RhAPPcast

Rheumatology Advanced Practice Providers (RhAPP)

This is the official podcast of Rheumatology Advanced Practice Providers (RhAPP), a non-profit 501c3 organization dedicated to developing educational programs, providing professional advancement services, and assembling resources for—and guided by—advanced practice providers (APPs).    Through our peer-to-peer network, we seek to support the integral role APPs play in the rheumatology healthcare community by providing the most relevant and timely information and communication for the treatment of their patients with rheumatic diseases. 

  1. Jun 11

    RhAPPcast: TYK2 Inhibition in PsA, Sjögren’s and SLE: What APPs Need to Know as Future Uses Emerge

    Stay ahead of the latest advancements in rheumatology with this in-depth RhAPPcast episode exploring TYK2 inhibition and its expanding role in immune-mediated diseases. Hosted by Amanda Mixon, PA-C, this episode features expert insights from Danielle Gatti-Palumbo, PharmD, and Jennifer Mylod, DNP, as they break down the science behind TYK2 signaling within the JAK-STAT pathway and its clinical relevance in conditions like psoriatic arthritis, systemic lupus erythematosus (SLE), and Sjögren’s syndrome. Learn how TYK2 inhibitors—such as deucravacitinib—are reshaping treatment strategies by targeting key cytokines like IL-12, IL-23, and type 1 interferons, offering a potentially effective oral alternative with a differentiated safety profile compared to traditional JAK inhibitors. The discussion highlights pivotal clinical trials including POETYK PSO-1, POETYK PSO-2, and emerging phase 3 data in psoriatic arthritis, as well as promising findings from the PAISLEY trial in lupus. Additionally, the episode explores the unmet need in Sjögren’s syndrome and how evolving trial designs and outcome measures may pave the way for future targeted therapies. Whether you're a rheumatology provider, advanced practice provider (APP), or healthcare professional interested in autoimmune disease management, this episode delivers key clinical insights, trial data, and future considerations shaping the next wave of immunomodulatory therapies. For more rheumatology education, check out the RhAPP Content Rheum or download the RhAPP ACE app.

    20 min
  2. Jun 4

    Medication Review: Deucravacitinib Dosing, Administration, DDIs, & Safety in Clinical Practice

    In this educational Medication Review, Claudia Rivera-Salas, DNP, provides a practical overview of deucravacitinib and its role in the treatment of immune-mediated diseases such as psoriatic arthritis and plaque psoriasis. This video highlights why deucravacitinib, a selective TYK2 inhibitor, is gaining attention for its unique mechanism of action and ease of use in clinical practice. Learn how deucravacitinib stands out as a once-daily oral therapy with a fixed dose—requiring no titration, no routine dose adjustments, and the flexibility to be taken with or without food, helping to support patient adherence. Claudia explains how its targeted inhibition of the TYK2 regulatory domain differentiates it from traditional JAK inhibitors, contributing to a favorable safety profile without boxed warnings for major adverse cardiovascular events (MACE), venous thromboembolism (VTE), malignancy, or serious infections observed in clinical trials. The discussion also covers key clinical considerations, including minimal drug-drug interactions, the lack of required routine lab monitoring, and important precautions for patients with severe hepatic impairment or those who are pregnant or breastfeeding. Currently approved for adults with moderate to severe plaque psoriasis and psoriatic arthritis, deucravacitinib is also being investigated across a range of autoimmune conditions. Watch this video to understand how deucravacitinib fits into modern rheumatology and dermatology treatment strategies, and why its balance of efficacy, safety, and convenience makes it a valuable option for both providers and patients managing chronic inflammatory diseases. For more rheumatology resources, visit the RhAPP Content Rheum, RhAPP ACE app, or follow RhAPP on Instagram, LinkedIn, or Facebook.

    2 min
  3. Jun 2

    Podcast: Weight, Wellness, and PsA: Empowering Conversations & Action in the Rheumatology Clinic

    Discover how obesity impacts outcomes in psoriatic arthritis in this insightful episode featuring expert perspectives from rheumatology clinicians, Amanda Mixon, PA-C and Jeannette Hart, PA-C. This discussion explores the growing recognition of obesity as a chronic, pro-inflammatory condition that not only worsens joint symptoms and physical function but also reduces treatment response in patients with psoriatic arthritis. Learn practical, real-world strategies for integrating weight assessment into routine rheumatology care, including how to approach sensitive conversations with patients in a stigma-free, supportive way. The episode highlights how even modest weight loss (5–10%) can improve disease activity, reduce inflammation, and enhance overall health outcomes. Clinicians will also gain insights into building obesity-focused care pathways within their practice, from lifestyle counseling and patient education to incorporating emerging pharmacologic options like GLP-1 therapies. Designed for healthcare professionals, this episode emphasizes the importance of empathy, patient partnership, and science-driven communication when addressing weight management in psoriatic arthritis. Whether you’re looking to improve patient engagement, optimize treatment response, or expand your approach to comprehensive inflammatory disease care, this conversation offers actionable guidance to elevate your clinical practice. For more expert-led education, visit the Content Rheum and stay up to date with the latest clinical insights in rheumatologic care.

    18 min

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About

This is the official podcast of Rheumatology Advanced Practice Providers (RhAPP), a non-profit 501c3 organization dedicated to developing educational programs, providing professional advancement services, and assembling resources for—and guided by—advanced practice providers (APPs).    Through our peer-to-peer network, we seek to support the integral role APPs play in the rheumatology healthcare community by providing the most relevant and timely information and communication for the treatment of their patients with rheumatic diseases. 

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