Modern Healthspan

Modern Healthspan
  • 3.9 (9)
  • Health & Fitness
  • Updated Semiweekly

Our channel provides longevity, anti-aging and health information. We interview experts in their field to get the latest information in the longevity space. You can also come to our YouTube channel for more information here https://www.youtube.com/channel/UCLFEKx_LchTLy_XwjPToJ3A

  1. 8h ago

    3-Drug Combo Extends Lifespan by 41% | Dr. Irina Conboy

    Join us as Dr. Irina Conboy, former UC Berkeley professor and Chief Science Officer at Generation Lab, reveals a groundbreaking metabolic senolytic discovery. Learn how combining Dichloroacetate (DCA), Metformin, and a 10-fold lower dose of Navitoclax selectively eliminates senescent and cancer cells, extending post-treatment lifespan by 41.7% in old mice without inducing frailty or platelet toxicity Cellular senescence and cancer share a critical metabolic vulnerability: damaged, short-circuiting mitochondria and an inflexible reliance on glycolysis for survival. While first-generation senolytics like Navitoclax (ABT-263) demonstrated high potency, severe clinical side effects like platelet destruction (thrombocytopenia) stalled their translation. In this episode, Dr. Irina Conboy breaks down her lab's landmark 2026 paper in Aging. By utilizing Dichloroacetate (DCA) to force pyruvate into damaged mitochondria and Metformin to inhibit Complex I ATP synthesis, the team created a metabolic vise that drains energy exclusively in cancer and senescent cells. With their defenses compromised, a 10-fold reduced dose of Navitoclax triggers selective apoptosis while completely sparing healthy human tissues and platelets. Dr. Conboy explains how intermittent administration in 18-month-old mice extended post-treatment lifespan by 41.7% (+102 days) and improved treadmill endurance with zero increase in frailty. She also shares Generation Lab's upcoming pharmacological injectable designed to replace invasive therapeutic plasma exchange (TPE). 🔬 Scientific Citations & References Mentioned: 1. Robinson, Z., Amiri, P., Mehdipour, M., Conboy, M. J., & Conboy, I. M. (2026). Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice. Aging, PMID: 42474306. 2. Jeon, O. H., et al., Campisi, J., & Conboy, I. M. (2022). Systemic induction of cellular senescence by old blood. Nature Metabolism, 4(8), 998-1006. 3. Mehdipour, M., et al., & Conboy, I. M. (2020). Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin. Aging, 12(10), 8790-8819. 🌐 Links in this video: - Generation Lab: https://generationlab.biotech Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://ax3.life/MODERN20 https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    3-Drug Combo Extends Lifespan by 41% | Dr. Irina Conboy

  2. Sep 28

    How to Rebuild Bone Density: The Truth About Calcium | Dr Connie Weaver

    Join us as Dr. Connie Weaver, Distinguished Research Professor at San Diego State University and National Academy of Medicine member, reveals the hidden science of bone loss, calcium bioavailability, and the gut-bone axis. Discover why fractures kill more people than most realize, why modern plant-forward diets are inadvertently blocking mineral absorption, how soluble corn fiber halts postmenopausal bone loss, and the strict 500mg calcium dosing rule you need to know. Osteoporotic fractures outnumber new diagnoses of heart disease and cancer combined, with 20% of hip fracture patients dying within 12 months. Yet bone health remains one of the most overlooked pillars of healthspan. In this episode, we sit down with Dr. Connie Weaver, one of the world's foremost authorities on mineral metabolism and bone remodeling. Dr. Weaver explains why nutrition plays a permissive role alongside resistance exercise, how the estrogen crash during menopause accelerates osteoclast bone resorption, and why high-dose Vitamin D trials have failed to stop fractures in the general population. She breaks down her landmark 3-decade research modeling calcium bioavailability across global diets (now integrated into Cronometer), revealing how high-oxalate and high-phytate plant diets are driving widespread calcium deficits. Finally, Dr. Weaver shares her groundbreaking discovery on the gut-bone axis - demonstrating how prebiotic soluble corn fiber feeds fiber-fermenting bacteria to stop postmenopausal bone loss - and clarifies the truth about calcium supplements and arterial plaque. 🔬 Scientific Citations & References Mentioned 1. Weaver, C. M., et al. (2016). Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner. The American Journal of Clinical Nutrition, 104(3), 837-843. 2. Weaver, C. M., et al. (2021). Modeling calcium bioavailability in US and global diets: Impact of phytate, oxalate, and plant-forward dietary shifts. The Journal of Nutrition, 151(10), 3120-3128. 3. Whisner, C. M., & Weaver, C. M. (2016). Soluble corn fiber enhances calcium absorption and alters the gut microbiome in adolescent males and females. British Journal of Nutrition, 116(11), 1849-1856. 4. Weaver, C. M., et al. (2016). Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporosis International, 27(1), 367-376. 🌐Links in this video - Dr. Connie Weaver's SDSU Faculty Page: https://ens.sdsu.edu/people/faculty/weaver-connie - Dr. Connie Weaver on LinkedIn: https://www.linkedin.com/in/connie-weaver-4754a39/ - USDA FoodData Central: https://fdc.nal.usda.gov/ - Cronometer (featuring Dr. Weaver's Bioavailability Model): https://cronometer.com/ Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://ax3.life/MODERN20 https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    How to Rebuild Bone Density: The Truth About Calcium | Dr Connie Weaver

  3. Sep 21

    A 10-Minute Gene Therapy That Protects You For 10+ Years | Dr Noah Davidsohn

    Join us as Dr. Noah Davidsohn, Co-Founder and Chief Scientific Officer of Rejuvenate Bio, reveals how systemic multi-gene therapy and in vivo partial cellular reprogramming can reverse age-related chronic diseases and double remaining lifespan. Discover the breakthrough science of AAV vector delivery, FGF21 and sTGFβR2 synergy, and companion animal clinical translation. What if a single gene therapy injection could simultaneously treat heart failure, kidney disease, and diabetes? In this episode, we sit down with Dr. Noah Davidsohn, CSO and Co-Founder of Rejuvenate Bio, spun out of George Church’s lab at Harvard Medical School. Dr. Davidsohn breaks down their landmark 2024 study in Cellular Reprogramming, which demonstrated a 109% increase in the remaining lifespan of extremely aged (124-week-old) wild-type mice using systemic AAV9 delivery of Yamanaka factors (OSK). He explains the mechanics of intermittent doxycycline pulsing to avoid tumor risks, the power of multi-gene master regulators like FGF21 and sTGFβR2 in RJB-01, and how treating companion dogs with Mitral Valve Disease serves as the ultimate translational bridge to human clinical trials. 🌐Links in this video - Rejuvenate Bio Website: https://www.rejuvenatebio.com - WeFund for Rejuvenate Bio: https://wefunder.com/rejuvenatebio Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://ax3.life/MODERN20 https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    A 10-Minute Gene Therapy That Protects You For 10+ Years | Dr Noah Davidsohn

  4. Sep 7

    The Proven Daily Protocol to Protect Your Memory | Dr. David Perlmutter

    In this episode, board-certified neurologist Dr. David Perlmutter, author of Brain Defenders, reveals how your brain’s immune cells, the microglia, hold the key to preventing cognitive decline and neurodegenerative disease. For decades, neurodegenerative research has fixated on amyloid plaques and tau tangles, treating the downstream smoke while ignoring the raging metabolic fire beneath. In this comprehensive masterclass, Dr. Perlmutter reveals why the real driver of brain aging lies within microglia, the brain's resident immune defenders. Under healthy conditions, microglia nurture synapses and clear debris. But when triggered by elevated blood glucose, gut dysbiosis, environmental air toxins, or lack of deep sleep, they flip into an aggressive, destructive phenotype that destroys brain connections. Dr. Perlmutter shares practical, evidence-based protocols to keep your microglia in their protective state: why a fasting glucose above 90 mg/dL poses hidden risks, how muscle-derived myokines cross the blood-brain barrier, the truth about adult hippocampal neurogenesis, and the exact supplement stack (including DHA, Akkermansia, Urolithin A, DHM, and rosmarinic acid) supported by peer-reviewed science. 🌐Links in this video Dr Perlmutter's book Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life on Amazon https://amzn.to/4y4U77Y Dr Perlmutter's home page https://drperlmutter.com/ Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    The Proven Daily Protocol to Protect Your Memory | Dr. David Perlmutter

  5. Aug 31

    How AI Predicts Your Exact Health 10 Years in Advance | Dr Dmitrii Chebanov

    Can AI simulate your exact biology to predict how long you will live? Today we sit down with Dr. Dmitri Chebanov, computational biologist from Memorial Sloan Kettering Cancer Center and Chief Scientist at Holivita, to explore how AI digital twins and multi-omics are turning reactive medicine into proactive longevity. For decades, health optimization has relied on trial and error: try a new supplement, change your diet, wait three months, and hope your blood work improves. But biology is complex, and standard medical care only reacts after disease develops. Dr. Dmitri Chebanov shares how cutting-edge transformer neural networks, trained on multi-omic patient data, can create a high-dimensional "Digital Twin" of your body. Originally developed to simulate clinical trials in oncology and reduce the 90% trial failure rate, this technology is now transitioning to personal longevity. We break down the three critical layers of a digital twin (whole genome sequencing, dynamic biomarkers like DNA methylation, and real-time symptoms), how to simulate lifestyle interventions before taking a single pill, and what the future of real-time predictive healthcare looks like

    How AI Predicts Your Exact Health 10 Years in Advance | Dr Dmitrii Chebanov

  6. Aug 25

    He Built a $1.5T Data Giant... Now He's Using AI to Cure Disease | Haresh Patel

    Silicon Valley tech entrepreneur Haresh Patel joins Modern Healthspan to reveal how applying systems engineering and artificial intelligence can solve healthcare's chronic diagnostic crisis. After a 55-year struggle across 12 failed medical diagnoses, Haresh founded Sanare Health AI to synthesize fragmented medical records, map longitudinal health timelines, and uncover root causes of chronic illness. Why does modern healthcare fail patients with complex chronic illness? In this deep-dive interview, Silicon Valley engineer and entrepreneur Haresh Patel explains how extreme medical specialization and transactional 13-minute doctor visits create data silos that mask the true root causes of disease. Drawing from his 55-year battle with unexplained chronic urticaria and his experience managing $1.5T in data platforms, Haresh details how his new venture, Sanare Health AI, unifies decades of scattered medical records with mind-body trauma timelines. Rather than replacing doctors, AI acts as a vital pressure-relief valve—synthesizing complex patient histories so clinicians can focus on meaningful dialogue and root-cause solutions rather than short-term symptom suppression. Discover why you must become the CEO of your own health, how 12-month timeline tracking uncovers hidden disease triggers, and the future of AI-driven personalized medicine. 🌐Links in this video https://sanarehealth.ai/ Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    He Built a $1.5T Data Giant... Now He's Using AI to Cure Disease | Haresh Patel

  7. Aug 10

    How This Peptide Drives Fat Loss & Preserves Muscle | Dr David Lee

    USC Gerontology Professor Dr. Changhan David Lee breaks down the discovery of MOTS-c, a novel mitochondrial-derived peptide that functions as an exercise mimetic, cellular stress responder, and immunomodulator. Are mitochondria more than just cellular powerhouses? In this episode of Modern Healthspan, Dr David Lee, Associate Professor at the USC Leonard Davis School of Gerontology and co-discoverer of MOTS-c, joins us for a deep dive into the emerging world of mitochondrial-derived peptides (MDPs). Dr. Lee explains how these small microproteins, encoded within the mitochondrial 12S rRNA locus, act as critical retrograde signaling molecules. We explore how MOTS-c translocates to the nucleus during metabolic stress, coordinates with AMPK and hypothalamic POMC neurons, and functions as an interferon-responsive host defense peptide. Additionally, Dr. Lee shares findings from preclinical models examining sarcopenia, muscle homeostasis, and age-related physical capacity, while providing an update on the current regulatory state, WADA anti-doping classification, and human translational pipeline of MDP research. 🌐Links in this video Dr David Lee's page at USC https://gero.usc.edu/faculty/lee/ 📚 References & Scientific Papers Mentioned: (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454. https://pmc.ncbi.nlm.nih.gov/articles/PMC4350682/ (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 12(1), 470. https://www.nature.com/articles/s41467-020-20790-0 (2021). Mitohormesis in hypothalamic POMC neurons mediates regular exercise-induced high-turnover metabolism. Cell Metabolism, 33(2), 334–349. https://www.sciencedirect.com/science/article/pii/S1550413121000036 (2018). The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metabolism, 28(3), 516–524. (2021). Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes. Cell Reports, 36(4), 109447. MOTS-c Coordinates Inter-Organellar Proteostasis for Adaptation to Chronic Metabolic Stress https://www.biorxiv.org/content/10.64898/2026.06.22.733272v1 Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    How This Peptide Drives Fat Loss & Preserves Muscle | Dr David Lee

  8. Aug 3

    LDL Only Matters IF You Have This One Thing | Dr John Osborne

    Discover how AI-guided Cardiac CT scanning detects hidden soft plaque and allows preventive cardiology to track and reverse heart disease before symptoms start Cardiovascular disease remains the leading cause of mortality worldwide, yet over half of affected individuals experience no warning signs before a major event. In this deep-dive interview, Dr. John Osborne, triple-board-certified preventive cardiologist and Chief Medical Officer at ClearCardio, outlines a paradigm shift from reactive symptom management to proactive disease eradication. Dr. Osborne explains why traditional blood panels and risk calculators often fail at the individual level, how arteries hide soft plaque through outward remodeling, and why standard calcium scores can offer a dangerous false sense of security. Discover how cutting-edge AI-enhanced Coronary CT Angiography (CCTA) allows clinicians to visualize, map, and measure arterial plaque down to $0.1mm. Learn how tailored lifestyle strategies, lipid management, and emerging therapeutics targeting Lp(a) can stabilize and reverse plaque to optimize long-term healthspan. 🌐Links in this video ClearCardio Web Page: https://clearcardio.com/ ClearCardio YouTube Channel : https://www.youtube.com/@ClearCardio PREVENT Online calculator - https://professional.heart.org/en/guidelines-and-statements/prevent-calculator Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    LDL Only Matters IF You Have This One Thing | Dr John Osborne
See All (373)

3.9
out of 5
9 Ratings

About

Our channel provides longevity, anti-aging and health information. We interview experts in their field to get the latest information in the longevity space. You can also come to our YouTube channel for more information here https://www.youtube.com/channel/UCLFEKx_LchTLy_XwjPToJ3A

Information

  • Creator
    Modern Healthspan
  • Years Active
    2021 - 2026
  • Episodes
    373
  • Rating
    Clean
  • Copyright
    © Modern Healthspan
  • Show Website
    Modern Healthspan

You Might Also Like