'Bone Up‪'‬ Dr Richie Abel (PhD) and Prof David Armstrong (MD)

The lads visited the BRS Meeting 2022 in Manchester to bring you up to date with the most recent discoveries in bone science.
We interviewed a wide variety of clinical and basic scientists from undergraduates taking their first steps in science all the way up to global professors setting treatment guidelines.
And to cap it all we won the Neil Mackenzie Public Engagement Award 2022!!

Welcome to the first bonus episode of Bone UP. The first new treatment fir osteoporosis in a decade has been approved in the UK, and many countries around the world.
Romosozumab is a new drug treatment for some people living with osteoporosis. It may be suitable if you’ve already broken a bone due to osteoporosis and are at high risk of breaking another.
Richie and David discuss the approval system in the UK, treatment guidelines and mechanism of action. Enjoy!

The lads talk to Kirstie Donaghey and Prof Stuart Ralston about pregnancy-associated osteoporosis.
Kirstie suffered multiple osteoporotic fractures shortly after giving birth to her son Freddy and explains the patient journey and perspectives from fracture to treatment. Stuart is a Rheumatologist from the University of Edinburgh with an interest in bone disease. He talks to us about his new research project to investigate osteoporosis in pregnancy.
If you would like to take part in Prof Ralston’s survey, follow one of these links:
PAO Survey (affected patients): https://is.gd/paosurvey2021
PAO Survey (unaffected): https://is.gd/paocontrols2021.

The lads talk to Craig Jones about the Royal Osteoporosis Society, a UK based charity that supports bone health around the globe
Craig is the Chief Executive Officer of the ROS and has led the development of a new strategy for tackling osteoporosis called ‘Breaking the Silence’. We had a wide-ranging chat about the new strategy and the role of medical charities: including everything from patient support and advocacy in the healthcare and government settings to finding research.
https://theros.org.uk/

The lads talk to Prof Gustavo Duque about the crosstalk between bone and muscle in ageing.
Gustavo is a geriatrician, clinical researcher and a world leader in ageing and musculoskeletal research, with a special interest in the treatment of frailty osteoporosis, sarcopenia and in older persons.
We had an exciting chat about the crosstalk between bone and muscle and how communication between the two organs is important for ageing and the risk of falls and fractures.
Prof Duque Gustavo is Chair of Medicine at the University of Melbourne.

The lads talk to Prof Kate Ward about the challenges caused by osteoporosis in Sub-Saharan Africa.
Kate is a key member of the FRACURES-E3 research study team investigating epidemiology, Economic Impact and Ethnography. We have a fascinating chat about the risk factors, management, and treatment of osteoporosis in Africa. Join us to hear all about this generation-defining bone research.
https://www.bristol.ac.uk/translational-health-sciences/research/musculoskeletal/rheumatology/research/global-musculoskeletal-health/fractures/