Modern Healthspan

Modern Healthspan
  • 3.8 (8)
  • Health & Fitness
  • Updated Semiweekly

Our channel provides longevity, anti-aging and health information. We interview experts in their field to get the latest information in the longevity space. You can also come to our YouTube channel for more information here https://www.youtube.com/channel/UCLFEKx_LchTLy_XwjPToJ3A

  1. Harvard: The 4-Year Study That Froze Aging For 3 Years | Dr JoAnn Manson

    4d ago

    Harvard: The 4-Year Study That Froze Aging For 3 Years | Dr JoAnn Manson

    Harvard Professor Dr. JoAnn Manson reveals the final results of the VITAL trial: a landmark study on Vitamin D, telomeres, and disease prevention. Is Vitamin D the most underrated molecule in longevity science? Dr. JoAnn Manson, Professor of Medicine at Harvard Medical School and lead investigator of the massive VITAL trial, joins us to present groundbreaking new data. We move past the traditional focus on bone health to explore how 2,000 IU of Vitamin D preserves telomere length, effectively slowing biological aging by three years. Dr. Manson discusses the 22% reduction in autoimmune diseases and the 17% reduction in advanced metastatic cancers found within the 25,000-participant study. We also tackle the "BMI Gap", the critical reason why Vitamin D benefits are often blunted in certain populations, and the importance of the Vitamin D/Omega-3 synergy. This conversation provides a definitive clinical roadmap for anyone using these supplements to extend their healthspan. Rooted in gold-standard randomized controlled trial data, this is an essential update on the science of aging well. MEDICAL DISCLAIMER: Modern Healthspan provides reports on peer-reviewed longevity research. We do not provide medical advice, diagnosis, or treatment. The clinical findings presented by Dr. JoAnn Manson from the VITAL trial are for informational use only. Please see your physician before starting 2,000 IU of Vitamin D or any other supplement protocol. 🌐Links in this video The VITAL Study home page: https://www.vitalstudy.org/ 🔬 Peer-Reviewed Research Cited The Autoimmune Breakthrough (VITAL Trial) Title: Vitamin D and marine omega fatty acid supplementation and incidence of autoimmune disease: VITAL randomized controlled trial Journal: The BMJ DOI: 10.1136/bmj-2021-066452 PubMed: 38272846 Impact: This landmark study of 25,871 participants demonstrated that five years of Vitamin D supplementation (2000 IU/day) resulted in a 22% lower rate of confirmed autoimmune disease. The Telomere & Biological Aging Analysis Title: Vitamin D Supplementation and Leucocyte Telomere Length in the VITAL Trial Journal: The American Journal of Clinical Nutrition (AJCN) PubMed: 40409468 Impact: An ancillary study showing that 2,000 IU of Vitamin D daily significantly buffered telomere shortening over time, effectively preserving the equivalent of three years of biological aging compared to the placebo group. The Cancer Metastasis Discovery Title: Vitamin D supplementation and total cancer incidence and mortality: the Vitamin D and OmegA-3 TriaL (VITAL) Journal: The American Journal of Clinical Nutrition (AJCN) DOI: 10.1093/ajcn/nqy135 PubMed: 21986389 Impact: This analysis revealed that while total cancer incidence did not drop significantly, Vitamin D supplementation was associated with a 17% reduction in advanced (metastatic or fatal) cancers. Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    54 min
  2. The Silent Fuel Crisis Starving Your Brain | Dr Stephen Cunnane

    May 25

    The Silent Fuel Crisis Starving Your Brain | Dr Stephen Cunnane

    Discover how the "Brain Energy Gap" drives cognitive decline and how ketones can rescue starving neurons. Dr. Stephen Cunnane explains the science of metabolic health, the BENEFIC trial, and how to fuel a hybrid brain for long-term longevity. Is Alzheimer’s actually a fuel shortage in the brain? In this interview, world-renowned researcher Dr. Stephen Cunnane breaks down the "Brain Energy Gap", a critical metabolic deficit where the brain loses its ability to utilize glucose efficiently as we age. While this energy gap can lead to Mild Cognitive Impairment (MCI) and Alzheimer’s, Dr. Cunnane’s groundbreaking research, including the landmark BENEFIC trial, shows that ketones can bypass this blockage to provide a vital backup fuel source. We dive deep into the hybrid brain concept, exploring how Medium Chain Triglycerides (MCTs) and specific dietary shifts can "rescue" cognitive function by doubling brain ketone uptake. Dr. Cunnane also discusses the "double jeopardy" of insulin resistance and why managing metabolic health is the most promising frontier for preventing neurodegeneration. Whether you are interested in brain health, longevity, or the clinical applications of ketogenic metabolic therapy, this technical deep dive offers essential insights into the future of healthy aging 🌐Links in this video A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6‐month RCT https://pmc.ncbi.nlm.nih.gov/articles/PMC8048678/ Improved brain energetics and cognition after a 6-month ketogenic intervention in mild cognitive impairment: Final results of the Benefic Trial https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.037961 A reduced carbohydrate diet improves glycemic regulation in hyperglycemic older people in a retirement home: the SAGE study https://cdnsciencepub.com/doi/10.1139/apnm-2024-0277 Time-Line Mitopure Urolithin A, 10% off Code MODERN https://tidd.ly/4bLCpgu Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    54 min
  3. The 20-Minute Strength Protocol: Reversing Muscle Loss After 60 | Dr Brad Shoenfeld

    May 18

    The 20-Minute Strength Protocol: Reversing Muscle Loss After 60 | Dr Brad Shoenfeld

    Muscle scientist Dr Brad Schoenfeld on how to stay strong after 60. Dr Brad Schoenfeld is a professor of exercise science at Lehman College, New York, and one of the world's most cited researchers on muscle hypertrophy. In this interview we cover the practical science of building and maintaining muscle as you age with a focus on what actually matters for healthspan and independence. We discuss how much training older adults really need, why power matters more than strength for fall prevention, and how to think about loads and reps after 60. Brad also explains why protein requirements increase with age, what the leucine threshold is and why it matters, and gives his frank assessment of the supplement landscape including the one he thinks has genuine evidence behind it. We also touch on VO2 max, balance, flexibility and the role of consistency. A practical, evidence-based conversation for anyone serious about staying strong and independent as they age. 🌐Links in this video Dr Schoenfeld's page https://www.lehman.edu/academics/health-human-services-nursing/exercise-sciences-recreation/bradley-schoenfeld/ Time-Line Mitopure Urolithin A, 10% off Code MODERN https://tidd.ly/4bLCpgu Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    59 min
  4. Should You Take a Multivitamin? A Harvard Researcher’s Verdict | Dr Howard Sesso & Dr Li Sidong

    May 13

    Should You Take a Multivitamin? A Harvard Researcher’s Verdict | Dr Howard Sesso & Dr Li Sidong

    Dr. Howard Sesso of Harvard explains the results of the COSMOS trial, identifying who actually benefits from a daily multivitamin and how it impacts biological aging. Is a daily multivitamin a life-extending "insurance policy" or just a waste of money? In this clip, Dr. Howard Sesso, Co-Principal Investigator of the landmark COSMOS trial, breaks down the clinical evidence from over 21,000 participants. We explore the "sweet spot" of nutritional insufficiency; where you aren't clinically deficient but lack the levels needed for optimal healthspan. Dr. Sesso and Dr. Sidong Li discuss how multivitamins specifically slowed the "epigenetic clock" in individuals with existing risk factors like hypertension and accelerated biological aging. We also cover the importance of "precision nutrition" and why the synergy of essential vitamins and minerals may be more effective than high-dose single supplements. If you’re looking for a common-sense, evidence-based approach to basic supplementation, this deep dive into the Harvard-led COSMOS data provides the answers you need. 🌐Links in this video COSMOS Trial home page https://cosmostrial.org/ Effects of daily multivitamin–multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial https://www.nature.com/articles/s41591-026-04239-3 Time-Line Mitopure Urolithin A, 10% off Code MODERN https://tidd.ly/4bLCpgu Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    57 min
  5. Beyond Senolytics: Immune Approaches to Senescent Cell Clearance | Dr Amit Sharma

    May 5

    Beyond Senolytics: Immune Approaches to Senescent Cell Clearance | Dr Amit Sharma

    Senescent cells — cells that have stopped dividing but refuse to die — accumulate with age and are increasingly recognised as a key driver of age-related disease. Most people in the longevity space are familiar with senolytics like dasatinib and quercetin, but a potentially more precise approach is emerging: harnessing the immune system itself to find and eliminate senescent cells. Dr. Amit Sharma leads the senescence immunology group at the Lifespan Research Institute, where his lab studies how natural killer cells and gamma delta T cells interact with senescent cells — and how that relationship breaks down with age. In this conversation, we explore the biology of immune surveillance of senescence, why it fails as we get older, and what his lab is doing to restore and enhance it. We also discuss the iron-ferroptosis connection, next-generation senolytics, and what the next decade might bring for senotherapy. 🌐Links in this video Lifespan Research Institute: https://lifespanresearchinstitute.io Dr Sharma's lab page https://lifespan.io/our-research/sharma-lab/ Time-Line Mitopure Urolithin A, 10% off Code MODERN https://tidd.ly/4bLCpgu Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    56 min
  6. The Aging Expert Reveals the Top 4 Longevity Molecules | Dr Nir Barzilai

    Apr 27

    The Aging Expert Reveals the Top 4 Longevity Molecules | Dr Nir Barzilai

    Longevity researcher Nir Barzilai on what centenarians reveal about aging and the four drugs scientists believe may target it directly. Dr Nir Barzilai has spent decades studying people who live to 100 and beyond. What he's found challenges many assumptions about aging, disease, and what we can actually do about them. In this conversation we cover what centenarian research really shows, including why they get the same diseases as the rest of us, just decades later, and what that means for the goal of longevity medicine. We then move into the practical territory: what criteria distinguish a drug that treats one disease from one that may target aging itself, which four currently approved drugs score highest on that framework, and how leading longevity physicians are beginning to use them in practice. We also discuss GLP-1 agonists in depth; their mechanisms, the emerging evidence for benefits well beyond weight loss, and the important caveats around muscle loss. Essential viewing for anyone following the science of healthy aging. 🌐Links in this video Dr Barzilai at Albert Einstein College of Medicine https://einsteinmed.edu/faculty/484/nir-barzilai Healthy Longevity Medicine Society https://hlms.co/ American Federation for Aging Research https://www.afar.org/ Academy for Health & Lifespan Research https://www.ahlresearch.org/ Time-Line Mitopure Urolithin A, 10% off Code MODERN https://tidd.ly/4bLCpgu Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    1 hr
  7. Targeting Visceral Fat and the Future of Weight-Independent Longevity| Dr. Mikhail Kolonin

    Apr 22

    Targeting Visceral Fat and the Future of Weight-Independent Longevity| Dr. Mikhail Kolonin

    GLP-1 drugs likesemaglutide and ozempic have become household names but how much do we reallyunderstand about what they're doing inside the body? In this episode I sit downwith Dr. Mikhail Kolonin, Professor and Director of the Center for Metabolicand Degenerative Diseases at UTHealth Houston's McGovern Medical School, whoselab has spent years uncovering the deeper biology of these drugs. We go far beyondweight loss. Dr. Kolonin explains how GLP-1 drugs trigger IL-6 signaling in fattissue, activating a thermogenic program that converts metabolically inactivewhite fat into energy-burning brown fat and how in some patients this isaccompanied by upregulation of telomerase, a protein with profound implicationsfor mitochondrial health and aging. We also tackle the muscle loss questiondirectly, examining what the latest research reveals about why lean mass losson GLP-1s exceeds simple caloric restriction, and what can realistically bedone about it.   🌐Linksin this video Dr Kolonin's page https://gsbs.uth.edu/directory/profile?id=b816c8de-c9b0-40f0-873c-42fa69db82e9   Time-LineMitopure Urolithin A, 10% off Code MODERN https://tidd.ly/4bLCpgu Qitone (10%off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder SeekingHealth supplements: 10% discount code Richard10https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrientshttps://crrnt.app/SEEK/EpM7paAO AX3 LifeAstaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15%discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Scienceall 10% discount with code MHS https://renuebyscience.com/  Nuchido Time+ 20% discount offirst purchase with code MODERN20 https://nuchido.com/MODERN If you would like tosupport our channel please consider signing up on patreonhttps://patreon.com/ModernHealthspan You can also find us onYouTube at https://www.youtube.com/c/modernhealthspan

    1h 6m
  8. How Urolithin A Boosts Muscle, Immune Function, and Brain Health | Dr. Anurag Singh

    Apr 13

    How Urolithin A Boosts Muscle, Immune Function, and Brain Health | Dr. Anurag Singh

    Dr. Anurag Singh, Chief Scientific Officer at Timeline Nutrition joins Modern Healthspan for an in-depth conversation about urolithin A and the science of mitophagy, the cellular process that cleans out damaged mitochondria. We explore the clinical evidence from multiple human trials: the ATLAS trial showing 12% muscle strength gains and 10% VO2 max improvements in sedentary middle-aged adults, independent studies in elite athletes demonstrating enhanced recovery and performance, and the groundbreaking MitoImmune trial published in Nature Aging revealing 20% increases in immune cell mitochondria in just 28 days. Dr. Singh provides practical guidance on dosing (500mg vs 1000mg), timing, and who benefits most from supplementation. We discuss why only 30% of people can produce urolithin A naturally from foods like pomegranates and berries, and how direct supplementation overcomes this limitation. Looking ahead, we cover Timeline's Healthspan XPrize semi-finalist status, ongoing blood-brain barrier research setting the stage for brain health trials, and Dr. Singh's vision for combining mitophagy activation with emerging therapies like mitochondrial transplantation. He also shares why he believes mitochondrial dysfunction is "the mother of all hallmarks of aging." Whether you're interested in the science of healthy aging, considering urolithin A supplementation, or want to understand the future of longevity medicine, this comprehensive conversation provides the evidence and insights you need. Topics covered: • What urolithin A is and how mitophagy works • ATLAS trial results: muscle, endurance, and inflammation • MitoImmune trial: immune system rejuvenation • Practical supplementation guide • Brain health research and future directions • The role of mitochondrial health in aging 🌐Links in this video Time-Line home page https://www.timeline.com/ ATLAS Trial: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults https://pubmed.ncbi.nlm.nih.gov/35584623/ Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial https://www.nature.com/articles/s43587-025-00996-x Time-Line Mitopure Urolithin A, 10% off Code MODERN https://tidd.ly/4bLCpgu Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw https://www.choosemuse.com Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

    55 min
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3.8
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About

Our channel provides longevity, anti-aging and health information. We interview experts in their field to get the latest information in the longevity space. You can also come to our YouTube channel for more information here https://www.youtube.com/channel/UCLFEKx_LchTLy_XwjPToJ3A

Information

  • Creator
    Modern Healthspan
  • Years Active
    2021 - 2026
  • Episodes
    358
  • Rating
    Clean
  • Copyright
    © Modern Healthspan
  • Show Website
    Modern Healthspan

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