The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
  • 4.7 (952)
  • Health & Fitness
  • Updated Daily

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

  1. 11 hrs ago

    Longevity Music, Anti-Aging Nasal Spray, How To Look 20, and more...

    Subtitle: A Nasal Spray Longevity Screen, Why Less Protein May Age You Better, Cadaver Skin Injectables, Art's Effect on Biological Age, and Which Anti-Aging Interventions Actually Move the Needle  Nasal Spray Ingredient Emerges As Unexpected Longevity Candidate In Massive Drug Screen  Researchers mapped 2,358 longevity-associated genes across the body's broader protein and signaling networks, then screened 6,442 approved drugs to see which ones nudged those aging pathways in a healthier direction. Oxymetazoline, the active ingredient in nasal sprays like Afrin, was among 21 standout candidates, with a predicted pathway running through the ACKR3 receptor and connecting to major aging proteins including NF-kB, TP53, and AKT1. Host Dave Asprey explains why this computational screen is a promising research lead rather than a protocol, and why chronic use of a vasoconstricting nasal spray carries real risks regardless of what a network analysis suggests.  Sources:  https://www.inc.com/lucia-auerbach/scientists-screened-6442-drugs-for-longevity-common-nasal-spray-emerged-as-a-surprising-candidate/91381000  https://www.sciencealert.com/medications-already-in-pharmacies-may-slow-aging-and-scientists-are-narrowing-them-down  https://pmc.ncbi.nlm.nih.gov/articles/PMC12425021/  ~~  New Review Of 350+ Studies Asks Whether Less Protein Means Longer Life  A review spanning more than 350 studies found that protein restriction consistently extended lifespan and improved metabolic health across mice, rats, flies, and fish, with smaller human studies showing improvements in body fat and fasting glucose even when total calorie intake rose. Researchers point to FGF21, a liver hormone that rises under protein or amino acid scarcity and boosts energy expenditure and glucose regulation, as a key mechanism. Host Dave Asprey breaks down why blanket protein advice fails older adults preserving muscle and highly active people just as badly as it fails everyone else, and why matching intake to actual biology beats maximizing protein at every meal.  Sources:  https://www.medicalnewstoday.com/articles/why-reducing-protein-intake-could-promote-healthy-aging-new-research  https://time.com/article/2026/08/03/eat-less-protein-age-better-live-longer/  https://www.sciencedaily.com/releases/2026/08/260801042811.htm  https://www.cell.com/cell-reports-blue/fulltext/S2949-8821(26)00079-9  https://pmc.ncbi.nlm.nih.gov/articles/PMC8991228/  https://www.eurekalert.org/news-releases/1137190  ~~  Processed Cadaver Skin Injectable Enters The Anti-Aging Market As Elravie Re2O  A new injectable called Elravie Re2O, short for "return to your 20s," is made from donated human skin processed to remove living cells and most genetic material, leaving a collagen-rich extracellular matrix that gets injected into the face and neck as a biological scaffold rather than a simple filler. Human-derived tissue matrices already have a track record in burn and wound care, but this specific product is not yet FDA-approved and lacks comparative trial data against existing fillers. Host Dave Asprey separates legitimate regenerative medicine from a novel cosmetic product still waiting on long-term safety and consistency data.  Sources:  https://nypost.com/2026/07/21/health/the-hottest-new-anti-aging-treatment-cadaver-skin/  https://www.newsobserver.com/living/article316698211.html  https://www.miamiherald.com/living/article316698295.html  https://pmc.ncbi.nlm.nih.gov/articles/PMC12985180/  https://laboderm-skin.com/elravie-re2o-application/  ~~  UCL Study Finds Weekly Arts Engagement Tracks With Slower Epigenetic Aging  A University College London study of more than 3,500 adults found that people who engaged weekly with arts and culture, including painting, music, museums, and theater, showed a roughly four percent slower pace of aging on the DunedinPACE clock and appeared about one biological year younger on PhenoAge, with the effect holding after adjusting for income, education, smoking, and physical activity. Benefits appeared whether people were actively creating art or simply attending performances and exhibits. Host Dave Asprey argues this expands what counts as a health input beyond molecules and devices, since novelty, meaning, and social connection influence the nervous system too.  Sources:  https://www.npr.org/2026/05/12/nx-s1-5818172/study-arts-slow-biological-aging  https://www.news-medical.net/news/20260511/Regular-arts-engagement-may-help-slow-biological-aging-process.aspx  https://studyfinds.com/arts-culture-may-slow-aging/  ~~  Review Of 41 Human Studies Ranks Which Interventions Actually Shift Epigenetic Clocks  A review of 41 human studies testing interventions against newer-generation epigenetic clocks found favorable changes for exercise, caloric restriction, omega-3s, plant-rich diets, multivitamins, semaglutide, pitavastatin, and ketamine, while nicotinamide riboside, rapamycin, and senolytics showed no detected clock improvement in the studies reviewed. Semaglutide produced the strongest single result, slowing DunedinPACE by about nine percent in a trial of adults with HIV-associated fat redistribution, though a separate fatty liver study produced mixed outcomes. Host Dave Asprey explains why a strong mechanistic story does not guarantee a moved biomarker, and why clinical outcomes, functional measures, and safety data all matter alongside any single clock reading.  Sources:  https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1836446/full  https://pubmed.ncbi.nlm.nih.gov/42294499/  https://www.news-medical.net/news/20260616/Semaglutide-omega-3s-and-diet-shift-epigenetic-aging-clocks-in-human-studies.aspx  https://www.nature.com/articles/s41514-026-00383-9  https://pmc.ncbi.nlm.nih.gov/articles/PMC12338914/  https://medicalxpress.com/news/2026-06-popular-glp-drug-biological-aging.html  https://www.creativebiomart.net/blog/semaglutide-may-slow-epigenetic-aging-in-humans  https://www.aging-us.com/article/202913/text  https://superpower.com/guides/can-you-reverse-epigenetic-age  https://www.nature.com/articles/d41586-026-01836-7  https://www.businessinsider.com/first-ever-reverse-aging-drug-was-just-injected-into-a-human-2026-6  ~~  This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into a computational drug-repurposing screen, the case for eating less protein, a new regenerative injectable made from human tissue, the biological effect of creative engagement, and a data-driven ranking of which longevity interventions actually move epigenetic clocks. Host Dave Asprey connects computational biology, nutrition science, regenerative medicine, and biomarker research into practical frameworks for evaluating what belongs in a real longevity protocol versus what belongs on a watch list.  New episodes every Tuesday, Thursday, Friday, and Sunday.  Keywords: oxymetazoline longevity, drug repurposing screen aging, ACKR3 receptor aging pathway, protein restriction longevity, FGF21 hormone aging, low protein diet healthspan, cadaver skin injectable, Elravie Re2O, extracellular matrix regenerative medicine, anti-aging injectable 2026, arts engagement biological age, DunedinPACE epigenetic clock, PhenoAge biological age, epigenetic clock interventions, semaglutide epigenetic aging, rapamycin epigenetic clock, senolytics human trials, biological age testing, biohacking news 2026, Dave Asprey, The Human Upgrade  Thank you to our sponsors!   - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off  - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.  - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE   Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com    Timestamps:  00:00 – Intro  00:19 – Anti-Aging Drug Screening  01:43 – Protein Restriction & Aging  03:36 – New Skin Injectable  05:23 – Arts & Longevity  07:30 – Biohacking Interventions Reviewed  08:51 – Semaglutide & Aging Clocks  09:29 – Closing Thoughts  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    Longevity Music, Anti-Aging Nasal Spray, How To Look 20, and more...

  2. 1d ago

    Here's How You Can Have a 3-hour Orgasm (real!)

    The Orgasm Code: How Pleasure Rewires Your Nervous System for Longevity & Healing | Regena Thomashauer (Mama Gena)    Most people think pleasure is a distraction from performance. This episode proves the opposite: your orgasm is a biohacking tool wired directly into your nervous system, your hormones, and your longevity.  Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Regena Thomashauer, known worldwide as Mama Gena, founder and CEO of the School of Womanly Arts and a New York Times bestselling author. For over three decades she has taught hundreds of thousands of women how to reclaim pleasure as a source of power, and her work has redefined what modern feminism and embodiment look like in practice.  Dave and Regena break down the actual biology behind orgasm: the oxytocin, prolactin, and endorphin cascade that shifts the body out of fight or flight and into repair, the role of sleep optimization in processing trauma, and how chronic disconnection from pleasure keeps people stuck in survival mode instead of human performance mode. They dig into semen retention research and its link to longevity and anti-aging, why shame around the body blocks neuroplasticity and emotional healing, and how learning to regulate arousal, rage, and surrender is its own form of nervous system hacking. This is a masterclass in reclaiming a part of your biology most people were never taught to understand, let alone optimize.  This is essential listening for anyone serious about biohacking, human performance, brain optimization, functional medicine, longevity, and building a body and mind that can hold more pleasure, more power, and more presence.  You'll Learn:  How orgasm triggers an oxytocin, prolactin, and endorphin cascade that lowers cortisol and drives real nervous system repair Why the Daoist approach to semen retention is tied to longevity and anti-aging in men How chronic shame and disconnection from the body block neuroplasticity and keep trauma stuck The link between sleep optimization, hormone regulation, and processing deep emotional wounds How to move rage and grief through the body instead of suppressing them Why relaxation, not effort, is the real key to expanding pleasure and human performance How devotional presence between partners creates measurable shifts in nervous system state   Thank you to our sponsors!       - ECHO Water | Go to http://echowater.com/daveand use code DAVE10 for 10% off your ECHO Flask.  - Suppgrade Labs | Get real restorative sleep with Quiet Mode. Use code DAVE15 at shopsuppgradelabs.com.  - Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time.  - Just Thrive | Get a free 90-day supply of Digestive Bitters (a $90 value) when you start a 90-day Just Thrive Probiotic subscription at https://get.justthrivehealth.com/pages/asprey  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Mama Gena, Regena Thomashauer, On Our Knees book, P***y A Reclamation, School of Womanly Arts, orgasm and oxytocin, prolactin endorphins orgasm, extended orgasm training, semen retention benefits, Daoist orgasm practices, Lafayette Morehouse, truth tantrum tender tantrum, clitoris anatomy explained, vulva versus vagina, goddess archetypes women, embodiment practice trauma, devotion versus attention, Dave Asprey Mama Gena, female pleasure biohacking, nervous system relaxation orgasm    Resources:    • Order Regena’s New Book On Our Knee’s and visit her website at: https://mamagenas.com/books/  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15?  • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/   • Upgrade Labs: https://upgradelabs.com        Timestamps:   00:00 – Trailer  01:21 –Intro  07:24 – Orgasm saved my life  16:34 – The body's medicine cabinet  20:08 – Meaning of On Our Knees  27:34 – Betrayal and forgiveness  37:05 – Righteous anger vs. stridence  47:02 – Semen retention practice  52:51 – Energetic heart connection  01:00:53 – Daoist orgasm equations  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    Here's How You Can Have a 3-hour Orgasm (real!)

  3. 3d ago

    I Take 150 Pills a Day (But This One Is My Workhorse) | Resbiotic

    The Gut-Lung Axis: The Missing Link in Chronic Inflammation & Aging | Dr. Vivek Lal  Your lungs have a microbiome, and almost no one is talking about it. This episode reveals the hidden pathway behind asthma, chronic inflammation, and slow aging, and gives you a science-backed way to biohack your breath from the inside out.   Get A generous discount on Resbiotic by going to: https://resbiotic.com/ and using code ‘DAVE20’    Host Dave Asprey sits down with Dr. Vivek Lal, MD, FAAP, a double board-certified physician scientist who discovered the gut-lung axis while running the Pulmonary Microbiome Lab at the University of Alabama at Birmingham. He serves as Director of Clinical Innovation at UAB's Marnix Heersink Institute of Biomedical Innovation and trained in pulmonary and vascular biology at UT Southwestern before completing MIT's executive program in drug and device development. As a serial entrepreneur through his venture studio Biostack Ventures, he founded and now serves as CEO of Resbiotic Nutrition, and also launched Alveolus Bio, an FDA-track pulmonary drug development company. His decade of research turned into the world's first probiotic built specifically for respiratory health.  Dave and Vivek break down MMP-9, the overlooked inflammatory pathway that drives collagen breakdown, chronic lung disease, and accelerated aging throughout the body. They cover why germ-free mice outperform normal mice, how antibiotics and toxic mold reshape your lung bacteria for years, why breathwork actually changes your lung microbiome, and how postbiotics and inhaled probiotics could become the next frontier in functional medicine. Along the way they get into supplement formulation, drug development red tape, and why self-experimentation should be treated as a right, not a privilege.   You'll Learn:  What the gut-lung axis is and how gut bacteria control inflammation in your lungs Why MMP-9 may be the next major longevity pathway after sirtuins How antibiotics, toxic mold, and vaping damage your lung microbiome long term Why breathwork and lung training measurably change your lung bacteria How postbiotics and inhaled probiotics could replace inhalers and steroids Why product-level clinical testing matters more than single-ingredient hype How self-experimentation, AI, and personalized data are reshaping medicine   Thank you to our sponsors!       - ELITE Performance Coaching | If you’d like to discover where you may be addicted to struggle, allergic to success, and what may be standing between you and your next breakthrough, visit FastestChange.com  - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.  - Caldera + Lab | Go to calroy.com/dave for the research, a discount, and a 45-day money back guarantee.  - Calroy | Go to calroy.com/dave for the research, a discount, and a 45-day money back guarantee.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: gut-lung axis, lung microbiome, MMP-9 inflammation pathway, Resbiotic review, does Resbiotic work, Resbiotic lung support, Dr. Vivek Lal, gut-lung axis probiotic, lung microbiome science, MMP-9 longevity pathway, MMP-9 collagen breakdown, best probiotic for lung health, probiotics for asthma, probiotics for allergies, inhaled probiotics FDA, postbiotics for inflammation, NLRP3 inflammasome, NF-kappa B pathway, breathwork lung microbiome, toxic mold lung bacteria, antibiotics lung damage, biohacking respiratory health, lung microbiome 2026, resbiotic.com discount code DAVE20, functional medicine for lungs, quit vaping lung health    Resources:    • Get a discount on Resbiotic by going to: https://resbiotic.com/ and using code ‘DAVE20’  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15?  • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/   • Upgrade Labs: https://upgradelabs.com      Timestamps:   00:00 – Cold Open  01:08 – Intro  05:17 – Discovering the Lung Microbiome  16:58 – Antibiotics' Effect on Lungs  20:30 – MMP-9 Explained  25:56 – NLRP3 & the Inflammasome  31:36 – The Right to Self-Experiment  42:04 – Lung Training  1:00:18 – Astronaut Microbiomes  1:12:33 – Closing & Discount Code  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    I Take 150 Pills a Day (But This One Is My Workhorse) | Resbiotic

  4. 5d ago

    I Wish I Knew This Anti-Aging Hack Sooner

    There is one molecule your body already makes that helps protect your cells from aging, but your production of it drops as you get older. In this video, I explain why glutathione is known as the body’s master antioxidant and why it plays a critical role in cellular defense, mitochondrial energy, immune regulation, and liver detoxification. You’ll discover why aging is not just your body “wearing out,” but the slow breakdown of your internal repair and antioxidant defense systems. You’ll also learn: -Why oxidative stress damages mitochondria and accelerates aging -How glutathione helps protect cells from daily stress -Why your liver uses huge amounts of glutathione for detox support -The difference between oral, liposomal, IV, and topical glutathione -Why delivery matters if you want your body to actually use it -How to stack glutathione with sleep, protein, sunlight, training, and sauna Try Danger Creatine: https://dangercoffee.com/products/danger-creatine Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Thank you to our sponsors! ECHO Water | Go to http://echowater.com/daveand use code DAVE10 for 10% off your ECHO Flask.The One Device | Use code DAVE for $10 off at theonedevice.com/daveiRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 00:00 – Intro: The Anti-Aging Molecule 02:59 – The Vicious Decline Cycle 04:15 – Step 1: Lower Oxidative Load 05:00 – Step 2: Support Mitochondria 05:41 – Introducing Glutathione 08:54 – Oral & Liposomal Glutathione 10:02 – IV Glutathione 10:17 – Topical/Transdermal Delivery 11:23 – The Glutaryl Solution 12:47 – Daily Routine & Final Thoughts Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    I Wish I Knew This Anti-Aging Hack Sooner

  5. Jul 31

    Chicken Diarrhea, TV Kills You Quicker, CO2 for Health, Deadly Hot Neighborhoods, and more...

    Viagra's Cancer Signal, TV's Toll on Your Brain, Heat and Accelerated Aging, and a New Way to Flush Your Brain Explained  Viagra's Active Ingredient May Block Cancer From Spreading  A study published in Cancer Research from the Weizmann Institute of Science, in collaboration with Clalit and the U.S. National Cancer Institute, found that sildenafil, the active ingredient in Viagra, may interfere with cancer cells' ability to metastasize by disrupting how they regulate cholesterol, a resource tumors need to detach and invade new tissue. The team combined mouse models and human cell cultures with more than twenty years of medical records covering roughly five million people, and found better survival outcomes among about forty thousand cancer patients who had taken sildenafil before diagnosis. Researchers also flagged a possible combination effect with statins. Host Dave Asprey breaks down why this cheap, off-patent drug class deserves more attention than it's getting, and where it fits alongside his own longevity protocol.  Source:  https://www.healthline.com/health-news/viagra-may-stop-cancer-from-spreading-study  ~~  Heavy TV Watching In Midlife Tied To Alzheimer's-Related Brain Changes  A nearly twenty-four-year study published in Alzheimer's & Dementia followed more than 1,700 adults, tracking TV habits in their early fifties and scanning their brains in their mid-seventies. Men who watched more TV showed greater white matter damage and smaller frontal and occipital lobes, while women showed no such association. Critically, people with desk jobs that kept them sedentary all day did not show the same brain changes, and the TV association held even after adjusting for exercise levels. Host Dave Asprey unpacks why passive screen time, not sitting itself, may be the real driver here.  Sources:  https://www.the-independent.com/life-style/tv-time-linked-alzheimers-study-b3023054.html  https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71582  ~~  Ambient Heat Exposure Linked To Faster Biological Aging  A Science Advances study of 3,686 older adults linked neighborhood-level heat index exposure to accelerated biological aging using DNA methylation clocks. Short-term heat exposure moved one clock significantly, while exposure sustained over a full year or six years moved all major clocks, with extreme-caution heat days tied to nearly a three-year jump in one aging measure and a five percent faster overall aging pace on another. Researchers point to inflammation and stress signaling as likely drivers. Host Dave Asprey explains why this is a fundamentally different kind of heat story than the sauna and cold-plunge conversation biohackers are used to.  Source:  https://www.science.org/doi/10.1126/sciadv.adr0616  ~~  Industrial Chicken Farming May Be Accelerating The Spread Of Drug-Resistant Bacteria  A genomic analysis of nearly 2,800 bacterial samples from chickens and wild birds across thirty countries, published in PNAS and covered by The Guardian, found a roughly hundredfold increase in Campylobacter strain transitions between wild birds and farmed chickens since 1900. Global chicken populations have grown sevenfold since the 1960s to about 27 billion birds, and researchers identified genetic adaptations tied to antimicrobial resistance developing inside that population. Sixty to eighty percent of human Campylobacter infections trace back to raw chicken, with links to post-infectious IBS in some cases. Host Dave Asprey connects the dots between industrial farming density and the gut-health stakes for anyone who eats chicken.  Sources:  https://www.theguardian.com/food/2026/jul/27/industrial-chicken-farming-accelerating-spread-of-diarrhoea-bacteria-study-finds  https://doi.org/10.1073/pnas.2609969123  ~~  VA Researchers Develop Breathing-Based "Brain Flush" For Parkinson's And Alzheimer's  VA researchers led by Dr. Henry Lin found a way to trigger the brain's glymphatic clearance system, normally active during deep sleep, in people who are awake, using alternating puffs of five percent carbon dioxide and room air every thirty-five seconds. In a study of thirty Parkinson's patients and thirty-three healthy controls, a single thirty-minute session produced measurable increases in blood levels of beta-amyloid, alpha-synuclein, and other waste proteins associated with neurodegeneration. The VA's Technology Transfer Program is now developing a patent and prototype device. Host Dave Asprey explains why this gives breathwork protocols a real physiological mechanism instead of just a hunch.  Source:  https://www.research.va.gov/currents/0426-Exciting-new-treatment-being-developed-for-Parkinsons-Alzheimers.cfm  ~~~  This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into an overlooked cancer drug repurposing story, the real difference between passive and active screen time, a new angle on heat as a biological stressor, the hidden gut-health cost of industrial poultry farming, and a breathing technique that may unlock your brain's own detox system. Host Dave Asprey connects clinical research, large-scale genomic data, and translational neuroscience into practical frameworks for improving longevity, gut health, and brain performance.  New episodes every Tuesday, Thursday, Friday, and Sunday.  Keywords: sildenafil cancer metastasis, Viagra cancer research, cholesterol cancer cells, PDE5 inhibitor longevity, TV Alzheimer's risk, screen time dementia, white matter brain aging, passive sedentary behavior brain, ambient heat epigenetic aging, DNA methylation clock, heat index biological aging, industrial chicken farming bacteria, Campylobacter antibiotic resistance, foodborne illness IBS, glymphatic system brain flush, CO2 breathing brain detox, Parkinson's Alzheimer's treatment, VA brain research, biohacking news 2026, Dave Asprey, The Human Upgrade  Thank you to our sponsors!   - Suppgrade Labs | Get real restorative sleep with Quiet Mode. Use code DAVE15 at shopsuppgradelabs.com.  - Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time.  - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE  Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com     Timestamps:  00:00 – Intro  00:19 – Story #1: Viagra & Cancer  02:01 – Story #2: TV Watching & Brain Aging  03:16 – Story #3: Heat Exposure & Biological Age  04:46 – Story #4: Chicken Farming  06:34 – Story #5: CO2 Therapy & Brain Detox  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    Chicken Diarrhea, TV Kills You Quicker, CO2 for Health, Deadly Hot Neighborhoods, and more...

  6. Jul 30

    The $18 Million Pills Nobody Can Explain | Igniton

    Inside Igniton: The Quantum Supplement Science Boosting Memory, Sleep, and Longevity    There's a subatomic particle most scientists don't even know exists, and one entrepreneur just spent $18 million building a private lab to prove it can upgrade your longevity, focus, and sleep. This episode goes inside the lasers, vacuum chambers, and cold plasma behind the new science of quantum-charged supplements.  Get 15% off your next purchase at: igniton.com/dave  Host Dave Asprey sits down with Ashley Grace, an executive working directly with Igniton, the company behind a new category of supplements charged with particles pulled from the surface of the sun.     Dave and Ashley dig into the science and the story behind Igniton: an $18 million private lab built to recreate solar conditions here on Earth, peer-reviewed studies showing major gains in memory, attention, and sleep, and the strange psychological and even bordering-on-supernatural shifts users report after months on the product. They also get into coherence, cellular entropy, and why some of the biggest breakthroughs in human performance and longevity may come from fields and frequencies rather than another pill.  This episode is essential listening for anyone into biohacking, nootropics, sleep optimization, brain optimization, and the cutting edge of anti-aging and functional medicine.  You'll Learn:  How Igniton's lab uses vacuum chambers, cold plasma, and lasers to charge supplement ingredients at a subatomic level The clinical results behind the cognition formula, including gains in mental performance, attention, and short-term memory Why the sleep formula showed a 25 percent increase in REM sleep in just two weeks, verified with wearables like Oura and Apple Watch How charged hydrogen may be boosting bioavailability of nootropics tied to neuroplasticity and mitochondria function The unexpected personal experiences, from heightened intuition to emotional regulation, that both Dave and Ashley report after sustained use Why longevity markers like IL-6 and CRP dropped in Igniton's clinical trials, and what that means for anti-aging and metabolism The next frontier for the company: a chair-based coherence technology already tested by NASA   Thank you to our sponsors!       - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.  - Neuronic | Go to www.neuronic.online Code DAVE for $100 off  - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.  - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Igniton supplement review, subatomic particle supplement, quantum charged supplements, does Igniton work, Igniton sleep formula REM, Igniton cognition supplement, Jirka Rysavy Gaia, holoton NASA chair, cold plasma supplement technology, charged hydrogen bioavailability, Igniton clinical study results, Igniton vs placebo study, best nootropic for focus 2026, supplements for REM sleep, quantum technology longevity, Igniton.com discount code, Ashley Grace Charlotte's Web, coherence and cellular aging, energy healing biohacking, intuition and meditation supplements  Resources:    • Get 15% off your next purchase at: igniton.com/dave  • Visit https://igniton.com to learn more about their processes and offerings • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15?  • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/   • Upgrade Labs: https://upgradelabs.com     Timestamps:   00:00 – Trailer  00:32 – Show Intro  06:15 – What Are Ignitons?  13:29 – How Ignitons Are Made  17:31 – Coherence & Longevity  22:18 – Water Molecule Charging  26:25 – Sleep Formula & REM Results  32:02 – Yogic Siddhis & Superpowers  38:43 – Dave's Amplified Abilities  43:31 – Energy Healing  46:22 – Consciousness Scale & Muscle Testing  51:08 – Discount Code Offer  55:12 – Closing  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    The $18 Million Pills Nobody Can Explain | Igniton

  7. Jul 28

    I Grew My Penis 2 Inches (What Works, And What Doesn't) | Alex Tatem

    Urologist Dr. Alex Tatum on Girth Enhancement, Testosterone, and Peptide Therapy  Most men will never ask their doctor the questions this episode answers. From safe, non-surgical girth enhancement to daily testosterone dosing to the peptides fighting for FDA access right now, this conversation covers what actually works, what's dangerous, and what your doctor probably won't bring up first.    Host Dave Asprey sits down with Dr. Alex Tatem, a board-certified urologist with fellowship training in male sexual and reproductive medicine. Dr. Tatem has built his practice and his YouTube following around pushing medicine beyond what the traditional medical establishment allows, with a focus on male girth enhancement, performance enhancement, peptides, and PEDs.  They break down the real science behind penis enhancement, including why length surgery still does not exist, how hyaluronic acid injections safely increase girth, and why silicone and PMMA fillers have left men permanently disfigured. Dave and Dr. Tatem also get into cutting-edge testosterone dosing strategies, the peptides driving the biggest gains in human performance and longevity, including BPC-157, TB-500, SS-31, and MOTS-c, and why PT-141 has become the most talked-about peptide for libido and sexual health.  You'll Learn:  Why hyaluronic acid injections have become the safest, most reproducible method for girth enhancement The truth about penis enlargement surgery, and why length enhancement still has no reliable surgical fix How daily microdosed testosterone compares to traditional weekly TRT protocols Why PT-141 and melanotan II are being used for libido, nitric oxide release, and even prostate health How BPC-157, TB-500, SS-31, and MOTS-c are changing recovery, mitochondria function, and metabolism The dangerous enhancement trends to avoid, including silicone implants and unregulated fillers Why the fight over peptide access at the FDA could determine the future of functional medicine and supplements in America  Thank you to our sponsors!       - Just Thrive | Get a free 90-day supply of Digestive Bitters (a $90 value) when you start a 90-day Just Thrive Probiotic subscription at https://get.justthrivehealth.com/pages/asprey  - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off  - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.  - ALP | Head to http://alppouch.com/ and use code DAVE for 20% off your first order.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: penis girth enhancement hyaluronic acid, penis enlargement that actually works, average penis size urologist, PT-141 for libido, melanotan II peptide, BPC-157 benefits, TB-500 for injury recovery, SS-31 dosing, MOTS-c peptide FDA, daily subQ testosterone dosing, oral testosterone undecanoate, TRT dosing protocols, Anavar for muscle recovery, silicone penile implant risks, PMMA filler complications, is penis enlargement surgery safe, hyaluronic acid girth injection cost, Dr. Alex Tatem urologist, peptides FDA regulation 2026  Resources:    • Check Out Dr. Tatem’s Content At: https://www.youtube.com/@DrAlexTatem  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15?  • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/   • Upgrade Labs: https://upgradelabs.com     Timestamps:   00:00 – Trailer  03:10 – Penis Enhancement Intro  13:32 – Dangerous Enhancement Methods  22:49 – Girth Procedure Explained  29:56 – Why Demand Is Rising  32:09 – Peptides for Men  41:26 – TRT and Testosterone  50:35 – Peptide Regulation Fight  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    I Grew My Penis 2 Inches (What Works, And What Doesn't) | Alex Tatem

  8. Jul 26

    Does This Sleep Fasting Hack Actually Cut Cortisol?

    You’ve probably tried everything to sleep better. Magnesium. Melatonin. Blackout curtains. Maybe even expensive sleep gadgets. But what if the real reason your sleep feels broken has nothing to do with any of those things? In this video, Dave Asprey explains a hidden biological process that controls whether your body stays in stress mode at night… or finally switches into deep recovery mode. He breaks down why so many people wake up exhausted, why cortisol stays elevated while you sleep, and why your body may never fully enter repair mode even if you’re technically asleep. You’ll learn how one overlooked habit affects your brain, metabolism, recovery, heart rate, and overnight repair systems, plus the surprising research that showed dramatic changes in sleep quality from a single adjustment. Once you understand this mechanism, you’ll never look at sleep the same way again. Try Danger Creatine: https://dangercoffee.com/products/danger-creatine Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash. The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state. Thank you to our sponsors! PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.Viome | Check it out at viome.com and use code 16DAVE for 16% off. It’s time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 00:00 – Trailer 00:53 – Sleep Environment Matters 03:44 – Red Light Bulbs 04:50 – Blackout Curtains 05:16 – Light-Blocking Glasses 07:16 – Morning Supplement Stack 07:41 – Creatine for the Brain 11:48 – MCT Oil Fuel 13:06 – Cellular Cleanup (Autophagy) 15:12 – Magnesium for Sleep 16:56 – Full Stack Recap 18:26 – Biohacking Is Accessibl Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    Does This Sleep Fasting Hack Actually Cut Cortisol?
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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

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