Dr. Mike Israetel joins Ralph Sutton and Marcus Antebi for a hilarious, uncensored conversation about fitness, health, weight loss, supplements, aging, and what actually works. Dr. Mike breaks down the benefits of resistance training and cardio, whether running 30 miles a week is too much, which supplements may actually be worth taking, and why some popular health products might just be expensive urine. They also dive into the rise of weight-loss drugs, why appetite may be one of the biggest factors in the obesity epidemic, what happens when people stop taking these medications, and how modern approaches to health have changed dramatically. Plus, Dr. Mike talks about his rise on YouTube, anxiety, social media, longevity, bodybuilding, steroids, peptides, and why making healthy choices easier isn't necessarily a bad thing. It’s health and fitness advice mixed with exactly the kind of chaos you’d expect from the goodsugar Podcast. 00:00 – Intro: Meet Dr. Mike Israetel 01:19 – Dr. Mike’s Origin Story: From Russia to Exercise Science 02:17 – Bodybuilding, Powerlifting & Brazilian Jiu-Jitsu 03:12 – Steroids, Aging & Training Through Pain 03:52 – Are Peptides Actually Worth It? 05:10 – Cardio vs. Strength Training for Longevity 06:53 – Is Running 30 Miles a Week Too Much? 07:35 – The Mental Benefits of Running 09:22 – Are Supplements Just Expensive Urine? 10:01 – Creatine, Collagen, Vitamins & Joint Supplements 10:58 – Dr. Mike’s Supplements Worth Considering 11:57 – NMN & Injectable Supplements 13:04 – Ralph Gets Roasted for Being 6'6" 14:13 – When Supplements Actually Make Sense 15:09 – Sauerkraut, Probiotics & Gut Health 16:05 – Broccoli Sprouts & Healthy Eating 16:58 – How Dr. Mike Became Huge on YouTube 18:21 – What Has Changed in Health & Fitness Science? 18:58 – Why “Lifestyle Change” Isn’t Always Enough 19:48 – Weight-Loss Drugs Changed Everything 21:21 – Does Taking a Weight-Loss Drug “Cheat” Weight Loss? 22:24 – Dr. Mike: If It Saves Your Life, Make It Easier 23:05 – Anxiety, Addiction & Weight-Loss Drugs 23:23 – Can Weight-Loss Drugs Reduce Addictive Behaviors? 24:13 – Why Modern Anxiety Feels Different 26:01 – Do You Gain the Weight Back After Stopping? 27:13 – Why Regaining Weight Isn’t a Knock Against the Drugs 28:16 – Social Media, Smartphones & The Anxious Generation 29:22 – Are Kids Today Actually Better Adjusted? 30:04 – Dr. Mike Gets Roasted Before Leaving 30:55 – Dr. Mike Reviews His Own Terrible Podcast Room TEXT us your questions at 718-306-3906! The goodsugar store is the epitome of cool, nestled at 3rd avenue + 69th street! 🛍️ Explore our trendsetting merchandise and catch those good vibes at https://www.ilovegoodsugar.com/. Follow the trendsetting hosts on social media: 📸 Marcus Antebi: / marcusantebi 📸 Ralph Sutton: / iamralphsutton 📸 Dr. Michael Israetel / drmikeisraetel See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.