Imagine handing an AI a job before you leave for the day — research customers, build a spreadsheet, draft emails, prepare a follow-up plan — and coming back to find it done. This episode compares six major products taking different approaches to that promise: Claude Cowork, Grok Bot, OpenAI Dots, Meta Muse, Microsoft Copilot Cowork, and Perplexity Computer. Claude Cowork, from Anthropic, targets knowledge work across files and connected tools, breaking larger jobs into parallel sub-tasks and scheduling recurring work; since September it's merged with regular Claude chat into one experience, and supported-plan tasks continue in the cloud after you close your laptop. Grok Bot, from xAI, takes a teammate-oriented approach with named Bots running on a persistent cloud computer with a browser, files, and a terminal that keeps working while your devices are off — but xAI's own FAQ is explicit that every Bot on an account shares that one computer, including files and browser sessions, so separate Bots are not separate security boundaries. OpenAI's Dots are always-on, project-persistent agents with their own cloud computer and browser, drawing on ChatGPT context and memory, rolling out gradually by account and region. Meta's Muse is a personal agent reachable through its own app or WhatsApp, running in a dedicated secure virtual machine, asking approval before sensitive actions like sending a message or making a purchase, and — per Meta — keeping Muse conversations and VM data out of its advertising systems. Microsoft Copilot Cowork is built for people already living in Microsoft 365, operating across Outlook, Teams, Word, Excel, PowerPoint, OneDrive, and SharePoint within a user's existing permissions; notably, Microsoft's own application card confirms Cowork runs on Anthropic's Claude models as a subprocessor, not Microsoft's own. Perplexity Computer centers on research and end-to-end projects, delegating work to subagents, switching between models per task, and connecting to services like Gmail, Slack, Notion, and Calendar. The episode is explicit that this is a product-design comparison, not a controlled benchmark, and closes on the shared risk underneath all six: an agent that can read email, access files, and send messages carries serious authority, so start with low-risk tasks, scope access tightly, require approval for consequential actions, and verify results rather than trusting the most impressive demo. Sources & References Anthropic: Claude Cowork product overview — https://claude.com/product/cowork Anthropic: Claude Cowork and chat are now one Claude — https://claude.com/blog/cowork-is-now-claude Anthropic: Get started with Claude Cowork — https://support.claude.com/en/articles/13345190-get-started-with-claude-cowork Anthropic: Use Claude Cowork on web, desktop, and mobile — https://support.claude.com/en/articles/15520349-use-claude-cowork-on-web-desktop-and-mobile xAI: Introducing Grok Bot — https://x.ai/news/introducing-grok-bot xAI: Grok Bot overview — https://docs.x.ai/grok-bot/overview xAI: Grok Bot FAQ — https://docs.x.ai/grok-bot/faq OpenAI: Meet dots — https://learn.chatgpt.com/docs/dots OpenAI: Getting started with your dot — https://help.openai.com/en/articles/20001530-getting-started-with-your-dot Meta: Introducing Muse: The World's First Personal AI Agent Built for Everyone — https://about.fb.com/news/2026/09/introducing-muse-personal-ai-agent/ Meta AI Research: How We Built Safety Into Muse — https://research.meta.ai/blog/security-and-safety-for-ai-agents-our-approach-with-muse Microsoft: Copilot Cowork overview — https://learn.microsoft.com/en-us/microsoft-365/copilot/cowork Microsoft: Copilot Cowork application card — https://learn.microsoft.com/en-us/microsoft-365/copilot/responsible-ai/copilot-cowork-application-card Voice narration is AI-generated.