Precision Pathology Podcast (P³)

Perelman School of Medicine, Pathology & Laboratory Medicine

Precision Pathology Podcast (P³) features monthly interviews hosted by George J. Netto, MD, Chair of Pathology and Laboratory Medicine at the University of Pennsylvania's Perelman School of Medicine. In each episode, he engages with global thought leaders and authors who are at the forefront of cutting- edge research in pathology and biomedical science. The discussions are easy to follow and highly informative, covering a wide range of groundbreaking technological advancements in precision diagnostics and therapeutics. Topics include digital and computational pathology, single-cell and spatial omics, as well as multiplex biomarker assessment, which are transforming diagnostics, targeted therapies, immunotherapy, and cellular therapeutics.

Episodes

  1. FEB 10

    Cutting Edge Technologies Unlocking Barrett's Esophagus Clonal Cell States

    In this episode, Dr. Sydney Shaffer shares her expertise on cutting-edge technologies, including single-cell and spatial transcriptomics, and their significance for understanding cancer biology. The guest discusses these tools in the context of her recent Nature Communications publication (https://doi.org/10.1038/s41467-025-66302-w), which provides a single-cell view of cell dynamics in Barrett’s esophagus and links cell states along the disease trajectory from its origin to cancer. #Barrett's #Esophagus #SpatialTranscriptomics #Dysplasia

  2. 12/23/2025

    Revolutionizing CNS Tumor Diagnostics: Intraoperative Methylation Profiling!

    Join Dr. George Netto as he discusses with Professor Felix Sahm, an international expert from Heidelberg University, his team's innovative multi-center study on intraoperative molecular profiling of central nervous system tumors (CNS). Learn how rapid methylation profiling could change the landscape of diagnostics and management of brain neoplasms. Don't miss this enlightening discussion! #Neuropathology #CNS #BrainTumors #MolecularProfiling #MethylationProfiling #PrecisionMedicine #ArtificialIntelligence

  3. 11/21/2025

    A Second Look at the Impact of TERTp Mutation on Meningioma Grade

    Join Dr. George Netto and Dr. Matija Snuderl of Langone Health at NY University as they discuss the significance of TERT promoter mutations in meningiomas and their implications for patient prognosis. This conversation sheds light on the need for reevaluation of molecular biomarkers in the grading of Meningiomas. #Meningioma #MolecularDiagnostics #TERTPromoter #Pathology #CancerResearch #TumorGrade

  4. 10/20/2025

    AI-Driven Biomarkers for Antibody-Drug Conjugates (ADC)

    In this episode, I discuss with Dr. Salgado, Co-Chair of the International Immuno-Oncology Biomarkers Working Group, his editorial (https://doi.org/10.1016/j.ccell.2025.03.020) on the recent Cancer Cell study by Ding Ma et al, presenting a predictive AI model for HER2-targeting ADC efficacy, incorporating immune system components, hormone receptor status, clinical staging, and HER2+ cell proportion.  #ImmunoOncology #HER2Biomarker #AntibodyDrugConjugates

  5. 08/27/2025

    Introduction to Precision Pathology Podcast

    Introducing P³ Podcast Welcome to P³, our new podcast series on Precision Pathology, created and hosted by Dr. George J. Netto, the Simon Flexner Professor and  Chair of Pathology and Laboratory Medicine at the University of Pennsylvania in Philadelphia, PA. In each episode, Dr. Netto will share his perspective on the latest discoveries in precision medicine through informal conversations with accomplished authors and thought leaders from around the world. These dynamic discussions are designed to keep you informed about the most critical publications from high-impact journals. Topics will cover a wide range of disruptive technological advances in diagnostics, prognostics, and predictors of therapeutic response—from digital and computational pathology to spatial and single-cell omics, cell-free nucleic acid assays, and the latest in cellular therapeutics. We hope you’ll enjoy listening and watching and find the conversations both informative and stimulating. We welcome your thoughts and feedback. Please feel free to connect by email (george.netto@pennmedicine.upenn.edu) or at Dr. Netto’s LinkedIn or Substack.

  6. 08/27/2025

    Pathology Foundation Model for Lung Cancer Bio-Marker Detection

    Rapid and accurate assessment of EGFR mutations in lung adenocarcinoma is critical for the management of NSCLC patients. PCR-based assays provide rapid results but with reduced accuracy compared with next-generation sequencing and can exhaust the increasingly valuable small amount of biopsy tissue available for predictive biomarkers. Computational biomarkers Leveraging modern foundation models may offer alternative solutions.  In this episode of Precision Pathology Podcast (P3), the host discusses with Dr. Chad Vanderbilt from the Department of Pathology and Laboratory Medicine at MSKCC in NY, his team’s recent study, published in Nature Medicine, using a large international clinical dataset of digital lung adenocarcinoma slides to develop a computational EGFR biomarker. The artificial-intelligence-assisted workflow has the potential to reduce the number of rapid molecular tests needed by up to 43%.

  • 6 Episodes

Ratings & Reviews

5
out of 5
3 Ratings

About

Precision Pathology Podcast (P³) features monthly interviews hosted by George J. Netto, MD, Chair of Pathology and Laboratory Medicine at the University of Pennsylvania's Perelman School of Medicine. In each episode, he engages with global thought leaders and authors who are at the forefront of cutting- edge research in pathology and biomedical science. The discussions are easy to follow and highly informative, covering a wide range of groundbreaking technological advancements in precision diagnostics and therapeutics. Topics include digital and computational pathology, single-cell and spatial omics, as well as multiplex biomarker assessment, which are transforming diagnostics, targeted therapies, immunotherapy, and cellular therapeutics.

Information

  • Creator
    Perelman School of Medicine, Pathology & Laboratory Medicine
  • Years Active
    2025 - 2026
  • Episodes
    6
  • Rating
    Clean
  • Copyright
    © Perelman School of Medicine, Pathology & Laboratory Medicine
  • Show Website
    Precision Pathology Podcast (P³)