keto-CTA and Lean Mass Hyper-Responders

    In this episode of The Feldman Protocol, what does emerging research actually reveal about cardiovascular risk in people who develop extreme LDL elevations on ketogenic diets — and how much remains genuinely unresolved? Zachary DiMattia (nutritional scientist, Penn State) joins Dave to discuss his published review on ketogenic diet–induced LDL elevations in normal-weight adults, presents preliminary findings from his controlled feeding study comparing low- and high-BMI responses to a ketogenic diet, and engages Dave in a frank debate over plaque progression data, the lipid hypothesis, and the novel regressor findings from the Keto-CTA cohort.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/54` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & key findings preview1:24 – Zachary's background intro5:02 – Path to nutrition research8:01 – Hashimoto's diagnosis journey13:27 – Elimination diet & gluten discovery21:49 – Interest in ketogenic LDL response26:03 – Penn State controlled feeding study design34:12 – Preliminary study results41:40 – Review paper overview51:04 – Lipid hypothesis steel-man debate1:05:49 – LMHR phenotype & clinical context1:18:35 – Proposed mechanisms beyond LEM1:26:14 – Keto-CTA plaque progression data1:40:41 – Regressor findings & noise floor1:49:09 – Miami Heart match analysis2:03:50 – Mechanisms: adiposity & cholesterol2:14:52 – Nature CT study comparison2:43:29 – Audience questions & closing thoughts#FeldmanProtocol #DaveFeldman #ZacharyDiMattia #LeanMassHyperResponder #KetogenicDiet #LDLCholesterol #Cardiovascular #Atherosclerosis #LipidResearch #NutritionalScience #CholesterolResearch #PlaqueProg #KetoCTA #LipidEnergyModel #Cardiometabolic #LowCarbResearch #Bloodwork #HeartHealth

  4. Oct 3

    Lauren Kennedy West on Schizoaffective Disorder, Ketogenic Therapy, and Psychiatric Identity

    In this episode of The Feldman Protocol, can what we eat meaningfully influence the course of serious mental illness? Dave sits down with Lauren Kennedy West (mental health advocate and YouTuber living with schizoaffective disorder) to explore her personal journey from multiple hospitalizations and misdiagnoses to adopting therapeutic ketosis. Lauren makes the case for metabolic psychiatry as a complement to traditional care, discusses the identity challenges of sharing her N-of-1 experiment publicly, reflects on navigating medication tapering, community polarization, the role of AI in personalized care, and the social complexity of restrictive eating.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/53` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & sucralose reaction1:14 – Lauren introduces herself2:46 – Early symptoms & the teenage years6:00 – First diagnosis journey8:20 – Hospitalizations & ECT11:46 – Dave's reflections on illness identity15:27 – YouTube channel origins19:32 – First attempt at ketogenic diet23:46 – Accessing metabolic psychiatry32:16 – Community reaction to going keto37:54 – Eating disorder concerns & food identity42:14 – The sushi experiment in San Francisco50:38 – Defined by wellness, not illness54:32 – Medication tapering & potentiation1:00:04 – Running, soccer & the ACL injury1:07:53 – Kids, diet, and parenting challenges1:17:00 – Metabolic Mind partnership & the course1:19:18 – Desk questions: dirty keto & sucralose1:23:08 – Meds vs. metabolic therapy: how it feels1:28:52 – Traveling keto & snack strategies1:39:31 – Community building & echo chambers1:47:42 – Social media, nuance & polarization1:58:11 – Platform challenges & demonetization2:05:53 – Patient autonomy & medical humility2:14:05 – Living well: nuance over narrative2:21:26 – AI in diagnostics & mental health care2:31:00 – AI sycophancy & trust concerns2:39:23 – The future of AI-assisted therapy2:46:09 – Parallels: AI guardrails & patient autonomy2:51:55 – Where to find Lauren#FeldmanProtocol #DaveFeldman #LaurenKennedyWest #MetabolicPsychiatry #KetogenicDiet #MentalHealth #Schizoaffective #SchizophreniaAwareness #BrainEnergy #TherapeuticKetosis #MentalWellness #NutritionAndMindHealth #AIInHealthcare #PatientAutonomy #LowCarbLife #ChristopherPalmer #MetabolicMind #MentalHealthAdvocacy

  5. Sep 24

    Arthur Agatston (Part 3) on Insulin Resistance, LP(a), and Why He Went Militantly Keto

    In this episode of The Feldman Protocol, how does metabolic health shape cardiovascular risk — and does the conventional focus on individual biomarkers miss the bigger picture? Dave Feldman sits down with cardiologist Arthur Agatston (MD), creator of the South Beach Diet and the coronary calcium score, to explore blood pressure guideline debates, insulin resistance and preeclampsia, the origins of the South Beach Diet, LP(a) and plaque progression in lean mass hyper-responders, HDL dysfunction, and the lipid energy model's structural hypothesis.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/52` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Introduction & cold open2:02 – Blood pressure monitoring technology6:57 – Dave & Arthur on BP guideline debates9:36 – Cholesterol targets & guideline pressures12:20 – Type 1 diabetes & low-carb care gaps15:26 – Joseph Kraft, insulin, and missed signals21:53 – Inertia in medicine & the role of AI27:06 – Insulin resistance, Kraft test & preeclampsia33:40 – Origins of the South Beach Diet40:17 – Carbohydrate addiction & personal experience51:32 – Elimination diets & unexpected symptom relief57:04 – Fat adaptation & lipoprotein dynamics1:00:00 – Triglycerides, remnant particles & VLDL1:05:11 – Particle size, ApoB & atherogenicity1:11:19 – LP(a) findings in lean mass hyper-responders1:19:45 – FH, plaque progression & LDL context1:33:31 – 4S trial, small dense LDL & statin data1:40:11 – HDL dysfunction & the HDL bump phenotype1:56:21 – Lipid energy model & structural hypothesis2:01:38 – Fat adaptation, F1, and closing reflections#FeldmanProtocol #DaveFeldman #ArthurAgatston #LipidEnergyModel #InsulinResistance #HeartHealth #CalciumScore #LDLCholesterol #MetabolicHealth #LowCarb #KetogenicDiet #ApoB #HDLDysfunction #Preeclampsia #SouthBeachDiet #Lipoproteins #CardiovascularResearch #FunctionalCardiology

  6. Sep 21

    Dr. Arthur Agatston (Part 2) - Why Did Most Keto Patients Show Zero Plaque Despite LDL of 250?

    In this episode of The Feldman Protocol, how does metabolic health shape cardiovascular risk — and what does that mean for interpreting cholesterol markers in lean, low-carb individuals? Arthur Agatston (MD) makes the case for a functional model of atherosclerosis progression, discusses AI-driven advances in cardiac imaging, argues for revisiting how blood pressure is measured and treated, and explores electrolyte management on ketogenic diets — all through a wide-ranging scientific conversation with Dave.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/51` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & intro7:11 – Late eating & metabolic effects12:37 – Western diet spreading globally18:07 – Personal fat threshold explained23:01 – Lipid energy model & LDL cycling30:26 – Exercise type & lipoprotein uptake38:39 – AI-enhanced cardiac imaging45:17 – Arterial flexibility & plaque burden53:20 – South Beach Diet origins1:00:39 – Scientific uncertainty in medicine1:06:41 – LMHR study: plaque findings1:16:57 – Plaque regression & calcification1:26:57 – Photon CT & next-gen imaging1:33:20 – Hypertension history & FDR1:41:30 – Blood pressure measurement issues1:49:44 – Keto, insulin & sodium loss1:55:09 – Overhydration & electrolyte balance2:00:08 – Electrolyte management on keto#FeldmanProtocol #DaveFeldman #ArthurAgatston #CardiovascularHealth #LowCarbDiet #LeanMassHyperResponder #LipidEnergyModel #HeartHealth #CACScore #KetogenicDiet #Atherosclerosis #BloodPressure #Electrolytes #MetabolicHealth #SouthBeachDiet #CardiacImaging #AIinMedicine #Cholesterol

  7. Sep 18

    The Stent Myth: Why Fixing a Blockage Isn’t a Cure - Dr. Arthur Agatston

    In this episode of The Feldman Protocol, how well do conventional cardiovascular risk metrics actually identify who is truly at risk for a heart attack decades before it happens? Cardiologist Arthur Agatston (MD) makes the case for coronary calcium scoring as an early detection tool, discusses the natural history of atherosclerotic plaque, revisits key moments in lipid science history, explores why stent placement in asymptomatic patients presents a more complex picture than intuition suggests, and shares observations on the evolving role of CT angiography and AI-assisted plaque analysis. 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/50` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & introduction 7:46 – Arthur's path into medicine 18:59 – Early cardiology & clinical trials 27:47 – Lipid science history & Ancel Keys 39:04 – Rabbit studies & lipoprotein discovery 47:15 – Ultra-fast CT arrives at Sinai 55:26 – Collateral vessels & total occlusion 1:00:00 – Ischemia trial: stents vs. medical therapy 1:05:01 – Back to the CAC origin story 1:13:09 – Soft vs. calcified plaque progression 1:21:40 – FH patient with zero CAC score 1:26:53 – The Agatston score is named 1:33:51 – Power of zero & plaque burden 1:39:35 – CAC vs. CT angiogram explained 1:44:19 – Resistance to new imaging technology 1:48:34 – Nutrition interest in the 1990s 1:49:25 – Heart Lung AI & plaque ratio research 1:51:11 – Closing reflections #FeldmanProtocol #DaveFeldman #ArthurAgatston #CoronaryCalcium #HeartHealth #Atherosclerosis #CardiacImaging #CACScore #LDL #Lipids #PlaqueBiology #CTAngiogram #CardiologyResearch #LowCarbDiet #LeanMassHyperResponder #HeartDiseasePrevention #LipidScience #CardiovascularResearch

  8. Sep 11

    Isabella Cooper – Part 2 – Ketogenic Diet and Cancer: What the Science Actually Shows

    In this episode of The Feldman Protocol, how does insulin influence cancer cell behavior — and what does that mean for metabolic approaches to the disease? Dave sits down with Isabella Cooper (PhD) to explore the glucose-ketone index and its practical limits, the role of glutamine alongside glucose in cancer metabolism, how mitochondrial dysfunction and cardiolipin loss may relate to tumor progression, the case for high-dose intravenous vitamin C, osteocyte biology and the surprising systemic roles of osteocalcin, and what makes a rigorous research culture. 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/49` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & intro 1:08 – Cancer metabolism overview 2:24 – Glucose-ketone index explained 5:01 – Lean mass hypersponders & glucose 9:18 – Acetone measurement & respiration 13:49 – Insulin, ketones & cancer signaling 19:05 – Growth factors & VEGF discussion 25:29 – Stomach acidity & nutrient absorption 32:08 – How cancer cells originate 35:43 – Cardiolipin, melatonin & apoptosis 43:05 – Diet quality & food as function 52:14 – Chemotherapy & metabolic protocols 1:03:36 – Patient outcomes & biopsy risks 1:14:32 – IV vitamin C trial findings 1:22:07 – Ideal cancer metabolism trial design 1:29:36 – Sunlight, melanin & mitochondria 1:37:20 – Osteocyte biology & osteocalcin 1:46:43 – Research culture & scientific rigor 1:54:36 – Most underappreciated biomarker #FeldmanProtocol #DaveFeldman #IsabellaCooper #CancerMetabolism #KetogenicDiet #Mitochondria #Insulin #GlucoseKetoneIndex #Osteocalcin #IntravenousVitaminC #Ketosis #MetabolicHealth #LowCarbScience #CancerResearch #Cardiolipin #Osteocytes #BloodWork #Hyperinsulinemia #MitochondrialHealth #PodcastScience

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4.7
out of 5
32 Ratings

About

Dave Feldman hosts the Feldman Protocol, a long form, in-person podcast largely covering science, nutrition, and technology – with a lot of personal stories, interests and pop culture mixed in.

Information

  • Creator
    Dave Feldman
  • Years Active
    2025 - 2026
  • Episodes
    55
  • Rating
    Explicit
  • Copyright
    © Dave Feldman
  • Show Website
    The Feldman Protocol

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