The Christian Mind Reset

The Christian Mind Reset

The Christian Mind Reset blends Scripture, psychology, and neuroscience to help you renew your thoughts and break mental strongholds. Hosted by April Joy DNP, APN-C (@thechristianpsychnp), each episode explores real struggles, intrusive thoughts, anxiety, and how God’s Word rewires the brain. Learn how to feed truth instead of strongholds and walk in the peace Christ promises. thechristianmindreset.substack.com

  1. 4d ago

    Episode 23: The Neuroscience of Trust: Why Betrayal Hurts and How God Restores

    Episode 23, Season 1 Show Notes Have you ever wondered why betrayal hurts so deeply—or why it can feel so difficult to trust again? In this episode of The Christian Mind Reset, we explore what psychology, neuroscience, and Scripture reveal about trust, betrayal, and healing. You’ll learn how God designed the brain to learn from repeated experiences, why broken trust affects both the mind and body, and how the Psalmist's example in the Psalms points us toward lasting hope. We’ll discuss attachment, neuroplasticity, predictive processing, emotional memory, and the neuroscience of social pain, while keeping Scripture at the center of the conversation. Rather than using science to validate God’s Word, we’ll see how studying God’s creation helps us better appreciate His design. In this episode, you’ll learn: * Why trust is built through repeated experiences of faithfulness. * How attachment shapes our earliest understanding of safety and relationships. * Why betrayal feels physically painful and what neuroscience says about social rejection. * How the brain updates its expectations after relational wounds. * The role of neuroplasticity in healing after betrayal. * Why remembering God’s faithfulness is one of the most powerful biblical practices for renewing the mind. * The difference between biblical forgiveness and rebuilding trust. * Practical encouragement for learning to trust God while exercising wisdom in relationships. Key Scriptures Psalm 9:10 Psalm 77 Proverbs 3:5–6 Lamentations 3:22–23 Hebrews 10:23 Malachi 3:6 Hebrews 13:8 John 2:24 Psalm 147:3 Connect with Dr. April Joy: Connect with Dr. April Joy: Substack: The Christian Mind Reset If you liked today’s episode, please subscribe, leave a review, follow, like, or share. You can find me on Instagram at @thechristianpsychnp and also on Instagram and Substack at The Christian Mind Reset for more Scripture, neuroscience, and practical tips for renewing your mind. Listen to The Christiand Min Reset on Apple, Spotify, and Substack. My eBook, The Christian Mind Reset: A 28-Day Psalms Guide to Biblical Meditation, Neuroscience, and Renewing Your Mind, is available in my Stan Store at https://stan.store/thechristianpsychnp and on my Substack. References Ainsworth, M. D. S., Blehar, M. C., Waters, E., & Wall, S. (1978). Patterns of attachment: A psychological study of the strange situation. Lawrence Erlbaum Associates. Berg, J., Dickhaut, J., & McCabe, K. (1995). Trust, reciprocity, and social history. Games and Economic Behavior, 10(1), 122–142. https://doi.org/10.1006/game.1995.1027 Bowlby, J. (1982). Attachment and loss: Vol. 1. Attachment (2nd ed.). Basic Books. (Original work published 1969) Carter, S C. (2018). Oxytocin and Human Evolution. Current topics in behavioral neurosciences, 35, 291–319. https://doi.org/10.1007/7854_2017_18 Clark, A. (2013). Whatever next? Predictive brains, situated agents, and the future of cognitive science. Behavioral and Brain Sciences, 36(3), 181–204. https://doi.org/10.1017/S0140525X12000477 Eisenberger, N. I. (2012). The neural bases of social pain: Evidence for shared representations with physical pain. Psychosomatic Medicine, 74(2), 126–135. https://doi.org/10.1097/PSY.0b013e3182464dd1 Eisenberger, N. I., Lieberman, M. D., & Williams, K. D. (2003). Does rejection hurt? An fMRI study of social exclusion. Science, 302(5643), 290–292. https://doi.org/10.1126/science.1089134 Freyd, J. J. (1996). Betrayal trauma: The logic of forgetting childhood abuse. Harvard University Press. Friston, K. (2010). The free-energy principle: A unified brain theory? Nature Reviews Neuroscience, 11(2), 127–138. https://doi.org/10.1038/nrn2787 Froemke, R. C., & Young, L. J. (2021). Oxytocin, neural plasticity, and social behavior. Annual Review of Neuroscience, 44, 359–381. https://doi.org/10.1146/annurev-neuro-102320-102847 Hancock, P. A., Kessler, T. T., Kaplan, A. D., Brill, J. C., & Szalma, J. L. (2023). How and why humans trust: A meta-analysis and elaborated model. Frontiers in Psychology, 14, Article 1081086. https://doi.org/10.3389/fpsyg.2023.1081086 Kandel, E. R., Koester, J. D., Mack, S. H., & Siegelbaum, S. A. (2021). Principles of neural science (6th ed.). McGraw Hill. Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435(7042), 673–676. https://doi.org/10.1038/nature03701 Lancaster, M. E., & Anbar, R. D. (2024, March 30). How oxytocin affects our relationships. Psychology Today. https://www.psychologytoday.com/us/blog/understanding-hypnosis/202402/how-oxytocin-affects-our-relationships McGaugh, J. L. (2004). The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annual Review of Neuroscience, 27, 1–28. https://doi.org/10.1146/annurev.neuro.27.070203.144157 Disclaimer: This podcast/letter is for informational purposes only. It contains general information, drawn from my experience, research, and best practices. It is not health care advice, and is not intended to replace the counsel of your health care provider. Consult your provider before starting any new treatments or making changes to your health routine. This message does not constitute a provider-patient relationship between us. If you are experiencing significant anxiety, distress, or need support, please seek care from a qualified healthcare professional. You may also consider reaching out to a licensed Christian counselor or pastor for additional support. Emails, portal messages, text messages, and other communications are not monitored and will not receive a response in an emergency or crisis, or regarding medical or therapy advice. These methods should never be used for medical advice, therapy, urgent, crisis, emergent, or time-sensitive concerns. If you are experiencing a medical or psychiatric emergency, are in crisis, having thoughts of harming yourself or others, or feel unsafe, call 911 (US), or contact your local emergency services, or go to the nearest emergency room or hospital immediately. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thechristianmindreset.substack.com

    Episode 23: The Neuroscience of Trust: Why Betrayal Hurts and How God Restores
  2. Jul 11

    Praise Is Spiritual Warfare: What David Knew About Worship, Neuroscience, and Renewing Your Mind

    Episode 22, Season 1 Show Notes Can praise actually change the way we experience a battle? What if God commands us to praise not only because He is worthy, but because He designed worship to strengthen His people? In this episode of The Christian Mind Reset, we explore the powerful connection among praise, worship, prayer, singing, and the renewing of the mind, drawing on both Scripture and neuroscience. Looking at the lives of David, Jehoshaphat, Paul and Silas, and Samuel, we’ll discover why praise is far more than an emotional response to victory. It is a spiritual discipline that helps us remember God’s faithfulness even as the battle is still before us. We’ll examine the neuroscience of attention, attentional bias, emotional memory, and the brain’s attentional filtering system, including the Reticular Activating System (RAS), to better understand why fear naturally captures our focus. We’ll also explore what research reveals about prayer, worship, singing, gratitude, lifting our hands, embodied cognition, and how these practices influence attention, emotional regulation, stress, and resilience. Finally, we’ll unpack the biblical meaning of an Ebenezer, why God repeatedly commands His people to remember, and how praise becomes an act of spiritual warfare that shifts our attention from fear to God's faithfulness. Whether you’re walking through anxiety, disappointment, unanswered prayers, grief, spiritual warfare, or a season of waiting, I pray this episode encourages you to remember that praise is not pretending your pain doesn’t exist. It is choosing to worship the God whose character never changes. In This Episode * Why praise is spiritual warfare * Why God commands us to sing * The neuroscience of praise and worship * Prayer and focused attention * Singing, stress, mood, and the immune system * Why lifting our hands matters * Embodied cognition and worship * David’s pattern of remembering God’s faithfulness * The neuroscience of attention and attentional bias * The Reticular Activating System (RAS) and the brain’s attentional filtering system * The amygdala, hippocampus, and emotional memory * Neuroplasticity and renewing the mind * Jehoshaphat and praising before the battle * Paul and Silas worshiping in prison * Ebenezer: Remembering God’s faithfulness * Practical ways to worship while you’re still waiting Scriptures Referenced Psalm 27 Psalm 34 Psalm 63 Psalm 77 Psalm 103 Psalm 134 Isaiah 26:3 Colossians 3:2 Romans 12:2 Hebrews 13:8 1 Samuel 7:12 2 Chronicles 20 Acts 16 Neuroscience & Psychology Concepts Attentional bias • Reticular Activating System (RAS) • Attention networks • Emotional regulation • Neuroplasticity • Amygdala • Hippocampus • Emotional memory • Focused attention • Prayer and the brain • Singing and worship • Embodied cognition • Gratitude • Secretory immunoglobulin A (sIgA) • Cortisol • Christian psychology • Faith and neuroscience Connect with Dr. April Joy: Connect with Dr. April Joy: Substack: The Christian Mind Reset If you liked today’s episode, please subscribe, leave a review, follow, like, or share. You can find me on Instagram at @thechristianpsychnp and also on Instagram and Substack at The Christian Mind Reset for more Scripture, neuroscience, and practical tips for renewing your mind. Listen to The Christiand Min Reset on Apple, Spotify, and Substack. My eBook, The Christian Mind Reset: A 28-Day Psalms Guide to Biblical Meditation, Neuroscience, and Renewing Your Mind, is available in my Stan Store at https://stan.store/thechristianpsychnp and on my Substack. References Bar-Haim, Y., Lamy, D., Pergamin, L., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). Threat-related attentional bias in anxious and nonanxious individuals: A meta-analytic study. Psychological Bulletin, 133(1), 1–24. https://doi.org/10.1037/0033-2909.133.1.1 Barsalou, L. W. (2008). Grounded cognition. Annual Review of Psychology, 59, 617–645. https://doi.org/10.1146/annurev.psych.59.103006.093639 Beck, R. J., Cesario, T. C., Yousefi, A., & Enamoto, H. (2000). Choral singing, performance perception, and immune system changes in salivary immunoglobulin A and cortisol. Music Perception, 18(1), 87–106. Draganski, B., Gaser, C., Busch, V., Schuierer, G., Bogdahn, U., & May, A. (2004). Neuroplasticity: Changes in grey matter induced by training. Nature, 427(6972), 311–312. https://doi.org/10.1038/427311a Fancourt, D., Williamon, A., Carvalho, L. A., Steptoe, A., Dow, R., & Lewis, I. (2016). Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carers. ecancermedicalscience, 10, 631. https://doi.org/10.3332/ecancer.2016.631 Fredrickson, B. L. (2001). The role of positive emotions in positive psychology: The broaden-and-build theory of positive emotions. American Psychologist, 56(3), 218–226. https://doi.org/10.1037/0003-066X.56.3.218 Kreutz, G., Bongard, S., Rohrmann, S., Hodapp, V., & Grebe, D. (2004). Effects of choir singing or listening on secretory immunoglobulin A, cortisol, and emotional state. Journal of Behavioral Medicine, 27(6), 623–635. https://doi.org/10.1007/s10865-004-0006-9 McGaugh, J. L. (2004). The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annual Review of Neuroscience, 27, 1–28. https://doi.org/10.1146/annurev.neuro.27.070203.144157 Newberg, A. B. (2014). The neuroscientific study of spiritual practices. Frontiers in Psychology, 5, 215. https://doi.org/10.3389/fpsyg.2014.00215 Posner, M. I., & Petersen, S. E. (1990). The attention system of the human brain. Annual Review of Neuroscience, 13, 25–42. https://doi.org/10.1146/annurev.ne.13.030190.000325 Thomas Nelson. (2017). The NKJV Study Bible (2nd ed.). Thomas Nelson. Disclaimer: This podcast/letter is for informational purposes only. It contains general information, drawn from my experience, research, and best practices. It is not health care advice, and is not intended to replace the counsel of your health care provider. Consult your provider before starting any new treatments or making changes to your health routine. This message does not constitute a provider-patient relationship between us. If you are experiencing significant anxiety, distress, or need support, please seek care from a qualified healthcare professional. You may also consider reaching out to a licensed Christian counselor or pastor for additional support. Emails, portal messages, text messages, and other communications are not monitored and will not receive a response in an emergency or crisis, or regarding medical or therapy advice. These methods should never be used for medical advice, therapy, urgent, crisis, emergent, or time-sensitive concerns. If you are experiencing a medical or psychiatric emergency, are in crisis, having thoughts of harming yourself or others, or feel unsafe, call 911 (US), or contact your local emergency services, or go to the nearest emergency room or hospital immediately This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thechristianmindreset.substack.com

    Praise Is Spiritual Warfare: What David Knew About Worship, Neuroscience, and Renewing Your Mind
  3. Jul 5

    Why Disappointment Hurts: What the Bible and Neuroscience Reveal

    Episode 21, Season 1 Show Notes Why does disappointment hurt so deeply? Whether it’s an unanswered prayer, a broken relationship, a diagnosis you never expected, or a dream that feels out of reach, disappointment has a way of shaking not only our hearts but also our understanding of God. In this episode of The Christian Mind Reset, we explore what happens in the brain when our expectations collide with reality, and how God’s Word offers hope amid unmet expectations. Together we’ll look at the neuroscience of disappointment, including prediction error, dopamine, the lateral habenula, hopelessness, neuroplasticity, and the brain’s remarkable capacity for resilience. We’ll spend time in Psalm 22, where David cries out with complete honesty, “My God, My God, why have You forsaken Me?” We’ll see why Jesus quoted those very words from the cross and what they teach us about bringing our disappointment to God without losing our faith. We’ll also discover how Psalm 34 reminds us that God’s goodness is not determined by our circumstances, but by His unchanging character. Finally, we’ll explore how Scripture and neuroscience beautifully agree that our repeated thoughts shape how we experience life, and how the Holy Spirit renews our minds as we continue to bring our disappointments back to the Lord. If you’ve ever wondered where God is in your waiting, this episode is for you. In this episode, we’ll discuss: • Why disappointment affects both the brain and the heart• The neuroscience of prediction error, dopamine, and unmet expectations• The role of the lateral habenula in disappointment and hopelessness• David’s honest prayer in Psalm 22• Why Jesus quoted Psalm 22 from the cross• How hopelessness changes our thinking—and how Scripture corrects it• Psalm 34 and trusting God’s character over our circumstances• Neuroplasticity, perseverance, and renewing your mind• Biblical declarations and a guided prayer for seasons of disappointment Key Scriptures Psalm 22Psalm 34Psalm 30:5Psalm 62:5Romans 5:3–5Romans 8:28Romans 12:2Lamentations 3:22–23Philippians 1:6Matthew 27:46 Mentioned Research Liu, R. T., Kleiman, E. M., Nestor, B. A., & Cheek, S. M. (2015). The hopelessness theory of depression: A quarter-century in review. Matsumoto, M., & Hikosaka, O. (2007). Lateral habenula as a source of negative reward signals. Schultz, W., Dayan, P., & Montague, P. R. (1997). A neural substrate of prediction and reward. Touroutoglou, A., Andreano, J. M., Dickerson, B. C., & Barrett, L. F. (2020). How the anterior mid-cingulate contributes to achieving goals. Cortex, 123, 12–29. Connect with Dr. April Joy: Connect with Dr. April Joy: Substack: The Christian Mind Reset If you liked today’s episode, please subscribe, leave a review, follow, like, or share. You can find me on Instagram at @thechristianpsychnp and also on Instagram and Substack at The Christian Mind Reset for more Scripture, neuroscience, and practical tips for renewing your mind. Listen to The Christian Min Reset on Apple, Spotify, and Substack. My eBook, The Christian Mind Reset: A 28-Day Psalms Guide to Biblical Meditation, Neuroscience, and Renewing Your Mind, is available in my Stan Store at https://stan.store/thechristianpsychnp and on my Substack. References Schultz, W., Dayan, P., & Montague, P. R. (1997). A neural substrate of prediction and reward. Science, 275(5306), 1593–1599. Link Matsumoto, M., & Hikosaka, O. (2007). Lateral habenula as a source of negative reward signals in dopamine neurons. Nature, 447(7148), 1111–1115. Link Liu, R. T., Kleiman, E. M., Nestor, B. A., & Cheek, S. M. (2015). The hopelessness theory of depression: A quarter century in review. Clinical Psychology: Science and Practice, 22(4), 345–365. Link Thomas Nelson. (2017). The NKJV Study Bible (2nd ed.). Thomas Nelson. Touroutoglou, A., Andreano, J., Dickerson, B. C., & Barrett, L. F. (2020). The tenacious brain: How the anterior mid-cingulate contributes to achieving goals. Cortex, 123, 12–29. Link Disclaimer: This podcast/letter is for informational purposes only. It contains general information, drawn from my experience, research, and best practices. It is not health care advice, and is not intended to replace the counsel of your health care provider. Consult your provider before starting any new treatments or making changes to your health routine. This message does not constitute a provider-patient relationship between us. If you are experiencing significant anxiety, distress, or need support, please seek care from a qualified healthcare professional. You may also consider reaching out to a licensed Christian counselor or pastor for additional support. Emails, portal messages, text messages, and other communications are not monitored and will not receive a response in an emergency or crisis, or regarding medical or therapy advice. These methods should never be used for medical advice, therapy, urgent, crisis, emergent, or time-sensitive concerns. If you are experiencing a medical or psychiatric emergency, are in crisis, having thoughts of harming yourself or others, or feel unsafe, call 911 (US), or contact your local emergency services, or go to the nearest emergency room or hospital immediately This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thechristianmindreset.substack.com

    Why Disappointment Hurts: What the Bible and Neuroscience Reveal
  4. Jul 1

    Waiting on God | The Neuroscience of Waiting, Biblical Hope, and Renewing Your Mind

    Episode 20, Season 1 Show Notes Why is waiting on God so difficult? If you’ve ever wondered why unanswered prayers feel so emotionally exhausting, why uncertainty can trigger anxiety, or why waiting can feel harder than receiving bad news, you’re not alone. In this episode of The Christian Mind Reset, we explore how neuroscience and Scripture together help us understand one of the hardest parts of the Christian life: waiting. You’ll discover why the brain naturally struggles with uncertainty, how our minds are wired to seek closure, and why seasons of waiting can leave us feeling discouraged even when our faith remains strong. We’ll also examine how God designed the brain to change through neuroplasticity and how renewing our minds with His truth can shape our experience of seasons of uncertainty. Then we’ll turn to Psalm 27, following David’s journey from the cave to the crown. Together we’ll study the beautiful Hebrew word qāvâ, often translated as “wait,” which means to bind together or become intertwined. David’s story reminds us that waiting is not passive—it is an invitation to become more deeply connected to God as He prepares us for what lies ahead. Whether you’re waiting for healing, restoration, direction, reconciliation, or an answer to prayer, this episode will encourage you to trust God’s timing, renew your mind, and remember that His silence is never His absence. In This Episode * Why uncertainty feels so stressful to the brain * The neuroscience of waiting and anxiety * Intolerance of uncertainty * Dopamine, anticipation, and delayed expectations * Neuroplasticity and renewing your mind * David’s years of waiting before becoming king * The Hebrew meaning of qāvâ * Psalm 27 and learning to wait with courage * Practical ways to renew your mind while you wait * Biblical declarations and a closing prayer Key Scriptures * Psalm 27:14 * Psalm 130:5–6 * Isaiah 40:31 * Romans 12:2 * Numbers 23:19 Connect with Dr. April Joy: Connect with Dr. April Joy: Substack: The Christian Mind Reset If you liked today’s episode, please subscribe, leave a review, follow, like, or share. You can find me on Instagram at @thechristianpsychnp and also on Instagram and Substack at The Christian Mind Reset for more Scripture, neuroscience, and practical tips for renewing your mind. Listen to The Christian Min Reset on Apple, Spotify, and Substack. My eBook, The Christian Mind Reset: A 28-Day Psalms Guide to Biblical Meditation, Neuroscience, and Renewing Your Mind, is available in my Stan Store at https://stan.store/thechristianpsychnp and on my Substack. References Clark, A. (2013). Whatever next? Predictive brains, situated agents, and the future of cognitive science. Behavioral and Brain Sciences, 36(3), 181–204. https://doi.org/10.1017/S0140525X12000477PMID: 23663408. (PubMed) Draganski, B., Gaser, C., Busch, V., Schuierer, G., Bogdahn, U., & May, A. (2004). Neuroplasticity: Changes in grey matter induced by training. Nature, 427(6972), 311–312. https://doi.org/10.1038/427311aPMID: 14737157. (PubMed) Dugas, M. J., Gagnon, F., Ladouceur, R., & Freeston, M. H. (1998). Generalized anxiety disorder: A preliminary test of a conceptual model. Behaviour Research and Therapy, 36(2), 215–226.PMID: 9613027. (PubMed) Dugas, M. J., & Robichaud, M. (2007). Cognitive-behavioral treatment for generalized anxiety disorder: From science to practice. Routledge. Gross, J. J. (1998). The emerging field of emotion regulation: An integrative review. Review of General Psychology, 2(3), 271–299. https://doi.org/10.1037/1089-2680.2.3.271 (Sage Journals) Hsu, M., Bhatt, M., Adolphs, R., Tranel, D., & Camerer, C. F. (2005). Neural systems responding to degrees of uncertainty in human decision-making. Science, 310(5754), 1680–1683. https://doi.org/10.1126/science.1115327PMID: 16339445. (PubMed) Kolb, B., & Gibb, R. (2011). Brain plasticity and behaviour in the developing brain. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 20(4), 265–276.PMID: 22114608. (PubMed) Masicampo, E. J., & Baumeister, R. F. (2011). Consider it done! Plan making can eliminate the cognitive effects of unfulfilled goals. Journal of Personality and Social Psychology, 101(4), 667–683. https://doi.org/10.1037/a0024192 McEwen, B. S. (2007). Physiology and neurobiology of stress and adaptation: Central role of the brain. Physiological Reviews, 87(3), 873–904. https://doi.org/10.1152/physrev.00041.2006PMID: 17615391. (PubMed) Mischel, W., Shoda, Y., & Rodriguez, M. I. (1989). Delay of gratification in children. Science, 244(4907), 933–938.PMID: 2658056. (PubMed) Ochsner, K. N., & Gross, J. J. (2005). The cognitive control of emotion. Trends in Cognitive Sciences, 9(5), 242–249. https://doi.org/10.1016/j.tics.2005.03.010PMID: 15866151. (PubMed) Schultz, W., Dayan, P., & Montague, P. R. (1997). A neural substrate of prediction and reward. Science, 275(5306), 1593–1599.PMID: 9054347. (PubMed) Thomas Nelson. (2017). The NKJV Study Bible (2nd ed.). Thomas Nelson. Disclaimer: This podcast/letter is for informational purposes only. It contains general information, drawn from my experience, research, and best practices. It is not health care advice, and is not intended to replace the counsel of your health care provider. Consult your provider before starting any new treatments or making changes to your health routine. This message does not constitute a provider-patient relationship between us. If you are experiencing significant anxiety, distress, or need support, please seek care from a qualified healthcare professional. You may also consider reaching out to a licensed Christian counselor or pastor for additional support. Emails, portal messages, text messages, and other communications are not monitored and will not receive a response in an emergency or crisis, or regarding medical or therapy advice. These methods should never be used for medical advice, therapy, urgent, crisis, emergent, or time-sensitive concerns. If you are experiencing a medical or psychiatric emergency, are in crisis, having thoughts of harming yourself or others, or feel unsafe, call 911 (US), or contact your local emergency services, or go to the nearest emergency room or hospital immediately This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thechristianmindreset.substack.com

    Waiting on God | The Neuroscience of Waiting, Biblical Hope, and Renewing Your Mind
  5. Jun 28

    The Neuroscience of Letting Go | Renewing Your Mind Through Biblical Surrender

    Episode 19, Season 1 Show Notes Why is letting go so difficult? If you’ve ever found yourself replaying painful memories, holding onto regret, struggling with control, or wondering why you keep returning to the same fears even after you’ve prayed about them, you’re not alone. In this episode of The Christian Mind Reset, we will examine how the biblical invitation to let go is brought into sharper focus by neuroscience and psychology, uncovering the ways God has intricately fashioned the mind to encounter freedom through the practice of surrender. We will consider how the brain encodes emotionally significant experiences, why uncertainty so often unsettles us, how cycles of rumination can entrap the mind, and how the reality of neuroplasticity echoes the biblical promise that our minds can be renewed. Yet long before neuroscience named these processes, Scripture was already inviting us to release burdens we were never created to bear in isolation. Together, we will trace the stories of Samuel, David, Paul, and ultimately Jesus, recognizing that biblical surrender is not denial or passivity, but a profound trust in the character of God—a trust that enables us to entrust what is heavy into His hands. We will also linger with Psalm 46, reflecting on what it means to hear God say, ‘Be still, and know that I am God,’ and how the Hebrew word raphah invites us to loosen our grip and cease striving. If you find yourself struggling to release the past, anxiety, grief, shame, fear, disappointment, control, or unanswered prayer, my hope is that this episode will remind you: the God who formed your mind is faithful to renew it. In This Episode • Why letting go is so difficult from a neuroscience perspective • Predictive processing and why the brain anticipates future threats • The roles of the amygdala, hippocampus, and prefrontal cortex • Emotional memory and why painful experiences are easier to remember • Memory reconsolidation and how healing changes our relationship to painful memories • Rumination, the default mode network, and repetitive thinking • Fear extinction, neuroplasticity, and renewing the mind • The psychology of control, grief, and uncertainty • Samuel mourning Saul (1 Samuel 16) • David’s response after the loss of his son (2 Samuel 12) • Paul’s encouragement to forget what lies behind (Philippians 3) • Psalm 46 and the biblical invitation to “Be still” • The Hebrew word raphah and the practice of releasing our grip • Jesus in Gethsemane as the ultimate picture of surrender Key Scriptures Psalm 46 1 Samuel 16:1 2 Samuel 12:15–23 Philippians 3:13–14 Romans 12:2 1 Peter 5:7 Matthew 11:28–30 Luke 22:42 Connect with Dr. April Joy: Connect with Dr. April Joy: Substack: The Christian Mind Reset If you liked today’s episode, please subscribe, leave a review, follow, like, or share. You can find me on Instagram at @thechristianpsychnp and also on Instagram and Substack at The Christian Mind Reset for more Scripture, neuroscience, and practical tips for renewing your mind. Listen to The Christian Min Reset on Apple, Spotify, and Substack. My eBook, The Christian Mind Reset: A 28-Day Psalms Guide to Biblical Meditation, Neuroscience, and Renewing Your Mind, is available in my Stan Store at https://stan.store/thechristianpsychnp and on my Substack. References Bar, M. (2009). The proactive brain: Memory for predictions. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1521), 1235–1243. Carleton, R. N. (2016). Fear of the unknown: One fear to rule them all? Journal of Anxiety Disorders, 41, 5–21. Friston, K. (2010). The free-energy principle: A unified brain theory? Nature Reviews Neuroscience, 11(2), 127–138. Fullana, M. A., Harrison, B. J., Soriano-Mas, C., et al. (2018). Neural signatures of human fear conditioning and fear extinction: A meta-analysis of fMRI studies. Biological Psychiatry, 84(8), 579–593. Hamilton, J. P., Farmer, M., Fogelman, P., & Gotlib, I. H. (2015). Depressive rumination, the default mode network, and the dark matter of clinical neuroscience. Biological Psychiatry, 78(4), 224–230. Kolb, B., & Gibb, R. (2011). Brain plasticity and behaviour in the developing brain. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 20(4), 265–276. LeDoux, J. E. (2000). Emotion circuits in the brain. Annual Review of Neuroscience, 23, 155–184. McGaugh, J. L. (2004). The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annual Review of Neuroscience, 27, 1–28. Nader, K., & Hardt, O. (2009). A single standard for memory: The case for reconsolidation. Nature Reviews Neuroscience, 10(3), 224–234. Pessoa, L. (2008). On the relationship between emotion and cognition. Nature Reviews Neuroscience, 9(2), 148–158. Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004). Extinction learning in humans: Role of the amygdala and vmPFC. Neuron, 43(6), 897–905. Thomas Nelson. (2017). The NKJV Study Bible (2nd ed.). Thomas Nelson. Disclaimer Disclaimer: This podcast/letter is for informational purposes only. It contains general information, drawn from my experience, research, and best practices. It is not health care advice, and is not intended to replace the counsel of your health care provider. Consult your provider before starting any new treatments or making changes to your health routine. This message does not constitute a provider-patient relationship between us. If you are experiencing significant anxiety, distress, or need support, please seek care from a qualified healthcare professional. You may also consider reaching out to a licensed Christian counselor or pastor for additional support. Emails, portal messages, text messages, and other communications are not monitored and will not receive a response in an emergency or crisis, or regarding medical or therapy advice. These methods should never be used for medical advice, therapy, urgent, crisis, emergent, or time-sensitive concerns. If you are experiencing a medical or psychiatric emergency, are in crisis, having thoughts of harming yourself or others, or feel unsafe, call 911 (US), or contact your local emergency services, or go to the nearest emergency room or hospital immediately. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thechristianmindreset.substack.com

  6. Jun 24

    Why Loneliness Hurts: The Neuroscience of Social Connection and What the Bible Says About Being Alone

    Eisode 18, Season 1 Show Notes Loneliness is more than an emotion. It affects the brain, the body, and the way we experience the world. In today’s episode of The Christian Mind Reset, Dr. April Joy explores the neuroscience, psychology, and biblical perspective on loneliness. You’ll learn why social rejection activates some of the same brain regions involved in physical pain, how chronic loneliness impacts stress hormones and overall health, and why God designed human beings for connection. Dr. Joy will discuss research on loneliness from neuroscientists such as Naomi Eisenberger and John Cacioppo, explore the surprising health benefits of strong relationships, and examine what Scripture teaches about friendship, community, and God’s presence during lonely seasons. We’ll look at Genesis 2:18, Psalm 27, Psalm 34, David and Jonathan’s friendship, and the role of the church in helping us move from isolation toward connection. Whether you’re walking through a season of loneliness, grieving a relationship, struggling to find community, or simply wanting to understand God’s design for human connection, this episode offers hope, practical encouragement, and biblical truth. In This Episode * What loneliness does to the brain * Why social rejection can feel physically painful * The role of the dorsal anterior cingulate cortex (dACC) * John Cacioppo’s research on chronic loneliness * Cortisol, inflammation, and the stress response * Loneliness in Gen Z and older adults * Why healthy relationships improve mental and physical health * Genesis 2:18 and God’s design for community * David and Jonathan’s friendship * The importance of church community and belonging * How God remains present when we feel alone * Practical steps toward building healthy relationships Key Scriptures * Genesis 2:18 * Ecclesiastes 4:9-12 * Proverbs 18:24 * Proverbs 27:17 * Psalm 27:10 * Psalm 34:18 * Hebrews 10:24-25 * 1 Thessalonians 5:11 * Matthew 28:20 * Hebrews 13:5 Key Takeaways * Loneliness is both a psychological and biological experience. * The brain processes social pain using some of the same neural networks involved in physical pain. * Chronic loneliness can increase stress, inflammation, and emotional distress. * Strong relationships are associated with better emotional health, resilience, and longevity. * God created human beings for connection and community. * Friendship is one of God’s gifts for encouragement, support, and growth. * Even when human relationships are absent, God’s presence is not. * Healing from loneliness often begins with one small step toward connection. Practical Challenge This week: * Spend time meditating on Psalm 27:10. * Reach out to one person through a text, phone call, or invitation. * Pray specifically for godly friendships and community. * Move beyond attending church and toward belonging by joining a group, volunteering, or introducing yourself to someone new. Connect with Dr. April Joy: Connect with Dr. April Joy: Substack: The Christian Mind Reset If you liked today’s episode, please subscribe, leave a review, follow, like, or share. You can find me on Instagram at @thechristianpsychnp and also on Instagram and Substack at The Christian Mind Reset for more Scripture, neuroscience, and practical tips for renewing your mind. My eBook, The Christian Mind Reset: A 28-Day Psalms Guide to Biblical Meditation, Neuroscience, and Renewing Your Mind, is available in my Stan Store at https://stan.store/thechristianpsychnp References Baek, E. C., Hyon, R., López, K., Du, M., Porter, M. A., & Parkinson, C. (2021). Lonely individuals process the world in idiosyncratic ways. Nature Communications, 12, 639. Cacioppo, J. T., & Cacioppo, S. (2018). The growing problem of loneliness. The Lancet, 391(10119), 426. Cigna. (2020). Loneliness and the workplace: 2020 U.S. report. Dunn, R. S. (2025). When you don’t have the words: Praying the Psalms. Lexham Press. Eisenberger, N. I., Lieberman, M. D., & Williams, K. D. (2003). Does rejection hurt? An fMRI study of social exclusion. Science, 302(5643), 290–292. Holt-Lunstad, J., Smith, T. B., & Layton, J. B. (2010). Social relationships and mortality risk: A meta-analytic review. PLoS Medicine, 7(7), e1000316. Koenig, H. G. (2012). Religion, spirituality, and health: The research and clinical implications. ISRN Psychiatry, 2012, 278730. National Institute on Aging. (2024). Loneliness and social isolation — tips for staying connected. Rote, S., & Hill, T. D. (2014). Religious attendance and loneliness in later life. The Gerontologist, 54(1), 39–50. Thomas Nelson. (2017). The NKJV Study Bible (2nd ed.). Thomas Nelson. Disclaimer: Disclaimer: This podcast/letter is for informational purposes only. It contains general information, drawn from my experience, research, and best practices. It is not health care advice, and is not intended to replace the counsel of your health care provider. Consult your provider before starting any new treatments or making changes to your health routine. This message does not constitute a provider-patient relationship between us. If you are experiencing significant anxiety, distress, or need support, please seek care from a qualified healthcare professional. You may also consider reaching out to a licensed Christian counselor or pastor for additional support. Emails, portal messages, text messages, and other communications are not monitored and will not receive a response in an emergency or crisis, or regarding medical or therapy advice. These methods should never be used for medical advice, therapy, urgent, crisis, emergent, or time-sensitive concerns. If you are experiencing a medical or psychiatric emergency, are in crisis, having thoughts of harming yourself or others, or feel unsafe, call 911 (US), or contact your local emergency services, or go to the nearest emergency room or hospital immediately. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thechristianmindreset.substack.com

    Why Loneliness Hurts: The Neuroscience of Social Connection and What the Bible Says About Being Alone
  7. Jun 23

    Anger, Neuroscience, and Biblical Truth: What the Bible Really Says About Anger

    Episode 17, Season 1 Show Notes Anger, Neuroscience, and Biblical Truth: What the Bible Really Says About Anger Is anger always sinful? Many Christians have been taught that anger is something to avoid, suppress, or feel guilty about. Yet Scripture tells a different story. Ephesians 4:26 says, “Be angry, and do not sin.” Even Jesus experienced anger without sinning, and God repeatedly invites His people to bring their emotions honestly before Him. In today’s episode of The Christian Mind Reset, Dr. April Joy explores anger through the lenses of neuroscience, psychology, Scripture, and theology. You’ll learn why anger is often a protective emotion, what happens in the brain during experiences of injustice and unfairness, and how neuroscience confirms the biblical distinction between feeling anger and acting on it. We’ll examine the fascinating research of Klimecki and colleagues on anger and emotional regulation, look at Jesus’ righteous anger in Mark 3, explore Jonah’s struggle with anger and disappointment, and reflect on David’s wisdom in Psalm 37. If you’ve ever struggled with resentment, bitterness, frustration, or guilt about being angry, this episode will help you understand how God designed emotions and how to process anger in a healthy, biblical way. In This Episode * What anger actually is from a neuroscience perspective * The difference between anger and aggression * Why suppressing anger often makes it worse * The role of the prefrontal cortex in emotional regulation * Jesus’ example of righteous anger * Jonah’s anger toward God’s mercy * Psalm 37 and trusting God with justice * Practical steps for processing anger biblically * Scripture declarations for emotional healing Key Scriptures * Psalm 4:4 * Psalm 7:11 * Psalm 37:8 * Mark 3:5 * Jonah 4:4 * Ephesians 4:26-27 * James 1:19-20 * Romans 12:19 * Hebrews 12:15 * 2 Timothy 1:7 Connect with Dr. April Joy: Connect with Dr. April Joy: Substack: The Christian Mind Reset If you liked today’s episode, please subscribe, leave a review, follow, like, or share. You can find me on Instagram at @thechristianpsychnp and also on Instagram and Substack at The Christian Mind Reset for more Scripture, neuroscience, and practical tips for renewing your mind. My eBook, The Christian Mind Reset: A 28-Day Psalms Guide to Biblical Meditation, Neuroscience, and Renewing Your Mind, is available in my Stan Store at https://stan.store/thechristianpsychnp References Denson, T. F., Pedersen, W. C., Ronquillo, J., & Nandy, A. S. (2009). The angry brain: Neural correlates of anger, angry rumination, and aggressive personality. Journal of Cognitive Neuroscience, 21(4), 734–744. https://doi.org/10.1162/jocn.2009.21051 Dunn, R. S. (2025). When you don’t have the words: Praying the Psalms. Lexham Press. Klimecki, O. M., Sander, D., & Vuilleumier, P. (2018). Distinct brain areas involved in anger versus punishment during social interactions. Scientific Reports, 8(1), 10556. https://doi.org/10.1038/s41598-018-28863-3 Shimbo, D., et al. (2024). The effects of negative emotions on vascular function. Journal of the American Heart Association Thomas Nelson. (2017). The NKJV study Bible (2nd ed.). Thomas Nelson Disclaimer: This podcast/letter is for informational purposes only. It contains general information, drawn from my experience, research, and best practices. It is not health care advice, and is not intended to replace the counsel of your health care provider. Consult your provider before starting any new treatments or making changes to your health routine. This message does not constitute a provider-patient relationship between us. If you are experiencing significant anxiety, distress, or need support, please seek care from a qualified healthcare professional. You may also consider reaching out to a licensed Christian counselor or pastor for additional support. Emails, portal messages, text messages, and other communications are not monitored and will not receive a response in an emergency or crisis, or regarding medical or therapy advice. These methods should never be used for medical advice, therapy, urgent, crisis, emergent, or time-sensitive concerns. If you are experiencing a medical or psychiatric emergency, are in crisis, having thoughts of harming yourself or others, or feel unsafe, call 911 (US), or contact your local emergency services, or go to the nearest emergency room or hospital immediately. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thechristianmindreset.substack.com

    Anger, Neuroscience, and Biblical Truth: What the Bible Really Says About Anger
  8. Jun 22

    Comparison, Contentment, and Keeping Your Eyes on God | Neuroscience, Psychology, and Psalm 73

    Episode 16, Season 1 Show Notes Why does comparison steal our peace so quickly? In today’s episode of The Christian Mind Reset, we explore the psychology, neuroscience, and biblical perspective on comparison, envy, contentment, and keeping our eyes on God. Using Psalm 73 as our anchor passage, we walk through Asaph’s honest struggle with comparison and discover how looking at everyone else’s life distorted his perspective. Long before psychologists studied social comparison, Scripture described what happens when we measure our lives against others. We’ll discuss Social Comparison Theory, the impact of social media on mental health, what neuroscience reveals about the brain’s reward system and social comparison, and why gratitude and worship help restore perspective. We’ll also look at Peter's comparison of himself to John, Paul’s teaching on examining our own work, and the invitation to run our own race with endurance. If you’ve ever felt behind, overlooked, discouraged, or tempted to compare your life to someone else’s, this episode is for you. In This Episode • Psalm 73 and the psychology of comparison • Why comparison often leads to discouragement and envy • Leon Festinger’s Social Comparison Theory • Social media, comparison, and mental health • The neuroscience of comparison and the brain’s reward system • Why the brain naturally notices what appears missing • Peter, John, and Jesus’ response to comparison • The vineyard workers and comparison-driven resentment • Contentment as a learned skill • Gratitude as an antidote to comparison • The Comparison Audit exercise • Daily declarations and prayer Key Scriptures Psalm 73:3 Psalm 73:17 Psalm 73:25–26 Psalm 16:6 John 21:20–22 Galatians 6:4–5 Hebrews 12:1–2 2 Corinthians 10:12 Ecclesiastes 4:4 Philippians 1:6 Philippians 4:11 Matthew 20:1–16 Key Takeaways Comparison distorts perspective. Worship restores perspective. Nothing changed about Asaph’s circumstances. Nothing changed about God’s faithfulness. What changed was where Asaph fixed his attention. Comparison asks, “Why them?” Faith asks, “Lord, what have You entrusted to me?” Comparison focuses on what is missing. Gratitude helps us remember what God has already provided. Connect with Dr. April Joy: Connect with Dr. April Joy: Substack: The Christian Mind Reset If you liked today’s episode, please subscribe, leave a review, follow, like, or share. You can find me on Instagram at @thechristianpsychnp and also on Instagram and Substack at The Christian Mind Reset for more Scripture, neuroscience, and practical tips for renewing your mind. My eBook, The Christian Mind Reset: A 28-Day Psalms Guide to Biblical Meditation, Neuroscience, and Renewing Your Mind, is available in my Stan Store at https://stan.store/thechristianpsychnp Resources The Christian Mind Reset Podcast The 28-Day Christian Mind Reset Guide Substack Articles on Neuroscience, Psychology, and Biblical Meditation References Emmons, R. A., & McCullough, M. E. (2003). Counting blessings versus burdens: An experimental investigation of gratitude and subjective well-being in daily life. Journal of Personality and Social Psychology, 84(2), 377–389. https://doi.org/10.1037/0022-3514.84.2.377 Festinger, L. (1954). A theory of social comparison processes. Human Relations, 7(2), 117–140. Fliessbach, K., Weber, B., Trautner, P., Dohmen, T., Sunde, U., Elger, C. E., & Falk, A. (2007). Social comparison affects reward-related brain activity in the human ventral striatum. Science, 318(5854), 1305–1308. Hunt, M. G., Marx, R., Lipson, C., & Young, J. (2018). No more FOMO: Limiting social media decreases loneliness and depression. Journal of Social and Clinical Psychology, 37(10), 751–768. Krasnova, H., Wenninger, H., Widjaja, T., & Buxmann, P. (2013). Envy on Facebook: A hidden threat to users’ life satisfaction. Proceedings of the International Conference on Information Systems. Takahashi, H., Kato, M., Matsuura, M., Mobbs, D., Suhara, T., & Okubo, Y. (2009). When your gain is my pain and your pain is my gain: Neural correlates of envy and schadenfreude. Science, 323(5916), 937–939. Wood, A. M., Froh, J. J., & Geraghty, A. W. A. (2010). Gratitude and well-being: A review and theoretical integration. Clinical Psychology Review, 30(7), 890–905. https://doi.org/10.1016/j.cpr.2010.03.005 Thanks for reading The Christian Mind Reset's Substack! Subscribe for free to receive new posts and podcasts, and support my work. Disclaimer Disclaimer: This podcast/letter is for informational purposes only. It contains general information, drawn from my experience, research, and best practices. It is not health care advice, and is not intended to replace the counsel of your health care provider. Consult your provider before starting any new treatments or making changes to your health routine. This message does not constitute a provider-patient relationship between us. If you are experiencing significant anxiety, distress, or need support, please seek care from a qualified healthcare professional. You may also consider reaching out to a licensed Christian counselor or pastor for additional support. Emails, portal messages, text messages, and other communications are not monitored and will not receive a response in an emergency or crisis, or regarding medical or therapy advice. These methods should never be used for medical advice, therapy, urgent, crisis, emergent, or time-sensitive concerns. If you are experiencing a medical or psychiatric emergency, are in crisis, having thoughts of harming yourself or others, or feel unsafe, call 911 (US), or contact your local emergency services, or go to the nearest emergency room or hospital immediately. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thechristianmindreset.substack.com

    Comparison, Contentment, and Keeping Your Eyes on God | Neuroscience, Psychology, and Psalm 73
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About

The Christian Mind Reset blends Scripture, psychology, and neuroscience to help you renew your thoughts and break mental strongholds. Hosted by April Joy DNP, APN-C (@thechristianpsychnp), each episode explores real struggles, intrusive thoughts, anxiety, and how God’s Word rewires the brain. Learn how to feed truth instead of strongholds and walk in the peace Christ promises. thechristianmindreset.substack.com

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