Callie Isley is 36, lives in Texas, and spent five years trying to become a mother — multiple fertility evaluations, IUIs, and a looming $25,000 IVF bill — before her story took an unexpected turn. In this deeply personal episode, Dr. Kylie Burton and Jessica Brickie sit down with Callie to talk through the emotional weight of infertility, the lifestyle changes that came before her pregnancy, and the surprise that changed everything. Callie walks through her and her husband's fertility journey: a low egg reserve diagnosis, her husband's low sperm motility, two failed rounds of IUI, and the sticker shock of IVF pricing with no insurance coverage. She's candid about the depression that set in as the years passed and friends around her started families of their own. A visit to her mother's holistic doctor — prompted by her mom, not her own initiative — led to bloodwork, a hard look at her lifestyle (including what she calls her "DoorDash diet"), and a recommendation to try microdosed tirzepatide. Six months and about 50 pounds later, she'd planned to come off the medication to prepare for IVF — and discovered she was pregnant instead. The conversation doesn't stop at the pregnancy news. Callie, Kylie, and Jessica dig into the emotional and relational toll infertility takes, the stigma around GLP-1 use that kept Callie from trying it sooner, and the broader idea that these peptides may be addressing an underlying metabolic picture — not just facilitating weight loss. The hosts are careful throughout to frame this as one woman's story and not a guarantee or a fertility treatment protocol. What You'll Learn Callie and her husband's fertility journey: a low egg reserve diagnosis, male factor infertility, two failed IUI attempts, and the cost gap between IUI and IVFThe emotional toll of infertility — including depression, strain on the marriage, and the isolation of watching friends start families firstHow a visit to a holistic doctor (at her mother's urging) led to bloodwork, lifestyle changes, and a recommendation to try microdosed tirzepatideCallie's six-month experience microdosing, including the protein-and-hydration-focused approach she took alongside itWhy she decided to come off the medication in preparation for IVF — and the timing of her subsequent pregnancyA discussion of period and cycle changes she noticed over the years, and how that fits into a broader conversation about metabolic and hormonal healthWhy the hosts frame stories like this as pointing to an underlying metabolic or inflammatory picture, not just a weight-loss outcomeThe role stigma and algorithm-driven social media played in delaying Callie's decision to try a GLP-1 in the first placeA candid, supportive conversation about how partners are affected differently by infertility, and how to talk about it Segment Breakdown Low Egg Reserve and Male Factor — The diagnostic journey for both Callie and her husbandIUI Attempts and IVF Sticker Shock — Treatment history and the financial reality of fertility careHolistic Labs, Lifestyle, and Inflammation — The appointment that changed her approachMicrodosing Tirzepatide and Rapid Change — Callie's six-month experience and the changes she noticedOff the Shot, Suddenly Pregnant — The timeline of stopping the medication and the pregnancy that followedPeriod Changes, COVID Stress, and Endometriosis — A closer look at her cycle history and possible underlying factorsAlgorithms, Education, and Sharing the Win — How social media shaped (and delayed) her decision to try a GLP-1 Guest Callie Isley lives in Texas with her husband. After a five-year fertility journey, she is now expecting and has chosen to share her story to support others navigating infertility. Find Callie: Instagram, Facebook, and TikTok — @Callieeisele (spelled C-A-L-L-I-E E-I-S-E-L-E) Where do you start with peptide therapy? What do you add next? If you're a go-getter, check out Dr. Kylie's new program AMPLIFY. You'll find it on the homepage of her website: drkylieburton.com Ready to explore peptide therapy for yourself? Join through Jessica's platform at B2BwithJess.com/peptides or through Dr. Kylie's platform at drkylieburton.com/shop. Want to offer peptide therapy in your business? Whether you're adding it to your existing practice or building something new, learn how to get started—and how we'll mentor you along the way—at drkylieburton.com/peptidesaffiliate. You can also get started through Jessica's platform at B2BwithJess.com. Legal Disclaimer: This podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any new health protocol. Dr. Kylie Burton and Jessica Briecke are affiliates and may receive compensation for referrals. Individual results may vary. You have the science. You have the tools. Now it's time to take the next step. This is PepTalk: Peptides Unpacked—science made simple, re...
