20 episodes

Physician's Weekly offers in-depth interviews with the most highly respected experts in the medical community, weighing in on landmark research, trending topics, and offering insight on issues affecting everyday medical practice. In collaboration with Medicom Medical Publishers, Physician's Weekly Podcast continues to maintain the company's nearly 40 year reputation as a trusted resource for healthcare professionals.

Physician's Weekly Podcast Physician's Weekly

    • Health & Fitness
    • 5.0 • 2 Ratings

Physician's Weekly offers in-depth interviews with the most highly respected experts in the medical community, weighing in on landmark research, trending topics, and offering insight on issues affecting everyday medical practice. In collaboration with Medicom Medical Publishers, Physician's Weekly Podcast continues to maintain the company's nearly 40 year reputation as a trusted resource for healthcare professionals.

    Health Equity & Where it Goes Wrong, Extending Time to Next Treatment for CLL

    Health Equity & Where it Goes Wrong, Extending Time to Next Treatment for CLL

    In this episode, we have two interviews: one general, but incredibly entertaining, about health equity and one on a clinical study in chronic lymphocytic leukemia (CLL). This last interview is with Ryan Jacobs, MD (Dept. Hematology, Atrium Health Levine Cancer Institute), who discusses his new real-world study using more than 2 years of EMRs that shows that patients with CLL treated with first-line Bruton’s tyrosine kinase inhibitor (BTKi) acalabrutinib were 89% more likely to initiate a next-line treatment when compared with patients treated with another BTKi first-line ibrutinib. But first, Physician’s Weekly Editorial Board member and frequent contributor Alex McDonald, MD, speaks with La Tanya Hines, MD, a board-certified obstetrician and gynecologist practicing in Los Angeles about health equity—what it is and where it goes wrong.
    Enjoy listening!
     
    Additional reading:
    https://www.diversityinmedicine.uci.edu/dr-la-tanya-hines/
    Jacobs R. et al, Real-World Comparison of Time to Next Treatment for Patients with CLL Initiated on First-Line Treatment with Ibrutinib Versus Acalabrutinib. Presented at the American Society of Hematology (ASH 2022) on Monday, December 12, 2022, Abstract 797.
    Lu X, et al. Real-World Adherence to First-Line Ibrutinib and Acalabrutinib Single-Agent Among Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. Clinical Lymphoma Myeloma and Leukemia, Volume 22, Supplement 2, 2022: S280-S281, abstract CLL-492

    Let us know what you thought of this week’s episode on Twitter: @physicianswkly
    Want to share your medical expertise, research, or unique experience in medicine on the PW podcast? Email us at editorial@physweekly.com!
    Thanks for listening!

    • 37 min
    inDEPTH: The Latest Gastrointestinal Cancer Research

    inDEPTH: The Latest Gastrointestinal Cancer Research

    Both interviews in this episode are with presenters at the 2023 ASCO Gastrointestinal Cancers symposium. Dr. Myriam Chalabi (Netherlands Cancer Institute) discusses the TARZAN trial, which found that, in patients with rectal cancer, neoadjuvant radiotherapy followed by atezolizumab and bevacizumab resulted in an encouraging complete response rate. The findings of this phase 1 study demonstrate that total mesorectal excision may be prevented in a significant proportion of patients, increasing the chance for organ preservation and reducing the risk for long-term morbidity related to surgery. It is a small but very exciting study!
    But first, Dr. Laura Dawson (Princess Margaret Cancer Centre, Toronto, Canada) reviews her phase 3 study of single-dose radiotherapy to manage pain from hepatocellular carcinoma and liver metastases. The results of this trial delivered encouragingly good results, beyond even the palliative endpoint. 
     
    Enjoy listening!
    Additional reading:
    1.    Dawson LA, et al. Canadian Cancer Trials Group HE.1: A phase III study of palliative radiotherapy for symptomatic hepatocellular carcinoma and liver metastases. LBA492, Rapid Abstract Session B: Cancers of the Pancreas, Small Bowel, and Hepatobiliary Tract, ASCO-GI 2023, San Francisco, CA, USA, 19-21 January.
    2.    Soliman H, Ringash J, Jiang H, Singh K, Kim J, Dinniwell R, Brade A, Wong R, Brierley J, Cummings B, Zimmermann C, Dawson LA. Phase II trial of palliative radiotherapy for hepatocellular carcinoma and liver metastases. J Clin Oncol. 2013 Nov 1;31(31):3980-6.
    3.    Verschoor YL, et al. Radiotherapy, atezolizumab, and bevacizumab in rectal cancers with the aim of organ preservation: The TARZAN study. Poster Session C: Cancers of the Colon, Rectum, and Anus, Abstract 158, 2023 ASCO GI Cancers Symposium, San Francisco, CA, USA, 19-21 January.
    4.      Chalabi M. Defying all odds in MMR-deficient rectal cancers. Cancer Cell. 2022 Sep 12;40(9):914-916. 



    Let us know what you thought of this week’s episode on Twitter: @physicianswkly
    Want to share your medical expertise, research, or unique experience in medicine on the PW podcast? Email us at editorial@physweekly.com!
    Thanks for listening!

    • 31 min
    Killing Senescent Cells to Delay Aging & the Liability of Referrals

    Killing Senescent Cells to Delay Aging & the Liability of Referrals

    Peter de Keizer (Associate Professor, University Medical Center Utrecht, Netherlands) and founder and managing director of Cleara Biotech B.V. discusses his drive to understand how cells that stop dividing and enter a “holding pattern,” known to cell biologists as senescence, drive disease and aging. We talk about how the peptides he has developed, called FOXO4 peptides, will enter clinical trials next year in patients with liver metastases. They work by selectively killing senescent cells, which in turn might unlock localized tissue regeneration programs. This is really cool stuff, and I bet most of you have never heard of this sort of approach!
    Also, our recurring guest, a board-certified radiologist and medical malpractice lawyer who goes by the pseudonym Dr. MedLaw, answers all our questions about liability associated with referrals, something we all do and probably haven’t considered to the depth she covers.

    Let us know what you thought of this week’s episode on Twitter: @physicianswkly
    Want to share your medical expertise, research, or unique experience in medicine on the PW podcast? Email us at editorial@physweekly.com!
    Thanks for listening!

    • 31 min
    97% With Knee Pain Struggle With ADLs, Physician Entrepreneurship Potential

    97% With Knee Pain Struggle With ADLs, Physician Entrepreneurship Potential

    Brian Carr, MD, discusses results of the Standing Up to Knee Pain: The Physical, Social, and Mental Impact of Knee OA survey, which polled 500 US adults who have been treated for chronic knee pain and/or osteoarthritis (OA) of the knee. It found that although 100% of patients have tried some form of treatment to address their pain, a staggering 97% still report that their daily lives are negatively impacted by their condition. The majority (75%) had trouble climbing stairs and exercising, and more than one-half reported that knee pain impaired their overall health and fitness.
    Also, Physician’s Weekly’s editorial Board member Alex McDonald, MD, speaks with Dana Corriel, MD, a board-certified internist, entrepreneur & digital strategist. She is the founder of an online platform that works to centralize the efforts of verified health experts (@SoMeDocs). They have a great conversation about the potential of entrepreneurship among doctors!

    Let us know what you thought of this week’s episode on Twitter: @physicianswkly
    Want to share your medical expertise, research, or unique experience in medicine on the PW podcast? Email us at editorial@physweekly.com!
    Thanks for listening!

    • 33 min
    Anticipated Medical Innovations for 2023

    Anticipated Medical Innovations for 2023

    As 2023 is upon us, we are probably being realistic to expect continued inflation, a choppy economy, COVID-19 disruptions in healthcare, and on-going supply chain disruptions continuing into the year. Some leaders in healthcare systems are even predicting an “exceptionally turbulent 2023.”1 While inflation appears to be stabilizing, the higher cost of consumer goods is making it difficult for some people to pay for medical services, therapies, and devices. As a result, healthcare consumers might put off buying prescriptions or medical devices that can help them treat or monitor a condition. 
    On the flip side, but much harder to predict, there will be a number of significant medical advances, many of which will be incremental improvements, and a few of which will be major breakthroughs. PW Podcast host Rachel Giles, MD, and PW editorial board member Alex McDonald, MD, discuss the trends to watch this year, from wearables and patient engagement to next-generation therapies and vaccines.
    Happy New Year!
    References:
    https://www2.deloitte.com/us/en/blog/health-care-blog/2022/2023-outlook-for-health-care-could-margins-staffing-stall-progress-to-future-of-health.htmlGene therapy pipeline 1Q2022-2Q 2025, CVS Health, February 2, 2022; Approved cellular and gene therapy products, FDA, September 19, 2022; The state of the industry, Alliance for Regenerative Medicine, January 26, 2021van Dyck CH, et al. Lecanemab in Early Alzheimer's Disease. N Engl J Med. 2022 Nov 29. doi: 10.1056/NEJMoa2212948. Epub ahead of print. https://www.nature.com/articles/d41586-022-03081-0 

    Let us know what you thought of this week’s episode on Twitter: @physicianswkly
    Want to share your medical expertise, research, or unique experience in medicine on the PW podcast? Email us at editorial@physweekly.com!
    Thanks for listening!

    • 29 min
    The Top Medical Innovations of 2022!

    The Top Medical Innovations of 2022!

    Co-hosts Dr. Alex McDonald and Dr. Rachel Giles give their perspectives, in no particular order of importance, on our choices for the top 14 medical innovations for 2022. Some are already in practice, while others are recent breakthroughs not quite ready for “prime time.” All-in-all it was a great year for medical science; let us know what you think the biggest medical innovations were in 2022! 

    We wish you a safe and healthy holiday season! We’ll be back the first week of January 2023 with an episode dedicated to looking at anticipated medical breakthroughs in 2023!
     

    Let us know what you thought of this week’s episode on Twitter: @physicianswkly
    Want to share your medical expertise, research, or unique experience in medicine on the PW podcast? Email us at editorial@physweekly.com!
    Thanks for listening!

    • 27 min

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