MS-Perspektive - The Multiple Sclerosis Podcast

Nele Handwerker
MS-Perspektive - The Multiple Sclerosis Podcast

In the MS-Perspektive Podcast, I present my view of multiple sclerosis and show you how you can make the best of the diagnosis. Because a beautiful and fulfilling life is also possible with multiple sclerosis. Here you will find information and strategies on how you can actively influence your course. In addition, I publish solo articles with my experiences, interview experts and on various topics related to living with MS as well as other affected people. In addition, there are a few episodes that serve the relaxation, positive attitude and stimulation.

  1. 4 DAYS AGO

    The Future of MS Care. Can Digital Twins Predict Your Disease Progression? With Prof. Tjalf Ziemssen

    Find out how digital twin technology based on AI and big data is transforming the treatment of Multiple Sclerosis by enabling personalized treatment, predicting disease progression, and optimizing patient management. You can read a shortened summary of the interview on my blog: https://ms-perspektive.com/100-digital-twin The concept of a digital twin is revolutionizing medicine, offering a new way to personalize treatments and predict disease progression. But what exactly does it mean for multiple sclerosis patients? In the 100th anniversary episode of the English MS-Perspektive Podcast, Prof. Tjalf Ziemssen, one of the world’s leading MS experts and innovators, explains how AI and big data are shaping the technology of digital twins to improve MS care. We discuss how this innovative approach differs from traditional monitoring tools, its potential for predicting disease progression, and how it could help neurologists adjust treatments sooner. Beyond medical care, digital twins can also support lifestyle adjustments and rehabilitation strategies. And they can show patients whether they are being well cared for or missing important checkups. Find out more about the real-world applications, current challenges and future possibilities of digital twin technology for people with MS. Sie sehen gerade einen Platzhalterinhalt von Podcast Player. Um auf den eigentlichen Inhalt zuzugreifen, klicken Sie auf den Button unten. Bitte beachten Sie, dass dabei Daten an Drittanbieter weitergegeben werden. "},"no_headings_message":"No headings were found on this page.","minimize_box":"yes","minimized_on":"tablet","hierarchical_view":"yes","min_height":{"unit":"px","size":"","sizes":[]},"min_height_tablet":{"unit":"px","size":"","sizes":[]},"min_height_mobile":{"unit":"px","size":"","sizes":[]}}" data-widget_type="table-of-contents.default"> Table of Contents Introduction Potential Benefits for MS Patients Realistic Applications & Current Challenges The Future of Digital Twins in MS Treatment Closing Thoughts & Call to Action Where can interested listeners follow your research or get involved? Prof. Tjalf Ziemssen: You can follow my work through academic publications, MS research platforms, and social media channels. We also encourage those interested to engage with patient organizations that support digital health initiatives. --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

    52 min
  2. FEB 5

    Insights from Groundbreaking MS Studies on Risks, Trends, and Equity an ECTRIMS Special

    Learn more about epidemiology of MS including risks, trends and where clincial trials need to be revised for better equity. You can read the full article on my blog: https://ms-perspektive.com/99-epidemiology In this overview of papers from ECTRIMS 2024, I have selected studies that look at development and frequency and influence progression. You will learn about the role of Epstein-Barr virus infections and the effects of social and health inequalities on the course of MS. These studies also highlight the growing need for inclusion in clinical trials and the importance of monitoring MS trends worldwide. By exploring these insights, we can better understand the complexities of MS and learn how they shape the future of care and research for the MS community. "},"no_headings_message":"No headings were found on this page.","minimize_box":"yes","minimized_on":"tablet","hierarchical_view":"yes","min_height":{"unit":"px","size":"","sizes":[]},"min_height_tablet":{"unit":"px","size":"","sizes":[]},"min_height_mobile":{"unit":"px","size":"","sizes":[]}}" data-widget_type="table-of-contents.default"> Table of Contents 1. Risk and onset of multiple sclerosis after infectious mononucleosis (IM): a population-based study of >650,000 cases of IM  2. Rising prevalence of Multiple Sclerosis in Switzerland – Results from the Swiss Multiple Sclerosis Registry 3. Multiple Sclerosis in the Greenlandic population 4. African American and Non-Hispanic White people with multiple sclerosis: social determinants of health and health inequities. 5. Clinical Trial Awareness among African Americans --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

    26 min
  3. JAN 29

    New Research for Managing Primary Progressive Multiple Sclerosis (PPMS) an ECTRIMS Special

    Latest treatments and research presented at ECTRIMS 2024 for managing primary progressive MS (PPMS). including innovative therapies like CAR T-cell therapy. You can read the full article on my blog: https://ms-perspektive.com/098-ppms-ectrims Primary Progressive Multiple Sclerosis (PPMS) presents unique challenges, as it often worsens without relapses and can significantly impact daily life. However, the growing body of research and treatment options is providing new hope for managing this condition. From exploring the effectiveness of established therapies like Ocrelizumab to cutting-edge advancements in CAR T-cell treatments, scientists and healthcare providers are uncovering ways to slow progression, improve outcomes, and enhance quality of life. This summary from ECTRIMS 2024 dives into the latest studies and innovations, offering insights to empower your MS journey. "},"no_headings_message":"No headings were found on this page.","minimize_box":"yes","minimized_on":"tablet","hierarchical_view":"yes","min_height":{"unit":"px","size":"","sizes":[]},"min_height_tablet":{"unit":"px","size":"","sizes":[]},"min_height_mobile":{"unit":"px","size":"","sizes":[]}}" data-widget_type="table-of-contents.default"> Table of Contents 1. Anti-CD20 therapies in drug-naive primary progressive multiple sclerosis patients: A multicenter real-life study 2. Design of KYSA-7, A Phase 2, Open-Label, Randomized, Multicenter Study of KYV-101, an Autologous Fully Human Anti-CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy, in Treatment Refractory Primary and Secondary Progressive Multiple Sclerosis 3. Efficacy and security of ocrelizumab in patients with primary progressive multiple sclerosis (ppms) in a tertiary care hospital multiple sclerosis unit 4. GA Depot (long-acting IM injection of glatiramer acetate) Impact on EDSS stability in Relapsing forms of Multiple Sclerosis (RMS) and Primary Progressive Multiple Sclerosis (PPMS) 5. Impact of age on safety and effectiveness outcomes in persons with relapsing and primary progressive multiple sclerosis treated with ocrelizumab in the German real-world CONFIDENCE study 6. Brain Volume Maps Identify Primary Progressive Multiple Sclerosis Patients at High Risk of Accelerated Atrophy --- Living with PPMS can feel overwhelming at times, but you are not alone. Research is advancing rapidly, with treatments and approaches designed to help slow progression, maintain independence, and enhance quality of life. Whether it’s monitoring your brain health, considering therapies like Ocrelizumab or GA Depot, or staying informed about revolutionary trials like CAR T-cell therapy, there is a growing arsenal of options to explore. Remember, your journey with MS is unique, and the best path forward is one tailored to your needs in collaboration with your healthcare team. Stay proactive, prioritize your well-being, and take comfort in knowing that science, advocacy, and community support are on your side. Every small step—whether it’s discussing a new treatment or making a lifestyle change—can bring you closer to a brighter future. Keep believing in your strength and the progress that’s being made for us and our community. See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

    31 min
  4. JAN 22

    Late-Onset Multiple Sclerosis (LOMS): Symptoms, treatment options, and prognosis with Dr. Abdulkadir Tunc

    Discover expert insights on Late-Onset Multiple Sclerosis (LOMS) from Assoc. Prof. Dr. Abdulkadir Tunç, a leading neurologist dedicated to advancing MS care and improving lives. You can read the interview on my blog: https://ms-perspektive.com/97-loms I am pleased to welcome Associate Professor Dr. Abdulkadir Tunç in this interview, a neurologist who has dedicated his career to understanding and treating multiple sclerosis (MS), including late-onset multiple sclerosis (LOMS). Dr. Tunç is passionate about helping people overcome the challenges of MS and improve their quality of life through personalized care and innovative research. Dr. Tunç’s continuing education, including his graduation from the renowned International Charcot MS Master’s Program, has given him an in-depth knowledge of the complexities of MS. He heads a neuroimmunology clinic at Sakarya University in Turkey, where he and his team specialize in finding the best treatments for each patient’s individual needs. Today, he shares insights into the management of LOMS and tips on how patients can live well with it. "},"no_headings_message":"No headings were found on this page.","minimize_box":"yes","minimized_on":"tablet","hierarchical_view":"yes","min_height":{"unit":"px","size":"","sizes":[]},"min_height_tablet":{"unit":"px","size":"","sizes":[]},"min_height_mobile":{"unit":"px","size":"","sizes":[]}}" data-widget_type="table-of-contents.default"> Table of Contents Introduction – Who is Assoc. Prof. Dr. Abdulkadir Tunc? Definition and Differences in Onset of LOMS Immunotherapies and Treatment Decisions Repair and Recovery Mechanisms Symptomatic Treatment and Quality of Life Prognosis and Progression of LOMS New Developments: BTK Inhibitors Quickfire Q&A Session Farewell Introduction – Who is Assoc. Prof. Dr. Abdulkadir Tunc? Assoc. Prof. Dr. Abdulkadir Tunc: Thank you for having me; it’s a pleasure to be here. I am Assoc. Prof. Dr. Abdulkadir Tunç, a neurologist specializing in neuroimmunology, particularly MS and autoimmune neuromuscular diseases. For over 10 years, I have been closely working with MS patients, providing care and contributing to research aimed at improving their quality of life. I am proud to have completed the prestigious International Charcot MS Master program, which deepened my understanding of MS and its management. Currently, I run neuroimmunology clinics at Sakarya University, where my team and I focus on personalized approaches to treatment. Beyond my clinical work, I actively participate in our national neurology study group and regularly attend international congresses to stay updated on the latest innovations in the field. On a personal note, I’m married and a father of two wonderful children. When I’m not working, I find joy in playing court tennis and swimming regularly—activities that help me recharge and maintain balance in my life. I believe that staying active and curious, both professionally and personally, is key to living fully. Finally, what message of hope or encouragement would you like to share with individuals living with MS? Assoc. Prof. Dr. Abdulkadir Tunc: To everyone living with MS, remember that you are not defined by this disease. Each day, we’re making progress in understanding MS and developing new treatments to improve lives. Stay hopeful, stay proactive, and never hesitate to lean on your support network. Together, we’re stronger, and together, we’ll continue moving forward. How and where can interested people follow your research activities? Assoc. Prof. Dr. Abdulkadir Tunc: You can follow my research and updates through academic platforms like ResearchGate or LinkedIn, where I share my latest publications and projects. I also collaborate with the MSBase Registry and participate in international MS-focused events, so stay tuned for updates from these communities as well. --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

    29 min
  5. JAN 15

    From Fatigue to Focus. The Power of Sleep and Exercise in Managing MS an ECTRIMS Special

    Improving sleep quality is vital for managing MS, reducing fatigue, enhancing cognitive function, and boosting overall well-being. You can find the complete summary on my blog: https://ms-perspektive.com/096-sleep Sleep is one of the most critical yet often underestimated aspects of managing MS. For many of us living with MS, poor sleep can worsen fatigue, brain fog, and other symptoms, making daily life even more challenging. The good news is that improving your sleep isn’t just possible—it can lead to meaningful improvements in your energy, mood, and overall well-being. In this summary from ECTRIMS 2024 papers, I’ll explore recent research on how sleep and physical activity interact in MS, along with tips to help you get the restorative rest you deserve. "},"no_headings_message":"No headings were found on this page.","minimize_box":"yes","minimized_on":"tablet","hierarchical_view":"yes","min_height":{"unit":"px","size":"","sizes":[]},"min_height_tablet":{"unit":"px","size":"","sizes":[]},"min_height_mobile":{"unit":"px","size":"","sizes":[]}}" data-widget_type="table-of-contents.default"> Table of Contents 1. Assessment of sleep quality and its relationship with physical activity in patients with Relapsing-Remiting Multiple Sclerosis 2. Sleep disorders and fatigue in multiple sclerosis: association and interaction. 3. Relationship between sleep disorders and information processing speed in multiple sclerosis 4. Ketogenic Diet in patients with Multiple Sclerosis: effect on Fatigue, Quality of Sleep and Sleepiness. 5. Adolescent sleep patterns, genetic predisposition, and risk of multiple sclerosis Good sleep is a cornerstone of managing MS and improving your quality of life. Small changes, like a consistent bedtime routine or light exercise, can have a big impact over time. Remember, you’re not alone in this journey, and each night of better rest brings you closer to more energized and fulfilling days. Take it one step—or one restful night—at a time, and know that you’re making a powerful investment in your health and well-being. You’ve got this! --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

    27 min
  6. JAN 8

    Hidden Challenges – Exploring Smoldering MS with Prof. Gavin Giovannoni

    Prof. Gavin Giovannoni explores the complexities of multiple sclerosis, the concept of "smoldering MS," and future treatment strategies. You can find the full transcript of the interview to read on my blog: https://ms-perspektive.com/95-smoldering-ms Welcome to today’s interview, in which I am accompanied by one of the most influential personalities in the field of multiple sclerosis, Prof. Gavin Giovannoni. Prof. Giovannoni is a renowned neurologist at the Royal London Hospital and a professor at Queen Mary University in London. Originally from South Africa, he has dedicated his career to understanding, treating and advancing research in multiple sclerosis (MS). Prof. Giovannoni is recognized for his groundbreaking insights and patient-centered approach and has significantly contributed to how we view and manage MS, particularly through his work on the concept of ’smoldering MS‘. In this interview, we’ll tap into his expertise and explore the complexities of MS, the evolving understanding of “smoldering MS”, and the future of treatment and management strategies. Whether you are a patient, carer, or healthcare professional, this conversation promises to be both informative and empowering. "},"no_headings_message":"No headings were found on this page.","minimize_box":"yes","minimized_on":"tablet","hierarchical_view":"yes","min_height":{"unit":"px","size":"","sizes":[]},"min_height_tablet":{"unit":"px","size":"","sizes":[]},"min_height_mobile":{"unit":"px","size":"","sizes":[]}}" data-widget_type="table-of-contents.default"> Table of Contents Introduction – Who is Prof. Gavin Giovannoni? Understanding Smoldering MS Treatment and Management Approaches Patient Perspectives and Challenges Quickfire Q&A Session Farewell Introduction – Who is Prof. Gavin Giovannoni? I am a neurologist at the Royal London Hospital and a professor at Queen Mary University in London. Originally from South Africa, I focus on research and treatment innovations in multiple sclerosis (MS), aiming to improve patient outcomes. Gavin, what message of hope would you like to share with people living with MS?  There has never been a more promising time for MS research and care. With advancements in treatments and diagnostics, we are moving closer to a future where MS is not only manageable but potentially curable. Stay hopeful and proactive in managing your health. Where can interested people learn more about your work? I have a thing called MS Selfie. It stands for MS Self Management. Now, there’s a newsletter that’s on Substack. They can register for that. And then there’s a microsite. That’s a curated site for people for self-management. I usually do one or two newsletters a week.  --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

    1h 3m
  7. JAN 1

    Effects of the Mediterranean diet on MS an ECTRIMS Special

    The mediterranean diet is healthy, tasty and contributes to a better quality of life when having MS from fatigue to brain health to mood. You can read the full article on my blog: https://ms-perspektive.com/94-mediterranean-diet This time, I have compiled papers on the Mediterranean diet that were presented at ECTRIMS 2024. The diet, which is high in fresh vegetables, fruits, nuts, olive oil, whole grains, and lean proteins, has been recommended for a long time. And the good thing is that it is more of a dietary approach that emphasizes healthy eating rather than prohibitions. The six studies presented show you how small lifestyle changes can have a big impact on your health and well-being. For example, the Mediterranean diet can support brain health, slow the progression of the disease, improve quality of life and even alleviate symptoms such as fatigue, anxiety and depression. Let these findings inspire you to make some delicious and health-promoting changes to your diet! "},"no_headings_message":"No headings were found on this page.","minimize_box":"yes","minimized_on":"tablet","hierarchical_view":"yes","min_height":{"unit":"px","size":"","sizes":[]},"min_height_tablet":{"unit":"px","size":"","sizes":[]},"min_height_mobile":{"unit":"px","size":"","sizes":[]}}" data-widget_type="table-of-contents.default"> Table of Contents 1. High adherence to the Mediterranean diet influences progressive Multiple Sclerosis course 2. Mediterranean Diet is Associated with a Proxy for Atrophy in Multiple Sclerosis 3. Mediterranean diet improves the quality of life in patients with Relapsing-remitting multiple sclerosis: our experience 4. Factors affecting psychological well-being index, adherence to medication, and Mediterranean diet in patients with multiple sclerosis 5. Differential DNA methylation significantly mediates the associations of Mediterranean diet with MS onset risk: results from the Ausimmune incident case-control study 6. A Higher Mediterranean Diet Score is Prospectively Associated with Better Mental Health and Quality of Life in a National Multiple Sclerosis Cohort --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

    28 min
  8. 12/25/2024

    Aging with MS an ECTRIMS Special

    Explore aging's impact on MS, highlighting research on cognition, inflammation, brain changes, and treatments. You can read the text version on my blog: https://ms-perspektive.com/093-aging-with-ms Living with multiple sclerosis in old age presents a unique challenge in understanding how the disease interacts with the natural aging process. This special ECTRIMS Review delves into groundbreaking studies exploring aging with MS, focusing on topics such as cognitive health, inflammation, brain changes, and diagnostic tools like OCT. Whether you are gaining insights into how MS develops in older age or looking for ways to proactively manage your health, this episode is packed with valuable information to help you navigate your path with confidence and knowledge. "},"no_headings_message":"No headings were found on this page.","minimize_box":"yes","minimized_on":"tablet","hierarchical_view":"yes","min_height":{"unit":"px","size":"","sizes":[]},"min_height_tablet":{"unit":"px","size":"","sizes":[]},"min_height_mobile":{"unit":"px","size":"","sizes":[]}}" data-widget_type="table-of-contents.default"> Table of Contents 1. Aging in People with Multiple Sclerosis: Cognitive Characteristics 2. Inflammaging and multiple sclerosis: inevitable partners in aging? 3. Aging intervenes in relationship between OCT and clinical or MRI outcome measures 4. Enlarged perivascular spaces are associated with brain microangiopathy and aging in multiple sclerosis 5. Levraging immunosenescence cellular signatures to evaluate the "immune-age": moving towards precision medicine in multiple sclerosis 6. Durable efficacy of cladribine tablets in an aging (> 50 years of age) MS patient population- A Real-World Experience --- Aging with MS can bring changes, but it also brings opportunities to refine the way you manage your disease. From understanding cognitive changes to taking advantage of new treatments and monitoring brain health, it’s important to stay informed and proactive. Remember: knowledge is power, and with the right strategies and support, you can continue to live a full life, regardless of your age. If any of these insights resonate with you, don’t hesitate to discuss them with your medical team and see how they can be applied to your treatment. See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

    33 min

About

In the MS-Perspektive Podcast, I present my view of multiple sclerosis and show you how you can make the best of the diagnosis. Because a beautiful and fulfilling life is also possible with multiple sclerosis. Here you will find information and strategies on how you can actively influence your course. In addition, I publish solo articles with my experiences, interview experts and on various topics related to living with MS as well as other affected people. In addition, there are a few episodes that serve the relaxation, positive attitude and stimulation.

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